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Also known as: 96036-03-2, Merrem, Meropenem anhydrous, Meropenemum, Antibiotic sm 7338, Meronem
Molecular Formula
C17H25N3O5S
Molecular Weight
383.5  g/mol
InChI Key
DMJNNHOOLUXYBV-PQTSNVLCSA-N
FDA UNII
YOP6PX0BAO

Meropenem
A thienamycin derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of bacterial infections, including infections in immunocompromised patients.
Meropenem anhydrous is a Penem Antibacterial.
1 2D Structure

Meropenem

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(4R,5S,6S)-3-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
2.1.2 InChI
InChI=1S/C17H25N3O5S/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4/h7-12,18,21H,5-6H2,1-4H3,(H,24,25)/t7-,8-,9+,10+,11-,12-/m1/s1
2.1.3 InChI Key
DMJNNHOOLUXYBV-PQTSNVLCSA-N
2.1.4 Canonical SMILES
CC1C2C(C(=O)N2C(=C1SC3CC(NC3)C(=O)N(C)C)C(=O)O)C(C)O
2.1.5 Isomeric SMILES
C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1S[C@H]3C[C@H](NC3)C(=O)N(C)C)C(=O)O)[C@@H](C)O
2.2 Other Identifiers
2.2.1 UNII
YOP6PX0BAO
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3-(5-dimethylcarbamoylpyrrolidin-3-ylthio)-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic Acid

2. Merrem

3. Penem

4. Ronem

5. Sm 7338

6. Sm-7338

7. Sm7338

2.3.2 Depositor-Supplied Synonyms

1. 96036-03-2

2. Merrem

3. Meropenem Anhydrous

4. Meropenemum

5. Antibiotic Sm 7338

6. Meronem

7. Meropenem [inn]

8. 119478-56-7

9. Mepm

10. Sm 7338

11. Chebi:43968

12. Sm-7338

13. Meropenemum [inn-latin]

14. Merrem I.v.

15. Meropenem (inn)

16. Meropenem, Anhydrous

17. (4r,5s,6s)-3-{[(3s,5s)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-6-[(1r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid

18. Meropenem Hydrate

19. Yop6px0bao

20. (4r,5s,6s)-3-[(3s,5s)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid

21. Ici-194660

22. (4r,5s,6s)-3-{[(3s,5s)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid

23. Ncgc00016962-01

24. Ici 194660

25. Dsstox_cid_25526

26. Dsstox_rid_80930

27. Dsstox_gsid_45526

28. Ici 194,660

29. Meropenem (as Trihydrate)

30. Meropen

31. (1r,5s,6s)-2-[(3s,5s)-5-dimethylaminocarbonylpyrrolidin-3-ylthio]-6-[(r)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic Acid

32. (4r,5s,6s)-3-(((3s,5s)-5-(dimethylcarbamoyl)pyrrolidin-3-yl)thio)-6-((r)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid

33. (4r,5s,6s)-3-[[(3s,5s)-5-[(dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-[(1r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid

34. Meronem (tn)

35. Cas-96036-03-2

36. Nsc-759621

37. Merrem I.v. (tn)

38. Sr-01000762894

39. Unii-yop6px0bao

40. Hsdb 8019

41. Merrem Iv

42. Meropenem,(s)

43. M2279

44. Brn 6940582

45. Meropenem (closed Form)

46. Meropenem [mi]

47. Prestwick0_001106

48. Prestwick1_001106

49. Prestwick2_001106

50. Prestwick3_001106

51. Chembl127

52. Epitope Id:195064

53. Meropenem [who-dd]

54. Schembl34442

55. Bspbio_001212

56. Mls001401437

57. Bidd:gt0851

58. 4-methyl-7-oxo-1-azabicyclo

59. Spbio_003086

60. Bpbio1_001334

61. Meropenem With Sodium Carbonate

62. Dtxsid7045526

63. Gtpl10829

64. Hms1571m14

65. Hms2051g08

66. Hms2090c05

67. Hms2098m14

68. Hms3715m14

69. Meropenem Aslo Known As Meropenemum

70. (4r,5s,6s)-3-[(3s,5s)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1s)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid

71. 1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic Acid, 3-(((3s,5s)-5-((dimethylamino)carbonyl)-3-pyrrolidinyl)thio)-6-((1r)-1-hydroxyethyl)-4-methyl-7-oxo-, (4r,5s,6s)-

72. Amy22192

73. Zinc3808779

74. Tox21_110715

75. Tox21_113794

76. Bdbm50129062

77. Mfcd00864966

78. Akos015920140

79. Tox21_110715_1

80. Ccg-100850

81. Cs-1865

82. Db00760

83. Ks-5224

84. Nc00100

85. [3.2.0]hept-2-ene-2-carboxylic Acid

86. Ncgc00179259-01

87. Ncgc00179259-06

88. Ncgc00179259-17

89. Ncgc00253670-01

90. Ncgc00262579-02

91. (6s)-2-{[(3s,5s)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-6-[(1r)-1-hydroxyethyl]-1beta-methyl-2,3-didehydro-1-carbapenam-3-carboxylic Acid

92. Hy-13678

93. Smr000469184

94. Ab00514051

95. D08185

96. M-2780

97. M05727

98. Ab00514051-02

99. Ab00698370-05

100. Pyrrolidin-3-ylthio)-6-((r)-1-hydroxyethyl)-

101. 036m032

102. Q421670

103. (4r,5s,6s)-3-((3s,5s)-5-(dimethylcarbamoyl)

104. Sr-01000762894-3

105. Sr-01000762894-4

106. Meropenem Trihydrate, Antibiotic For Culture Media Use Only

107. (1r,5s,6s)-2-[(3s,5s)-5-(dimethylaminocarbonyl)pyrrolidin-3-ylthio]-6-[(r)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic Acid

108. (4r,5s,6s)-3-(((3s,5s)-5-(dimethylcarbamoyl)-3-pyrrolidinyl)thio)-6-((1r)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic Acid

109. (4r,5s,6s)-3-(((3s,5s)-5-(dimethylcarbamoyl)pyrrolidin-3-yl)thio)-6-((r)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylicacid

110. (4r,5s,6s)-3-((3s,5s)-5-(dimethylcarbamoyl)pyrrolidin-3-ylthio)-6-((r)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid

111. (4r,5s,6s)-3-[[(3s,5s)-5-(dimethylaminocarbonyl)-3-pyrrolidinyl]thio]-6-[(1r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid

112. (4r,6s)-3-((3s,5s)-5-(dimethylcarbamoyl)pyrrolidin-3-ylthio)-6-((r)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid

113. 1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic Acid, 3-((5-((dimethylamino)carbonyl)-3-pyrrolidinyl)thio)-6-(1-hydroxyethyl)-4-methyl-7-oxo-, (4r-(3(s*,5s*),4-alpha,5-beta,6-beta(r*)))-

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 383.5 g/mol
Molecular Formula C17H25N3O5S
XLogP3-2.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass383.15149208 g/mol
Monoisotopic Mass383.15149208 g/mol
Topological Polar Surface Area136 Ų
Heavy Atom Count26
Formal Charge0
Complexity679
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameMeropenem
PubMed HealthMeropenem (Injection)
Drug ClassesAntibiotic
Drug LabelMeropenem for Injection, USP (I.V.) is a sterile, pyrogen-free, synthetic, broad-spectrum, carbapenem antibiotic for intravenous administration. It is (4R,5S,6S)-3-[[(3S,5S)-5-(Dimethylcarbamoyl)-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-...
Active IngredientMeropenem
Dosage FormInjectable
RouteInjection
Strength500mg/vial; 1gm/vial
Market StatusPrescription
CompanyHospira; Sandoz; Acs Dobfar

