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Chemistry

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Also known as: 1622-79-3, 1-(4-fluorophenyl)-4-(4-methylpiperidin-1-yl)butan-1-one hydrochloride, Methylperone hydrochloride, Melperone hcl, Nsc-760102, 1-(4-fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone hydrochloride
Molecular Formula
C16H23ClFNO
Molecular Weight
299.81  g/mol
InChI Key
MQHYXXIJLKFQGY-UHFFFAOYSA-N
FDA UNII
88G640374K

Melperone
1 2D Structure

Melperone

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-(4-fluorophenyl)-4-(4-methylpiperidin-1-yl)butan-1-one;hydrochloride
2.1.2 InChI
InChI=1S/C16H22FNO.ClH/c1-13-8-11-18(12-9-13)10-2-3-16(19)14-4-6-15(17)7-5-14;/h4-7,13H,2-3,8-12H2,1H3;1H
2.1.3 InChI Key
MQHYXXIJLKFQGY-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1CCN(CC1)CCCC(=O)C2=CC=C(C=C2)F.Cl
2.2 Other Identifiers
2.2.1 UNII
88G640374K
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Buronil

2. Eunerpan

3. Harmosin

4. Libernal

5. Mel-puren

6. Melneurin

7. Melperomerck

8. Melperon

9. Melperon Abz

10. Melperon Al

11. Melperon Azu

12. Melperon Beta

13. Melperon Fg 5111

14. Melperon Stada

15. Melperon Von Ct

16. Melperon-neuraxpharm

17. Melperon-ratiopharm

18. Melperon-rph

19. Melperon-teva

20. Melperone

21. Methylperon

22. Metylperon

23. Metylperon Hydrochloride

2.3.2 Depositor-Supplied Synonyms

1. 1622-79-3

2. 1-(4-fluorophenyl)-4-(4-methylpiperidin-1-yl)butan-1-one Hydrochloride

3. Methylperone Hydrochloride

4. Melperone Hcl

5. Nsc-760102

6. 1-(4-fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone Hydrochloride

7. 1-butanone, 1-(4-fluorophenyl)-4-(4-methyl-1-piperidinyl)-, Hydrochloride (1:1)

8. 88g640374k

9. Buronil (tn)

10. Metylperon Hydrochloride

11. Mls001424296

12. Chembl4551527

13. Dtxsid10936649

14. Pharmakon1600-01502266

15. Melperone Hydrochloride [mi]

16. Mfcd00270922

17. Nsc760102

18. Akos016007345

19. Ccg-101176

20. Melperone Hydrochloride [mart.]

21. Nc00426

22. Melperone Hydrochloride [who-dd]

23. As-77510

24. Smr000468736

25. B7078

26. Cs-0024369

27. D08172

28. J-009916

29. Q27269931

30. 1-[3-(p-fluorobenzoyl)propyl]-4-methylpiperaziniumchloride

31. 1-(4-fluorophenyl)-4-(4-methyl-piperidin-1-yl)butan-1-one Hydrochloride

32. 1-(4-fluorophenyl)-4-(4-methylpiperidin-1-yl)butan-1-one Hcl

33. 1-(4-fluorophenyl)-4-(4-methylpiperidin-1-yl)butan-1-one;hydrochloride

34. 1-(4-fluorophenyl)-4-(4-methylpiperidin-1-yl)butan-1-onehydrochloride

35. 1-(4-fluorophenyl)-4-(4-methylpiperidin-1-yl)butan-1-one--hydrogen Chloride (1/1)

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 299.81 g/mol
Molecular Formula C16H23ClFNO
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Exact Mass299.1452202 g/mol
Monoisotopic Mass299.1452202 g/mol
Topological Polar Surface Area20.3 Ų
Heavy Atom Count20
Formal Charge0
Complexity279
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antipsychotic Agents

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)


FDF Dossiers

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01

Neuraxpharm

Spain
BIO Partnering at JPM
Not Confirmed
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Neuraxpharm

Spain
arrow
BIO Partnering at JPM
Not Confirmed

Melperone hydrochloride

Brand Name :

Dosage Form : Film Coated Tablet

Dosage Strength : 0MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Spain

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02

Neuraxpharm

Spain
BIO Partnering at JPM
Not Confirmed
arrow

Neuraxpharm

Spain
arrow
BIO Partnering at JPM
Not Confirmed

Melperone hydrochloride

Brand Name :

Dosage Form : Film Coated Tablet

Dosage Strength : 25MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Spain

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03

Neuraxpharm

Spain
BIO Partnering at JPM
Not Confirmed
arrow

Neuraxpharm

Spain
arrow
BIO Partnering at JPM
Not Confirmed

Melperone hydrochloride

Brand Name :

Dosage Form : Film Coated Tablet

Dosage Strength : 50MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Spain

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04

Neuraxpharm

Spain
BIO Partnering at JPM
Not Confirmed
arrow

Neuraxpharm

Spain
arrow
BIO Partnering at JPM
Not Confirmed

Melperone hydrochloride

Brand Name :

Dosage Form : Film Coated Tablet

Dosage Strength : 100MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Spain

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05

Neuraxpharm

Spain
BIO Partnering at JPM
Not Confirmed
arrow

Neuraxpharm

Spain
arrow
BIO Partnering at JPM
Not Confirmed

Melperone hydrochloride

Brand Name :

Dosage Form : Oral Solution

Dosage Strength : 25MG/5ML

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Spain

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06

Country
BIO Partnering at JPM
Not Confirmed
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Country
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BIO Partnering at JPM
Not Confirmed

melperonhydroklorid

Brand Name : Buronil

Dosage Form : FILM COATED PILL

Dosage Strength : 25 MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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07

Country
BIO Partnering at JPM
Not Confirmed
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Country
arrow
BIO Partnering at JPM
Not Confirmed

melperonhydroklorid

Brand Name : Buronil

Dosage Form : TABLET

Dosage Strength : 10 MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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08

Country
BIO Partnering at JPM
Not Confirmed
arrow

Country
arrow
BIO Partnering at JPM
Not Confirmed

melperonhydroklorid

Brand Name : Buronil

Dosage Form : FILM COATED PILL

Dosage Strength : 50 MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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ABOUT THIS PAGE

Melperone Manufacturers

A Melperone manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Melperone, including repackagers and relabelers. The FDA regulates Melperone manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Melperone API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Melperone manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Melperone Suppliers

A Melperone supplier is an individual or a company that provides Melperone active pharmaceutical ingredient (API) or Melperone finished formulations upon request. The Melperone suppliers may include Melperone API manufacturers, exporters, distributors and traders.

click here to find a list of Melperone suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Melperone USDMF

A Melperone DMF (Drug Master File) is a document detailing the whole manufacturing process of Melperone active pharmaceutical ingredient (API) in detail. Different forms of Melperone DMFs exist exist since differing nations have different regulations, such as Melperone USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Melperone DMF submitted to regulatory agencies in the US is known as a USDMF. Melperone USDMF includes data on Melperone's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Melperone USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Melperone suppliers with USDMF on PharmaCompass.

Melperone GMP

Melperone Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Melperone GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Melperone GMP manufacturer or Melperone GMP API supplier for your needs.

Melperone CoA

A Melperone CoA (Certificate of Analysis) is a formal document that attests to Melperone's compliance with Melperone specifications and serves as a tool for batch-level quality control.

Melperone CoA mostly includes findings from lab analyses of a specific batch. For each Melperone CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Melperone may be tested according to a variety of international standards, such as European Pharmacopoeia (Melperone EP), Melperone JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Melperone USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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