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1. 2-(acetyloxy)-n,n,n-trimethyl-1-propanaminium Chloride
2. Acetyl 2 Methylcholine Chloride
3. Acetyl Beta Methacholine Chloride
4. Acetyl Beta Methylcholine
5. Acetyl-2-methylcholine Chloride
6. Acetyl-beta-methacholine Chloride
7. Acetyl-beta-methylcholine
8. Chloride, Methacholine
9. Mecholine
10. Mecholyl
11. Methacholine
12. Provocholine
13. Provokit
1. 62-51-1
2. Acetyl-beta-methylcholine Chloride
3. Provocholine
4. Mecholyl Chloride
5. Methacholine (chloride)
6. Acetyl-2-methylcholine Chloride
7. 1-propanaminium, 2-(acetyloxy)-n,n,n-trimethyl-, Chloride
8. (2-acetoxypropyl)trimethylammonium Chloride
9. 2-acetyloxypropyl(trimethyl)azanium;chloride
10. O-acetyl-beta-methylcholine Chloride
11. Acetyl-
12. A-methylcholine Chloride
13. Nsc-757090
14. 0w5etf9m2k
15. Mls000069656
16. Chebi:50142
17. Amechol
18. Mecholyl
19. Provokit
20. Smr000059224
21. Dsstox_cid_3271
22. Mecholine Chloride
23. Dsstox_rid_76951
24. Dsstox_gsid_23271
25. 2-acetyloxy-n,n,n-trimethylpropan-1-aminium Chloride
26. Methacholinium Chloride
27. (+/-)-(2-hydroxypropyl)trimethylammonium Chloride Acetate
28. Metacolina Cloruro
29. Metacolina Cloruro [dcit]
30. Cloruro De Metacolina
31. Methacholini Chloridum
32. Beta-methylacetylcholine Chloride
33. Cloruro De Metacolina [spanish]
34. Chlorure De Methacholine [french]
35. Chlorure De Methacholine
36. Sr-01000000215
37. Methacholini Chloridum [inn-latin]
38. Einecs 200-537-2
39. Cloruro De Metacolina [inn-spanish]
40. Dl-acetyl-beta-methylcholine Chloride
41. Unii-0w5etf9m2k
42. Chlorure De Methacholine [inn-french]
43. (+-)-acetyl-beta-methylcholine Chloride
44. Ai3-51680
45. Trimethyl-beta-acetoxypropylammonium Chloride
46. Prestwick_981
47. Provocholine (tn)
48. (2-hydroxypropyl)trimethylammonium Chloride Acetate
49. Methacholine Chloride, Crystal, Usp
50. Methacholine Chloride [usp:inn:ban]
51. Cas-62-51-1
52. Opera_id_1285
53. Ncgc00016282-01
54. Regid_for_cid_6114
55. Schembl69104
56. Mls001148375
57. Spectrum1500391
58. (+-)-(2-hydroxypropyl)trimethylammonium Chloride Acetate
59. Chembl1200764
60. Dtxsid7023271
61. Acetyl-ss--methylcholine Chloride
62. Hms1570g20
63. Hms1920l11
64. Hms2091d06
65. Hms2097g20
66. Hms2232b07
67. Hms3260e11
68. Hms3371l18
69. Hms3714g20
70. Hms3885a21
71. Methacholine Chloride [mi]
72. Pharmakon1600-01500391
73. Methacholine Chloride [inn]
74. Methacholine Chloride [jan]
75. O-acetyl-
76. A-methylcholine Chloride
77. Ammonium, (2-hydroxypropyl)trimethyl-, Chloride, Acetate
78. Hy-a0083
79. Acetyl- Beta -methylcholine Chloride
80. Tox21_110348
81. Tox21_500025
82. 1-propanaminium, 2-(acetyloxy)-n,n,n-trimethyl-, Chloride, (+-)-
83. Ccg-39988
84. Methacholine Chloride [vandf]
85. Mfcd00011817
86. Nsc757090
87. Methacholine Chloride [mart.]
88. Acetyl B-methylcholine Chloride 98%+
89. Akos015892295
90. Methacholine Chloride (jan/usp/inn)
91. Methacholine Chloride [usp-rs]
92. Methacholine Chloride [who-dd]
93. Tox21_110348_1
94. Fs-4023
95. Lp00025
96. Nsc 757090
97. Ncgc00015045-09
98. Ncgc00093548-01
99. Ncgc00093548-02
100. Ncgc00093548-03
101. Ncgc00093548-04
