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    Chemistry

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    Also known as: Medroxyprogesterone 17-acetate, 71-58-9, Provera, Metigestrona, Depo-provera, Farlutin
    Molecular Formula
    C24H34O4
    Molecular Weight
    386.5  g/mol
    InChI Key
    PSGAAPLEWMOORI-PEINSRQWSA-N
    FDA UNII
    C2QI4IOI2G
    Medroxyprogesterone Acetate
    A synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms.
    1 2D Structure

    Medroxyprogesterone Acetate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [(6S,8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
    2.1.2 InChI
    InChI=1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1
    2.1.3 InChI Key
    PSGAAPLEWMOORI-PEINSRQWSA-N
    2.1.4 Canonical SMILES
    CC1CC2C(CCC3(C2CCC3(C(=O)C)OC(=O)C)C)C4(C1=CC(=O)CC4)C
    2.1.5 Isomeric SMILES
    C[C@H]1C[C@@H]2[C@H](CC[C@]3([C@H]2CC[C@@]3(C(=O)C)OC(=O)C)C)[C@@]4(C1=CC(=O)CC4)C
    2.2 Other Identifiers
    2.2.1 UNII
    C2QI4IOI2G
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. (6 Alpha)-17-(acetoxy)-6-methylpregn-4-ene-3,20-dione

    2. 6 Alpha Methyl 17alpha Hydroxyprogesterone Acetate

    3. 6-alpha-methyl-17alpha-hydroxyprogesterone Acetate

    4. Curretab

    5. Cycrin

    6. Depo Medroxyprogesterone Acetate

    7. Depo Provera

    8. Depo-medroxyprogesterone Acetate

    9. Depo-provera

    10. Depoprovera

    11. Farlutal

    12. Gestapuran

    13. Medroxyprogesterone 17 Acetate

    14. Medroxyprogesterone 17-acetate

    15. Medroxyprogesterone 17-acetate, (6 Alpha,17 Alpha)-isomer

    16. Medroxyprogesterone 17-acetate, (6 Beta)-isomer

    17. Perlutex

    18. Pregn-4-ene-3,20-dione, 17-(acetyloxy)-6-methyl-, (6alpha)-

    19. Provera

    20. Veramix

    2.3.2 Depositor-Supplied Synonyms

    1. Medroxyprogesterone 17-acetate

    2. 71-58-9

    3. Provera

    4. Metigestrona

    5. Depo-provera

    6. Farlutin

    7. Gestapuran

    8. Perlutex

    9. Veramix

    10. Methylacetoxyprogesterone

    11. Amen

    12. Medroxyacetate Progesterone

    13. Clinovir

    14. Depcorlutin

    15. Deporone

    16. Lutopolar

    17. Nadigest

    18. Prodasone

    19. Progestalfa

    20. Progevera

    21. Proverone

    22. Repromix

    23. Sirprogen

    24. Supprestral

    25. Nidaxin

    26. Oragest

    27. Depo-promone

    28. Promone-e

    29. Nsc-26386

    30. 6-alpha-methyl-17-alpha-acetoxyprogesterone

    31. Cycrin

    32. Medroxyprogesteroneacetate

    33. Depo-subq Provera 104

    34. Depot-medroxyprogesterone Acetate

    35. 6-alpha-methyl-17-alpha-hydroxyprogesterone Acetate

    36. 17alpha-hydroxy-6alpha-methylprogesterone Acetate

    37. 6alpha-methyl-17alpha-hydroxyprogesterone Acetate

    38. 6alpha-methyl-4-pregnene-3,20-dion-17alpha-ol Acetate

    39. Depot Medroxyprogesterone Acetate

    40. Dp150

    41. Pregn-4-ene-3,20-dione, 17-(acetyloxy)-6-methyl-, (6alpha)-

    42. 17-acetoxy-6alpha-methylprogesterone

    43. Aragest

    44. Ralovera

    45. 6alpha-methyl-17-acetoxy Progesterone

    46. Hysron

    47. Provera Dosepak

    48. Depo-clinovir

    49. Depo-ralovera

    50. (6alpha)-6-methyl-3,20-dioxopregn-4-en-17-yl Acetate

    51. Nsc-21171

    52. U 8839

    53. C2qi4ioi2g

    54. Medroxyprogesterone (acetate)

    55. Mls000069442

    56. (6alpha)-17-(acetyloxy)-6-methylpreg-4-ene-3,20-dione

    57. Chebi:6716

    58. Onco-provera

    59. Map

    60. Medrosterona

    61. Clinofem

    62. Cykrina

    63. Depocon

    64. Indivina

    65. Mepastat

    66. Meprate

    67. Repromap

    68. Smr000059125

    69. Sumiferm

    70. Suprestral

    71. Tv-46046

    72. Veraplex

    73. Dugen

    74. Pregn-4-ene-3,20-dione, 17-(acetyloxy)-6-methyl-, (6a)-

    75. Depo-progestin

    76. Depo-prodasone

    77. Depo-progevera

    78. Perlutex Leo

    79. Dsstox_cid_5527

    80. Depo-map

    81. Aragest 5

    82. Med-pro

    83. Mpa-beta

    84. Dsstox_rid_77819

    85. Mpa Hexal

    86. Mpa-noury

    87. Dsstox_gsid_25527

    88. [(6s,8r,9s,10r,13s,14s,17r)-17-acetyl-6,10,13-trimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-17-yl] Acetate

