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Chemistry

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Also known as: 41100-52-1, Memantine hcl, Namenda, 3,5-dimethyl-1-adamantanamine hydrochloride, 3,5-dimethyladamantan-1-amine hydrochloride, Akatinol
Molecular Formula
C12H22ClN
Molecular Weight
215.76  g/mol
InChI Key
LDDHMLJTFXJGPI-UHFFFAOYSA-N
FDA UNII
JY0WD0UA60

Memantine Hydrochloride
AMANTADINE derivative that has some dopaminergic effects. It has been proposed as an antiparkinson agent.
1 2D Structure

Memantine Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3,5-dimethyladamantan-1-amine;hydrochloride
2.1.2 InChI
InChI=1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H
2.1.3 InChI Key
LDDHMLJTFXJGPI-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC12CC3CC(C1)(CC(C3)(C2)N)C.Cl
2.2 Other Identifiers
2.2.1 UNII
JY0WD0UA60
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1,3-dimethyl-5-aminoadamantane

2. 1-amino-3,5-dimethyladamantane

3. Axura

4. D 145

5. D-145

6. D145

7. Ebixa

8. Memantin

9. Memantine

10. Namenda

2.3.2 Depositor-Supplied Synonyms

1. 41100-52-1

2. Memantine Hcl

3. Namenda

4. 3,5-dimethyl-1-adamantanamine Hydrochloride

5. 3,5-dimethyladamantan-1-amine Hydrochloride

6. Akatinol

7. Axura

8. Namenda Xr

9. Memary

10. Ebixa

11. Memantine Mylan

12. 1-amino-3,5-dimethyladamantane Hydrochloride

13. Memantine Merz

14. Memantine.hcl

15. Memantine Accord

16. Memantine Lek

17. Memantine (hydrochloride)

18. Acrescent

19. Balaxur

20. Auxura

21. Unii-jy0wd0ua60

22. 3,5-dimethyladamantan-1-amine;hydrochloride

23. Jy0wd0ua60

24. Mfcd00214336

25. Memantine Ratiopharm

26. Memantine Hydrochloride [usan]

27. Chebi:64323

28. Sun-y7017

29. Nsc-102290

30. 3,5-dimethyladamantan-1-aminium Chloride

31. D-145

32. Mls001332605

33. 3,5-dimethyl-1-aminoadamantane Hydrochloride

34. (3,5-dimethyl-1-adamantyl)amine Hydrochloride

35. 3,5-dimethyltricyclo(3.3.1.1(3,7))decan-1-amine Hydrochloride

36. Fp-01

37. 1,3-dimethyl-5-adamantanamine Hcl

38. 3,5-dimethyltricyclo[3.3.1.13,7]decan-1-amine Hydrochloride

39. 41100-52-1 (hcl)

40. Tricyclo[3.3.1.13,7]decan-1-amine, 3,5-dimethyl-, Hydrochloride

41. D 145

42. Mantine

43. Ebixza

44. 3,5-dimethyl-tricyclo[3.3.1.13,7]decan-1-amine Hydrochloride

45. 3,5-dimethyltricyclo(3.3.1.13,7)decan-1-amine Hydrochloride

46. 3,5-dimethyltricyclo(3.3.1.1(sup 3,7))decan-1-amine Hydrochloride

47. Tricyclo(3.3.1.1(sup 3,7))decan-1-amine, 3,5-dimethyl-, Hydrochloride

48. 3,5-dimethyl-1-adamantylamine

49. 3,5-dimethyl-1-aminoadamantane

50. Smr000875213

51. Sr-01000075458

52. Sun Y7017

53. Einecs 255-219-6

54. Namenda (tn)

55. Memary (tn)

56. Marixino

57. Nsc 102290

58. D-145 (hydrochloride)

59. Schembl3053

60. C12h21n.hcl

61. Chembl1699

62. Mls001332606

63. Spectrum1501121

64. Hy-b0365a

65. Dtxsid90961439

66. Memantine Hydrochloride (namenda)

67. N06dx01

68. Nmi-131

69. Hms1571c17

70. Hms1921h03

71. Pharmakon1600-01501121

72. Memantine Hydrochloride (jan/usp)

73. Memantine Hydrochloride [mi]

74. Tox21_500861

75. Ac-559

76. Ccg-39018

77. Memantine Hydrochloride [jan]

78. Mrz-2/145

79. Nsc102290

80. Nsc757843

81. S2043

82. Akos015889460

83. Bcp9000253

84. Lp00861

85. Memantine Hydrochloride [mart.]

86. Nc00680

87. Memantine Hydrochloride [usp-rs]

88. Memantine Hydrochloride [who-dd]

89. Ncgc00094186-01

90. Ncgc00094186-02

91. Ncgc00094186-03

92. Ncgc00261546-01

93. As-13331

94. Bm164662

95. Memantine Hydrochloride [ema Epar]

96. Sy057917

97. 3,5-dimethyladamantan-1-aminehydrochloride

98. Am20070534

99. D3608

100. Eu-0100861

101. Ft-0650723

102. M-145

103. Memantine Hydrochloride [orange Book]

104. Sw060653-4

105. 1-amino-3,5-dimethyl-adamantane Hydrochloride

106. 3,5-dimethyladamantan-1-amine Hy-drochloride

107. 3,5-dimethyladamantan-1-amine;hydrochloride.

