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Chemistry

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Also known as: 62-51-1, Acetyl-beta-methylcholine chloride, Provocholine, Mecholyl chloride, Methacholine (chloride), Acetyl-2-methylcholine chloride
Molecular Formula
C8H18ClNO2
Molecular Weight
195.69  g/mol
InChI Key
JHPHVAVFUYTVCL-UHFFFAOYSA-M
FDA UNII
0W5ETF9M2K

Methacholine Chloride
A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)
1 2D Structure

Methacholine Chloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-acetyloxypropyl(trimethyl)azanium;chloride
2.1.2 InChI
InChI=1S/C8H18NO2.ClH/c1-7(11-8(2)10)6-9(3,4)5;/h7H,6H2,1-5H3;1H/q+1;/p-1
2.1.3 InChI Key
JHPHVAVFUYTVCL-UHFFFAOYSA-M
2.1.4 Canonical SMILES
CC(C[N+](C)(C)C)OC(=O)C.[Cl-]
2.2 Other Identifiers
2.2.1 UNII
0W5ETF9M2K
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-(acetyloxy)-n,n,n-trimethyl-1-propanaminium Chloride

2. Acetyl 2 Methylcholine Chloride

3. Acetyl Beta Methacholine Chloride

4. Acetyl Beta Methylcholine

5. Acetyl-2-methylcholine Chloride

6. Acetyl-beta-methacholine Chloride

7. Acetyl-beta-methylcholine

8. Chloride, Methacholine

9. Mecholine

10. Mecholyl

11. Methacholine

12. Provocholine

13. Provokit

2.3.2 Depositor-Supplied Synonyms

1. 62-51-1

2. Acetyl-beta-methylcholine Chloride

3. Provocholine

4. Mecholyl Chloride

5. Methacholine (chloride)

6. Acetyl-2-methylcholine Chloride

7. 1-propanaminium, 2-(acetyloxy)-n,n,n-trimethyl-, Chloride

8. (2-acetoxypropyl)trimethylammonium Chloride

9. 2-acetyloxypropyl(trimethyl)azanium;chloride

10. O-acetyl-beta-methylcholine Chloride

11. Acetyl-

12. A-methylcholine Chloride

13. Nsc-757090

14. 0w5etf9m2k

15. Mls000069656

16. Chebi:50142

17. Amechol

18. Mecholyl

19. Provokit

20. Smr000059224

21. Dsstox_cid_3271

22. Mecholine Chloride

23. Dsstox_rid_76951

24. Dsstox_gsid_23271

25. 2-acetyloxy-n,n,n-trimethylpropan-1-aminium Chloride

26. Methacholinium Chloride

27. (+/-)-(2-hydroxypropyl)trimethylammonium Chloride Acetate

28. Metacolina Cloruro

29. Metacolina Cloruro [dcit]

30. Cloruro De Metacolina

31. Methacholini Chloridum

32. Beta-methylacetylcholine Chloride

33. Cloruro De Metacolina [spanish]

34. Chlorure De Methacholine [french]

35. Chlorure De Methacholine

36. Sr-01000000215

37. Methacholini Chloridum [inn-latin]

38. Einecs 200-537-2

39. Cloruro De Metacolina [inn-spanish]

40. Dl-acetyl-beta-methylcholine Chloride

41. Unii-0w5etf9m2k

42. Chlorure De Methacholine [inn-french]

43. (+-)-acetyl-beta-methylcholine Chloride

44. Ai3-51680

45. Trimethyl-beta-acetoxypropylammonium Chloride

46. Prestwick_981

47. Provocholine (tn)

48. (2-hydroxypropyl)trimethylammonium Chloride Acetate

49. Methacholine Chloride, Crystal, Usp

50. Methacholine Chloride [usp:inn:ban]

51. Cas-62-51-1

52. Opera_id_1285

53. Ncgc00016282-01

54. Regid_for_cid_6114

55. Schembl69104

56. Mls001148375

57. Spectrum1500391

58. (+-)-(2-hydroxypropyl)trimethylammonium Chloride Acetate

59. Chembl1200764

60. Dtxsid7023271

61. Acetyl-ss--methylcholine Chloride

62. Hms1570g20

63. Hms1920l11

64. Hms2091d06

65. Hms2097g20

66. Hms2232b07

67. Hms3260e11

68. Hms3371l18

69. Hms3714g20

70. Hms3885a21

71. Methacholine Chloride [mi]

72. Pharmakon1600-01500391

73. Methacholine Chloride [inn]

74. Methacholine Chloride [jan]

75. O-acetyl-

76. A-methylcholine Chloride

77. Ammonium, (2-hydroxypropyl)trimethyl-, Chloride, Acetate

78. Hy-a0083

79. Acetyl- Beta -methylcholine Chloride

80. Tox21_110348

81. Tox21_500025

82. 1-propanaminium, 2-(acetyloxy)-n,n,n-trimethyl-, Chloride, (+-)-

83. Ccg-39988

84. Methacholine Chloride [vandf]

85. Mfcd00011817

86. Nsc757090

87. Methacholine Chloride [mart.]

88. Acetyl B-methylcholine Chloride 98%+

89. Akos015892295

