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Chemistry

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Also known as: Menaquinone-4, Vitamin k2, 863-61-6, Menaquinone 4, 11032-49-8, Kaytwo
Molecular Formula
C31H40O2
Molecular Weight
444.6  g/mol
InChI Key
DKHGMERMDICWDU-GHDNBGIDSA-N
FDA UNII
27Y876D139

Vitamin K2
Menatetrenone is a menaquinone compound and form of vitamin K2 with potential antineoplastic activity. Menatetrenone may act by modulating the signalling of certain tyrosine kinases, thereby affecting several transcription factors including c-myc and c-fos. This agent inhibits tumor cell growth by inducing apoptosis and cell cycle arrest.
1 2D Structure

Vitamin K2

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl]naphthalene-1,4-dione
2.1.2 InChI
InChI=1S/C31H40O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,12,14,16,18-20H,9-11,13,15,17,21H2,1-6H3/b23-14+,24-16+,25-20+
2.1.3 InChI Key
DKHGMERMDICWDU-GHDNBGIDSA-N
2.1.4 Canonical SMILES
CC1=C(C(=O)C2=CC=CC=C2C1=O)CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C
2.1.5 Isomeric SMILES
CC1=C(C(=O)C2=CC=CC=C2C1=O)C/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CCC=C(C)C
2.2 Other Identifiers
2.2.1 UNII
27Y876D139
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (e,e,e)-isomer Of Menatetrenone

2. 2-methyl-3-all-trans-tetraprenyl-1,4-naphthoquinone

3. 2-methyl-3-trans-tetraprenyl-1,4-naphthoquinone

4. Kefton-2

5. Menaquinone 4

6. Menaquinone-4

7. Vitamin K2(20)

8. Vitamin Mk-4

2.3.2 Depositor-Supplied Synonyms

1. Menaquinone-4

2. Vitamin K2

3. 863-61-6

4. Menaquinone 4

5. 11032-49-8

6. Kaytwo

7. Kefton-2

8. Menaquinone K4

9. Vitamin Mk 4

10. Vitamin K2(20)

11. Menatetrenona

12. Menatetrenonum

13. Menatetranone

14. Mk-4

15. Kaytwo N

16. 2-methyl-3-[(2e,6e,10e)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl]naphthalene-1,4-dione

17. 6041-00-5

18. 2-methyl-3-trans-tetraprenyl-1,4-naphthoquinone

19. 2-methyl-3-geranylgeranyl-1,4-naphthoquinone

20. Mls000028742

21. 2-methyl-3-((2e,6e,10e)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl)naphthalene-1,4-dione

22. Chebi:78277

23. 2-methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-naphthoquinone

24. Smr000058955

25. 27y876d139

26. 1,4-naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-

27. Dsstox_cid_28895

28. 1,4-naphthalenedione, 2-methyl-3-((2e,6e,10e)3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-

29. Vitamin K2(sub 20)

30. Menatetrenone [inn:jan]

31. Mk4

32. Menatetrenonum [inn-latin]

33. K2(sub 20)

34. Menatetrenona [inn-spanish]

35. Glakay

36. E3100

37. Menaquinone(4)

38. Unii-27y876d139

39. Ncgc00183125-01

40. 2-methyl-3-((2e,6e,10e)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl)naphthalene-1,4-dione

41. Mfcd00079646

42. Vitamin K2 (tn)

43. Opera_id_148

44. 2-methyl-3-tetraprenyl-1,4-naphthoquinone

45. Menatetrenone [inn]

46. Menatetrenone [jan]

47. 2-methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-naphthochinon

48. Dsstox_rid_80857

49. Dsstox_rid_83163

50. Menatetrenone (jp17/inn)

51. Dsstox_gsid_45406

52. Dsstox_gsid_48969

53. Menaquinone 4 [mi]

54. 1,4-naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-, (e,e,e)-

55. Menaquinone;vitamin K2

56. Menatetrenone [mart.]

57. Schembl434553

58. Schembl571912

59. Menatetrenone [who-dd]

60. Vitamin K2 (mk-4) Solution

61. Chembl259223

62. Mq-4

63. Dtxsid6048969

64. Menaquinone-4 [usp-rs]

65. Hms2230j06

66. Ea-0167

67. Amy22672

68. Hy-b2156

69. Zinc3874199

70. Tox21_110567

71. Tox21_113413

72. Bdbm50423776

73. S5082

74. Akos025311021

75. Akos037645019

76. Menaquinone (k2), Analytical Standard

77. Ccg-269176

78. Db12148

79. 2-methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-naphthalenedione

80. 2-methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetrenyl)-1,4-naphthoquinone