2 of 4  
Drug NameMerrem
PubMed HealthMeropenem (Injection)
Drug ClassesAntibiotic
Drug LabelMERREM I.V. (meropenem for injection) is a sterile, pyrogen-free, synthetic, broad-spectrum, carbapenem antibiotic for intravenous administration. It is (4R,5S,6S)-3- [[(3S,5S)-5-(Dimethylcarbamoyl)-3-pyrrolidinyl]thio]-6- [(1R)-1-hydroxyethyl]-4-m...
Active IngredientMeropenem
Dosage FormInjectable
RouteInjection
Strength500mg/vial; 1gm/vial
Market StatusPrescription
CompanyAstrazeneca

3 of 4  
Drug NameMeropenem
PubMed HealthMeropenem (Injection)
Drug ClassesAntibiotic
Drug LabelMeropenem for Injection, USP (I.V.) is a sterile, pyrogen-free, synthetic, broad-spectrum, carbapenem antibiotic for intravenous administration. It is (4R,5S,6S)-3-[[(3S,5S)-5-(Dimethylcarbamoyl)-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-...
Active IngredientMeropenem
Dosage FormInjectable
RouteInjection
Strength500mg/vial; 1gm/vial
Market StatusPrescription
CompanyHospira; Sandoz; Acs Dobfar

4 of 4  
Drug NameMerrem
PubMed HealthMeropenem (Injection)
Drug ClassesAntibiotic
Drug LabelMERREM I.V. (meropenem for injection) is a sterile, pyrogen-free, synthetic, broad-spectrum, carbapenem antibiotic for intravenous administration. It is (4R,5S,6S)-3- [[(3S,5S)-5-(Dimethylcarbamoyl)-3-pyrrolidinyl]thio]-6- [(1R)-1-hydroxyethyl]-4-m...
Active IngredientMeropenem
Dosage FormInjectable
RouteInjection
Strength500mg/vial; 1gm/vial
Market StatusPrescription
CompanyAstrazeneca

4.2 Therapeutic Uses

Anti-Bacterial Agents

National Library of Medicine's Medical Subject Headings online file (MeSH, 2012)


Meropenem is used for the treatment of intra-abdominal infections, including complicated appendicitis and peritonitis, caused by susceptible bacteria. The drug may be used as monotherapy for the treatment of intra-abdominal infections caused by susceptible viridans streptococci, Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa, Bacteroides fragilis, B. thetaiotaomicron, or Peptostreptococcus. Because meropenem has a broad spectrum of antibacterial activity, the drug may be used empirically to treat intra-abdominal infections before identification of the causative organism. /Included in US product labeling/

American Society of Health-System Pharmacists 2011; Drug Information 2011. Bethesda, MD. 2011, p. 186


Meropenem is used for the treatment of bacterial meningitis caused by susceptible Streptococcus pneumoniae, Haemophilus influenzae (including beta-lactamase-producing strains), or Neisseria meningitidis in children 3 months of age and older. /Included in US product labeling/

American Society of Health-System Pharmacists 2011; Drug Information 2011. Bethesda, MD. 2011, p. 187


The drug also is used in the treatment of meningitis in adults. /NOT included in US product labeling/

American Society of Health-System Pharmacists 2011; Drug Information 2011. Bethesda, MD. 2011, p. 187


For more Therapeutic Uses (Complete) data for Meropenem (20 total), please visit the HSDB record page.


4.3 Drug Warning

Serious and occasionally fatal hypersensitivity reactions (e.g., anaphylaxis) reported with beta-lactams. If hypersensitivity occurs, discontinue meropenem and institute appropriate therapy as indicated (e.g., epinephrine, corticosteroids, and maintenance of an adequate airway and oxygen).

American Society of Health-System Pharmacists 2011; Drug Information 2011. Bethesda, MD. 2011, p. 189


Adverse effects reported in 1% or more of patients receiving meropenem including GI effects (diarrhea, nausea, vomiting, constipation), local reactions (pain and inflammation at injection site, phlebitis/thrombophlebitis), headache, anemia, rash, pruritus, sepsis, apnea, shock, glossitis, and oral candidiasis.

