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Chemistry

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Also known as: 25681-89-4, Medronate disodium [usan], Disodium methylene diphosphonate, Disodium medronate, Disodium dihydrogen methylenediphosphonate, Hay5mt18l3
Molecular Formula
CH4Na2O6P2
Molecular Weight
219.97  g/mol
InChI Key
RXSYPQBNTPQOTQ-UHFFFAOYSA-L
FDA UNII
HAY5MT18L3

Medronate Disodium
1 2D Structure

Medronate Disodium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
disodium;hydroxy-[[hydroxy(oxido)phosphoryl]methyl]phosphinate
2.1.2 InChI
InChI=1S/CH6O6P2.2Na/c2-8(3,4)1-9(5,6)7;;/h1H2,(H2,2,3,4)(H2,5,6,7);;/q;2*+1/p-2
2.1.3 InChI Key
RXSYPQBNTPQOTQ-UHFFFAOYSA-L
2.1.4 Canonical SMILES
C(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+]
2.2 Other Identifiers
2.2.1 UNII
HAY5MT18L3
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Disodium Methanediphosphonate

2. Methane Diphosphonate

3. Methylene Diphosphonate

4. Methylene Diphosphonate, (32)p-labeled

5. Methylene Diphosphonate, Disodium Salt

6. Methylene Diphosphonate, Tetrasodium Salt

7. Methylene Diphosphonate, Tetrasodium Salt, (32)p-labeled

8. Methylene Diphosphonate, Tin(4+) Salt, (113)sn-labeled

9. Methylene Diphosphonate, Trisodium Salt

10. Methylene Diphosphonic Acid

2.3.2 Depositor-Supplied Synonyms

1. 25681-89-4

2. Medronate Disodium [usan]

3. Disodium Methylene Diphosphonate

4. Disodium Medronate

5. Disodium Dihydrogen Methylenediphosphonate

6. Hay5mt18l3

7. Disodium Hydroxy-[[hydroxy(oxido)phosphoryl]methyl]phosphinate

8. Methylenebisphosphonic Acid-p,p'-disodium Salt

9. Phosphonic Acid, Methylenebis-, Disodium Dihydrogen Salt

10. Phosphonic Acid, P , P '-methylenebis-

11. Disodium;hydroxy-[[hydroxy(oxido)phosphoryl]methyl]phosphinate

12. Medronate Disodium (usan)

13. Sodium Methylenediphosphonate

14. Unii-hay5mt18l3

15. Disodium Methanediphosphonate

16. Schembl133343

17. Medronate Disodium [ii]

18. Chembl2105165

19. Dtxsid70948566

20. Medronate Disodium [vandf]

21. Medronate Disodium [mart.]

22. Medronate Disodium [who-dd]

23. Mfcd02258977

24. Akos017345141

25. D04886

26. Q27279835

27. Phosphonic Acid, P,p'-methylenebis-, Sodium Salt (1:2)

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 219.97 g/mol
Molecular Formula CH4Na2O6P2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass219.92785040 g/mol
Monoisotopic Mass219.92785040 g/mol
Topological Polar Surface Area121 Ų
Heavy Atom Count11
Formal Charge0
Complexity147
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Information
1 of 1  
Drug NameCis-mdp
PubMed HealthTechnetium Tc 99m Medronate
Drug ClassesDiagnostic Agent, Radiopharmaceutical Imaging
Active IngredientTechnetium tc-99m medronate
Dosage FormInjectable
RouteInjection
Strengthn/a
Market StatusPrescription
CompanyPharmalucence

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Bone Density Conservation Agents

Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. (See all compounds classified as Bone Density Conservation Agents.)


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