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Methotrimeprazine Maleate

Egis Levomepromazine Maleate

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Minakem delivers API, HPAPI, steroids & CDMO services for generics with FDA/GMP certification, regulatory know-how & proven success.

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xyz-pharma-m-2024-10-07

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Polpharma is a Polish CDMO of APIs and a significant European API producer, delivering products to companies worldwide.

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EUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

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CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

14 API Suppliers, 1 USDMF, 5 CEP/COS, 3 JDMF, 1 EU WC, 8 Listed Suppliers, $ API Reference Price

14 API Suppliers
1 USDMF
5 CEP/COS
3 JDMF
1 EU WC
8 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

2 Drugs in Development

2 Drugs in Development

INTERMEDIATES

8 Intermediates Suppliers

8 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

35 FDF Dossiers, 1 FDA Orange Book, 15 Europe, 10 Canada, 9 Listed Dossiers

35 FDF Dossiers
1 FDA Orange Book
15 Europe
10 Canada
9 Listed Dossiers

DIGITAL CONTENT

2 NEWS #PharmaBuzz

media
2 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

10 Finished Drug Prices

globalSalesInformation
10 Finished Drug Prices

MARKET PLACE

6 APIs, 4 FDF Dossiers

marketPlace
6 APIs
4 FDF Dossiers

REF. STANDARDS & IMPURITIES

2 EDQM , 1 USP

otherSolutions
2 EDQM
1 USP

Egis Levomepromazine Maleate

Synopsis

ACTIVE PHARMA INGREDIENTS

14

API Suppliers

1

USDMF

5

CEP/COS

CEP/COS Certifications

3

JDMF

1

EU WC

0

KDMF

0

NDC API

0

VMF

8

Listed Suppliers

API REF. PRICE (USD/KG)

$

$ 407

MARKET PLACE

6

API

4

FDF

8INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

35

FDF Dossiers

1

FDA Orange Book

FDA (Orange Book)

15

Europe

10

Canada

0

Australia

0

South Africa

9

Listed Dossiers

2DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

2

EDQM

1

USP

0

JP

0

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

2

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

NA

Annual Reports (USD Million)

NA

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 7104-38-3, Methotrimeprazine maleate, Levo mepromazine maleate, Milezin, Minozinan, Neuractil

Molecular Formula

C₂₃H₂₈N₂O₅S

Molecular Weight

444.5 g/mol

InChI Key

IFLZPECPTYCEBR-VIEYUMQNSA-N

FDA UNII

5KN5Y9V01K

Levomepromazine Maleate

1 2D Structure

Levomepromazine Maleate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(Z)-but-2-enedioic acid;(2R)-3-(2-methoxyphenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine

2.1.2 InChI

InChI=1S/C19H24N2OS.C4H4O4/c1-14(12-20(2)3)13-21-16-7-5-6-8-18(16)23-19-10-9-15(22-4)11-17(19)21;5-3(6)1-2-4(7)8/h5-11,14H,12-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-;/m1./s1

2.1.3 InChI Key

IFLZPECPTYCEBR-VIEYUMQNSA-N

2.1.4 Canonical SMILES

CC(CN1C2=CC=CC=C2SC3=C1C=C(C=C3)OC)CN(C)C.C(=CC(=O)O)C(=O)O

2.1.5 Isomeric SMILES

C[C@@H](CN1C2=CC=CC=C2SC3=C1C=C(C=C3)OC)CN(C)C.C(=C\C(=O)O)\C(=O)O

2.2 Other Identifiers

2.2.1 UNII

5KN5Y9V01K

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. 7104-38-3

2. Methotrimeprazine Maleate

3. Levo Mepromazine Maleate

4. Milezin

5. Minozinan

6. Neuractil

7. Neurocil

8. Sofmin

9. Levomepromazine Hydrogen Maleate

10. Hirnamin

11. Nozinan

12. Tisercin

13. Veractil

14. Levomepromazinum

15. 5kn5y9v01k

16. Methoprazine

17. (2r)-3-(2-methoxyphenothiazin-10-yl)-n,n,2-trimethylpropan-1-amine Maleate

18. (z)-but-2-enedioic Acid;(2r)-3-(2-methoxyphenothiazin-10-yl)-n,n,2-trimethylpropan-1-amine