81. Ncgc00181325-01

82. Ncgc00181325-03

83. As-17910

84. As-56161

85. Cas-863-61-6

86. Cs-0020307

87. M2398

88. A17083

89. D00100

90. E-0167

91. 863v616

92. A935204

93. Q192354

94. 1,4-naphthalenedione, 2-methyl-3-[(2e,6e,10e)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl]-

95. 2-methyl-3-[(2e,6e,10e)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl]-1,4-naphthoquinone

96. Vitamin K2 (mk-4) Solution, 100 Mug/ml In Acetonitrile, Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 444.6 g/mol
Molecular Formula C31H40O2
XLogP38.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count11
Exact Mass444.302830514 g/mol
Monoisotopic Mass444.302830514 g/mol
Topological Polar Surface Area34.1 Ų
Heavy Atom Count33
Formal Charge0
Complexity855
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count3
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Therapeutic Uses

There is no typical dosage for vitamin K. Some multivitamin preparations contain vitamin K as vitamin K1 (phylloquinone or phytonadione) or vitamin K2 (menaquinones) at doses of 25 to 100 ug.

PDR for Nutritional Supplements 2nd ed. Thomson Reuters, Montvale, NJ 2008, p. 711


Vitamin K is used to treat anticoagulant-induced prothrombin deficiency caused by warfarin, hyporprothrombinemia secondary to antibiotic therapy and hypoprothrombinemia secondary to vitamin C deficiency from various causes, including malabsorption syndromes. /Vitamin K/

PDR for Nutritional Supplements 2nd ed. Thomson Reuters, Montvale, NJ 2008, p. 709


Because hemorrhagic disease of the newborn can be effectively prevented by administrating vitamin K, infants born in the US and Canada routinely receive 0.5-1 mg pf phylloquinone intramuscularly or 2.0 mg orally within 6 hours of birth. This practice is supported by both US and Canadian pediatric societies. /Phylloquinone/

National Academies of Sciences Institute of Medicine; Vitamin K. In: Dietary Reference Intakes. p.255-61 (2006) National Academies Press, Washington, DC


The current recommendations of the American Academy of Pediatrics advise that "vitamin K (phylloquinone) should be given to all newborns as a single, intramuscular dose of 0.5-1 mg" and if this advice is followed, the disease /Vitamin K deficiency bleeding/ is effectively prevented. /Vitamin K/

Suttie JW; Vitamin K. In: Encyclopedia of Dietary Supplements, ed. Coates PM et al; Marcel Dekker, New York, NY pp. 771-82 (2005)


For more Therapeutic Uses (Complete) data for Vitamin K2 (8 total), please visit the HSDB record page.


4.2 Drug Warning

... MK-7 induced more complete carboxylation of osteocalcin, and hematologists should be aware that preparations supplying 50 ug/d or more of MK-7 may interfere with oral anticoagulant treatment in a clinically relevant way.

PMID:17158229 Schurgers LJ et al; Blood 109 (8): 3279-83 (2007)


It has been suggested that vitamin K may have roles in osteoporosis and vascular health. However, this is difficult to establish on the basis of the studies performed thus far. /Vitamin K/

National Academies of Sciences Institute of Medicine; Vitamin K. In: Dietary Reference Intakes. p.255-61 (2006) National Academies Press, Washington, DC


Pregnant women and nursing mothers should avoid supplemental intakes of vitamin K greater than RDA amounts (65 ug daily) unless higher amounts are prescribed by their physicians. /Vitamin K/

PDR for Nutritional Supplements 2nd ed. Thomson Reuters, Montvale, NJ 2008, p. 711


Individuals on chronic warfarin therapy may require dietary counseling on how to maintain steady vitamin K intake levels. Because habitual vitamin K intake may modulate warfarin dosage in patients using this anticoagulant, these individuals should maintain their normal dietary and supplementation patterns once an effective dose of warfarin has been established. /Vitamin K/