90. Methacholine Chloride (jan/usp/inn)

91. Methacholine Chloride [usp-rs]

92. Methacholine Chloride [who-dd]

93. Tox21_110348_1

94. Fs-4023

95. Lp00025

96. Nsc 757090

97. Ncgc00015045-09

98. Ncgc00093548-01

99. Ncgc00093548-02

100. Ncgc00093548-03

101. Ncgc00093548-04

102. Ncgc00093548-05

103. Ncgc00260710-01

104. Methacholine Chloride [orange Book]

105. Db-054187

106. Eu-0100025

107. Ft-0628268

108. M0073

109. Methacholine Chloride [usp Monograph]

110. A 2251

111. A-1480

112. C75939

113. D04970

114. A833819

115. 2-acetoxy-n,n,n-trimethylpropan-1-aminium Chloride

116. Q-200715

117. Sr-01000000215-2

118. Sr-01000000215-4

119. Sr-01000000215-7

120. Q26841250

121. 2-(acetyloxy)-n,n,n-trimethylpropan-1-aminium Chloride

122. 1-propanaminium, 2-(acetyloxy)-n,n,n-trimethyl-, Chloride (1:1)

123. 1-propanaminium, 2-(acetyloxy)-n,n,n-trimethyl-, Chloride, (+/-)-

2.4 Create Date
2005-06-29
3 Chemical and Physical Properties
Molecular Weight 195.69 g/mol
Molecular Formula C8H18ClNO2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass195.1026065 g/mol
Monoisotopic Mass195.1026065 g/mol
Topological Polar Surface Area26.3 Ų
Heavy Atom Count12
Formal Charge0
Complexity138
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameProvocholine
PubMed HealthMethacholine (By breathing)
Drug ClassesDiagnostic Agent, Bronchial
Drug LabelProvocholine (methacholine chloride powder for inhalation) is a parasympathomimetic (cholinergic)) bronchoconstrictor agent to be administered in solution only, by inhalation, for diagnostic purposes. Each 20 mL vial contains 100 mg of methacholine...
Active IngredientMethacholine chloride
Dosage FormFor solution
RouteInhalation
Strength100mg/vial
Market StatusPrescription
CompanyMethapharm

2 of 2  
Drug NameProvocholine
PubMed HealthMethacholine (By breathing)
Drug ClassesDiagnostic Agent, Bronchial
Drug LabelProvocholine (methacholine chloride powder for inhalation) is a parasympathomimetic (cholinergic)) bronchoconstrictor agent to be administered in solution only, by inhalation, for diagnostic purposes. Each 20 mL vial contains 100 mg of methacholine...
Active IngredientMethacholine chloride
Dosage FormFor solution
RouteInhalation
Strength100mg/vial
Market StatusPrescription
CompanyMethapharm

4.2 Drug Indication

Diagnosis of asthma


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Miotics

Agents causing contraction of the pupil of the eye. Some sources use the term miotics only for the parasympathomimetics but any drug used to induce miosis is included here. (See all compounds classified as Miotics.)


Muscarinic Agonists

Drugs that bind to and activate muscarinic cholinergic receptors (RECEPTORS, MUSCARINIC). Muscarinic agonists are most commonly used when it is desirable to increase smooth muscle tone, especially in the GI tract, urinary bladder and the eye. They may also be used to reduce heart rate. (See all compounds classified as Muscarinic Agonists.)


Parasympathomimetics

Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here. (See all compounds classified as Parasympathomimetics.)


Bronchoconstrictor Agents

Agents causing the narrowing of the lumen of a bronchus or bronchiole. (See all compounds classified as Bronchoconstrictor Agents.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Cholinergic Receptor Agonist [EPC]; Cholinergic Agonists [MoA]

API SUPPLIERS

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USDMF

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Apotex Pharmachem Inc

Canada

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Siegfried Ag

Switzerland

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Siegfried Ag

Switzerland
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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 4909