108. D04905

109. M 9292

110. Memantine Hydrochloride [usp Monograph]

111. Namzaric Component Memantine Hydrochloride

112. Memantine Hydrochloride Component Of Namzaric

113. Sr-01000075458-1

114. Sr-01000075458-3

115. Sr-01000075458-8

116. Q27133218

117. Z1551429722

118. Tricyclo(3.3.1.1(3,7))decan-1-amine, 3,5-dimethyl-, Hydrochloride

119. Tricyclo[3.3.1.13,7]decan-1-amine, 3,5-dimethyl-, Hydrochloride (1:1) (ca Index Name)

120. 1-amino-3,5-dimethyladamantane . Hcl 3,5-dimethyl-1-aminoadamantane . Hcl Memantine . Hydrochloride

2.4 Create Date
2005-07-19
3 Chemical and Physical Properties
Molecular Weight 215.76 g/mol
Molecular Formula C12H22ClN
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Exact Mass215.1440774 g/mol
Monoisotopic Mass215.1440774 g/mol
Topological Polar Surface Area26 Ų
Heavy Atom Count14
Formal Charge0
Complexity240
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 6  
Drug NameMemantine hydrochloride
PubMed HealthMemantine (By mouth)
Drug ClassesCentral Nervous System Agent
Drug LabelNamenda (memantine hydrochloride) is an orally active NMDA receptor antagonist. The chemical name for memantine hydrochloride is 1-amino-3,5-dimethyladamantane hydrochloride with the following structural formula: The molecular formula is C12H21N...
Active IngredientMemantine hydrochloride
Dosage FormTablet
Routeoral; Oral
Strength5mg; 10mg
Market StatusTentative Approval
CompanyAmneal Pharms; Alembic; Upsher Smith; Mylan Pharma; Unichem Pharms (usa); Apotex; Lupin Pharms; Aurobindo Pharma; Torrent Pharms; Macleods Pharms; Jubilant Life

2 of 6  
Drug NameNamenda
PubMed HealthMemantine (By mouth)
Drug ClassesCentral Nervous System Agent
Drug LabelNamenda (memantine hydrochloride) is an orally active NMDA receptor antagonist. The chemical name for memantine hydrochloride is 1-amino-3,5-dimethyladamantane hydrochloride with the following structural formula: The molecular formula is C12H21N...
Active IngredientMemantine hydrochloride
Dosage FormTablet; Solution
RouteOral
Strength2mg/ml; 5mg; 10mg
Market StatusPrescription
CompanyForest Labs

3 of 6  
Drug NameNamenda xr
Drug LabelNAMENDA XR is an orally active NMDA receptor antagonist. The chemical name for memantine hydrochloride is 1-amino-3,5-dimethyladamantane hydrochloride with the following structural formula: The molecular formula is C12H21NHCl and the molecular wei...
Active IngredientMemantine hydrochloride
Dosage FormCapsule, extended release
RouteOral
Strength7mg; 14mg; 21mg; 28mg
Market StatusPrescription
CompanyForest Labs

4 of 6  
Drug NameMemantine hydrochloride
PubMed HealthMemantine (By mouth)
Drug ClassesCentral Nervous System Agent
Drug LabelNamenda (memantine hydrochloride) is an orally active NMDA receptor antagonist. The chemical name for memantine hydrochloride is 1-amino-3,5-dimethyladamantane hydrochloride with the following structural formula: The molecular formula is C12H21N...
Active IngredientMemantine hydrochloride
Dosage FormTablet
Routeoral; Oral
Strength5mg; 10mg
Market StatusTentative Approval
CompanyAmneal Pharms; Alembic; Upsher Smith; Mylan Pharma; Unichem Pharms (usa); Apotex; Lupin Pharms; Aurobindo Pharma; Torrent Pharms; Macleods Pharms; Jubilant Life

