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    Chemistry

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    Also known as: 135-07-9, Enduron, Aquatensen, Duretic, Methyclothiazid, Methycyclothiazide
    Molecular Formula
    C9H11Cl2N3O4S2
    Molecular Weight
    360.2  g/mol
    InChI Key
    CESYKOGBSMNBPD-UHFFFAOYSA-N
    FDA UNII
    R00UUL4SRN
    Methyclothiazide
    A thiazide diuretic with properties similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p825)
    Methyclothiazide is a Thiazide Diuretic. The physiologic effect of methyclothiazide is by means of Increased Diuresis.
    1 2D Structure

    Methyclothiazide

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-16,2,4-benzothiadiazine-7-sulfonamide
    2.1.2 InChI
    InChI=1S/C9H11Cl2N3O4S2/c1-14-9(4-10)13-6-2-5(11)7(19(12,15)16)3-8(6)20(14,17)18/h2-3,9,13H,4H2,1H3,(H2,12,15,16)
    2.1.3 InChI Key
    CESYKOGBSMNBPD-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CN1C(NC2=CC(=C(C=C2S1(=O)=O)S(=O)(=O)N)Cl)CCl
    2.2 Other Identifiers
    2.2.1 UNII
    R00UUL4SRN
    2.3 Synonyms
    2.3.1 Depositor-Supplied Synonyms

    1. 135-07-9

    2. Enduron

    3. Aquatensen

    4. Duretic

    5. Methyclothiazid

    6. Methycyclothiazide

    7. Enduronum

    8. Methychlothiazide

    9. Methylclothiazide

    10. Methylcyclothiazide

    11. Methylchlorothiazide

    12. Aquaresen

    13. Ciba 7272-su

    14. Nsc-110431

    15. 2h-1,2,4-benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxide

    16. Aquatensen;enduron

    17. Nsc 110431

    18. Methyclothiazide, (+)-

    19. Methyclothiazide, (-)-

    20. 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2h-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

    21. R00uul4srn

    22. R6kdh2s0sx

    23. 6-chloro-3-chloromethyl-2-methyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide

    24. Mls002704228

    25. Chebi:6847

    26. L3h46uac61

    27. 6-chloro-3-(chloromethyl)-2-methyl-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

    28. Nsc110431

    29. 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1$l^{6},2,4-benzothiadiazine-7-sulfonamide

    30. Naturon (van)

    31. Ncgc00167446-01

    32. Meticlotiazida

    33. Meticlotiazide

    34. Methyclothiazidum

    35. Meticlotiazide [dcit]

    36. Dsstox_cid_3313

    37. Dsstox_rid_76970

    38. Dsstox_gsid_23313

    39. 96783-15-2

    40. Meticlotiazida [inn-spanish]

    41. Methyclothiazidum [inn-latin]

    42. 2h-1,2,4-benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxide, (+)-

    43. 2h-1,2,4-benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxide, (-)-

    44. 96783-14-1

    45. Cas-135-07-9

    46. Enduron (tn)

    47. Hsdb 3363

    48. Einecs 205-172-2

    49. Ci-625

    50. Brn 0765361

    51. Unii-l3h46uac61

    52. Methyclothiazide (jan/usp/inn)

    53. Methyclothiazide [usan:usp:inn:ban:jan]

    54. Unii-r00uul4srn

    55. Unii-r6kdh2s0sx

    56. Chembl1577

    57. Schembl49396

    58. Methyclothiazide [mi]

    59. (+-)-6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2h-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

    60. Methyclothiazide [inn]

    61. Methyclothiazide [jan]

    62. Methyclothiazide [hsdb]

    63. Methyclothiazide [usan]

    64. Gtpl7235

    65. Methyclothiazide [vandf]

    66. Dtxsid6023313

    67. Methyclothiazide [mart.]

    68. Methyclothiazide [usp-rs]

    69. Methyclothiazide [who-dd]

    70. Hms3264d19

    71. Hms3652e06

    72. Pharmakon1600-01503841

    73. Hy-b0562

    74. Tox21_112450

    75. Nsc760078

    76. S4057

    77. Methyclothiazide [orange Book]

    78. Akos015896465

    79. Tox21_112450_1

    80. Ccg-213705

    81. Db00232

    82. Ks-5138

    83. Nsc-760078

    84. Eutron Component Methyclothiazide

    85. Methyclothiazide [usp Monograph]

    86. Ncgc00167446-02

    87. Ncgc00167446-03

    88. 2h-1,2,4-benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxide, (+-)-

    89. 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2h-1,2, 4-benzothiadiazine-7-sulfonamide 1,1-dioxide