    89. Map (steroid)

    90. 17alpha-acetoxy-6alpha-methylprogesterone

    91. 6alpha-methyl-17alpha-acetoxyprogesterone

    92. Depomedroxyprogesterone Acetate

    93. Mpa Gym

    94. Depo-medroxyprogesterone Acetate

    95. Depo-subq Provera

    96. Cas-71-58-9

    97. Ccris 371

    98. 17.alpha.-acetoxy-6.alpha.-methylprogesterone

    99. Medroxyprogesterone Acetate [jan]

    100. Einecs 200-757-9

    101. Unii-c2qi4ioi2g

    102. 6alpha-methyl-17-acetoxyprogesterone

    103. Nsc 21171

    104. Depo-provera Contraceptive

    105. 17-acetoxy-6-alpha-methylprogesterone

    106. (6.alpha.-pregn-4-ene-3, 17-(acetyloxy)-6-methyl-

    107. 17.alpha.-hydroxy-6-.alpha.-methylprogesterone Acetate

    108. Pregn-4-ene-3, 17-hydroxy-6.alpha.-methyl-, Acetate

    109. 6-alpha-methyl-17-acetoxy Progesterone

    110. Brn 2066112

    111. Pregn-4-ene-3, 17-(acetyloxy)-6-methyl-, (6.alpha.)-

    112. Medroxyprogesterone-17-acetate

    113. Ai3-60127

    114. Pregn-4-ene-3,20-dione, 17-(acetyloxy)-6-methyl-, (6.alpha.)-

    115. 17-acetoxy-6.alpha.-methylprogesterone

    116. 6.alpha.-methyl-17-acetoxyprogesterone

    117. Ncgc00094713-01

    118. 17alpha-hydroxy-6-alpha-methylprogesterone Acetate

    119. Progesterone, 17-hydroxy-6alpha-methyl-, Acetate

    120. 17-alpha-hydroxy-6-alpha-methylprogesterone Acetate

    121. Provera (tn)

    122. Depo-provera (tn)

    123. 6alpha-methyl-17alpha-acetoxypregn-4-ene-3,20-dione

    124. Medroxyprogesterone Acetate [usp:jan]

    125. 17-alpha-acetoxy-6-alpha-methylpregn-4-ene-3,20-dione

    126. 17alpha-acetoxy-6-alpha-methylpregn-4-ene-3,20-dione

    127. 6-alpha-methyl-17-alpha-acetoxypregn-4-ene-3,20-dione

    128. Progesterone, 17-alpha-hydroxy-6-alpha-methyl-, Acetate

    129. Medroxyprogesterone Acetate [progestins]

    130. 6-alpha-methyl-4-pregnene-3,20-dion-17-alpha-ol Acetate

    131. 6.alpha.-methyl-17.alpha.-acetoxyprogesterone

    132. (6-alpha)-17-(acetyloxy)-6-methylpreg-4-ene-3,20-dione

    133. 17alpha-hydroxy-6alpha-methylpregn-4-ene-3,20-dione Acetate

    134. 6alpha-pregn-4-ene-3,20-dione, 17-(acetyloxy)-6-methyl-

    135. Cpd000653524

    136. 17-alpha-hydroxy-6-alpha-methylpregn-4-ene-3,20-dione Acetate

    137. Medroxyprogesteroni Acetas

    138. Opera_id_1110

    139. Medroxyprogesterone-acetate

    140. 17.alpha.-hydroxy-6.alpha.-methylprogesterone Acetate

    141. 6.alpha.-methyl-17.alpha.-hydroxyprogesterone Acetate

    142. Medroxiprogesterone Acetate

    143. Chembl717

    144. Schembl4276

    145. 6.alpha.-methyl-17.alpha.-acetoxypregn-4-ene-3,20-dione

    146. 17.alpha.-acetoxy-6-.alpha.-methylpregn-4-ene-3,20-dione

    147. 4-08-00-02212 (beilstein Handbook Reference)

    148. 6.alpha.-methyl-4-pregnene-3,20-dion-17.alpha.-ol Acetate

    149. Mls001148217

    150. Mls002207115

    151. 17.alpha.-hydroxy-6.alpha.-methylpregn-4-ene-3,20-dione Acetate

    152. Depo-subq Provera 104 (tn)

    153. Dtxsid0025527

    154. Hms2233o07

    155. Hms2235e05

    156. Hms3259o14

    157. Hms3884b10

    158. Pregn-4-ene-3,20-dione, 17-hydroxy-6alpha-methyl-, Acetate

    159. (6-alpha)-pregn-4-ene-3,20-dione, 17-(acetyloxy)-6-methyl-

    160. (6s,8r,9s,10r,13s,14s,17r)-17-acetyl-6,10,13-trimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl Acetate

