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1. 11-hydroxy-6-methylprogesterone
2. Hms Liquifilm
3. Hms Suspension
1. 2668-66-8
2. Hydroxymesterone
3. Medrifar
4. Medrocort
5. Medritonic
6. Visudrisone
7. Hms Liquifilm
8. 6alpha-methyl-11beta-hydroxyprogesterone
9. U-8471
10. Nsc-63278
11. Medrysone (usan)
12. 11beta-hydroxy-6alpha-methylpregn-4-ene-3,20-dione
13. Gsh 1043
14. (6s,8s,9s,10r,11s,13s,14s,17s)-17-acetyl-11-hydroxy-6,10,13-trimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
15. D2ufc189xf
16. Mls000028714
17. Chebi:34829
18. U 8471
19. 11.beta.-hydroxy-6.alpha.-methylpregn-4-ene-3,20-dione
20. Smr000058693
21. Medrysone [usan]
22. Dsstox_cid_25371
23. Dsstox_rid_80833
24. Dsstox_gsid_45371
25. Medriabioptal
26. Medrysonum
27. Sedesterol
28. Spectramedryn
29. Medrisona
30. Medrisone
31. Medriusar
32. Medroftal
33. Medrisone [dcit]
34. Medrysonum [inn-latin]
35. Medrisona [inn-spanish]
36. Unii-d2ufc189xf
37. Medrysone [usan:usp:inn]
38. Prestwick_89
39. Ncgc00016616-01
40. Cas-2668-66-8
41. Einecs 220-208-7
42. Nsc 63278
43. 11beta-hydroxy-6alpha-methylprogesterone
44. Cpd000058693
45. Medrysone [inn]
46. Opera_id_635
47. Medrysone [mi]
48. 6-alpha-methyl-11-beta-hydroxyprogesterone
49. Prestwick0_000743
50. Prestwick1_000743
51. Prestwick2_000743
52. Prestwick3_000743
53. Medrysone [vandf]
54. Progesterone, 11beta-hydroxy-6alpha-methyl-
55. 11.beta.-hydroxy-6.alpha.-methylprogesterone
56. 6.alpha.-methyl-11.beta.-hydroxyprogesterone
57. Medrysone [mart.]
58. Hms (tn)
59. Medrysone [who-dd]
60. Schembl4493
61. Bspbio_000726
62. Mls001076155
63. Mls002207230
64. Mls002222162
65. Spbio_002665
66. Bpbio1_000800
67. Gtpl7086
68. Medrysone [orange Book]
69. 11-beta-hydroxy-6-alpha-methylpregn-4-ene-3,20-dione
70. Chembl1201173
71. Dtxsid6045371
72. 6-methyl-11-hydroxyprogesterone
73. Bcbcmap01_000088
74. 6a-methyl-11b-hydroxyprogesterone
75. Hms1570e08
76. Hms2097e08
77. Hms2232f13
78. Hms3259a22
79. Hms3714e08
80. Caa66866
81. Hy-b1076
82. Nsc63278
83. Zinc3977945
84. Tox21_110526
85. Akos024285179
86. Pregn-4-ene-3,20-dione, 11-hydroxy-6-methyl-, (6.alpha.,11.beta.)-
87. Tox21_110526_1
88. Ccg-220743
89. Cs-4632
90. Db00253
91. Nc00599
92. Smp1_000061
93. 6+/--methyl-11(2)-hydroxyprogesterone
94. Ncgc00179460-01
95. Ncgc00179460-03
96. D02289
97. 668m668
98. Progesterone, 11.beta.-hydroxy-6.alpha.-methyl-
99. Sr-01000721900
100. Q6807292
101. Sr-01000721900-3
102. Brd-k56515112-001-03-4
103. Brd-k56515112-001-21-6
104. Pregn-4-ene-3, 11.beta.-hydroxy-6.alpha.-methyl-
105. Wln: L E5 B666 Ov Mutj A1 Cq E1 Fv1 L1
106. Pregn-4-ene-3,20-dione, 11beta-hydroxy-6alpha-methyl-
107. Pregn-4-ene-3,20-dione, 11-beta-hydroxy-6-alpha-methyl-
108. Medrysone, United States Pharmacopeia (usp) Reference Standard
109. Pregn-4-ene-3, 11-hydroxy-6-methyl-, (6.alpha.,11.beta.)-
110. Pregn-4-ene-3,20-dione, 11-hydroxy-6-methyl-, (6alpha,11beta)-
111. (1s,2r,8s,10s,11s,14s,15s,17s)-14-acetyl-17-hydroxy-2,8,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
112. (6s,10r,11s,13s,17s)-17-acetyl-11-hydroxy-6,10,13-trimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
| Molecular Weight | 344.5 g/mol |
|---|---|
| Molecular Formula | C22H32O3 |
| XLogP3 | 2.7 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 1 |
| Exact Mass | 344.23514488 g/mol |
| Monoisotopic Mass | 344.23514488 g/mol |
| Topological Polar Surface Area | 54.4 Ų |
| Heavy Atom Count | 25 |
| Formal Charge | 0 |