National Academies of Sciences Institute of Medicine; Vitamin K. In: Dietary Reference Intakes. p.255-61 (2006) National Academies Press, Washington, DC


For more Drug Warnings (Complete) data for Vitamin K2 (6 total), please visit the HSDB record page.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Hemostatics

Agents acting to arrest the flow of blood. Absorbable hemostatics arrest bleeding either by the formation of an artificial clot or by providing a mechanical matrix that facilitates clotting when applied directly to the bleeding surface. These agents function more at the capillary level and are not effective at stemming arterial or venous bleeding under any significant intravascular pressure. (See all compounds classified as Hemostatics.)


5.2 Absorption, Distribution and Excretion

Vitamin K, mainly in the form of vitamin K1, is principally absorbed from the jejunum and ileum. ... Vitamin K is delivered to the enterocytes in micelles formed from bile salts and other substances. Vitamin K is secreted by enterocytes into the lymphatics in the form of chylomicrons. It enters the circulation via the thoracic duct and is carried in the circulation to various tissues including hepatic, bone and spleen, in the form of chylomicron remnants. In the liver, some vitamin K is stored, some is oxidized to inactive end products and some is secreted with VLDL (very low density lipoprotein). Approximately 50% of vitamin K is carried in the plasma in the form of VLDL, about 25% in LDL (low-density lopoprotein) and about 25% in HDL (high-density lipoprotein). /Vitamin K/

PDR for Nutritional Supplements 2nd ed. Thomson Reuters, Montvale, NJ 2008, p. 709


Excretion of vitamin K and its metabolites is mainly via the feces. Some urinary excretion of vitamin K also occurs. /Vitamin K/

PDR for Nutritional Supplements 2nd ed. Thomson Reuters, Montvale, NJ 2008, p. 710


...Menaquinones are adequately absorbed from the GI tract only if bile salts are present. Menaquinones and its water-soluble derivatives, however, are absorbed even in the absence of bile. ... Menaquinones are absorbed almost entirely by way of the lymph. /Menaquinones/

Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 1565


Menaquinone forms of vitamin K are produced by bacteria in the lower bowel, where the forms appear in large amounts. However, their contributuion to the maintenance of vitamin K status has been difficult to assess. Although the content is extremely variable, the human liver contains about 10 times as much vitamin K as a mixture of menaquinones than as phylloquinone. /Menaquinones/

National Academies of Sciences Institute of Medicine; Vitamin K. In: Dietary Reference Intakes. p.255-61 (2006) National Academies Press, Washington, DC


5.3 Metabolism/Metabolites

A major pathway of vitamin K metabolism is that which is involved in the reduction and recycling of the epoxide formed by the carboxylase. /Vitamin K/

Suttie JW; Vitamin K. In: Encyclopedia of Dietary Supplements, ed. Coates PM et al; Marcel Dekker, New York, NY pp. 771-82 (2005)


Vitamin K undergoes some oxidative metabolism. /Vitamin K/

PDR for Nutritional Supplements 2nd ed. Thomson Reuters, Montvale, NJ 2008, p. 710


5.4 Mechanism of Action

In vivo and in vitro studies have shown that vitamin K may directly act on bone metabolism. In vitro studies have demonstrated that vitamin K2 inhibits bone resorption by, in part, inhibiting the production of bone resorbing substances such as prostaglandin E2 and interleukin-6. Vitamin K2 has been reported to enhance human osteoblast-induced mineralization in vitro and to inhibit bone loss in steroid-treated rats and ovariectomized rats.

PDR for Nutritional Supplements 2nd ed. Thomson Reuters, Montvale, NJ 2008, p. 709


Certain naphthoquinones, in particular the synthetic vitamin K menadione, have been found to have antitumor activity in vitro and in vivo. Vitamin K2 has been found to induce the in vitro differentiation of myeloid leukemic cell lines. The mechanism of the possible anticarcinogenic activity of vitamin K is not well understood. Menadione is an oxidative stress inducer and its possible anticarcinogenic activity may, in part, be explained by induction of apoptotic cell death. One study suggested that the induction of apoptosis by menadione is mediated by the Fas/Fas ligand system. Another study reported that menadione induces cell cycle arrest and cell death by inhibiting Cda 25 phosphatase.