5 of 6  
Drug NameNamenda
PubMed HealthMemantine (By mouth)
Drug ClassesCentral Nervous System Agent
Drug LabelNamenda (memantine hydrochloride) is an orally active NMDA receptor antagonist. The chemical name for memantine hydrochloride is 1-amino-3,5-dimethyladamantane hydrochloride with the following structural formula: The molecular formula is C12H21N...
Active IngredientMemantine hydrochloride
Dosage FormTablet; Solution
RouteOral
Strength2mg/ml; 5mg; 10mg
Market StatusPrescription
CompanyForest Labs

6 of 6  
Drug NameNamenda xr
Drug LabelNAMENDA XR is an orally active NMDA receptor antagonist. The chemical name for memantine hydrochloride is 1-amino-3,5-dimethyladamantane hydrochloride with the following structural formula: The molecular formula is C12H21NHCl and the molecular wei...
Active IngredientMemantine hydrochloride
Dosage FormCapsule, extended release
RouteOral
Strength7mg; 14mg; 21mg; 28mg
Market StatusPrescription
CompanyForest Labs

4.2 Drug Indication

Treatment of patients with moderate to severe Alzheimer's disease.


Treatment of patients with moderate to severe Alzheimers disease.


Treatment of patients with moderate to severe Alzheimers disease.


Treatment of patients with moderate to severe Alzheimers disease.


Treatment of patients with moderate to severe Alzheimer's disease.


Treatment of patients with moderate to severe Alzheimers disease


Treatment of patients with moderate to severe Alzheimers disease.


Treatment of patients with moderate to severe Alzheimers disease.


Treatment of Alzheimers disease


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Antiparkinson Agents

Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)


Dopamine Agents

Any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons. (See all compounds classified as Dopamine Agents.)


Excitatory Amino Acid Antagonists

Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists. (See all compounds classified as Excitatory Amino Acid Antagonists.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
NMDA Receptor Antagonists [MoA]; N-methyl-D-aspartate Receptor Antagonist [EPC]
5.3 ATC Code

N06DX01


N06DX01


N06DX01


N06DX01


N06DX01


N06DX01


N06DX01


N06DX01


N06D


N06DA52


Listed Suppliers

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Olpha

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Virtual BoothOlpha, a JSC AB City subsidiary, is a leading Baltic firm with 50 years of experience in medicines & chemical pharmaceuticals.

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Memantine Hydrochloride

About the Company : Olpha, the subsidiary of JSC AB City, is one of the largest companies in the Baltic states with 50 years of experience in the production of medicines & chemical pharmaceutical prod...

Olpha, the subsidiary of JSC AB City, is one of the largest companies in the Baltic states with 50 years of experience in the production of medicines & chemical pharmaceutical products. The range of product portfolio developed by the company, includes 60 formulations, 25 APIs & >20 intermediates, including medicinal products for the nervous system, cardiovascular health, as well as antiviral, antibacterial & anti-allergic drugs. The health care products created by Olpha ensure both, the even more broader access of users to the necessary medicinal products, as well as the company’s growth & reputation in the global market.
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Virtual BoothTransoPharm USA works in the Sourcing and Management of Active Pharmaceutical Ingredients.

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Memantine Hydrochloride

About the Company : Transo-Pharm, a fully licensed and certified distributor, specializes in pharmaceutical components for the health and veterinary industries. It offers support to clients throughout...

Transo-Pharm, a fully licensed and certified distributor, specializes in pharmaceutical components for the health and veterinary industries. It offers support to clients throughout the entire API life cycle, from product development through sales. Transo-Pharm serves as a sourcing and regulatory marketing agent for API manufacturers. It aids clients in establishing DMFs and provides GMP consulting. With a dedicated regulatory department, a warehouse, proprietary IPs for API processes, and partnerships with laboratories, Transo-Pharm offers a wide range of services. It operates from its offices in Shanghai, Hong Kong, Singapore, and the US.
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LGM Pharma

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Virtual BoothLGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

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Memantine Hydrochloride

About the Company : LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, ...

LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, analytical method development and testing, and commercial manufacturing. LGM Pharma offers custom API synthesis, analytical development, and regulatory services. With a network of over 300 accredited CGMP manufacturing partners, LGM provides unparalleled supply chain security. And, with over 100,000 square feet of FDA-inspected cGMP manufacturing and warehouse capacity, LGM Pharma provides a one-stop solution for solid dose, powder, semi-solid and liquid drugs.
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Suanfarma

Spain
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Memantine Hydrochloride

About the Company : Suanfarma founded in 1993, is a B2B life science partner committed to health & innovation by developing, manufacturing, & distributing high-quality APIs for the pharmaceutical indu...