American Society of Health-System Pharmacists 2011; Drug Information 2011. Bethesda, MD. 2011, p. 190


Seizures and other adverse CNS effects reported during meropenem therapy, especially in those with underlying CNS disorders (e.g., brain lesions, history of seizures), bacterial meningitis, or compromised renal function. Do not exceed recommended dosage, especially in those with known factors that predispose to seizures. Anticonvulsant therapy should be continued in those with known seizure disorders. If focal tremors, myoclonus, or seizures occur, evaluate the patient neurologically, initiate anticonvulsant therapy if necessary, and determine whether meropenem dosage should be decreased or the drug discontinued.

American Society of Health-System Pharmacists 2011; Drug Information 2011. Bethesda, MD. 2011, p. 189


Partial cross-allergenicity among beta-lactam antibiotics, including penicillins, cephalosporins, and other beta-lactams. Prior to initiation of meropenem therapy, make careful inquiry concerning previous hypersensitivity reactions to meropenem, cephalosporins, penicillins, or other drugs.

American Society of Health-System Pharmacists 2011; Drug Information 2011. Bethesda, MD. 2011, p. 189


For more Drug Warnings (Complete) data for Meropenem (8 total), please visit the HSDB record page.


4.4 Drug Indication

For use as single agent therapy for the treatment of the following infections when caused by susceptible isolates of the designated microorganisms: complicated skin and skin structure infections due to Staphylococcus aureus (b-lactamase and non-b-lactamase producing, methicillin-susceptible isolates only), Streptococcus pyogenes, Streptococcus agalactiae, viridans group streptococci, Enterococcus faecalis (excluding vancomycin-resistant isolates), Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Bacteroides fragilis and Peptostreptococcus species; complicated appendicitis and peritonitis caused by viridans group streptococci, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides fragilis, B. thetaiotaomicron, and Peptostreptococcus species. Also for use in the treatment of bacterial meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae (b-lactamase and non-b-lactamase-producing isolates), and Neisseria meningitidis.


FDA Label


Treatment of bacterial sepsis, Treatment of bacterial meningitis


5 Pharmacology and Biochemistry
5.1 Pharmacology

Meropenem is a broad-spectrum carbapenem antibiotic. It is active against Gram-positive and Gram-negative bacteria. Meropenem exerts its action by penetrating bacterial cells readily and interfering with the synthesis of vital cell wall components, which leads to cell death.


5.2 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


5.3 FDA Pharmacological Classification
5.3.1 Active Moiety
MEROPENEM ANHYDROUS
5.3.2 FDA UNII
YOP6PX0BAO
5.3.3 Pharmacological Classes
Penem Antibacterial [EPC]; Carbapenems [CS]
5.4 ATC Code

J01DH02

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


J - Antiinfectives for systemic use

J01 - Antibacterials for systemic use

J01D - Other beta-lactam antibacterials

J01DH - Carbapenems

J01DH02 - Meropenem


5.5 Absorption, Distribution and Excretion

Route of Elimination

Approximately 70% of the intravenously administered dose is recovered as unchanged meropenem in the urine over 12 hours, after which little further urinary excretion is detectable.


Approximately 70% of the intravenously administered dose is recovered as unchanged meropenem in the urine over 12 hours, after which little further urinary excretion is detectable. Urinary concentrations of meropenem in excess of 10 ug/mL are maintained for up to 5 hours after a 500 mg dose.

US Natl Inst Health; DailyMed. Current Medication Information for MEROPENEM injection, powder, for solution (October 2011). Available from, as of February 8, 2012: https://dailymed.nlm.nih.gov/dailymed/search.cfm?startswith=meropenem


Meropenem is distributed into most body tissues and fluids, including bronchial mucosa, lung, bile, gynecologic tissue (endometrium, myometrium, ovary, cervix, fallopian tube), muscle, heart valves, skin, interstitial and peritoneal fluid, and CSF. Plasma protein binding is approximately 2%. The drug is partially metabolized to at least one microbiologically inactive metabolite. About 70% of an IV dose is eliminated in urine as unchanged drug by tubular secretion and glomerular filtration.