PDR for Nutritional Supplements 2nd ed. Thomson Reuters, Montvale, NJ 2008, p. 709


Vitamin K is involved as a cofactor in the posttranslational gamma-carboxylation of glutamic acid residues of certain proteins in the body. These proteins include the vitamin K-dependent coagulation factors II (prothrombin), VII (proconvertin), IX (Christmas factor), X (Stuart factor), protein C, protein S, protein Zv and a growth-arrest-specific factor (Gas6). In contrast to the other vitamin K-dependent proteins in the blood coagulation cascade, protein C and protein X serve anticoagulant roles. The two vitamin K-dependent proteins found in bone are osteocalcin, also known as bone G1a (gamma-carboxyglutamate) protein or BGP, and the matrix G1a protein or MGP. Gamma-carboxylation is catalyzed by the vitamin K-dependent gamma-carboxylases. /Vitamin K/

PDR for Nutritional Supplements 2nd ed. Thomson Reuters, Montvale, NJ 2008, p. 708


The primary gene product of the vitamin K-dependent proteins contains a very homologous domain between the amino terminus of the mature protein and the signal sequence that targets the polypeptide for the secretory pathway. This "propeptide" region appears to be both a "docking" or "recognition " site for the enzyme and a modulator of the activity of the enzyme by decreasing the apparent Km of the Glu site substrate. ... A key finding essential to a complete understanding of the detailed mechanism of action of this enzyme has been the identification of an intermediate chemical form of vitamin K, which could be sufficiently basic to abstract the gamma-hydrogen of the glutamyl residue. It has been proposed that the initial attack of O(2) at the naphthoquinone carbonyl carbon adjacent to the methyl group results in the formation of a dioxetane ring, which generates an alkoxide intermediate. /Vitamin K/

Suttie JW; Vitamin K. In: Encyclopedia of Dietary Supplements, ed. Coates PM et al; Marcel Dekker, New York, NY pp. 771-82 (2005)


For more Mechanism of Action (Complete) data for Vitamin K2 (8 total), please visit the HSDB record page.


USDMF

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Kappa Bioscience As

Norway

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GDUFA

DMF Review : N/A

Rev. Date :

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DMF Number : 30205

Submission : 2016-02-25

Status : Inactive

Type : II

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Menatetrenone

Registration Number : 218MF10262

Registrant's Address : Poligono Inds. Mas Puigvert Ctra. National II, Km. 680,5,08389 Palafolls, Barcelona, ...

Initial Date of Registration : 2006-02-17

Latest Date of Registration : 2019-02-26

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Menatetrenone

Registration Number : 218MF10404

Registrant's Address : Plot No. 64/A & 65/B, Phase-I, IDA, Jeedimetla, Hyderabad-500 055, Telangana State, I...

Initial Date of Registration : 2006-04-14

Latest Date of Registration : 2007-01-10

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Menatetrenone

Registration Number : 217MF11114

Registrant's Address : 25 Kanda Nishikicho 1-chome, Chiyoda-ku, Tokyo

Initial Date of Registration : 2005-12-05

Latest Date of Registration : 2007-08-01

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Sanyo Fine Co., Ltd.

Gabon
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Sanyo Fine Co., Ltd.

Gabon
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Japanese Pharmacopoeia Menatetrenone (for manufacturing only)

Registration Number : 226MF10065

Registrant's Address : Osaka Prefecture, Osaka City, Nishi Ward, Awaza 1-12-18

Initial Date of Registration : 2014-03-11

Latest Date of Registration : 2023-12-19

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Virtual BoothFaran Shimi: Leading producer of high-quality APIs & alkaloid opiates, serving major pharmaceutical companies across the Middle East.

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Vitamin K2

About the Company : Faran Shimi Pharmaceutical Company, established in 2001 and affiliated with Golrang Pharmaceutical Investment Co, manufactures high-quality Active Pharmaceutical Ingredients (APIs)...

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About the Company : GF Fermentech, a subsidiary of GenoFocus, specializes in producing bioactive materials using core technologies centered around strain development, fermentation, biotransformation, ...

