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1. Barium Methanesulfonate
2. Bms-480188
3. Methanesulfonate
4. Methanesulfonic Acid, Ammonia Salt
5. Methanesulfonic Acid, Chromium (2+) Salt
6. Methanesulfonic Acid, Chromium (3+) Salt
7. Methanesulfonic Acid, Cobalt (2+) Salt
8. Methanesulfonic Acid, Copper (2+) Salt
9. Methanesulfonic Acid, Iron (2+) Salt
10. Methanesulfonic Acid, Iron (3+)salt
11. Methanesulfonic Acid, Nickel (2+) Salt
12. Methanesulfonic Acid, Potassium Salt
13. Methanesulfonic Acid, Silver (1+) Salt
14. Methanesulfonic Acid, Sodium Salt
15. Methylsulfonate
16. Potassium Mesylate
17. Potassium Methanesulfonate
1. 75-75-2
2. Methylsulfonic Acid
3. Methanesulphonic Acid
4. Mesylate
5. Mesylic Acid
6. Kyselina Methansulfonova
7. Sulfomethane
8. Methansulfonsaeure
9. Nsc 3718
10. Ch3so3h
11. Mfcd00007518
12. Chebi:27376
13. 22515-76-0
14. Msa
15. Nsc-3718
16. 12eh9m7279
17. Ammoniummethanesulfonate
18. Ccris 2783
19. Kyselina Methansulfonova [czech]
20. Hsdb 5004
21. Einecs 200-898-6
22. Brn 1446024
23. Methane Sulfonic Acid
24. Ai3-28532
25. Unii-12eh9m7279
26. Metanesulfonic Acid
27. Methansulfonic Acid
28. Msoh
29. Methansulphonic Acid
30. Methylsulphonic Acid
31. 03s
32. Methyl Sulfonic Acid
33. Methyl-sulfonic Acid
34. Methane-sulfonic Acid
35. Meso3h
36. Methane Sulphonic Acid
37. Methanesulphonic-acid-
38. Lactic Acid(dl)
39. Ammonium Methanesulphonate
40. Ch3so2oh
41. H3cso3h
42. Dsstox_cid_6422
43. Wln: Wsq1
44. Ec 200-898-6
45. Dsstox_rid_78109
46. Methane Sulfonic Acid 99%
47. Methanesulfonic Acid Solution
48. Dsstox_gsid_26422
49. 4-04-00-00010 (beilstein Handbook Reference)
50. Methanesulfonic Acid, 99.5%
51. Methanesulfonic Acid, Anhydrous
52. Chembl3039600
53. Dl-malicacidmonosodiumsalt
54. Dtxsid4026422
55. Methanesulfonic Acid [ii]
56. Methanesulfonic Acid [mi]
57. Methanesulfonic Acid, Hplc Grade
58. Nsc3718
59. Methanesulfonic Acid, >=99.0%
60. Methanesulfonic Acid [hsdb]
61. Tox21_201073
62. Stl264182
63. Methane Sulfonic Acid, 70% Solution
64. Akos009146947
65. At25153
66. J1.465f
67. Cas-75-75-2
68. Ncgc00248914-01
69. Ncgc00258626-01
70. Bp-12823
71. Db-075013
72. Ft-0628287
73. M0093
74. M2059
75. Methanesulfonic Acid, >=99.0%, Reagentplus(r)
76. Methanesulfonic Acid, For Hplc, >=99.5% (t)
77. A934985
78. Methanesulfonic Acid Solution, 70 Wt. % In H2o
79. Q414168
80. J-521696
81. Methanesulfonic Acid, Vetec(tm) Reagent Grade, 98%
82. F1908-0093
83. Z940713430
84. Methanesulfonic Acid Solution, 4 M (with 0.2% (w/v) Tryptamine)
85. Methanesulfonic Acid Concentrate, 0.1 M Ch3so3h In Water (0.1n), Eluent Concentrate For Ic
86. Methanesulfonic Acid, Pharmagrade, Manufactured Under Appropriate Gmp Controls For Pharma Or Biopharmaceutical Production
| Molecular Weight | 96.11 g/mol |
|---|---|
| Molecular Formula | CH4O3S |
| XLogP3 | -0.9 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 0 |
| Exact Mass | 95.98811516 g/mol |
| Monoisotopic Mass | 95.98811516 g/mol |
| Topological Polar Surface Area | 62.8 Ų |
| Heavy Atom Count | 5 |
| Formal Charge | 0 |
| Complexity | 92.6 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Not absorbed /through skin/; excreted /unchanged/ in rats after 1 g/kg administered sc. /From table/
Patty, F. (ed.). Industrial Hygiene and Toxicology: Volume II: Toxicology. 2nd ed. New York: Interscience Publishers, 1963., p. 1844