American Society of Health-System Pharmacists 2011; Drug Information 2011. Bethesda, MD. 2011, p. 190


At the end of a 30 minute intravenous infusion of a single dose of Meropenem for injection (IV) in healthy volunteers, mean peak plasma concentrations of meropenem are approximately 23 ug/mL (range 14-26) for the 500 mg dose and 49 ug/mL (range 39-58) for the 1 g dose. A 5-minute intravenous bolus injection of Meropenem for injection (IV) in healthy volunteers results in mean peak plasma concentrations of approximately 45 ug/mL (range 18-65) for the 500 mg dose and 112 ug/mL (range 83-140) for the 1 g dose. Following intravenous doses of 500 mg, mean plasma concentrations of meropenem usually decline to approximately 1 ug/mL at 6 hours after administration. No accumulation of meropenem in plasma was observed with regimens using 500 mg administered every 8 hours or 1 g administered every 6 hours in healthy volunteers with normal renal function.

US Natl Inst Health; DailyMed. Current Medication Information for MEROPENEM injection, powder, for solution (October 2011).


5.6 Metabolism/Metabolites

Primarily excreted unchanged. There is one metabolite which is microbiologically inactive.


There is one metabolite of meropenem that is microbiologically inactive.

US Natl Inst Health; DailyMed. Current Medication Information for MEROPENEM injection, powder, for solution (October 2011). Available from, as of February 8, 2012: https://dailymed.nlm.nih.gov/dailymed/search.cfm?startswith=meropenem


5.7 Biological Half-Life

Approximately 1 hour in adults and children 2 years of age and older with normal renal function. Approximately 1.5 hours in children 3 months to 2 years of age.


The plasma half-life of meropenem is approximately 1 hour in adults with normal renal function and 1.5 hours in children 3 months to 2 years of age. Plasma half-life is increased and clearance of the drug is decreased in patients with renal impairment.

American Society of Health-System Pharmacists 2011; Drug Information 2011. Bethesda, MD. 2011, p. 190


5.8 Mechanism of Action

The bactericidal activity of meropenem results from the inhibition of cell wall synthesis. Meropenem readily penetrates the cell wall of most Gram-positive and Gram-negative bacteria to reach penicillin-binding- protein (PBP) targets. Its strongest affinities are toward PBPs 2, 3 and 4 of Escherichia coli and Pseudomonas aeruginosa; and PBPs 1, 2 and 4 of Staphylococcus aureus.


The bactericidal activity of meropenem results from the inhibition of cell wall synthesis. Meropenem readily penetrates the cell wall of most Gram-positive and Gram-negative bacteria to reach penicillin-binding-protein (PBP) targets. Its strongest affinities are toward PBPs 2, 3 and 4 of Escherichia coli and Pseudomonas aeruginosa; and PBPs 1, 2, and 4 of Staphylococcus aureus. Bactericidal concentrations (defined as a 3 log10 reduction in cell counts within 12 to 24 hours) are typically 1-2 times the bacteriostatic concentrations of meropenem, with the exception of Listeria monocytogenes, against which lethal activity is not observed.

US Natl Inst Health; DailyMed. Current Medication Information for MEROPENEM injection, powder, for solution (October 2011). Available from, as of February 8, 2012: https://dailymed.nlm.nih.gov/dailymed/search.cfm?startswith=meropenem


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USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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USDMF Inactive-api CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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10

Kyongbo Pharmaceutical Co., Ltd

South Korea

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Kyongbo Pharmaceutical Co., Ltd

South Korea

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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USDMF Inactive-api CEP/COS Inactive-api JDMF EU-WC NDC KDMF VMF Others AUDIT
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CEP/COS

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03

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Certificate Number : R0-CEP 2011-361 - Rev 00

Status : Withdrawn by Holder

Issue Date : 2014-05-20

Type : Chemical

Substance Number : 2234

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04

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Certificate Number : R0-CEP 2012-089 - Rev 00

Status : Withdrawn by Holder

Issue Date : 2014-04-07

Type : Chemical

Substance Number : 2234

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05

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06

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07

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08

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09

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Certificate Number : R0-CEP 2015-241 - Rev 01

Status : Withdrawn by Holder

Issue Date : 2018-01-12

Type : Chemical

Substance Number : 2234

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10

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Certificate Number : R0-CEP 2015-148 - Rev 00

Status : Withdrawn by EDQM Failure to CEP pro...