    161. Cbp-1011

    162. Hy-b0469

    163. Nsc21171

    164. Nsc26386

    165. Zinc5029557

    166. Tox21_111319

    167. Tox21_200141

    168. Bdbm50067678

    169. S2567

    170. Akos015894870

    171. Tox21_111319_1

    172. Ac-2174

    173. Ccg-264965

    174. Db00603

    175. Nc00574

    176. Medroxyprogesterone Acetate (jp17/usp)

    177. Mrf-0000023

    178. Ncgc00022037-03

    179. Ncgc00022037-04

    180. Ncgc00022037-05

    181. Ncgc00022037-07

    182. Ncgc00257695-01

    183. Ncgc00263480-01

    184. As-13981

    185. Medroxyprogesterone Acetate [iarc]

    186. Smr000653524

    187. Medroxyprogesterone Acetate [mart.]

    188. Medroxyprogesterone Acetate [vandf]

    189. Medroxyprogesterone 17-acetate [mi]

    190. Medroxyprogesterone Acetate [usp-rs]

    191. Medroxyprogesterone Acetate [who-dd]

    192. Medroxyprogesterone Acetate [who-ip]

    193. C08150

    194. C76275

    195. D00951

    196. Ab00384270-14

    197. Ab00384270_15

    198. Medroxyprogesterone 17-acetate, >=97% (hplc)

    199. Medroxyprogesterone Acetate [orange Book]

    200. Medroxyprogesteroni Acetas [who-ip Latin]

    201. 010m483

    202. Medroxyprogesterone Acetate [ep Monograph]

    203. Medroxyprogesterone Acetate [usp Monograph]

    204. Megestrol Acetate Impurity A [ep Impurity]

    205. Lunelle Component Medroxyprogesterone Acetate

    206. Prempro Component Medroxyprogesterone Acetate

    207. Q2823834

    208. (6?)-6-methyl-3,20-dioxopregn-4-en-17-yl Acetate

    209. 6.alpha.-pregn-4-ene-3, 17-(acetyloxy)-6-methyl-

    210. Medroxyprogesterone Acetate Component Of Lunelle

    211. Medroxyprogesterone Acetate Component Of Prempro

    212. Premphase Component Medroxyprogesterone Acetate

    213. Medroxyprogesterone Acetate Component Of Premphase

    214. Medroxyprogesterone 17-acetate 100 Microg/ml In Methanol/water

    215. Medroxyprogesterone-17-acetate 100 Microg/ml In Acetonitrile

    216. 17-hydroxy-6.alpha.-methylpregn-4-ene-3,20-dione Acetate

    217. Medroxyprogesterone 17-acetate, Vetranal(tm), Analytical Standard

    218. Medroxyprogesterone Acetate, European Pharmacopoeia (ep) Reference Standard

    219. Medroxyprogesterone Acetate, Pharmaceutical Secondary Standard; Certified Reference Material

    220. Medroxyprogesterone Acetate, United States Pharmacopeia (usp) Reference Standard

    221. Medroxyprogesterone Acetate For Peak Identification, European Pharmacopoeia (ep) Reference Standard

    222. Medroxyprogesterone Acetate For System Suitability, European Pharmacopoeia (ep) Reference Standard

    223. Medroxyprogesterone Acetate, For Performance Test, European Pharmacopoeia (ep) Reference Standard

    2.4 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 386.5 g/mol
    Molecular Formula C24H34O4
    XLogP34.1
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count3
    Exact Mass386.24570956 g/mol
    Monoisotopic Mass386.24570956 g/mol
    Topological Polar Surface Area60.4 Ų
    Heavy Atom Count28
    Formal Charge0
    Complexity767
    Isotope Atom Count0
    Defined Atom Stereocenter Count7
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 8  
    Drug NameDepo-provera
    PubMed HealthMedroxyprogesterone
    Drug ClassesAntineoplastic Agent, Contraceptive, Contraceptive, Progestin, Endocrine-Metabolic Agent
    Drug LabelDepo-Provera CI contains medroxyprogesterone acetate, a derivative of progesterone, as its active ingredient. Medroxyprogesterone acetate is active by the parenteral and oral routes of administration. It is a white to off-white; odorless crystalline...
    Active IngredientMedroxyprogesterone acetate
    Dosage FormInjectable
    RouteInjection
    Strength400mg/ml; 150mg/ml
    Market StatusPrescription
    CompanyPharmacia And Upjohn

    2 of 8  
    Drug NameDepo-subq provera 104
    PubMed HealthMedroxyprogesterone
    Drug ClassesAntineoplastic Agent, Contraceptive, Contraceptive, Progestin, Endocrine-Metabolic Agent
    Drug LabelMedroxyprogesterone acetate tablets contain medroxyprogesterone acetate, which is a derivative of progesterone. It is a white to off-white, odorless crystalline powder, stable in air, melting between 200 and 210It is freely soluble in chloroform, sol...
    Active IngredientMedroxyprogesterone acetate
    Dosage FormInjectable
    Routesuspension; Subcutaneous
    Strength104mg/0.65ml
    Market StatusPrescription
    CompanyPfizer; Pharmacia And Upjohn