| Complexity | 650 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 8 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
For the treatment of allergic conjunctivitis, vernal conjunctivitis, episcleritis, and epinephrine sensitivity.
FDA Label
Medrysone is a topical anti-inflammatory corticoidsteroids for ophthalmic use. In patients with increased intraocular pressure and in those susceptible to a rise in intraocular pressure, there is less effect on pressure with medrysone than with dexamethasone or betamethasone. Corticoidsteroids inhibit the edema, fibrin deposition, capillary dilation, and phagocytic migration of the acute inflammatory response, as well as capillary proliferation, deposition of collagen, and scar formation.
Glucocorticoids
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (See all compounds classified as Glucocorticoids.)
S - Sensory organs
S01 - Ophthalmologicals
S01B - Antiinflammatory agents
S01BA - Corticosteroids, plain
S01BA08 - Medrysone
Absorption
Rapidly absorbed following oral administration.
There is no generally accepted explanation for the mechanism of action of ocular corticosteroids. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. Initially, the drug binds to the glucocorticoid receptor in the cytosol. This migrates to the nucleus and binds to genetic elements which cause activation and repression of the involved genes in the inflammatory pathway.
ABOUT THIS PAGE
A Medrysone manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Medrysone, including repackagers and relabelers. The FDA regulates Medrysone manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Medrysone API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
A Medrysone supplier is an individual or a company that provides Medrysone active pharmaceutical ingredient (API) or Medrysone finished formulations upon request. The Medrysone suppliers may include Medrysone API manufacturers, exporters, distributors and traders.
click here to find a list of Medrysone suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
A Medrysone DMF (Drug Master File) is a document detailing the whole manufacturing process of Medrysone active pharmaceutical ingredient (API) in detail. Different forms of Medrysone DMFs exist exist since differing nations have different regulations, such as Medrysone USDMF, ASMF (EDMF), JDMF, CDMF, etc.
A Medrysone DMF submitted to regulatory agencies in the US is known as a USDMF. Medrysone USDMF includes data on Medrysone's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Medrysone USDMF is kept confidential to protect the manufacturer’s intellectual property.
click here to find a list of Medrysone suppliers with USDMF on PharmaCompass.
Medrysone Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Medrysone GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Medrysone GMP manufacturer or Medrysone GMP API supplier for your needs.
A Medrysone CoA (Certificate of Analysis) is a formal document that attests to Medrysone's compliance with Medrysone specifications and serves as a tool for batch-level quality control.
Medrysone CoA mostly includes findings from lab analyses of a specific batch. For each Medrysone CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Medrysone may be tested according to a variety of international standards, such as European Pharmacopoeia (Medrysone EP), Medrysone JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Medrysone USP).
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