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Melengestrol Acetate

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ACTIVE PHARMA INGREDIENTS

5 API Suppliers, 2 VMF, 5 Listed Suppliers

5 API Suppliers
2 VMF
5 Listed Suppliers

INTERMEDIATES

4 Intermediates Suppliers

4 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

2 FDF Dossiers, 1 Canada, 1 Listed Dossiers

2 FDF Dossiers
1 Canada
1 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Nanjing Well Pharmaceutical, 1 BASF, 1 Finar, 1 Valens Pharmachem

relatedExcipients
1 Nanjing Well Pharmaceutical
1 BASF
1 Finar
1 Valens Pharmachem

EXCIPIENTS BY APPLICATIONS

3 Topical, 2 Film Formers & Plasticizers, 2 Solubilizers, 1 Emulsifying Agents, 1 Thickeners and Stabilizers, 1 Parenteral

excipientsByApplications
3 Topical
2 Film Formers & Plasticizers
2 Solubilizers
1 Emulsifying Agents
1 Thickeners and Stabilizers
1 Parenteral

REF. STANDARDS & IMPURITIES

3 USP , 3 Others

otherSolutions
3 USP
3 Others

Chemwerth Melengestrol Acetate

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

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Health Canada Patents

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10EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 2919-66-6, Bdh 1921, Nsc-70968, Mga 100, Mga 500, 17-hydroxy-6-methyl-16-methylenepregna-4,6-diene-3,20-dione acetate

Molecular Formula

C₂₅H₃₂O₄

Molecular Weight

396.5 g/mol

InChI Key

UDKABVSQKJNZBH-DWNQPYOZSA-N

FDA UNII

4W5HDS3936

A 6-methyl PROGESTERONE acetate with reported glucocorticoid activity and effect on ESTRUS.

1 2D Structure

Melengestrol Acetate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[(8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-16-methylidene-3-oxo-1,2,8,9,11,12,14,15-octahydrocyclopenta[a]phenanthren-17-yl] acetate

2.1.2 InChI

InChI=1S/C25H32O4/c1-14-11-19-20(23(5)9-7-18(28)13-21(14)23)8-10-24(6)22(19)12-15(2)25(24,16(3)26)29-17(4)27/h11,13,19-20,22H,2,7-10,12H2,1,3-6H3/t19-,20+,22+,23-,24+,25+/m1/s1

2.1.3 InChI Key

UDKABVSQKJNZBH-DWNQPYOZSA-N

2.1.4 Canonical SMILES

CC1=CC2C(CCC3(C2CC(=C)C3(C(=O)C)OC(=O)C)C)C4(C1=CC(=O)CC4)C

2.1.5 Isomeric SMILES

CC1=C[C@@H]2[C@H](CC[C@]3([C@H]2CC(=C)[C@@]3(C(=O)C)OC(=O)C)C)[C@@]4(C1=CC(=O)CC4)C

2.2 Other Identifiers

2.2.1 UNII

4W5HDS3936

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Acetate, Melengestrol

2. Melengestrol

2.3.2 Depositor-Supplied Synonyms

1. 2919-66-6

2. Bdh 1921

3. Nsc-70968

4. Mga 100

5. Mga 500

6. 17-hydroxy-6-methyl-16-methylenepregna-4,6-diene-3,20-dione Acetate

7. Mls001332590

8. [(8r,9s,10r,13s,14s,17r)-17-acetyl-6,10,13-trimethyl-16-methylidene-3-oxo-1,2,8,9,11,12,14,15-octahydrocyclopenta[a]phenanthren-17-yl] Acetate

9. Chebi:34831

10. 17a-acetoxy-6-methyl-16-methylene-4,6-pregnadiene-3,20-dione

11. 17-(acetyloxy)-6-methyl-16-methylenepregna-4,6-diene-3,20-dione

12. 4w5hds3936

13. Pregna-4,6-diene-3,20-dione, 17-(acetyloxy)-6-methyl-16-methylene-

14. Mga

15. Dsstox_cid_28158

16. Dsstox_rid_82720

17. Dsstox_gsid_48184

18. Melengestrol Acetate 100 Microg/ml In Acetonitrile

19. Mga, Veterinary

20. Malengestrol Acetate

21. Mga (veterinary)

22. Smr000857077

23. Cas-2919-66-6

24. Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-16-methylene-, Acetate

25. Mga 100 (steroid)

26. Melengestrol Acetate [usan]

27. Nsc70968

28. Unii-4w5hds3936

29. Ccris 7800

30. Melengestrol Acetate [usan:usp]

31. Ncgc00160544-01

32. Einecs 220-859-7

33. Nsc 70968

34. Melengestrol Acetate (usp)

35. Schembl4520

36. Mls001332589

37. 6-dehydro-16-methylene-6-methyl-17-acetoxyprogesterone

38. Chembl1328968

39. Dtxsid5048184

40. Melengestrol Acetate [mi]

41. Hms2090n06

42. Hms2233n13

43. Hms3715d05

44. Zinc4216828

45. Tox21_111887

46. Tox21_303411

47. Melengestrol Acetate [mart.]

48. Melengestrol Acetate [usp-rs]

49. Akos015895715

50. Tox21_111887_1

51. Ccg-221132

52. Db14659

53. Melengestrol Acetate [green Book]

54. Ncgc00166298-01

55. Ncgc00166298-02

56. Ncgc00257329-01

57. Bs-42198

58. Melengestrol Acetate, >=97.0% (hplc)

59. Hy-111614

60. Melengestrol Acetate [usp Monograph]

61. Cs-0088572

62. D04900

63. Ab00918404-04

64. 919m666

65. Q6812180

66. W-107000

67. 17-(acetyloxy)-6-methyl-16-methylenepregna-4,20-dione

68. Melengestrol Acetate, Vetranal(tm), Analytical Standard

69. 17-hydroxy-6-methyl-16-methylenepregna-4,20-dione Acetate

70. Pregna-4,20-dione, 17-(acetyloxy)-6-methyl-16-methylene-

71. 17alpha-acetoxy-6-methyl-16-methylene-4,6-pregnadiene-3,20-dione

72. 17alpha-acetoxy-6-methyl-16-methylenepregna-4,6-diene-3,20-dione

73. Pregna-4,20-dione, 17-hydroxy-6-methyl-16-methylene-, Acetate

74. Melengestrol Acetate, United States Pharmacopeia (usp) Reference Standard

75. (8r,9s,10r,13s,14s,17r)-17-acetyl-6,10,13-trimethyl-16-methylene-3-oxo-2,3,8,9,10,11,12,13,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-17-yl Acetate

2.4 Create Date

2005-03-26

3 Chemical and Physical Properties

Molecular Formula	C₂₅H₃₂O₄
Molecular Weight	396.5 g/mol
XLogP3	3.1
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	396.23005950 g/mol
Monoisotopic Mass	396.23005950 g/mol
Topological Polar Surface Area	60.4 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	893
Isotope Atom Count	0
Defined Atom Stereocenter Count	6
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Glucocorticoids

A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (See all compounds classified as Glucocorticoids.)

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