    3 of 8  
    Drug NameMedroxyprogesterone acetate
    Drug Labeldepo-subQ provera 104 contains medroxyprogesterone acetate (MPA), a derivative of progesterone, as its active ingredient. Medroxyprogesterone acetate is active by the parenteral and oral routes of administration. It is a white to off-white, odorless...
    Active IngredientMedroxyprogesterone acetate
    Dosage FormTablet; Injectable
    RouteInjection; Oral
    Strength2.5mg; 150mg/ml; 5mg; 10mg
    Market StatusPrescription
    CompanyTeva Pharms Usa; Sandoz; Barr

    4 of 8  
    Drug NameProvera
    Active IngredientMedroxyprogesterone acetate
    Dosage FormTablet
    RouteOral
    Strength2.5mg; 5mg; 10mg
    Market StatusPrescription
    CompanyPharmacia And Upjohn

    5 of 8  
    Drug NameDepo-provera
    PubMed HealthMedroxyprogesterone
    Drug ClassesAntineoplastic Agent, Contraceptive, Contraceptive, Progestin, Endocrine-Metabolic Agent
    Drug LabelDepo-Provera CI contains medroxyprogesterone acetate, a derivative of progesterone, as its active ingredient. Medroxyprogesterone acetate is active by the parenteral and oral routes of administration. It is a white to off-white; odorless crystalline...
    Active IngredientMedroxyprogesterone acetate
    Dosage FormInjectable
    RouteInjection
    Strength400mg/ml; 150mg/ml
    Market StatusPrescription
    CompanyPharmacia And Upjohn

    6 of 8  
    Drug NameDepo-subq provera 104
    PubMed HealthMedroxyprogesterone
    Drug ClassesAntineoplastic Agent, Contraceptive, Contraceptive, Progestin, Endocrine-Metabolic Agent
    Drug LabelMedroxyprogesterone acetate tablets contain medroxyprogesterone acetate, which is a derivative of progesterone. It is a white to off-white, odorless crystalline powder, stable in air, melting between 200 and 210It is freely soluble in chloroform, sol...
    Active IngredientMedroxyprogesterone acetate
    Dosage FormInjectable
    Routesuspension; Subcutaneous
    Strength104mg/0.65ml
    Market StatusPrescription
    CompanyPfizer; Pharmacia And Upjohn

    7 of 8  
    Drug NameMedroxyprogesterone acetate
    Drug Labeldepo-subQ provera 104 contains medroxyprogesterone acetate (MPA), a derivative of progesterone, as its active ingredient. Medroxyprogesterone acetate is active by the parenteral and oral routes of administration. It is a white to off-white, odorless...
    Active IngredientMedroxyprogesterone acetate
    Dosage FormTablet; Injectable
    RouteInjection; Oral
    Strength2.5mg; 150mg/ml; 5mg; 10mg
    Market StatusPrescription
    CompanyTeva Pharms Usa; Sandoz; Barr

    8 of 8  
    Drug NameProvera
    Active IngredientMedroxyprogesterone acetate
    Dosage FormTablet
    RouteOral
    Strength2.5mg; 5mg; 10mg
    Market StatusPrescription
    CompanyPharmacia And Upjohn

    4.2 Drug Indication

    Medroxyprogesterone acetate (MPA) oral tablets are indicated to treat secondary amenorrhea, reduce the incidence of endometrial hyperplasia in postmenopausal women, and to treat abnormal uterine bleeding due to hormonal imbalance, not organic pathology. Oral tablets containing MPA and conjugated estrogens are indicated to prevent postmenopausal osteoporosis and to treat moderate to severe menopausal symptoms such as vasomotor symptoms, vulvar atrophy, and vaginal atrophy. Subcutaneous MPA is indicated to prevent pregnancy and manage pain associated with endometriosis. Intramuscular MPA is indicated to prevent pregnancy, and at higher concentrations for palliative treatment of endometrial or renal carcinoma.

    FDA Label

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Medroxyprogesterone acetate (MPA) inhibits gonadotropin production, reduces nuclear estrogen receptors and DNA synthesis in epithelial cells of the endometrium, and induces p53 dependant apoptosis in cancer cell lines. MPA oral tablets have a half life of 40-60 hours and other formulations can have half lives that are considerably longer, so the duration of action is long. The therapeutic window is wide as patients may take doses ranging from 5mg orally daily to 1000mg as a depo injection weekly. Long term use of MPA is associated with a reduction in bone density and patients who taking MPA during adolescence may have lower peak bone mass than untreated patients, which can also increase the risk of osteoporosis and fractures in the future.

    5.2 MeSH Pharmacological Classification

    Contraceptive Agents, Female

    Chemical substances or agents with contraceptive activity in females. Use for female contraceptive agents in general or for which there is no specific heading. (See all compounds classified as Contraceptive Agents, Female.)

    Contraceptive Agents, Male

    Chemical substances or agents with contraceptive activity in males. Use for male contraceptive agents in general or for which there is no specific heading. (See all compounds classified as Contraceptive Agents, Male.)

