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4 SPI Pharma, 2 Faran Shimi Pharmaceutical, 9 Gangwal Healthcare, 1 Pfanstiehl, 1 Actylis, 3 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 2 BASF, 2 DFE Pharma, 4 Gangwal Chemicals, 1 Ideal Cures Pvt Ltd, 2 Ingredion Pharma Solutions, 6 Kerry, 7 Microlex e.U, 1 Pharmatrans-Sanaq, 2 Pluviaendo, 2 Prachin Chemical, 13 Roquette, 1 Seppic, 3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 8 Sigachi Industries, 2 Vasa Pharmachem

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33 Fillers, Diluents & Binders, 21 Direct Compression, 13 Thickeners and Stabilizers, 12 Co-Processed Excipients, 10 Lubricants & Glidants, 9 Disintegrants & Superdisintegrants, 8 Granulation, 7 Taste Masking, 6 Coating Systems & Additives, 6 Controlled & Modified Release, 5 Chewable & Orodispersible Aids, 1 Parenteral, 1 Film Formers & Plasticizers, 1 Rheology Modifiers, 1 Emulsifying Agents

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33 Fillers, Diluents & Binders
21 Direct Compression
13 Thickeners and Stabilizers
12 Co-Processed Excipients
10 Lubricants & Glidants
9 Disintegrants & Superdisintegrants
8 Granulation
7 Taste Masking
6 Coating Systems & Additives
6 Controlled & Modified Release
5 Chewable & Orodispersible Aids
1 Parenteral
1 Film Formers & Plasticizers
1 Rheology Modifiers
1 Emulsifying Agents

Synopsis

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Chemistry

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Also known as: 76-90-4, Cantil, Cantilaque, Colibantil, Gastropidil, Cantilon

Molecular Formula

C₂₁H₂₆BrNO₃

Molecular Weight

420.3 g/mol

InChI Key

JRRNZNSGDSFFIR-UHFFFAOYSA-M

FDA UNII

APX8D32IX1

1 2D Structure

Mepenzolate Bromide

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(1,1-dimethylpiperidin-1-ium-3-yl) 2-hydroxy-2,2-diphenylacetate;bromide

2.1.2 InChI

InChI=1S/C21H26NO3.BrH/c1-22(2)15-9-14-19(16-22)25-20(23)21(24,17-10-5-3-6-11-17)18-12-7-4-8-13-18;/h3-8,10-13,19,24H,9,14-16H2,1-2H3;1H/q+1;/p-1

2.1.3 InChI Key

JRRNZNSGDSFFIR-UHFFFAOYSA-M

2.1.4 Canonical SMILES

C[N+]1(CCCC(C1)OC(=O)C(C2=CC=CC=C2)(C3=CC=CC=C3)O)C.[Br-]