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About the Company : At Kappa Bioscience we are proud to offer you high purity vitamin K2 as menaquinone-7 (MK-7). As the innovative leader and first mover of vitamin K2 MK-7, we have extensive knowle...

At Kappa Bioscience we are proud to offer you high purity vitamin K2 as menaquinone-7 (MK-7). As the innovative leader and first mover of vitamin K2 MK-7, we have extensive knowledge about vitamins and are currently the only vendor with vitamin K2 as pure MK-7 in various formulations. Based on the self-affirmed GRAS approval, our K2 MK-7 can also be used in conventional foods. Kappa Bioscience is the pioneer in development and production of the only synthetic and biologically active all-trans menaquinone-7 (vitamin K2 MK-7), marketed under the K2VITAL® brand name. Kappa Ingredients GmbH, a wholly owned division of Kappa Bioscience,
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Menadiona

Spain
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About the Company : MENADIONA is an independent privately-owned company, founded in 1970. Ever since, the company has been involved in manufacturing active ingredients (APIs) and key intermediates for...

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Novozymes

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About the Company : A world leading partner of pharmaceutical and medical device companies offering high-quality and safe biologically-based ingredients and technologies - hyaluronic acid, recombinant...

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Otto Brandes

Germany
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Vitamin K2

About the Company : Otto Brandes Gmbh was founded in 1923 and is an independent distributor of high quality Pharmaceutical Active Ingredients and excipients for the pharmaceutical industry. We regard ...

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PK Components

Poland
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Vitamin K2

About the Company : PK Components is a Polish distributor of raw materials for the production of dietary supplements and for the food industry. Our hallmark is a stable market position, customer trust...

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Vitamin K2

About the Company : Specializing in the health industry, LonierHerb Ltd specializes in plant extracts and offers a comprehensive service chain that encompasses micro-encapsulation, natural colorants, ...