    Antineoplastic Agents, Hormonal

    Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079) (See all compounds classified as Antineoplastic Agents, Hormonal.)

    Contraceptive Agents, Hormonal

    Contraceptive agents that act on the ENDOCRINE SYSTEM. (See all compounds classified as Contraceptive Agents, Hormonal.)

    5.3 FDA Pharmacological Classification
    5.3.1 Pharmacological Classes
    Progestin [EPC]; Progesterone Congeners [CS]
    5.4 Absorption, Distribution and Excretion

    Absorption

    Absorption of oral medroxyprogesterone acetate (MPA) varies considerably between formulations. A 1000mg oral dose reaches an average Cmax of 145-315nmol/L while a 500mg oral dose reaches an average Cmax of 33-178nmol/L with a Tmax of 1-3 hours and a lag time of half an hour. The AUC of a 500mg oral dose of MPA was 543.4-1981.1nmol\*L/h depending on formulation. Intramuscular MPA reaches a Cmax of 4.691.52nmol/L with a Tmax of 4.752.09 days and an AUC of 81.5827.64days\*nmol/L. Subcutaneous MPA reaches a Cmax of 3.831.56nmol/L with a Tmax of 6.522.07 days and an AUC of 72.2638.73days\*nmol/L. However, the pharmacokinetics of MPA may also vary depending on injection site.

    Route of Elimination

    The majority of medroxyprogesterone acetate (MPA) is eliminated in the urine as glucuronide conjugates and a minority of sulphate conjugates. Glucuronide conjugates are also detected in the feces. Determining the exact ratio of metabolites and parent compound eliminated in the urine and feces is difficult as the metabolite profile in the urine is not significantly different and radio labelling studies are not readily available.

    Volume of Distribution

    The volume of distribution of medroxyprogesterone acetate is 203L.

    Clearance

    The mean clearance of medroxyprogesterone acetate (MPA) is 1668146L/day or 21.94.3L/kg/day. Due to the high inter patient variability in MPA pharmacokinetics, clearance has been reported to be 1600-4000L/day.

    5.5 Metabolism/Metabolites

    Medroxyprogesterone acetate undergoes beta hydroxylation to form the metabolites 6-beta (M-2), 2-beta (M-4), and 1-beta-hydroxymedroxyprogesterone acetate (M-3). M-2 and M-4 are further metabolized to 2-beta,6-beta-dihydroxymedroxyprogesterone (M-1). M-3 is further metabolized to 1,2-dehydromedroxyprogesterone acetate (M-5).

    Medroxyprogesterone Acetate has known human metabolites that include M-2, M-3, and Medroxyprogesterone Acetate.

    S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560

    5.6 Biological Half-Life

    Oral medroxyprogesterone acetate (MPA) has an absorption half life of 15-30min and a biological half life of 40-60 hours. Intramuscular MPA has an absorption half life of 0.860.30 days and an elimination half life of 24.0321.74 days. Subcutaneous MPA has an absorption half life of 1.050.56 days and an elimination half life of 30.9015.11 days.

    5.7 Mechanism of Action

    Medroxyprogesterone acetate (MPA) inhibits the production of gonadotropin, preventing follicular maturation and ovulation, which is responsible for its ability to prevent pregnancy. This action also thins the endometrium. MPA reduces nuclear estrogen receptors and DNA synthesis in epithelial cells of the endometrium. MPA can also induce p53 dependant apoptosis in certain cancer cell lines, and inhibit GABA-A receptors.