Issue Date : 2017-08-23

Type : Chemical

Substance Number : 2234

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EU WC

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Kopran

India
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Kopran

India
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Meropenem For Injection USP

Date of Issue : 2022-08-31

Valid Till : 2025-07-14

Written Confirmation Number : WC-0090

Address of the Firm : K4/4, Additional MIDC, Bivwadi, Taluk Mahad, Dist Raigad-402302, Maharashtra, In...

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02

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Meropenem USP

Date of Issue : 2018-12-05

Valid Till : 2021-04-01

Written Confirmation Number : WC-0420

Address of the Firm : Unit-II A-619 & 630 RIICO Industrial Area Bhiwadi-301019 Distt. Alwar Rajasthan

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03

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Meropenem USP (Sterile)

Date of Issue : 2018-12-05

Valid Till : 2021-04-01

Written Confirmation Number : WC-0420-A

Address of the Firm : A-619 & 630, RIICO Ind. Area, Bhiwadi-301 019, Dist. Alwar, Rajasthan

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04

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Meropenem for injection

Date of Issue : 2020-04-16

Valid Till : 2022-07-06

Written Confirmation Number : WC-0378A2

Address of the Firm : Plot No 100 Sector 56, HSIIDC, Kundli district sonepat, Haryana

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05

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Meropenem for Injection (USP) (Sterile dry mixture of Meropenem and Sodium Carbonate)

Date of Issue : 2016-07-06

Valid Till : 2019-07-06

Written Confirmation Number : WC-0378

Address of the Firm : Plot No. 100 Sector 56 Phase IV, HSIIDC Kundli, District Sonepat Haryana India