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CO., LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI - PU DONG","customer":"ADVANCED VITAL ENZYMES ","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"565","totalValueFC":"28793.8","currency":"USD","unitRateINR":"48303.6","date":"09-Aug-2024","totalValueINR":"2415180.08","totalValueInUsd":"28793.8","indian_port":"Bombay Air","hs_no":"29362990","bill_no":"4974593","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI - PU DONG","supplierAddress":"A01-02-1, A02-01-1BINHAI INDUSTRIAL PARK,HAOJIANG DISTRICT, SHANTOU CHINA","customerAddress":"SUN MAGNETICA,A WING,5TH FLOOR"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1726252200,"product":"VITAMIN K2 AS MK-7 M POWDER MALTODEXTRIN 2000 PPM(BATCH NO.CM24000818)","address":"OLD NO.24 NEW NO.5,1ST MAIN ROAD,","city":"CHENNAI , TAMIL NADU.","supplier":"GENCOR","supplierCountry":"ITALY","foreign_port":"MILAN","customer":"GENCOR","customerCountry":"INDIA","quantity":"150.00","actualQuantity":"150","unit":"KGS","unitRateFc":"207","totalValueFC":"31457.1","currency":"USD","unitRateINR":"17574.3","date":"14-Sep-2024","totalValueINR":"2636145","totalValueInUsd":"31457.1","indian_port":"Madras Air","hs_no":"29362930","bill_no":"5614655","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN","supplierAddress":"301 KAM ON BUILDING 176-A,QUEENS RO AD CENTRAL, HONG KONG SDNF HONG KONG","customerAddress":"OLD NO.24 NEW NO.5,1ST MAIN ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1726857000,"product":"VITAMIN K2 (MK-7)","address":"BASEMENT & GF PLOT NO-683,BLOCK-CW","city":"SANJAY GANDHI TRANSPORT NAGAR,DELHI","supplier":"SEEBIO BIOTECH (SHANGHAI) CO., LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"NUTRA ZONE","customerCountry":"INDIA","quantity":"300.00","actualQuantity":"300","unit":"KGS","unitRateFc":"230","totalValueFC":"69657.7","currency":"USD","unitRateINR":"19458","date":"21-Sep-2024","totalValueINR":"5837400","totalValueInUsd":"69657.7","indian_port":"Delhi Air","hs_no":"29362990","bill_no":"5735121","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"BUILDING 5, NO. 508, CHUANHONG ROAD SDNF PUDONG SHANGHAI SDNF","customerAddress":"BASEMENT & GF PLOT NO-683,BLOCK-CW"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1726857000,"product":"VITAMIN K2 OIL ( IMPORT UNDER 100% EOU)","address":"Koyikkalethu Veeyapuram","city":"Alappuzha","supplier":"WELLGREEN TECHNOLOGY CO,LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI - PU DONG","customer":"MOLECULES BIO LABS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"4.00","actualQuantity":"4","unit":"KGS","unitRateFc":"485","totalValueFC":"1980.5","currency":"USD","unitRateINR":"41492.6","date":"21-Sep-2024","totalValueINR":"165970.4","totalValueInUsd":"1980.5","indian_port":"Cochin Air","hs_no":"29362990","bill_no":"5729881","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI - PU DONG","supplierAddress":"1001, BUILDING 2, LANJI CENTER, NO. 72 KEJI 2 ROAD XI AN, CHINA CN","customerAddress":"Koyikkalethu Veeyapuram"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730485800,"product":"VITAMIN K2(MK-4) OIL 1.3% ( IMPORT UNDER 100% EOU )","address":"Koyikkalethu Veeyapuram","city":"Alappuzha","supplier":"WELLGREEN TECHNOLOGY CO,LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI - PU DONG","customer":"MOLECULES BIO LABS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"11.00","actualQuantity":"11","unit":"KGS","unitRateFc":"188","totalValueFC":"2105.2","currency":"USD","unitRateINR":"16150.3","date":"02-Nov-2024","totalValueINR":"177652.96","totalValueInUsd":"2105.2","indian_port":"Cochin Air","hs_no":"29362990","bill_no":"6456134","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI - PU DONG","supplierAddress":"1001, BUILDING 2, LANJI CENTER, NO. 72 KEJI 2 ROAD XI AN, CHINA CN","customerAddress":"Koyikkalethu Veeyapuram"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1734892200,"product":"VITAMIN K2 OIL(IMPORT UNDER 100% EOU) V","address":"Koyikkalethu Veeyapuram","city":"Alappuzha","supplier":"WELLGREEN TECHNOLOGY CO. ","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"MOLECULES BIO LABS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"485","totalValueFC":"4906","currency":"USD","unitRateINR":"41685.8","date":"23-Dec-2024","totalValueINR":"416857.5","totalValueInUsd":"4906","indian_port":"Cochin Air","hs_no":"29362990","bill_no":"7418364","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"1001, BUILDING2, LANJI CENTER, NO.72 KEJI 2 ROAD, XI AN SDNF CN","customerAddress":"Koyikkalethu Veeyapuram"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1735324200,"product":"K2VITAL 5% MCT OIL (1 KG) VITAMIN K2 ALL TRANS MK-7 IN MCT OIL (BATCH NO- BN75000000526)K2VITAL 5% MCT OIL (1 KG) VITAMIN K2 ALL TRANS MK-7 IN MCT O","address":"220,UDYOG BHAVAN","city":"MUMBAI,MAHARASHTRA","supplier":"KAPPA BIOSCIENCE","supplierCountry":"NORWAY","foreign_port":"HAMBURG - FUHLSBUETT","customer":"S.A. PHARMACHEM","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"7099.5","totalValueFC":"7181.4","currency":"USD","unitRateINR":"610200","date":"28-Dec-2024","totalValueINR":"610200","totalValueInUsd":"7181.4","indian_port":"Bombay Air","hs_no":"29362990","bill_no":"7509439","productDescription":"API","marketType":"REGULATED MARKET","country":"NORWAY","selfForZScoreResived":"Pharma Grade","supplierPort":"HAMBURG - FUHLSBUETT","supplierAddress":"FRIESENWEG 2222763 HAMBURG SDNF SDNF GERMANY","customerAddress":"220,UDYOG BHAVAN"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1735583400,"product":"MEDIQ7 VITAMIN K2 - SOUTH KOREA MEDIQ7 VITAMIN K2 - SOUTH KOREA","address":"401 4TH FL WINDSOR HOUSE CST RD","city":"MUMBAI, MAHARASHTRA.","supplier":"GF FERMENTECH INC","supplierCountry":"REPUBLIC OF KOREA","foreign_port":"SEOUL - INCHEON INT\\'","customer":"ROYAL DSM","customerCountry":"INDIA","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"149","totalValueFC":"1507.2","currency":"USD","unitRateINR":"12806.6","date":"31-Dec-2024","totalValueINR":"128065.5","totalValueInUsd":"1507.2","indian_port":"Bombay Air","hs_no":"29362930","bill_no":"7546945","productDescription":"API","marketType":"","country":"REPUBLIC OF KOREA","selfForZScoreResived":"Pharma Grade","supplierPort":"SEOUL - INCHEON INT\\'","supplierAddress":"74-12, GEUMHOSEONMAL-GIL BUGANG-MYE ON, SEJONG-SI 30077, S. KOREA SDNF Korea, Republic of","customerAddress":"401 4TH FL WINDSOR HOUSE CST RD"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1736620200,"product":"VITAMIN K2 (MENAQUINONE-4) (FOR TESTING AND ANALYSIS PURPOSEONLY)VITAMIN K2 (MENAQUINONE-4) (FOR TESTING AND ANALYSIS PURPOSE","address":"MANISHA PLAZA SONAPUR LANE,","city":"MUMBAI,MAHARASHTRA","supplier":"HEBEI SUNCO BIOTECH CO., LTD","supplierCountry":"CHINA","foreign_port":"SUDEREYI","customer":"ZIM LABORATORIES","customerCountry":"INDIA","quantity":"0.20","actualQuantity":"200","unit":"GMS","unitRateFc":"6.5","totalValueFC":"1305.6","currency":"USD","unitRateINR":"562.9","date":"12-Jan-2025","totalValueINR":"112580","totalValueInUsd":"1305.6","indian_port":"Bombay Air","hs_no":"29362990","bill_no":"7748782","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SUDEREYI","supplierAddress":"ROOM 2305 ZHONGYE SHENGSHI PLAZA NO 66 XIABNGTAI ROAD SHIJIA ZHUANG ZH UANG - 0, , CHINA CHINA","customerAddress":"MANISHA PLAZA SONAPUR LANE,"}]
02-Jan-2021
25-Feb-2025
KGS
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Average Price (USD/KGS)