Marinosulfonomonas methylotropha strain TR3 is a marine methylotroph that uses methanesulfonic acid (MSA) as a sole carbon and energy source. The genes from M. methylotropha strain TR3 encoding methanesulfonate monooxygenase, the enzyme responsible for the initial oxidation of MSA to formaldehyde and sulfite, were cloned and sequenced. They were located on two gene clusters on the chromosome of this bacterium. A 5.0-kbp HindIII fragment contained msmA, msmB, and msmC, encoding the large and small subunits of the hydroxylase component and the ferredoxin component, respectively, of the methanesulfonate monooxygenase, while a 6.5-kbp HindIII fragment contained duplicate copies of msmA and msmB, as well as msmD, encoding the reductase component of methanesulfonate. Both sets of msmA and msmB genes were virtually identical, and the derived msmA and msmB sequences of M. methylotropha strain TR3, compared with the corresponding hydroxylase from the terrestrial MSA utilizer Methylosulfonomonas methylovora strain M2 were found to be 82 and 69% identical. The msmA gene was investigated as a functional gene probe for detection of MSA-utilizing bacteria. PCR primers spanning a region of msmA which encoded a unique Rieske [2Fe-2S] binding region were designed. These primers were used to amplify the corresponding msmA genes from newly isolated Hyphomicrobium, Methylobacterium, and Pedomicrobium species that utilized MSA, from MSA enrichment cultures, and from DNA samples extracted directly from the environment. The high degree of identity of these msmA gene fragments, compared to msmA sequences from extant MSA utilizers, indicated the effectiveness of these PCR primers in molecular microbial ecology.
Baxter, NJ et al; Appl Environ Microbiol 68 (1) 289-96 (2002) https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11772638
Methylating agents are potent carcinogens that are mutagenic and cytotoxic towards bacteria and mammalian cells. Their effects can be ascribed to an ability to modify DNA covalently. Pioneering studies of the chemical reactivity of methylating agents towards DNA components and their effectiveness as animal carcinogens identified O(6)-methylguanine (O(6)meG) as a potentially important DNA lesion. Subsequent analysis of the effects of methylating carcinogens in bacteria and cultured mammalian cells - including the discovery of the inducible adaptive response to alkylating agents in Escherichia coli - have defined the contributions of O(6)meG and other methylated DNA bases to the biological effects of these chemicals. More recently, the role of O(6)meG in killing mammalian cells has been revealed by the lethal interaction between persistent DNA O(6)meG and the mismatch repair pathway. Here, ...the results which led to the identification of the biological consequences of persistent DNA O(6)meG are reviewed. ... The possible consequences for a human cell of chronic exposure to low levels of a methylating agent /are considered/. Such exposure may increase the probability that the cell's mismatch repair pathway becomes inactive. Loss of mismatch repair predisposes the cell to mutation induction, not only through uncorrected replication errors but also by methylating agents and other mutagens. /Alkylating agents/
Bignami M et al Mutat Res 462 (2-3): 71-82 (2000). Available from, as of November 20, 2009: https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10767619
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