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06

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Meropenem Sterile IH/USP

Date of Issue : 2022-07-06

Valid Till : 2025-07-04

Written Confirmation Number : WC-0216

Address of the Firm : Industrial Area-3, A. B. Road, Dewas (M.P.)-455001

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API Reference Price

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LTD","customerCountry":"INDIA","quantity":"20.00","actualQuantity":"20","unit":"KGS","unitRateFc":"360","totalValueFC":"7279.1","currency":"USD","unitRateINR":"30582","date":"28-Oct-2024","totalValueINR":"611640","totalValueInUsd":"7279.1","indian_port":"Delhi Air","hs_no":"29419090","bill_no":"6379134","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Non-sterile","supplierPort":"CHENGDU","supplierAddress":"LTD. 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E. MOSES","city":"MUMBAI ,MAHARASHTRA","supplier":"M\/S. GANGXIANG INTERNATIONAL HOLDINGS (HK) LIMITED","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"KOPRAN","customerCountry":"INDIA","quantity":"1500.00","actualQuantity":"1500","unit":"KGS","unitRateFc":"370","totalValueFC":"560339.1","currency":"USD","unitRateINR":"31524","date":"11-Nov-2024","totalValueINR":"47286000","totalValueInUsd":"560339.1","indian_port":"Bombay Air","hs_no":"29419090","bill_no":"6613381","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Non-sterile","supplierPort":"SHANGHAI","supplierAddress":"LEVEL 54 HOPEWELL CENTRE 183 QUEENS ROAD EAST HK SDNF HK","customerAddress":"PARIJAT HOUSE,1076,DR. E. MOSES"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1732732200,"product":"MEROPENEM TRIHYDRATE IP (NON STERILE)","address":"VILLAGE SAIDPURA,TEHSIL DERABASSI,","city":"MOHALI (PUNJAB)","supplier":"CHONGQING TIANDI PHARMACEUTICAL CO.LTD","supplierCountry":"CHINA","foreign_port":"CHENGDU","customer":"NECTAR LIFE SCIENCES LIMITED","customerCountry":"INDIA","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"350","totalValueFC":"3539.9","currency":"USD","unitRateINR":"29872.5","date":"28-Nov-2024","totalValueINR":"298725","totalValueInUsd":"3539.9","indian_port":"Delhi Air","hs_no":"29419090","bill_no":"6926915","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Non-sterile","supplierPort":"CHENGDU","supplierAddress":"NO.1 SHENYANG ROAD ZHONGZHOU AVENUE ZHONGXIAN COUNTY CHONGQING CITY Ch ongqing, , CHINA CHINA","customerAddress":"VILLAGE SAIDPURA,TEHSIL DERABASSI,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1733337000,"product":"MEROPENEM TRIHYDRATE (NON STERILE) IP MEROPENEM TRIHYDRATE (NON STERILE) IP","address":"M-134, 2ND FLOOR","city":"NEW DELHI","supplier":"SHENZHEN HAIBIN PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"CHENGDU","customer":"RAJASTHAN ANTIBIOTICS","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"330","totalValueFC":"331.5","currency":"USD","unitRateINR":"28165.5","date":"05-Dec-2024","totalValueINR":"28165.5","totalValueInUsd":"331.5","indian_port":"Delhi Air","hs_no":"29411090","bill_no":"7066492","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Non-sterile","supplierPort":"CHENGDU","supplierAddress":"2003 SHENYAN ROAD YANTIAN DISTRICT SHENZHEN PR CHINA Shenzhen - 518081 , , CHINA CHINA","customerAddress":"M-134, 2ND FLOOR"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1733337000,"product":"MEROPENEM TRIHYDRATE (NON STERILE) IP MEROPENEM TRIHYDRATE (NON STERILE) IP","address":"M-134, 2ND FLOOR","city":"NEW DELHI","supplier":"SHENZHEN HAIBIN PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"CHENGDU","customer":"RAJASTHAN ANTIBIOTICS","customerCountry":"INDIA","quantity":"1000.00","actualQuantity":"1000","unit":"KGS","unitRateFc":"330","totalValueFC":"331479.8","currency":"USD","unitRateINR":"28165.5","date":"05-Dec-2024","totalValueINR":"28165500","totalValueInUsd":"331479.8","indian_port":"Delhi Air","hs_no":"29411090","bill_no":"7066464","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Non-sterile","supplierPort":"CHENGDU","supplierAddress":"2003 SHENYAN ROAD YANTIAN DISTRICT SHENZHEN PR CHINA Shenzhen - 518081 , , CHINA CHINA","customerAddress":"M-134, 2ND FLOOR"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1733682600,"product":"MEROPENEM TRIHYDRATE (NON STERILE) MEROPENEM TRIHYDRATE (NON STERILE)","address":"1705, 4TH FLOOR, ONKAR BHAWAN","city":"DELHI","supplier":"SHENZHEN HAIBIN PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"STERILE INDIA PVT. 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02-Jan-2021
23-Dec-2024
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Quantity (KGS) & Unit rate (USD/KGS) over time

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DOSAGE - POWDER;INTRAVENOUS - 1GM/VIAL;1GM/VI...DOSAGE - POWDER;INTRAVENOUS - 1GM/VIAL;1GM/VIAL

USFDA APPLICATION NUMBER - 209776

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DOSAGE - INJECTABLE;INJECTION - 1GM/VIAL

USFDA APPLICATION NUMBER - 50706

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DOSAGE - INJECTABLE;INJECTION - 500MG/VIAL

USFDA APPLICATION NUMBER - 50706

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ABOUT THIS PAGE

Looking for 119478-56-7 / Meropenem API manufacturers, exporters & distributors?