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Quantity (KGS) & Unit rate (USD/KGS) over time

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FDF Dossiers

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01

Interphex
Not Confirmed
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Interphex
Not Confirmed

Vitamin D3; Vitamin K2; Calcium

Brand Name :

Dosage Form :

Dosage Strength : 1000IU; 9MCG; 90MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

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02

Interphex
Not Confirmed
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Interphex
Not Confirmed

Vitamin K2

Brand Name :

Dosage Form :

Dosage Strength : 55MCG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

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03

Interphex
Not Confirmed
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Interphex
Not Confirmed

Vitamin K2

Brand Name :

Dosage Form :

Dosage Strength : 200MCG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

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04

Interphex
Not Confirmed
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Interphex
Not Confirmed

Vitamin D3; Vitamin K2

Brand Name :

Dosage Form :

Dosage Strength : 2000IU; 15MCG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

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05

Interphex
Not Confirmed
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Interphex
Not Confirmed

Vitamin D3; Vitamin K2

Brand Name :

Dosage Form :

Dosage Strength : 400IU; 55MCG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

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06

Interphex
Not Confirmed
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Interphex
Not Confirmed

Vitamin D3; Vitamin K2; Vitamin B12; Ascorbic Acid

Brand Name : Cogito® prolife, Immun

Dosage Form : Soft-Gum

Dosage Strength : 25MCG; 75MCG; 5MCG; 80MG

Packaging : 1.8G

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Germany

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07

EmergoPharm

Poland
Interphex
Not Confirmed
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EmergoPharm

Poland
arrow
Interphex
Not Confirmed

Vitamin D3; Vitamin K2

Brand Name : DeVit D3 + K2

Dosage Form : Sublingual Spray; Sublingual Spray

Dosage Strength : 400IU; 10MCG

Packaging : 400 Doses

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Poland

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08

NV Labs

Netherlands
Interphex
Not Confirmed
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NV Labs