    90. As-12982

    91. Smr001550236

    92. Enduronyl Component Methyclothiazide

    93. Methyclothiazide Component Of Eutron

    94. Diutensen-r Component Methyclothiazide

    95. Ft-0654252

    96. Sw219271-1

    97. Methyclothiazide Component Of Enduronyl

    98. C07765

    99. D00656

    100. Wln: T66 Bswn Em Dhj C1 D1g Hg Iszw

    101. Ab01014600_03

    102. Ab01014600_04

    103. Methyclothiazide Component Of Diutensen-r

    104. 135m079

    105. A806880

    106. Q6823919

    107. Brd-a95340155-001-05-5

    108. 3-amino-3-(2,5-dihydroxy-phenyl)-propionicacid

    109. Z1550675459

    110. 6-chloro-3-(chloromethyl)-3,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

    111. (+/-)-6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2h-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

    112. 2h-1,2,4-benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxide, (+/-)-

    113. 2h-1,4-benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxide

    114. 6-chloranyl-3-(chloromethyl)-2-methyl-1,1-bis(oxidanylidene)-3,4-dihydro-1$l^{6},2,4-benzothiadiazine-7-sulfonamide

    115. 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1?^{6},2,4-benzothiadiazine-7-sulfonamide

    116. 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-16,2,4-benzothiadiazine-7-sulfonamide

    117. 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1lambda6,2,4-benzothiadiazine-7-sulfonamide

    118. 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-2h-1$l^{6},2,4-benzothiadiazine-7-sulfonamide

    119. 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-2h-1lambda6,2,4-benzothiadiazine-7-sulfonamide

    120. 6-chloro-3-(chloromethyl)-2-methyl-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide #

    121. 6-chloro-3-(chloromethyl)-2-methyl-3,4-dihydro-2h-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 360.2 g/mol
    Molecular Formula C9H11Cl2N3O4S2
    XLogP31.4
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count2
    Exact Mass358.9568036 g/mol
    Monoisotopic Mass358.9568036 g/mol
    Topological Polar Surface Area126 Ų
    Heavy Atom Count20
    Formal Charge0
    Complexity571
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameMethyclothiazide
    PubMed HealthMethyclothiazide (Oral route)
    Drug ClassesCardiovascular Agent, Diuretic, Thiazide
    Drug LabelMethyclothiazide, a diuretic-antihypertensive agent, is a member of the benzothiadiazine (thiazide) class of drugs. It is an analogue of hydrochlorothiazide and occurs as a white to practically white crystalline powder which is basically odorless. Me...
    Active IngredientMethyclothiazide
    Dosage FormTablet
    RouteOral
    Strength5mg
    Market StatusPrescription
    CompanyMylan Pharms

    2 of 2  
    Drug NameMethyclothiazide
    PubMed HealthMethyclothiazide (Oral route)
    Drug ClassesCardiovascular Agent, Diuretic, Thiazide
    Drug LabelMethyclothiazide, a diuretic-antihypertensive agent, is a member of the benzothiadiazine (thiazide) class of drugs. It is an analogue of hydrochlorothiazide and occurs as a white to practically white crystalline powder which is basically odorless. Me...
    Active IngredientMethyclothiazide
    Dosage FormTablet
    RouteOral
    Strength5mg
    Market StatusPrescription
    CompanyMylan Pharms

    4.2 Therapeutic Uses

    Diuretics, Thiazide

    National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

    Thiazides...may be used to control edema associated with premenstrual tension and to reduce fluid retention following administration of corticosteroids or estrogens. /thiazide diuretics/

    American Medical Association, AMA Department of Drugs, AMA Drug Evaluations. 3rd ed. Littleton, Massachusetts: PSG Publishing Co., Inc., 1977., p. 81

    Indications include edema associated with congestive heart failure, hepatic cirrhosis with ascites, corticosteroid and estrogen therapy, and some forms of renal function impairment including nephrotic syndrome, acute glomerulonephritis, and chronic renal failure. /Included in US product labeling; Thiazide diuretics/

    MICROMEDEX Thomson Health Care. USPDI - Drug Information for the Health Care Professional. 22nd ed. Volume 1. MICROMEDEX Thomson Health Care, Greenwood Village, CO. 2002. Content Reviewed and Approved by the U.S. Pharmacopeial Convention, Inc., p. 1242

    Thiazide diuretics are indicated either alone or as adjunctive therapy in the treatment of hypertension. /Included in US product labeling; Thiazide diuretics/

    MICROMEDEX Thomson Health Care. USPDI - Drug Information for the Health Care Professional. 22nd ed. Volume 1. MICROMEDEX Thomson Health Care, Greenwood Village, CO. 2002. Content Reviewed and Approved by the U.S. Pharmacopeial Convention, Inc., p. 1242

    For more Therapeutic Uses (Complete) data for METHYCLOTHIAZIDE (10 total), please visit the HSDB record page.

