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Medronate Disodium

Synopsis, Chemistry

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Also known as: 25681-89-4, Medronate disodium [usan], Disodium methylene diphosphonate, Disodium medronate, Disodium dihydrogen methylenediphosphonate, Hay5mt18l3

Molecular Formula

CH₄Na₂O₆P₂

Molecular Weight

219.97 g/mol

InChI Key

RXSYPQBNTPQOTQ-UHFFFAOYSA-L

FDA UNII

HAY5MT18L3

1 2D Structure

Medronate Disodium

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

disodium;hydroxy-[[hydroxy(oxido)phosphoryl]methyl]phosphinate

2.1.2 InChI

InChI=1S/CH6O6P2.2Na/c2-8(3,4)1-9(5,6)7;;/h1H2,(H2,2,3,4)(H2,5,6,7);;/q;2*+1/p-2

2.1.3 InChI Key

RXSYPQBNTPQOTQ-UHFFFAOYSA-L

2.1.4 Canonical SMILES

C(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+]

2.2 Other Identifiers

2.2.1 UNII

HAY5MT18L3

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Disodium Methanediphosphonate

2. Methane Diphosphonate

3. Methylene Diphosphonate

4. Methylene Diphosphonate, (32)p-labeled

5. Methylene Diphosphonate, Disodium Salt

6. Methylene Diphosphonate, Tetrasodium Salt

7. Methylene Diphosphonate, Tetrasodium Salt, (32)p-labeled

8. Methylene Diphosphonate, Tin(4+) Salt, (113)sn-labeled

9. Methylene Diphosphonate, Trisodium Salt

10. Methylene Diphosphonic Acid

2.3.2 Depositor-Supplied Synonyms

1. 25681-89-4

2. Medronate Disodium [usan]

3. Disodium Methylene Diphosphonate

4. Disodium Medronate

5. Disodium Dihydrogen Methylenediphosphonate

6. Hay5mt18l3

7. Disodium Hydroxy-[[hydroxy(oxido)phosphoryl]methyl]phosphinate

8. Methylenebisphosphonic Acid-p,p'-disodium Salt

9. Phosphonic Acid, Methylenebis-, Disodium Dihydrogen Salt

10. Phosphonic Acid, P , P '-methylenebis-

11. Disodium;hydroxy-[[hydroxy(oxido)phosphoryl]methyl]phosphinate

12. Medronate Disodium (usan)

13. Sodium Methylenediphosphonate

14. Unii-hay5mt18l3

15. Disodium Methanediphosphonate

16. Schembl133343

17. Medronate Disodium [ii]

18. Chembl2105165

19. Dtxsid70948566

20. Medronate Disodium [vandf]

21. Medronate Disodium [mart.]

22. Medronate Disodium [who-dd]

23. Mfcd02258977

24. Akos017345141

25. D04886

26. Q27279835

27. Phosphonic Acid, P,p'-methylenebis-, Sodium Salt (1:2)

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	CH₄Na₂O₆P₂
Molecular Weight	219.97 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	219.92785040 g/mol
Monoisotopic Mass	219.92785040 g/mol
Topological Polar Surface Area	121 Å²
Heavy Atom Count	11
Formal Charge	0
Complexity	147
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Drug Information

1 of 1
Drug Name	Cis-mdp
PubMed Health	Technetium Tc 99m Medronate
Drug Classes	Diagnostic Agent, Radiopharmaceutical Imaging
Active Ingredient	Technetium tc-99m medronate
Dosage Form	Injectable
Route	Injection
Strength	n/a
Market Status	Prescription
Company	Pharmalucence

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Bone Density Conservation Agents

Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. (See all compounds classified as Bone Density Conservation Agents.)