102. Ncgc00093548-05
103. Ncgc00260710-01
104. Methacholine Chloride [orange Book]
105. Db-054187
106. Eu-0100025
107. Ft-0628268
108. M0073
109. Methacholine Chloride [usp Monograph]
110. A 2251
111. A-1480
112. C75939
113. D04970
114. A833819
115. 2-acetoxy-n,n,n-trimethylpropan-1-aminium Chloride
116. Q-200715
117. Sr-01000000215-2
118. Sr-01000000215-4
119. Sr-01000000215-7
120. Q26841250
121. 2-(acetyloxy)-n,n,n-trimethylpropan-1-aminium Chloride
122. 1-propanaminium, 2-(acetyloxy)-n,n,n-trimethyl-, Chloride (1:1)
123. 1-propanaminium, 2-(acetyloxy)-n,n,n-trimethyl-, Chloride, (+/-)-
Molecular Weight | 195.69 g/mol |
---|---|
Molecular Formula | C8H18ClNO2 |
Hydrogen Bond Donor Count | 0 |
Hydrogen Bond Acceptor Count | 3 |
Rotatable Bond Count | 4 |
Exact Mass | 195.1026065 g/mol |
Monoisotopic Mass | 195.1026065 g/mol |
Topological Polar Surface Area | 26.3 Ų |
Heavy Atom Count | 12 |
Formal Charge | 0 |
Complexity | 138 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 1 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently Bonded Unit Count | 2 |
1 of 2 | |
---|---|
Drug Name | Provocholine |
PubMed Health | Methacholine (By breathing) |
Drug Classes | Diagnostic Agent, Bronchial |
Drug Label | Provocholine (methacholine chloride powder for inhalation) is a parasympathomimetic (cholinergic)) bronchoconstrictor agent to be administered in solution only, by inhalation, for diagnostic purposes. Each 20 mL vial contains 100 mg of methacholine... |
Active Ingredient | Methacholine chloride |
Dosage Form | For solution |
Route | Inhalation |
Strength | 100mg/vial |
Market Status | Prescription |
Company | Methapharm |
2 of 2 | |
---|---|
Drug Name | Provocholine |
PubMed Health | Methacholine (By breathing) |
Drug Classes | Diagnostic Agent, Bronchial |
Drug Label | Provocholine (methacholine chloride powder for inhalation) is a parasympathomimetic (cholinergic)) bronchoconstrictor agent to be administered in solution only, by inhalation, for diagnostic purposes. Each 20 mL vial contains 100 mg of methacholine... |
Active Ingredient | Methacholine chloride |
Dosage Form | For solution |
Route | Inhalation |
Strength | 100mg/vial |
Market Status | Prescription |
Company | Methapharm |
Diagnosis of asthma
Miotics
Agents causing contraction of the pupil of the eye. Some sources use the term miotics only for the parasympathomimetics but any drug used to induce miosis is included here. (See all compounds classified as Miotics.)
Muscarinic Agonists
Drugs that bind to and activate muscarinic cholinergic receptors (RECEPTORS, MUSCARINIC). Muscarinic agonists are most commonly used when it is desirable to increase smooth muscle tone, especially in the GI tract, urinary bladder and the eye. They may also be used to reduce heart rate. (See all compounds classified as Muscarinic Agonists.)
Parasympathomimetics
Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here. (See all compounds classified as Parasympathomimetics.)
Bronchoconstrictor Agents
Agents causing the narrowing of the lumen of a bronchus or bronchiole. (See all compounds classified as Bronchoconstrictor Agents.)