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LIMITED","customerCountry":"INDIA","quantity":"212.00","actualQuantity":"212","unit":"KGS","unitRateFc":"650","totalValueFC":"139113.5","currency":"USD","unitRateINR":"54990","date":"27-Sep-2024","totalValueINR":"11657880","totalValueInUsd":"139113.5","indian_port":"Bombay Air","hs_no":"29372300","bill_no":"5834486","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"SEGRATE AIRPRT MILAN","supplierAddress":"VIA PAVIA 1,GROPELLO CAIROLI PV 27027 SDNF IT","customerAddress":"23-24, KALPTARU COURT, DR.C.G.ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728844200,"product":"MEDROXYPROGESTERONE ACETATE IP","address":"304,MOHAN PLACE,L.S.C.BLOCK-C","city":"DELHI","supplier":"ZHEJIANG XIANJU PHARMACEUTICAL CO,LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"AKUMS DRUGS & PHARMACEUTICALS LTD","customerCountry":"INDIA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"300","totalValueFC":"30294","currency":"USD","unitRateINR":"25455","date":"14-Oct-2024","totalValueINR":"2545500","totalValueInUsd":"30294","indian_port":"Delhi Air","hs_no":"29372300","bill_no":"6104528","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"NO.1 XIANYAO ROAD XIANJU ZHEJIANG X IANJU, Zhejiang, CHINA SDNF CHINA","customerAddress":"304,MOHAN PLACE,L.S.C.BLOCK-C"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1731349800,"product":"MEDROXYPROGESTERONE ACETATE","address":"NARBAVI, NO.3,LAKSHMANAN STREET,","city":"CHENNAI\/TAMILNADU","supplier":"HUBEI GEDIAN HUMANWELL PHARMACEUTICAL CO., L TD.","supplierCountry":"CHINA","foreign_port":"WUHAN","customer":"CAPLIN POINT LABORATORIES LIMITED","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"400","totalValueFC":"403.8","currency":"USD","unitRateINR":"34080","date":"12-Nov-2024","totalValueINR":"34080","totalValueInUsd":"403.8","indian_port":"Madras Air","hs_no":"29372900","bill_no":"6632224","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"WUHAN","supplierAddress":"GEDIAN ECONOMIC DEVELOPMENT DISTRICT, E-ZHOU436070, HUBEI, CHINA CN","customerAddress":"NARBAVI, NO.3,LAKSHMANAN STREET,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1731349800,"product":"MEDROXYPROGESTERONE","address":"30 ABHISHEK AVENUE","city":"BHARUCH","supplier":"ZHEJIANG UEASY BUSINESS ","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"SANJIVANI PHARMA","customerCountry":"INDIA","quantity":"18.72","actualQuantity":"18.72","unit":"KGS","unitRateFc":"240","totalValueFC":"4536","currency":"USD","unitRateINR":"20448","date":"12-Nov-2024","totalValueINR":"382786.56","totalValueInUsd":"4536","indian_port":"Bombay Air","hs_no":"29372900","bill_no":"6627143","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"ROOM 302 NO.22 CHANGCHENG STREET GO NGSHU DISTRICT HANGZHOU CHINA SDNF CHINA","customerAddress":"30 ABHISHEK AVENUE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1732041000,"product":"MEDROXYPROGESTERONE ACETATE USP","address":"515 MODERN INDUSTRIAL ESTATE","city":"BAHADURGARH","supplier":"TIANJIN FENGHE PHARMACEUTICALS CO.,LTD","supplierCountry":"CHINA","foreign_port":"HANGCHOW (HANGZHOU)","customer":"BELCO PHARMA","customerCountry":"INDIA","quantity":"30.00","actualQuantity":"30","unit":"KGS","unitRateFc":"360","totalValueFC":"10916.7","currency":"USD","unitRateINR":"30708","date":"20-Nov-2024","totalValueINR":"921240","totalValueInUsd":"10916.7","indian_port":"Delhi Air","hs_no":"29372900","bill_no":"6774385","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HANGCHOW (HANGZHOU)","supplierAddress":"14-1-202 YANG LIU QING LIU YUAN, XIQING DISTRICT, TIANJIN,, CHINA","customerAddress":"515 MODERN INDUSTRIAL ESTATE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1732127400,"product":"MEDROXYPROGESTERONE ACETATE (D.I.LIC NO.IL\/BD-012903 RC\/BD-002643)","address":"108, MARINE CHEMBERS, 43, NEW","city":"MUMBAI","supplier":"WUHAN JIULONG PHARMACEUTICAL CO., LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"B.M. CHEMIE","customerCountry":"INDIA","quantity":"75.00","actualQuantity":"75","unit":"KGS","unitRateFc":"330","totalValueFC":"25017.4","currency":"USD","unitRateINR":"28149","date":"21-Nov-2024","totalValueINR":"2111175","totalValueInUsd":"25017.4","indian_port":"Bombay Air","hs_no":"29372900","bill_no":"6790611","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"NO.77, OPTICS VALLEY SEVENTH ROAD, EAST LAKE HIGH-TECH DISTRICT, WHUHA N 430206 HUBEI, , CHINA CHINA","customerAddress":"108, MARINE CHEMBERS, 43, NEW"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1734028200,"product":"MEDROXYPROGESTERONE ACETATE CHEMICALS","address":"NO.18,DR NAIR ROAD, T NAGAR,","city":"CHENNAI","supplier":"TAPI TECHNOLOGY & API SERVICES","supplierCountry":"NETHERLANDS","foreign_port":"MEXICO