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Chemistry

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Also known as: Mepirizole, 18694-40-1, Mebron, Methopyrimazole, 4-methoxy-2-(5-methoxy-3-methyl-1h-pyrazol-1-yl)-6-methylpyrimidine, Mepirizol
Molecular Formula
C11H14N4O2
Molecular Weight
234.25  g/mol
InChI Key
RHAXSHUQNIEUEY-UHFFFAOYSA-N
FDA UNII
3B46O2FH8I

Mepirizole
4-Methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidine. A pyrimidinyl pyrazole with antipyretic, analgesic, and anti-inflammatory activity.
1 2D Structure

Mepirizole

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidine
2.1.2 InChI
InChI=1S/C11H14N4O2/c1-7-5-9(16-3)13-11(12-7)15-10(17-4)6-8(2)14-15/h5-6H,1-4H3
2.1.3 InChI Key
RHAXSHUQNIEUEY-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=CC(=NC(=N1)N2C(=CC(=N2)C)OC)OC
2.2 Other Identifiers
2.2.1 UNII
3B46O2FH8I
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Mepirizole

2. Methopyrimazole

2.3.2 Depositor-Supplied Synonyms

1. Mepirizole

2. 18694-40-1

3. Mebron

4. Methopyrimazole

5. 4-methoxy-2-(5-methoxy-3-methyl-1h-pyrazol-1-yl)-6-methylpyrimidine

6. Mepirizol

7. Da-398

8. Epirizolum [inn-latin]

9. 4-methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidine

10. Pyrimidine, 4-methoxy-2-(5-methoxy-3-methyl-1h-pyrazol-1-yl)-6-methyl-

11. Mls000028844

12. 3b46o2fh8i

13. 1-(4-methoxy-6-methyl-2-pyrimidinyl)-3-methyl-5-methoxypyrazole

14. 2-(3-methoxy-5-methylpyrazol-2-yl)-4-methoxy-6-methylpyrimidine

15. 2-(3-methyl-5-methoxy-1-pyrazolyl)-4-methoxy-6-methylpyrimidine

16. Ncgc00016737-01

17. Smr000058715

18. 4-methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidin

19. Cas-18694-40-1

20. Dsstox_cid_25422

21. Dsstox_rid_80869

22. Dsstox_gsid_45422

23. Mepirizol [german]

24. Epirizolum

25. Epirizol

26. Epirizol [inn-spanish]

27. Pyrimidine,4-methoxy-2-(5-methoxy-3-methyl-1h-pyrazol-1-yl)-6-methyl-

28. Epirizole [usan:inn:jan]

29. Einecs 242-507-1

30. Brn 0751084

31. Unii-3b46o2fh8i

32. Prestwick_201

33. Mebron (tn)

34. Epirizole [inn]

35. Epirizole [jan]

36. Opera_id_598

37. Epirizole [mi]

38. Epirizole [usan]

39. Prestwick0_000032

40. Prestwick1_000032

41. Prestwick2_000032

42. Prestwick3_000032

43. Epirizole [mart.]

44. 4-methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidin [german]

45. Epirizole (jp17/usan)

46. Epirizole [who-dd]

47. Schembl23765

48. Bspbio_000123

49. 5-25-18-00012 (beilstein Handbook Reference)

50. Mls001148256

51. Mls001424179

52. Spbio_002044

53. Mepirizole, Analytical Standard

54. Bpbio1_000137

55. Chembl1411693

56. Dtxsid4045422

57. Chebi:31545

58. Zinc57412

59. Hms1568g05

60. Hms2052a07

61. Hms2095g05

62. Hms2232e23

63. Hms3370d19

64. Hms3394a07

65. Hms3712g05

66. Tox21_110584

67. Pyrimidine, 4-methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methyl-

68. Akos016000700

69. Tox21_110584_1

70. Ccg-101087

71. Db08991

72. Nc00337

73. Ncgc00016737-02

74. Ncgc00016737-04

75. Hy-103595

76. Cs-0022015

77. Ft-0637738

78. Mls000028844-02

79. D01394

80. 694m401

81. Sr-01000721915

82. J-012020

83. Q5383219

84. Sr-01000721915-3

85. Brd-k39339537-001-03-8

86. 2-(3-methyl-5-methoxy-1-pyrazolyl)-4-methoxy-6-methyl-pyrimidine

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 234.25 g/mol
Molecular Formula C11H14N4O2
XLogP31.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass234.11167570 g/mol
Monoisotopic Mass234.11167570 g/mol
Topological Polar Surface Area62.1 Ų
Heavy Atom Count17
Formal Charge0
Complexity254
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)


ABOUT THIS PAGE

Mepirizole Manufacturers

A Mepirizole manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Mepirizole, including repackagers and relabelers. The FDA regulates Mepirizole manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Mepirizole API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Mepirizole Suppliers

A Mepirizole supplier is an individual or a company that provides Mepirizole active pharmaceutical ingredient (API) or Mepirizole finished formulations upon request. The Mepirizole suppliers may include Mepirizole API manufacturers, exporters, distributors and traders.

click here to find a list of Mepirizole suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Mepirizole USDMF

A Mepirizole DMF (Drug Master File) is a document detailing the whole manufacturing process of Mepirizole active pharmaceutical ingredient (API) in detail. Different forms of Mepirizole DMFs exist exist since differing nations have different regulations, such as Mepirizole USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Mepirizole DMF submitted to regulatory agencies in the US is known as a USDMF. Mepirizole USDMF includes data on Mepirizole's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Mepirizole USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Mepirizole suppliers with USDMF on PharmaCompass.

Mepirizole GMP

Mepirizole Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Mepirizole GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Mepirizole GMP manufacturer or Mepirizole GMP API supplier for your needs.

Mepirizole CoA

A Mepirizole CoA (Certificate of Analysis) is a formal document that attests to Mepirizole's compliance with Mepirizole specifications and serves as a tool for batch-level quality control.

Mepirizole CoA mostly includes findings from lab analyses of a specific batch. For each Mepirizole CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Mepirizole may be tested according to a variety of international standards, such as European Pharmacopoeia (Mepirizole EP), Mepirizole JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Mepirizole USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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