GDUFA
DMF Review : N/A
Rev. Date :
Pay. Date :
DMF Number : 11758
Submission : 1995-11-28
Status : Active
Type : II
GDUFA
DMF Review : N/A
Rev. Date :
Pay. Date :
DMF Number : 4909
Submission : 1983-03-16
Status : Inactive
Type : II
GDUFA
DMF Review : N/A
Rev. Date :
Pay. Date :
DMF Number : 2868
Submission : 1977-02-24
Status : Inactive
Type : II
Registration Number : 304MF10146
Registrant's Address : Via Bedeschi, 22 24040 Chignolo d'Isola (Bergamo) Italy
Initial Date of Registration : 2022-11-02
Latest Date of Registration : 2022-11-02
NDC Package Code : 54236-010
Start Marketing Date : 2009-11-23
End Marketing Date : 2025-12-31
Dosage Form (Strength) : POWDER (1kg/kg)
Marketing Category : BULK INGREDIENT
Regulatory Info : RX
Registration Country : USA
Brand Name : PROVOCHOLINE
Dosage Form : FOR SOLUTION;INHALATION
Dosage Strength : 100MG/VIAL
Packaging :
Approval Date : 1986-10-31
Application Number : 19193
Regulatory Info : RX
Registration Country : USA
Regulatory Info : DISCN
Registration Country : USA
Brand Name : PROVOCHOLINE
Dosage Form : FOR SOLUTION;INHALATION
Dosage Strength : 1600MG/VIAL
Packaging :
Approval Date : 2016-08-29
Application Number : 19193
Regulatory Info : DISCN
Registration Country : USA
Regulatory Info :
Registration Country : Canada
Brand Name : PROVOCHOLINE
Dosage Form : POWDER FOR SOLUTION
Dosage Strength : 100MG/VIAL
Packaging : 20/50ML
Approval Date :
Application Number : 2239656
Regulatory Info :
Registration Country : Canada
Regulatory Info :
Registration Country : Canada
Brand Name : PROVOCHOLINE
Dosage Form : POWDER FOR SOLUTION
Dosage Strength : 1280MG/VIAL
Packaging : 20 ML
Approval Date :
Application Number : 2243834
Regulatory Info :
Registration Country : Canada
Regulatory Info :
Registration Country : Canada
Brand Name : PROVOCHOLINE
Dosage Form : POWDER FOR SOLUTION
Dosage Strength : 1600MG/VIAL
Packaging : 50ML
Approval Date :
Application Number : 2288826
Regulatory Info :
Registration Country : Canada
Regulatory Info :
Registration Country : Canada
Brand Name : METHACHOLINE OMEGA
Dosage Form : POWDER FOR SOLUTION
Dosage Strength : 100MG/VIAL
Packaging : 30ML VIAL
Approval Date :
Application Number : 2263890
Regulatory Info :
Registration Country : Canada
Regulatory Info :
Registration Country : Canada
Brand Name : METHACHOLINE OMEGA
Dosage Form : POWDER FOR SOLUTION
Dosage Strength : 1600MG/VIAL
Packaging : 50ML VIAL
Approval Date :
Application Number : 2263912
Regulatory Info :
Registration Country : Canada
Market Place
REF. STANDARDS & IMPURITIES
ABOUT THIS PAGE
A Methacholine Chloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Methacholine Chloride, including repackagers and relabelers. The FDA regulates Methacholine Chloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Methacholine Chloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
A Methacholine Chloride supplier is an individual or a company that provides Methacholine Chloride active pharmaceutical ingredient (API) or Methacholine Chloride finished formulations upon request. The Methacholine Chloride suppliers may include Methacholine Chloride API manufacturers, exporters, distributors and traders.
click here to find a list of Methacholine Chloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
A Methacholine Chloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Methacholine Chloride active pharmaceutical ingredient (API) in detail. Different forms of Methacholine Chloride DMFs exist exist since differing nations have different regulations, such as Methacholine Chloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.
A Methacholine Chloride DMF submitted to regulatory agencies in the US is known as a USDMF. Methacholine Chloride USDMF includes data on Methacholine Chloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Methacholine Chloride USDMF is kept confidential to protect the manufacturer’s intellectual property.
click here to find a list of Methacholine Chloride suppliers with USDMF on PharmaCompass.
The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.
The Methacholine Chloride Drug Master File in Japan (Methacholine Chloride JDMF) empowers Methacholine Chloride API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).
PMDA reviews the Methacholine Chloride JDMF during the approval evaluation for pharmaceutical products. At the time of Methacholine Chloride JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.
click here to find a list of Methacholine Chloride suppliers with JDMF on PharmaCompass.
National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Methacholine Chloride as an active pharmaceutical ingredient (API).
The FDA updates the NDC directory daily. The NDC numbers for Methacholine Chloride API and other APIs are published in this directory by the FDA.
The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.
Pharmaceutical companies that manufacture Methacholine Chloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.
The NDC directory also contains data on finished compounded human drug products that contain Methacholine Chloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Methacholine Chloride NDC to their finished compounded human drug products, they may choose to do so.
click here to find a list of Methacholine Chloride suppliers with NDC on PharmaCompass.
Methacholine Chloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Methacholine Chloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Methacholine Chloride GMP manufacturer or Methacholine Chloride GMP API supplier for your needs.
A Methacholine Chloride CoA (Certificate of Analysis) is a formal document that attests to Methacholine Chloride's compliance with Methacholine Chloride specifications and serves as a tool for batch-level quality control.
Methacholine Chloride CoA mostly includes findings from lab analyses of a specific batch. For each Methacholine Chloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Methacholine Chloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Methacholine Chloride EP), Methacholine Chloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Methacholine Chloride USP).
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