CITY","customer":"STERIL-GENE LIFE SCIENCES (P) LTD","customerCountry":"INDIA","quantity":"20.00","actualQuantity":"20","unit":"KGS","unitRateFc":"1150","totalValueFC":"23184.3","currency":"USD","unitRateINR":"98497.5","date":"13-Dec-2024","totalValueINR":"1969950","totalValueInUsd":"23184.3","indian_port":"Madras Air","hs_no":"29420090","bill_no":"7214186","productDescription":"API","marketType":"REGULATED MARKET","country":"NETHERLANDS","selfForZScoreResived":"Pharma Grade","supplierPort":"MEXICO CITY","supplierAddress":"PIET HEIN 107 1019 GM AMSTERDAM THE NETHERLANDS NETHERLANDS","customerAddress":"NO.18,DR NAIR ROAD, T NAGAR,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1735151400,"product":"MEDROXYPROGESTERONE ACETATE (D.I.LIC NO.IL\/BD-012903 RC\/BD-002643)MEDROXYPROGESTERONE ACETATE (D.I.LIC NO.IL\/BD-012903 RC\/BD-0","address":"108, MARINE CHEMBERS, 43, NEW","city":"MUMBAI","supplier":"WUHAN JIULONG PHARMACEUTICAL CO., LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"B.M. CHEMIE","customerCountry":"INDIA","quantity":"75.00","actualQuantity":"75","unit":"KGS","unitRateFc":"330","totalValueFC":"25035.8","currency":"USD","unitRateINR":"28363.5","date":"26-Dec-2024","totalValueINR":"2127262.5","totalValueInUsd":"25035.8","indian_port":"Bombay Air","hs_no":"29372900","bill_no":"7463171","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"NO.77, OPTICS VALLEY SEVENTH ROAD, EAST LAKE HIGH-TECH DISTRICT, WHUHA N 430206 HUBEI, , CHINA CHINA","customerAddress":"108, MARINE CHEMBERS, 43, NEW"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1735237800,"product":"MEDROXYPROGESTERONE ACETATE MICRO.ST (BATCH NO.0602494) (90 GMS FREE SAMPLE)","address":"Plot No.564\/A\/22 ,\u00a0 Road No.92,Jubilee Hills ,\u00a0 Hyderabad , \u00a0HYDERABAD ,\u00a0 TELANGANA,\u00a0 500096","city":"N\/A","supplier":"AXPLORA","supplierCountry":"ITALY","foreign_port":"MALPENSA APT\/MILANO","customer":"SENADOR LABORATORIES PRIVATE LIMITED","customerCountry":"INDIA","quantity":"218.00","actualQuantity":"218","unit":"KGS","unitRateFc":"897.9","totalValueFC":"198010","currency":"USD","unitRateINR":"77177.6","date":"27-Dec-2024","totalValueINR":"16824713","totalValueInUsd":"198010","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29372300","bill_no":"1003493","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MALPENSA APT\/MILANO","supplierAddress":"N\/A","customerAddress":"Plot No.564\/A\/22 ,\u00a0 Road No.92,Jubilee Hills ,\u00a0 Hyderabad , \u00a0HYDERABAD ,\u00a0 TELANGANA,\u00a0 500096"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1735237800,"product":"MEDROXYPROGESTERONE ACETATE MICRO ST (BATCH NO.0612494\/0622494) (180 GMS FREE SAMPLE)","address":"Plot No.564\/A\/22 ,\u00a0 Road No.92,Jubilee Hills ,\u00a0 Hyderabad , \u00a0HYDERABAD ,\u00a0 TELANGANA,\u00a0 500096","city":"N\/A","supplier":"AXPLORA","supplierCountry":"ITALY","foreign_port":"MALPENSA APT\/MILANO","customer":"SENADOR LABORATORIES PRIVATE LIMITED","customerCountry":"INDIA","quantity":"435.00","actualQuantity":"435","unit":"KGS","unitRateFc":"900","totalValueFC":"396020.1","currency":"USD","unitRateINR":"77355","date":"27-Dec-2024","totalValueINR":"33649425","totalValueInUsd":"396020.1","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29372300","bill_no":"1003495","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MALPENSA APT\/MILANO","supplierAddress":"VIA PAVIA 1 27027 GROPELLO CAIROLI ITALY","customerAddress":"Plot No.564\/A\/22 ,\u00a0 Road No.92,Jubilee Hills ,\u00a0 Hyderabad , \u00a0HYDERABAD ,\u00a0 TELANGANA,\u00a0 500096"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1735237800,"product":"MEDROXYPROGESTERONE ACETATE MICRO ST.(BATCH NO.0652494\/0662494) (180 GMS FREE SAMPLE)","address":"Plot No.564\/A\/22 ,\u00a0 Road No.92,Jubilee Hills ,\u00a0 Hyderabad , \u00a0HYDERABAD ,\u00a0 TELANGANA,\u00a0 500096","city":"N\/A","supplier":"AXPLORA","supplierCountry":"ITALY","foreign_port":"MALPENSA APT\/MILANO","customer":"SENADOR LABORATORIES PRIVATE LIMITED","customerCountry":"INDIA","quantity":"435.00","actualQuantity":"435","unit":"KGS","unitRateFc":"900","totalValueFC":"396020.1","currency":"USD","unitRateINR":"77355","date":"27-Dec-2024","totalValueINR":"33649425","totalValueInUsd":"396020.1","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29372300","bill_no":"1003494","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MALPENSA APT\/MILANO","supplierAddress":"VIA PAVIA 1 27027 GROPELLO CAIROLI ITALY","customerAddress":"Plot No.564\/A\/22 ,\u00a0 Road No.92,Jubilee Hills ,\u00a0 Hyderabad , \u00a0HYDERABAD ,\u00a0 TELANGANA,\u00a0 500096"}]
    11-Feb-2021
    27-Dec-2024
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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - TABLET;ORAL - 10MG