19. Methotrimeprazine Maleat Salt

20. Unii-5kn5y9v01k

21. Levomepromazinmaleat

22. Hirnamin (tn)

23. Einecs 230-412-8

24. Levomepromazine Maleate [usan:jan]

25. Ncgc00016681-01

26. Cas-7104-38-3

27. Dsstox_cid_25399

28. Dsstox_rid_80853

29. Dsstox_gsid_45399

30. Schembl218717

31. Levomepromazinum [hpus]

32. Chembl1725730

33. Dtxsid4045399

34. Hms1570o16

35. Hms2097o16

36. Hms3714o16

37. Levomepromazine Maleate [mi]

38. Tox21_110559

39. Levomepromazine Maleate [jan]

40. Levomepromazine Maleate [usan]

41. Akos025116974

42. Levomepromazine Maleate (jp17/usan)

43. Ccg-220797

44. Levomepromazine Maleate [mart.]

45. Levomepromazine Maleate [who-dd]

46. 10h-phenothiazine-10-propanamine, 2-methoxy-n,n,.beta.-trimethyl-, (.beta.r)-, (2z)-2-butenedioate (1:1)

47. Cs-0455065

48. L0299

49. Levomepromazine Maleate [ep Monograph]

50. D02248

51. 104l383

52. Sr-01000872673

53. Sr-01000872673-1

54. Q27262488

55. Levomepromazine Maleate 1.0 Mg/ml In Methanol (as Free Base)

56. (betar)-2-methoxy-n,n,beta-trimethyl-10h-phenothiazine-10-propanamine (2z)-2-butenedioate

57. (r)-3-(2-methoxy-10h-phenothiazin-10-yl)-n,n,2-trimethylpropan-1-amine Maleate

58. But-2-enedioic Acid;(2r)-3-(2-methoxyphenothiazin-10-yl)-n,n,2-trimethylpropan-1-amine

59. (2r)-3-(2-methoxy-10h-phenothiazin-10-yl)-n,n,2-trimethylpropan-1-amine (2z)-but-2-enedioate

60. (2r)-3-(2-methoxy-10h-phenothiazin-10-yl)-n,n,2-trimethylpropan-1-amine Hydrogen (2z)-but-2-enedioate

61. 10h-phenothiazine-10-propanamine, 2-methoxy-n,n,beta-trimethyl-, (betar)-, (2z)-2-butenedioate (1:1)

2.4 Create Date

2005-10-11

3 Chemical and Physical Properties

Molecular Formula	C₂₃H₂₈N₂O₅S
Molecular Weight	444.5 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	7
Exact Mass	444.17189317 g/mol
Monoisotopic Mass	444.17189317 g/mol
Topological Polar Surface Area	116 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	497
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

API SUPPLIERS

01

Egis Pharmaceuticals PLC

Hungary

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Cosmoprof India

Not Confirmed

Egis is a Hungarian generic pharma company with 110 years history. Our activities incorporate all areas of the pharma value chain.

Contact Supplier

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Hungary

Digital Content

USDMF CEP/COS

JDMF EU-WC NDC KDMF VMF ASMF, BR

AUDIT

Egis Pharmaceuticals

Product Web Link

Digital Content

02

EUROAPI

France

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

EUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

Contact Supplier

Contact Supplier

France

Digital Content

USDMF CEP/COS

JDMF EU-WC NDC KDMF VMF ROW

AUDIT

EUROAPI Compnay Banner

Product Web Link

Digital Content

03

Cohance Lifesciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Cosmoprof India

Not Confirmed

Cohance Lifesciences, offers full range of CDMO services for small molecule APIs, intermediates, ADCs, Pellets and Formulations.

Contact Supplier

Contact Supplier

India

Digital Content

USDMF CEP/COS

JDMF EU-WC

NDC KDMF VMF Others AUDIT

Product Web Link

Digital Content

04

Egis Pharmaceuticals PLC

Hungary

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Cosmoprof India

Not Confirmed

Egis is a Hungarian generic pharma company with 110 years history. Our activities incorporate all areas of the pharma value chain.