2.2 Other Identifiers

2.2.1 UNII

APX8D32IX1

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Cantil

2. Mepenzolate

3. Mepenzolate Bromide, (+-)-isomer

4. Mepenzolate Iodide

5. Mepenzolic Acid

6. Mepenzolic Acid, Bromine Salt

7. Mepenzolic Acid, Bromine Salt, 1-(methyl-(14)c)-labeled

8. N-methyl-3-piperidylbenzilate Methyl Bromide

2.3.2 Depositor-Supplied Synonyms

1. 76-90-4

2. Cantil

3. Cantilaque

4. Colibantil

5. Gastropidil

6. Cantilon

7. Colopiril

8. Delevil

9. Eftoron

10. Tralanta

11. Trancolon

12. Colum

13. Mepenzolate (bromide)

14. Jb 340

15. 3-(2-hydroxy-2,2-diphenylacetoxy)-1,1-dimethylpiperidin-1-ium Bromide

16. 3-hydroxy-1,1-dimethylpiperidinium Bromide Benzilate

17. N-methyl-3-piperidyl Benzilate Methobromide

18. N-methyl-3-piperidyl Benzilate Methyl Bromide

19. Cantril

20. N-methyl-3-piperidyldiphenylglycolate Methobromide

21. Benzilic Acid, 1-methyl-3-piperidyl Ester Methobromide

22. Nsc-4358

23. An-6437

24. Apx8d32ix1

25. Hy-17585

26. Ft-0671006

27. Trokonil

28. Piperidinium, 3-((hydroxydiphenylacetyl)oxy)-1,1-dimethyl-, Bromide

29. Piperidinium, 3-[(hydroxydiphenylacetyl)oxy]-1,1-dimethyl-, Bromide

30. (1,1-dimethylpiperidin-1-ium-3-yl) 2-hydroxy-2,2-diphenylacetate;bromide

31. Dsstox_cid_3252

32. (1,1-dimethylpiperidin-1-ium-3-yl) 2-hydroxy-2,2-diphenylacetate,bromide

33. Dsstox_rid_76941

34. Dsstox_gsid_23252

35. Mepenzolati Bromidum

36. Bromure De Mepenzolate

37. Bromuro De Mepenzolato

38. 1-methyl-3-piperidyl Benzilate Methyl Bromide

39. Mepenzolati Bromidum [inn-latin]

40. Bromure De Mepenzolate [inn-french]

41. Mepenzolone Bromide

42. Bromuro De Mepenzolato [inn-spanish]

43. Smr000058832

44. Cantil (tn)

45. 1-methyl-3-piperidyl Benzilate Methylbromide

46. Mepenzolate Methylbromide

47. Sr-01000765452

48. Nsc 4358

49. Einecs 200-992-7

50. Unii-apx8d32ix1

51. 3-((hydroxydiphenylacetyl)oxy)-1,1-dimethylpiperidinium Bromide

52. Benzilic Acid, Ester With 3-hydroxy-1,1-dimethylpiperidinium Bromide

53. Prestwick_100

54. Piperidinium, 3-hydroxy-1,1-dimethyl-, Bromide, Benzilate

55. Mepenzolate Bromide [usp:inn:ban:jan]

56. Cas-76-90-4

57. Ncgc00016314-01

58. Chembl1724

59. Schembl99030

60. Mls001076678

61. Mls002222165

62. Spectrum1500383

63. Chebi:6753

64. Dtxsid4023252

65. Mepenzolate Bromide [mi]

66. Hms501p18

67. Mepenzolate Bromide [inn]

68. Mepenzolate Bromide [jan]

69. Nsc4358

70. Mepenzolate Bromide (jp17/inn)

71. Hms1570c07

72. Hms1920l05

73. Hms2091b18

74. Hms2097c07

75. Hms2231p11

76. Hms3259o19

77. Hms3369a20

78. Hms3714c07

79. Pharmakon1600-01500383

80. Piperidinium,1-dimethyl-, Bromide

81. Mepenzolate Bromide [vandf]

82. 3-[(hydroxy-diphenylacetyl)oxy]-1,1-dimethylpiperidinium Bromide

83. 3-{[hydroxy(diphenyl)acetyl]oxy}-1,1-dimethylpiperidinium Bromide

84. Mepenzolate Bromide [mart.]

85. Tox21_110367

86. Ccg-40131

87. Mepenzolate Bromide [who-dd]

88. Nsc757099

89. Akos015962135

90. Tox21_110367_1

91. Cs-3578

92. Nc00518

93. Nsc-757099

94. Mepenzolate Bromide [orange Book]

95. Ncgc00094716-01

96. Ncgc00094716-02

97. Ncgc00178896-05

98. Wln: T6ktj A1 A1 Covxqr&r &e

99. Ac-15989

100. As-75556

101. Benzilic Acid,1-dimethylpiperidinium Bromide

102. Piperidinium,1-dimethyl-, Bromide, Benzilate

103. D00720

104. D94756

105. A865394

106. Sr-01000765452-2

107. Sr-01000765452-3

108. Q27274055

109. 3-(2-hydroxy-2,2-diphenylacetoxy)-1,1-dimethylpiperidinium Bromide

110. 3-(2-hydroxy-2,2-diphenylacetoxy)-1,1-dimethylpiperidin-1-iumbromide

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₁H₂₆BrNO₃
Molecular Weight	420.3 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Exact Mass	419.10961 g/mol
Monoisotopic Mass	419.10961 g/mol
Topological Polar Surface Area	46.5 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	432
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Cantil
PubMed Health	Mepenzolate (By mouth)
Drug Classes	Gastrointestinal Agent
Drug Label	CANTIL tablets for oral administration contain 25 mg mepenzolate bromide USP. The anticholinergic agent mepenzolate bromide USP chemically is 3-[(hydroxydiphenylacetyl)oxy]-1,1-dimethylpiperidinium bromide and has the following structure:Mepenzolate...
Active Ingredient	Mepenzolate bromide
Dosage Form	Tablet
Route	Oral
Strength	25mg
Market Status	Prescription
Company	Sanofi Aventis Us

2 of 2
Drug Name	Cantil
PubMed Health	Mepenzolate (By mouth)
Drug Classes	Gastrointestinal Agent
Drug Label	CANTIL tablets for oral administration contain 25 mg mepenzolate bromide USP. The anticholinergic agent mepenzolate bromide USP chemically is 3-[(hydroxydiphenylacetyl)oxy]-1,1-dimethylpiperidinium bromide and has the following structure:Mepenzolate...
Active Ingredient	Mepenzolate bromide
Dosage Form	Tablet
Route	Oral
Strength	25mg
Market Status	Prescription
Company	Sanofi Aventis Us

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Chewable & Orodispersible Aids

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Mepenzolate Bromide

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CHEMISTRY

Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

1 API Suppliers

1 JDMF

1 Listed Suppliers

FINISHED DOSAGE FORMULATIONS

2 FDF Dossiers

2 FDA Orange Book

RELATED EXCIPIENT COMPANIES

4 SPI Pharma

2 Faran Shimi Pharmaceutical

9 Gangwal Healthcare

1 Pfanstiehl

1 Actylis

3 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

2 BASF

2 DFE Pharma

4 Gangwal Chemicals

1 Ideal Cures Pvt Ltd

2 Ingredion Pharma Solutions

6 Kerry

7 Microlex e.U

1 Pharmatrans-Sanaq

2 Pluviaendo

2 Prachin Chemical

13 Roquette

1 Seppic

3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

8 Sigachi Industries

2 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

33 Fillers, Diluents & Binders

21 Direct Compression

13 Thickeners and Stabilizers

12 Co-Processed Excipients

10 Lubricants & Glidants

9 Disintegrants & Superdisintegrants

8 Granulation

7 Taste Masking

6 Coating Systems & Additives

6 Controlled & Modified Release

5 Chewable & Orodispersible Aids

1 Parenteral

1 Film Formers & Plasticizers

1 Rheology Modifiers

1 Emulsifying Agents

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

PATENTS & EXCLUSIVITIES

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GLOBAL SALES INFORMATION

76 RELATED EXCIPIENT COMPANIES

134EXCIPIENTS BY APPLICATIONS

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