Submission : 1983-03-16

Status : Inactive

Type : II

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Sigma F And D Div Ltd

U.S.A

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Methacholine Chloride

Registration Number : 304MF10146

Registrant's Address : Via Bedeschi, 22 24040 Chignolo d'Isola (Bergamo) Italy

Initial Date of Registration : 2022-11-02

Latest Date of Registration : 2022-11-02

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METHACHOLINE CHLORIDE

NDC Package Code : 54236-010

Start Marketing Date : 2009-11-23

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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METHACHOLINE CHLORIDE

Brand Name : PROVOCHOLINE

Dosage Form : FOR SOLUTION;INHALATION

Dosage Strength : 100MG/VIAL

Packaging :

Approval Date : 1986-10-31

Application Number : 19193

Regulatory Info : RX

Registration Country : USA

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METHACHOLINE CHLORIDE

Brand Name : PROVOCHOLINE

Dosage Form : FOR SOLUTION;INHALATION

Dosage Strength : 1600MG/VIAL

Packaging :

Approval Date : 2016-08-29

Application Number : 19193

Regulatory Info : DISCN

Registration Country : USA

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METHACHOLINE CHLORIDE

Brand Name : PROVOCHOLINE

Dosage Form : POWDER FOR SOLUTION

Dosage Strength : 100MG/VIAL

Packaging : 20/50ML

Approval Date :

Application Number : 2239656

Regulatory Info :

Registration Country : Canada

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METHACHOLINE CHLORIDE

Brand Name : PROVOCHOLINE

Dosage Form : POWDER FOR SOLUTION

Dosage Strength : 1280MG/VIAL

Packaging : 20 ML

Approval Date :

Application Number : 2243834

Regulatory Info :

Registration Country : Canada

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METHACHOLINE CHLORIDE

Brand Name : PROVOCHOLINE

Dosage Form : POWDER FOR SOLUTION

Dosage Strength : 1600MG/VIAL

Packaging : 50ML

Approval Date :

Application Number : 2288826

Regulatory Info :

Registration Country : Canada

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METHACHOLINE CHLORIDE

Brand Name : METHACHOLINE OMEGA

Dosage Form : POWDER FOR SOLUTION

Dosage Strength : 100MG/VIAL

Packaging : 30ML VIAL

Approval Date :

Application Number : 2263890

Regulatory Info :

Registration Country : Canada

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METHACHOLINE CHLORIDE

Brand Name : METHACHOLINE OMEGA

Dosage Form : POWDER FOR SOLUTION

Dosage Strength : 1600MG/VIAL

Packaging : 50ML VIAL

Approval Date :

Application Number : 2263912

Regulatory Info :

Registration Country : Canada

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ABOUT THIS PAGE

Methacholine Chloride Manufacturers

A Methacholine Chloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Methacholine Chloride, including repackagers and relabelers. The FDA regulates Methacholine Chloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Methacholine Chloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Methacholine Chloride Suppliers

A Methacholine Chloride supplier is an individual or a company that provides Methacholine Chloride active pharmaceutical ingredient (API) or Methacholine Chloride finished formulations upon request. The Methacholine Chloride suppliers may include Methacholine Chloride API manufacturers, exporters, distributors and traders.

click here to find a list of Methacholine Chloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Methacholine Chloride USDMF

A Methacholine Chloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Methacholine Chloride active pharmaceutical ingredient (API) in detail. Different forms of Methacholine Chloride DMFs exist exist since differing nations have different regulations, such as Methacholine Chloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Methacholine Chloride DMF submitted to regulatory agencies in the US is known as a USDMF. Methacholine Chloride USDMF includes data on Methacholine Chloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Methacholine Chloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Methacholine Chloride suppliers with USDMF on PharmaCompass.

Methacholine Chloride JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Methacholine Chloride Drug Master File in Japan (Methacholine Chloride JDMF) empowers Methacholine Chloride API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Methacholine Chloride JDMF during the approval evaluation for pharmaceutical products. At the time of Methacholine Chloride JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Methacholine Chloride suppliers with JDMF on PharmaCompass.

Methacholine Chloride NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Methacholine Chloride as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Methacholine Chloride API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Methacholine Chloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Methacholine Chloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Methacholine Chloride NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Methacholine Chloride suppliers with NDC on PharmaCompass.

Methacholine Chloride GMP

Methacholine Chloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Methacholine Chloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Methacholine Chloride GMP manufacturer or Methacholine Chloride GMP API supplier for your needs.

Methacholine Chloride CoA

A Methacholine Chloride CoA (Certificate of Analysis) is a formal document that attests to Methacholine Chloride's compliance with Methacholine Chloride specifications and serves as a tool for batch-level quality control.

Methacholine Chloride CoA mostly includes findings from lab analyses of a specific batch. For each Methacholine Chloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Methacholine Chloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Methacholine Chloride EP), Methacholine Chloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Methacholine Chloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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