Find MEN1703 manufacturers, exporters & distributors on PharmaCompass

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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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API Suppliers

API Suppliers

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USDMF

US DMFs Filed

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CEP/COS

CEP/COS Certifications

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JDMF

JDMFs Filed

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EU WC

EU WC

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KDMF

KDMF

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NDC API

NDC API

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VMF

NDC API

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Listed Suppliers

Other Suppliers

API REF. PRICE (USD/KG)

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MARKET PLACE

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API

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FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

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FDF Dossiers

FDF Dossiers

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FDA Orange Book

FDA (Orange Book)

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Europe

Europe

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Canada

Canada

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Australia

Australia

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South Africa

South Africa

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Listed Dossiers

Listed Dossiers

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

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EDQM

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USP

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JP

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Others

PATENTS & EXCLUSIVITIES

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US Patents

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US Exclusivities

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Health Canada Patents

DIGITAL CONTENT

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Data Compilation #PharmaFlow

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Stock Recap #PipelineProspector

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Weekly News Recap #Phispers

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News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid

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Annual Reports

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Finished Drug Prices

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0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Sel24-b489, Sel-24 free base, 9m7x64vtli, Sel24-b289, 1616359-00-2, 1h-benzimidazole, 5,6-dibromo-1-(1-methylethyl)-4-nitro-2-(4-piperidinyl)-
Molecular Formula
C15H18Br2N4O2
Molecular Weight
446.14  g/mol
InChI Key
UOUBCIJIWDLRGM-UHFFFAOYSA-N
FDA UNII
9M7X64VTLI

MEN1703
PIM/FLT3 Kinase Inhibitor SEL24 is an orally available inhibitor of PIM family serine/threonine protein kinases and mutant forms of FMS-related tyrosine kinase 3 (FLT3; STK1) with potential antineoplastic activity. PIM/FLT3 kinase inhibitor SEL24 binds to and inhibits the kinase activities of PIM-1, -2 and -3, and mutant forms of FLT3, which may result in the interruption of the G1/S phase cell cycle transition, an inhibition of cell proliferation, and an induction of apoptosis in tumor cells that overexpress PIMs or express mutant forms of FLT3. FLT3, a tyrosine kinase receptor that is overexpressed or mutated in various cancers, plays a role in signaling pathways that regulate hematopoietic progenitor cell proliferation, and in leukemic cell proliferation and survival. PIM kinases, downstream effectors of many cytokine and growth factor signaling pathways, including the FLT3 signaling pathway, play key roles in cell cycle progression and apoptosis inhibition and may be overexpressed in various malignancies.
1 2D Structure

MEN1703

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5,6-dibromo-4-nitro-2-piperidin-4-yl-1-propan-2-ylbenzimidazole
2.1.2 InChI
InChI=1S/C15H18Br2N4O2/c1-8(2)20-11-7-10(16)12(17)14(21(22)23)13(11)19-15(20)9-3-5-18-6-4-9/h7-9,18H,3-6H2,1-2H3
2.1.3 InChI Key
UOUBCIJIWDLRGM-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C)N1C2=CC(=C(C(=C2N=C1C3CCNCC3)[N+](=O)[O-])Br)Br
2.2 Other Identifiers
2.2.1 UNII
9M7X64VTLI
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Sel24-b489

2. Sel-24 Free Base

3. 9m7x64vtli

4. Sel24-b289

5. 1616359-00-2

6. 1h-benzimidazole, 5,6-dibromo-1-(1-methylethyl)-4-nitro-2-(4-piperidinyl)-

7. 5,6-dibromo-1-(1-methylethyl)-4-nitro-2-(4-piperidinyl)-1h-benzimidazole

8. 5,6-dibromo-4-nitro-2-(piperidin-4-yl)-1-(propan-2-yl)-1h-1,3-benzimidazole

9. Unii-9m7x64vtli

10. Chembl4467168

11. Schembl15826208

12. Hy-120758

13. Cs-0079085

2.4 Create Date
2014-07-28
3 Chemical and Physical Properties
Molecular Weight 446.14 g/mol
Molecular Formula C15H18Br2N4O2
XLogP33.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass445.97760 g/mol
Monoisotopic Mass443.97965 g/mol
Topological Polar Surface Area75.7 Ų
Heavy Atom Count23
Formal Charge0
Complexity442
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

MEN1703 Manufacturers

A MEN1703 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of MEN1703, including repackagers and relabelers. The FDA regulates MEN1703 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. MEN1703 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

MEN1703 Suppliers

A MEN1703 supplier is an individual or a company that provides MEN1703 active pharmaceutical ingredient (API) or MEN1703 finished formulations upon request. The MEN1703 suppliers may include MEN1703 API manufacturers, exporters, distributors and traders.

MEN1703 GMP

MEN1703 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of MEN1703 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right MEN1703 GMP manufacturer or MEN1703 GMP API supplier for your needs.

MEN1703 CoA

A MEN1703 CoA (Certificate of Analysis) is a formal document that attests to MEN1703's compliance with MEN1703 specifications and serves as a tool for batch-level quality control.

MEN1703 CoA mostly includes findings from lab analyses of a specific batch. For each MEN1703 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

MEN1703 may be tested according to a variety of international standards, such as European Pharmacopoeia (MEN1703 EP), MEN1703 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (MEN1703 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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