Contact Supplier

Contact Supplier

Hungary

Digital Content

USDMF CEP/COS

JDMF EU-WC NDC KDMF VMF ASMF, BR

AUDIT

Egis Pharmaceuticals

Product Web Link

Digital Content

05

Cohance Lifesciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Cosmoprof India

Not Confirmed

Cohance Lifesciences, offers full range of CDMO services for small molecule APIs, intermediates, ADCs, Pellets and Formulations.

Contact Supplier

Contact Supplier

India

Digital Content

USDMF CEP/COS

JDMF EU-WC NDC KDMF VMF Others AUDIT

Product Web Link

Digital Content

06

RHODIA INC US 08512-7500 Cranbury

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Cosmoprof India

Not Confirmed

07

Molkem

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Cosmoprof India

Not Confirmed

08

Biotechnica DWC

Algeria

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Cosmoprof India

Not Confirmed

09

Allchem Lifescience

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Cosmoprof India

Not Confirmed

10

AXYNTIS Group

France

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Cosmoprof India

Not Confirmed

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USDMF

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CEP/COS

01

EGIS Pharmaceuticals PLC Budapest H...

Hungary

Cosmoprof India

Not Confirmed

Egis is a Hungarian generic pharma company with 110 years history. Our activities incorporate all areas of the pharma value chain.

Contact Supplier

Contact Supplier

Hungary

Digital Content

Levomepromazine maleate, Process 2

Certificate Number : R1-CEP 2016-215 - Rev 01

Status : Valid

Issue Date : 2023-03-31

Type : Chemical

Substance Number : 925

Egis Pharmaceuticals

Product Web Link

Digital Content

02

EGIS Pharmaceuticals PLC Budapest H...

Hungary

Cosmoprof India

Not Confirmed

Egis is a Hungarian generic pharma company with 110 years history. Our activities incorporate all areas of the pharma value chain.

Contact Supplier

Contact Supplier

Hungary

Digital Content

Levomepromazine maleate

Certificate Number : R1-CEP 1997-058 - Rev 06

Status : Valid

Issue Date : 2023-03-20

Type : Chemical

Substance Number : 925

Egis Pharmaceuticals

Product Web Link

Digital Content

03

EUROAPI FRANCE Vertolaye FR

France

EUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

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France

Digital Content

Levomepromazine maleate

Certificate Number : R1-CEP 2002-218 - Rev 05

Status : Valid

Issue Date : 2023-02-07

Type : Chemical

Substance Number : 925

EUROAPI Compnay Banner

Product Web Link

Digital Content

04

COHANCE LIFESCIENCES LIMITED Mumbai...

India

Cosmoprof India

Not Confirmed

Cohance Lifesciences, offers full range of CDMO services for small molecule APIs, intermediates, ADCs, Pellets and Formulations.

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India

Digital Content

Levomepromazine maleate

Certificate Number : CEP 2018-144 - Rev 04

Status : Valid

Issue Date : 2024-07-10

Type : Chemical

Substance Number : 925

Product Web Link

Digital Content

05

ZCL CHEMICALS LTD. Mumbai IN

India

Cosmoprof India

Not Confirmed

Cohance Lifesciences, offers full range of CDMO services for small molecule APIs, intermediates, ADCs, Pellets and Formulations.

Contact Supplier

Contact Supplier

India

Digital Content

Levomepromazine maleate

Certificate Number : R0-CEP 2012-263 - Rev 00

Status : Withdrawn by Holder

Issue Date : 2014-03-25

Type : Chemical

Substance Number : 925

Product Web Link

Digital Content

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JDMF

01

Ace Japan Co., Ltd.

Japan

Cosmoprof India

Not Confirmed

02

API Corporation Ltd.

Japan

Cosmoprof India

Not Confirmed

03

CENTIP HARM

France

Cosmoprof India

Not Confirmed

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EU WC

01

Cohance Lifesciences

India

Cosmoprof India

Not Confirmed

Cohance Lifesciences, offers full range of CDMO services for small molecule APIs, intermediates, ADCs, Pellets and Formulations.

Contact Supplier

Contact Supplier

India

Digital Content

Levomepromazine Maleate EP/BP

Date of Issue : 2022-08-25

Valid Till : 2025-07-02

Written Confirmation Number : WC-0195

Address of the Firm : Plot No. 3102/B, GIDC, Industrial Estate, Ankleshwar-393 002, Bharuch, Gujarat I...

Product Web Link

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Listed Suppliers

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API Reference Price

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Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

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Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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