Netherlands
arrow
Interphex
Not Confirmed

Vitamin K2; Vitamin D3

Brand Name :

Dosage Form : Softgel

Dosage Strength : 120MCG; 2000IU

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Netherlands

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09

ZRS LABS

India
Interphex
Not Confirmed
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ZRS LABS

India
arrow
Interphex
Not Confirmed

Calcium Citrate; Magnesium Hydroxide; Zinc sulfate monohydrate; Vitamin D3; Calcitriol; Vitamin K 2

Brand Name :

Dosage Form : Tablet

Dosage Strength : 1000MG; 100MG; 7.5MG; 0.25MCG; 50MCG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

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10

ZRS LABS

India
Interphex
Not Confirmed
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ZRS LABS

India
arrow
Interphex
Not Confirmed

Calcium Citrate; Calcitriol; Zinc; Magnesium Hydroxide; Vitamin K 2

Brand Name :

Dosage Form : Tablet

Dosage Strength : 250MG; 0.25MCG; 7.5MG; 100MG; 750MCG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

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ABOUT THIS PAGE

Looking for 863-61-6 / Vitamin K2 API manufacturers, exporters & distributors?

Vitamin K2 manufacturers, exporters & distributors 1

100

PharmaCompass offers a list of Vitamin K2 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Vitamin K2 manufacturer or Vitamin K2 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Vitamin K2 manufacturer or Vitamin K2 supplier.

PharmaCompass also assists you with knowing the Vitamin K2 API Price utilized in the formulation of products. Vitamin K2 API Price is not always fixed or binding as the Vitamin K2 Price is obtained through a variety of data sources. The Vitamin K2 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Vitamin K2

Synonyms

Menaquinone-4, 863-61-6, Menaquinone 4, 11032-49-8, Kaytwo, Kefton-2

Cas Number

863-61-6

Unique Ingredient Identifier (UNII)

27Y876D139

About Vitamin K2

Menatetrenone is a menaquinone compound and form of vitamin K2 with potential antineoplastic activity. Menatetrenone may act by modulating the signalling of certain tyrosine kinases, thereby affecting several transcription factors including c-myc and c-fos. This agent inhibits tumor cell growth by inducing apoptosis and cell cycle arrest.

Menatetrenone Manufacturers

A Menatetrenone manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Menatetrenone, including repackagers and relabelers. The FDA regulates Menatetrenone manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Menatetrenone API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Menatetrenone manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Menatetrenone Suppliers

A Menatetrenone supplier is an individual or a company that provides Menatetrenone active pharmaceutical ingredient (API) or Menatetrenone finished formulations upon request. The Menatetrenone suppliers may include Menatetrenone API manufacturers, exporters, distributors and traders.

click here to find a list of Menatetrenone suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Menatetrenone USDMF

A Menatetrenone DMF (Drug Master File) is a document detailing the whole manufacturing process of Menatetrenone active pharmaceutical ingredient (API) in detail. Different forms of Menatetrenone DMFs exist exist since differing nations have different regulations, such as Menatetrenone USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Menatetrenone DMF submitted to regulatory agencies in the US is known as a USDMF. Menatetrenone USDMF includes data on Menatetrenone's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Menatetrenone USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Menatetrenone suppliers with USDMF on PharmaCompass.

Menatetrenone JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Menatetrenone Drug Master File in Japan (Menatetrenone JDMF) empowers Menatetrenone API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Menatetrenone JDMF during the approval evaluation for pharmaceutical products. At the time of Menatetrenone JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Menatetrenone suppliers with JDMF on PharmaCompass.

Menatetrenone GMP

Menatetrenone Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Menatetrenone GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Menatetrenone GMP manufacturer or Menatetrenone GMP API supplier for your needs.

Menatetrenone CoA

A Menatetrenone CoA (Certificate of Analysis) is a formal document that attests to Menatetrenone's compliance with Menatetrenone specifications and serves as a tool for batch-level quality control.

Menatetrenone CoA mostly includes findings from lab analyses of a specific batch. For each Menatetrenone CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Menatetrenone may be tested according to a variety of international standards, such as European Pharmacopoeia (Menatetrenone EP), Menatetrenone JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Menatetrenone USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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