    4.3 Drug Warning

    Because hypokalemia accelerates glucose intolerance, fall in serum potassium level can aggravate diabetes. Diuretic therapy may cause pronounced hypokalemia in presence of incr mineralocorticoid activity due to primary adrenal disease...or corticosteroid therapy. /thiazide diuretics/

    American Medical Association, AMA Department of Drugs, AMA Drug Evaluations. 3rd ed. Littleton, Massachusetts: PSG Publishing Co., Inc., 1977., p. 84

    Reversible elevation of blood urea nitrogen level may occur... This prerenal azotemia is caused by decrease in renal blood flow and glomerular filtration rate secondary to reduction in blood volume induced by diuretic. ...thiazides may directly depress renal blood flow. /thiazide diuretics/

    American Medical Association, AMA Department of Drugs, AMA Drug Evaluations. 3rd ed. Littleton, Massachusetts: PSG Publishing Co., Inc., 1977., p. 84

    Necrotizing vasculitis of skin and kidney has occurred in elderly patients, but its relationship to thiazides is still unproved. /thiazide diuretics/

    American Medical Association, AMA Department of Drugs, AMA Drug Evaluations. 3rd ed. Littleton, Massachusetts: PSG Publishing Co., Inc., 1977., p. 86

    When cardiac decompensation or hypertension is accompanied by significant impairment of renal function, thiazides should be admin with caution because of their capacity to aggravate renal insufficiency. /thiazide diuretics/

    Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 832

    For more Drug Warnings (Complete) data for METHYCLOTHIAZIDE (19 total), please visit the HSDB record page.

    4.4 Minimum/Potential Fatal Human Dose

    3. 3= Moderately toxic: probable oral lethal dose (human) 0.5-5 g/kg, between 1 oz and 1 pint for 70 Kg person (150 lb). /thiazide diuretics/

    Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-239

    4.5 Drug Indication

    For use in the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension. Also used as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Methyclothiazide, a diuretic-antihypertensive agent, is a member of the benzothiadiazine (thiazide) class of drugs. Methyclothiazide has a per mg natriuretic activity approximately 100 times that of the prototype thiazide, chlorothiazide. At maximal therapeutic dosages, all thiazides are approximately equal in their diuretic/natriuretic effects. Like other benzothiadiazines, methyclothiazide also has antihypertensive properties, and may be used for this purpose either alone or to enhance the antihypertensive action of other drugs.

    5.2 MeSH Pharmacological Classification

    Diuretics

    Agents that promote the excretion of urine through their effects on kidney function. (See all compounds classified as Diuretics.)

    Sodium Chloride Symporter Inhibitors

    Agents that inhibit SODIUM CHLORIDE SYMPORTERS. They act as DIURETICS. Excess use is associated with HYPOKALEMIA. (See all compounds classified as Sodium Chloride Symporter Inhibitors.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    METHYCLOTHIAZIDE
    5.3.2 FDA UNII
    L3H46UAC61
    5.3.3 Pharmacological Classes
    Chemical Structure [CS] - Thiazides
    5.4 ATC Code

    C - Cardiovascular system

    C03 - Diuretics

    C03A - Low-ceiling diuretics, thiazides

    C03AA - Thiazides, plain

    C03AA08 - Methyclothiazide

    5.5 Absorption, Distribution and Excretion

    Absorption

    Rapidly absorbed following oral administration.

    Thiazides are absorbed from GI tract and owe their usefulness largely to their effectiveness by oral route. Absorption is relatively rapid. Most agents show demonstrable diuretic effect within hr after oral administration. /thiazide diuretics/

    Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 831

    In general, thiazides with relatively long durations of action show proportionately high degrees of both binding to plasma proteins and reabsorption by renal tubules. ... Drug passes readily through placental barrier to fetus. All thiazides probably undergo active secretion in proximal tubule. /thiazide diuretics/

    Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 831

    Methyclothiazide is absorbed from the GI tract. Little information is available on the extent of absorption and the distribution of methyclothiazide in the body. Methyclothiazide is excreted unchanged in urine.

    McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 2554

    5.6 Metabolism/Metabolites

    Methyclothiazide is excreted unchanged in urine.

    McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 2554

    5.7 Mechanism of Action

    Methyclothiazide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle, altering electrolyte transfer in the proximal tubule. This results in excretion of sodium, chloride, and water and, hence, diuresis. As a diuretic, methyclothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like methyclothiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of methyclothiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.

    Acute admin of thiazides increases the excretion of uric acid. However, uric acid excretion is reduced following chronic admin... . The acute effects of inhibitors of Na+-Cl- symport on Ca2+ excretion are variable; when admin chronically, thiazide diuretics decr Ca2+ excretion. The mechanism is unknown but may involve increased proximal reabsorption due to volume depletion as well as direct effects of thiazides to incr Ca2+ reabsorption in the /distal convoluted tubule/. Thiazide diuretics may cause a mild magnesuria by a poorly understood mechanism, and there is increasing awareness that long-term use of thiazide diuretics may cause magnesium deficiency, particularly in the elderly. /Thiazide diuretics/

    Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill, 2001., p. 775

    Thiazides inhibit reabsorption of sodium and ...chloride in distal segment. ... As /a/ class...have important action on excretion of potassium that results from increased secretion of cation by distal tubule. ... Glomerular filtration rate may be reduced by thiazides, particularly with iv admin for exptl purposes. /thiazide diuretics/

    Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 901

    Nature of chemical interaction between thiazides and specific renal receptors responsible for chloruretic effect is not known; no critical enzymatic reactions have been identified. /thiazides/

    Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 901

    Thiazide diuretics increase urinary excretion of sodium and water by inhibiting sodium reabsorption in the early distal tubules. They increase the rate of delivery of tubular fluid and electrolytes to the distal sites of hydrogen and potassium ion secretion, while plasma volume contraction increases aldosterone production. The increased delivery and increase in aldosterone levels promote sodium reabsorption at the distal tubules, thus increasing the loss of potassium and hydrogen ions. /Thiazide diuretics/

    MICROMEDEX Thomson Health Care. USPDI - Drug Information for the Health Care Professional. 22nd ed. Volume 1. MICROMEDEX Thomson Health Care, Greenwood Village, CO. 2002. Content Reviewed and Approved by the U.S. Pharmacopeial Convention, Inc., p. 1243

    The antidiuretic effect of thiazide diuretics is a result of mild sodium and water depletion leading to increased reabsorption of glomerular filtrate in the proximal renal tubule and reduced delivery of tubular fluid available for excretion. /Thiazide diuretics/

    MICROMEDEX Thomson Health Care. USPDI - Drug Information for the Health Care Professional. 22nd ed. Volume 1. MICROMEDEX Thomson Health Care, Greenwood Village, CO. 2002. Content Reviewed and Approved by the U.S. Pharmacopeial Convention, Inc., p. 1243

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    Methyclothiazide Manufacturers

    A Methyclothiazide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Methyclothiazide, including repackagers and relabelers. The FDA regulates Methyclothiazide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Methyclothiazide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Methyclothiazide manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Methyclothiazide Suppliers

    A Methyclothiazide supplier is an individual or a company that provides Methyclothiazide active pharmaceutical ingredient (API) or Methyclothiazide finished formulations upon request. The Methyclothiazide suppliers may include Methyclothiazide API manufacturers, exporters, distributors and traders.

    click here to find a list of Methyclothiazide suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Methyclothiazide USDMF

    A Methyclothiazide DMF (Drug Master File) is a document detailing the whole manufacturing process of Methyclothiazide active pharmaceutical ingredient (API) in detail. Different forms of Methyclothiazide DMFs exist exist since differing nations have different regulations, such as Methyclothiazide USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Methyclothiazide DMF submitted to regulatory agencies in the US is known as a USDMF. Methyclothiazide USDMF includes data on Methyclothiazide's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Methyclothiazide USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Methyclothiazide suppliers with USDMF on PharmaCompass.

    Methyclothiazide NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Methyclothiazide as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Methyclothiazide API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Methyclothiazide as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Methyclothiazide and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Methyclothiazide NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Methyclothiazide suppliers with NDC on PharmaCompass.

    Methyclothiazide GMP

    Methyclothiazide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Methyclothiazide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Methyclothiazide GMP manufacturer or Methyclothiazide GMP API supplier for your needs.

    Methyclothiazide CoA

    A Methyclothiazide CoA (Certificate of Analysis) is a formal document that attests to Methyclothiazide's compliance with Methyclothiazide specifications and serves as a tool for batch-level quality control.

    Methyclothiazide CoA mostly includes findings from lab analyses of a specific batch. For each Methyclothiazide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Methyclothiazide may be tested according to a variety of international standards, such as European Pharmacopoeia (Methyclothiazide EP), Methyclothiazide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Methyclothiazide USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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