Suanfarma founded in 1993, is a B2B life science partner committed to health & innovation by developing, manufacturing, & distributing high-quality APIs for the pharmaceutical industry innovatively & sustainably. Backed by a robust global network of 12 strategically located local offices, we cater to the needs of over 400 active customers in 70+ countries. At Suanfarma we offer our CDMO capacity for fermentation & chemical synthesis projects, offering a One Stop Shop service with a solid track record, & which allows us to achieve success in the development, scaling, manufacturing, & commercialization of an API, either innovative or generic.
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Virtual BoothCohance Lifesciences, offers full range of CDMO services for small molecule APIs, intermediates, ADCs, Pellets and Formulations.

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Memantine

About the Company : Cohance Lifesciences is a leading CDMO and API platform, offering products and services across all phases of a molecule’s lifecycle from development to commercialzation. With our...

Cohance Lifesciences is a leading CDMO and API platform, offering products and services across all phases of a molecule’s lifecycle from development to commercialzation. With our expertise in complex chemistries, we provide end-to-end CDMO services to global innovators and have delivered numerous projects from concept to commercialization over the years.As a global API player, we serve customers across nearly 60 countries with 80+ molecules backed by robust R&D, regulatory capabilities and manufacturing infrastructure. We are among the top backward integrated exporters of pellets and have strong development and manufacturing capabilities.
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Virtual BoothDRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

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Memantine Hydrochloride

About the Company : Founded in 1984, DRL is well-known for its generic APIs and its track record in drug product development. It is one of the earliest pharma API manufacturers with a diverse portfoli...

Founded in 1984, DRL is well-known for its generic APIs and its track record in drug product development. It is one of the earliest pharma API manufacturers with a diverse portfolio that provides high-quality, low-cost APIs to leading pharma companies in 80+ countries. It has 8 USFDA-inspected facilities – 6 in India & 1 each in Mexico & the UK & are inspected by international regulatory authorities on a regular basis. Its facilities are supplemented by formulation facilities that provide a wide range of dosage forms. Product(s) under patent(s) are offered only for R&D purposes U/S 107A of the Patent Act and not for commercial sale
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Virtual BoothJai Radhe Sales is your partner for all your sourcing needs.

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About the Company : Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete ...

Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete sourcing solutions for pharmaceutical products from India, including technical and regulatory assistance. It believes in providing its customers with high-quality products at reasonable prices. It has always endeavored to achieve global standards in the field of pharmaceuticals and has carved out a niche for itself through new methods based on current market needs. Today, it has established itself as a truly global company, with exports to almost every continent.
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Virtual BoothHRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

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Memantine Hydrochloride

About the Company : HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It...

HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It offers services such as sourcing, manufacturing & supply, helping partners enter new markets worldwide. Its strong partnerships with major players in the pharma and food additive industries help HRV Global effectively promote projects and products. HRV Global represents over 30 large Indian drugmakers, primarily targeting Europe, the US & the Middle East markets. Headquartered in India, HRV Global has offices in the US, Switzerland, Dubai, Lithuania & Turkey.
HRV Global Life Sciences

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Memantine Hydrochloride

About the Company : Alembic Pharmaceuticals Limited is a leading pharmaceutical company in India. The Company is vertically integrated with the ability to develop, manufacture and market pharmaceutica...

Alembic Pharmaceuticals Limited is a leading pharmaceutical company in India. The Company is vertically integrated with the ability to develop, manufacture and market pharmaceutical products, pharmaceutical substances and Intermediates.
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CHEMO

Spain
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CHEMO

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About the Company : More than 35 years of dedication to quality, service and pursuit of excellence, CHEMO was founded by Hugo Sigman, M.D., and Silvia Gold, Biochemist, in Spain (Barcelona), in 1977, ...

More than 35 years of dedication to quality, service and pursuit of excellence, CHEMO was founded by Hugo Sigman, M.D., and Silvia Gold, Biochemist, in Spain (Barcelona), in 1977, and starts business activities trading with pharmaceutical raw materials. In the 80's, the company expanded its operations into the Industrial Business, developing and manufacturing active pharmaceutical ingredients (APIs) in Italy (Industriale Chimica) and in Spain (Quimica Sintetica). In the 90's, CHEMO starts developing and manufacturing high quality and technology finished dosage forms (FDFs).
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API Reference Price

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12-Jan-2021
23-Oct-2024
KGS
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Quantity (KGS) & Unit rate (USD/KGS) over time

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - TABLET;ORAL - 10MG

USFDA APPLICATION NUMBER - 21487

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DOSAGE - TABLET;ORAL - 5MG

USFDA APPLICATION NUMBER - 21487

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DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 14M...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 14MG

USFDA APPLICATION NUMBER - 22525

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DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 21M...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 21MG

USFDA APPLICATION NUMBER - 22525

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DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 28M...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 28MG

USFDA APPLICATION NUMBER - 22525

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DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 7MG...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 7MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 22525

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