Meropenem manufacturers, exporters & distributors 1

17

PharmaCompass offers a list of Meropenem API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Meropenem manufacturer or Meropenem supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Meropenem manufacturer or Meropenem supplier.

PharmaCompass also assists you with knowing the Meropenem API Price utilized in the formulation of products. Meropenem API Price is not always fixed or binding as the Meropenem Price is obtained through a variety of data sources. The Meropenem Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Meropenem

Synonyms

96036-03-2, Merrem, Meropenem anhydrous, Meropenemum, Antibiotic sm 7338, Meronem

Cas Number

119478-56-7

Unique Ingredient Identifier (UNII)

YOP6PX0BAO

About Meropenem

A thienamycin derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of bacterial infections, including infections in immunocompromised patients.

Meropenem Manufacturers

A Meropenem manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Meropenem, including repackagers and relabelers. The FDA regulates Meropenem manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Meropenem API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Meropenem manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Meropenem Suppliers

A Meropenem supplier is an individual or a company that provides Meropenem active pharmaceutical ingredient (API) or Meropenem finished formulations upon request. The Meropenem suppliers may include Meropenem API manufacturers, exporters, distributors and traders.

click here to find a list of Meropenem suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Meropenem USDMF

A Meropenem DMF (Drug Master File) is a document detailing the whole manufacturing process of Meropenem active pharmaceutical ingredient (API) in detail. Different forms of Meropenem DMFs exist exist since differing nations have different regulations, such as Meropenem USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Meropenem DMF submitted to regulatory agencies in the US is known as a USDMF. Meropenem USDMF includes data on Meropenem's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Meropenem USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Meropenem suppliers with USDMF on PharmaCompass.

Meropenem JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Meropenem Drug Master File in Japan (Meropenem JDMF) empowers Meropenem API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Meropenem JDMF during the approval evaluation for pharmaceutical products. At the time of Meropenem JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Meropenem suppliers with JDMF on PharmaCompass.

Meropenem KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Meropenem Drug Master File in Korea (Meropenem KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Meropenem. The MFDS reviews the Meropenem KDMF as part of the drug registration process and uses the information provided in the Meropenem KDMF to evaluate the safety and efficacy of the drug.

After submitting a Meropenem KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Meropenem API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Meropenem suppliers with KDMF on PharmaCompass.

Meropenem CEP

A Meropenem CEP of the European Pharmacopoeia monograph is often referred to as a Meropenem Certificate of Suitability (COS). The purpose of a Meropenem CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Meropenem EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Meropenem to their clients by showing that a Meropenem CEP has been issued for it. The manufacturer submits a Meropenem CEP (COS) as part of the market authorization procedure, and it takes on the role of a Meropenem CEP holder for the record. Additionally, the data presented in the Meropenem CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Meropenem DMF.

A Meropenem CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Meropenem CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Meropenem suppliers with CEP (COS) on PharmaCompass.

Meropenem WC

A Meropenem written confirmation (Meropenem WC) is an official document issued by a regulatory agency to a Meropenem manufacturer, verifying that the manufacturing facility of a Meropenem active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Meropenem APIs or Meropenem finished pharmaceutical products to another nation, regulatory agencies frequently require a Meropenem WC (written confirmation) as part of the regulatory process.

click here to find a list of Meropenem suppliers with Written Confirmation (WC) on PharmaCompass.

Meropenem NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Meropenem as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Meropenem API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Meropenem as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Meropenem and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Meropenem NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Meropenem suppliers with NDC on PharmaCompass.

Meropenem GMP

Meropenem Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Meropenem GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Meropenem GMP manufacturer or Meropenem GMP API supplier for your needs.

Meropenem CoA

A Meropenem CoA (Certificate of Analysis) is a formal document that attests to Meropenem's compliance with Meropenem specifications and serves as a tool for batch-level quality control.

Meropenem CoA mostly includes findings from lab analyses of a specific batch. For each Meropenem CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Meropenem may be tested according to a variety of international standards, such as European Pharmacopoeia (Meropenem EP), Meropenem JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Meropenem USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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