    USFDA APPLICATION NUMBER - 11839

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    DOSAGE - TABLET;ORAL - 2.5MG

    USFDA APPLICATION NUMBER - 11839

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    DOSAGE - TABLET;ORAL - 5MG

    USFDA APPLICATION NUMBER - 11839

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    DOSAGE - INJECTABLE;INJECTION - 100MG/ML **Fe...DOSAGE - INJECTABLE;INJECTION - 100MG/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 12541

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    DOSAGE - INJECTABLE;INJECTION - 400MG/ML

    USFDA APPLICATION NUMBER - 12541

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    DOSAGE - INJECTABLE;INJECTION - 150MG/ML

    USFDA APPLICATION NUMBER - 20246

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    USP

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    ABOUT THIS PAGE

    Medroxyprogesterone Acetate Manufacturers

    A Medroxyprogesterone Acetate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Medroxyprogesterone Acetate, including repackagers and relabelers. The FDA regulates Medroxyprogesterone Acetate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Medroxyprogesterone Acetate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Medroxyprogesterone Acetate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Medroxyprogesterone Acetate Suppliers

    A Medroxyprogesterone Acetate supplier is an individual or a company that provides Medroxyprogesterone Acetate active pharmaceutical ingredient (API) or Medroxyprogesterone Acetate finished formulations upon request. The Medroxyprogesterone Acetate suppliers may include Medroxyprogesterone Acetate API manufacturers, exporters, distributors and traders.

    click here to find a list of Medroxyprogesterone Acetate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Medroxyprogesterone Acetate USDMF

    A Medroxyprogesterone Acetate DMF (Drug Master File) is a document detailing the whole manufacturing process of Medroxyprogesterone Acetate active pharmaceutical ingredient (API) in detail. Different forms of Medroxyprogesterone Acetate DMFs exist exist since differing nations have different regulations, such as Medroxyprogesterone Acetate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Medroxyprogesterone Acetate DMF submitted to regulatory agencies in the US is known as a USDMF. Medroxyprogesterone Acetate USDMF includes data on Medroxyprogesterone Acetate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Medroxyprogesterone Acetate USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Medroxyprogesterone Acetate suppliers with USDMF on PharmaCompass.

    Medroxyprogesterone Acetate JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Medroxyprogesterone Acetate Drug Master File in Japan (Medroxyprogesterone Acetate JDMF) empowers Medroxyprogesterone Acetate API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Medroxyprogesterone Acetate JDMF during the approval evaluation for pharmaceutical products. At the time of Medroxyprogesterone Acetate JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Medroxyprogesterone Acetate suppliers with JDMF on PharmaCompass.

    Medroxyprogesterone Acetate KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Medroxyprogesterone Acetate Drug Master File in Korea (Medroxyprogesterone Acetate KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Medroxyprogesterone Acetate. The MFDS reviews the Medroxyprogesterone Acetate KDMF as part of the drug registration process and uses the information provided in the Medroxyprogesterone Acetate KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Medroxyprogesterone Acetate KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Medroxyprogesterone Acetate API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Medroxyprogesterone Acetate suppliers with KDMF on PharmaCompass.

    Medroxyprogesterone Acetate CEP

    A Medroxyprogesterone Acetate CEP of the European Pharmacopoeia monograph is often referred to as a Medroxyprogesterone Acetate Certificate of Suitability (COS). The purpose of a Medroxyprogesterone Acetate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Medroxyprogesterone Acetate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Medroxyprogesterone Acetate to their clients by showing that a Medroxyprogesterone Acetate CEP has been issued for it. The manufacturer submits a Medroxyprogesterone Acetate CEP (COS) as part of the market authorization procedure, and it takes on the role of a Medroxyprogesterone Acetate CEP holder for the record. Additionally, the data presented in the Medroxyprogesterone Acetate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Medroxyprogesterone Acetate DMF.

    A Medroxyprogesterone Acetate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Medroxyprogesterone Acetate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Medroxyprogesterone Acetate suppliers with CEP (COS) on PharmaCompass.

    Medroxyprogesterone Acetate NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Medroxyprogesterone Acetate as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Medroxyprogesterone Acetate API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Medroxyprogesterone Acetate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Medroxyprogesterone Acetate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Medroxyprogesterone Acetate NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Medroxyprogesterone Acetate suppliers with NDC on PharmaCompass.

    Medroxyprogesterone Acetate GMP

    Medroxyprogesterone Acetate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Medroxyprogesterone Acetate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Medroxyprogesterone Acetate GMP manufacturer or Medroxyprogesterone Acetate GMP API supplier for your needs.

    Medroxyprogesterone Acetate CoA

    A Medroxyprogesterone Acetate CoA (Certificate of Analysis) is a formal document that attests to Medroxyprogesterone Acetate's compliance with Medroxyprogesterone Acetate specifications and serves as a tool for batch-level quality control.

    Medroxyprogesterone Acetate CoA mostly includes findings from lab analyses of a specific batch. For each Medroxyprogesterone Acetate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Medroxyprogesterone Acetate may be tested according to a variety of international standards, such as European Pharmacopoeia (Medroxyprogesterone Acetate EP), Medroxyprogesterone Acetate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Medroxyprogesterone Acetate USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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