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    Chemistry

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    Also known as: Methylcobalamin, 13422-55-4
    Molecular Formula
    C63H91CoN13O14P
    Molecular Weight
    1344.4  g/mol
    InChI Key
    ZFLASALABLFSNM-UHFFFAOYSA-L
    Methylcobalamin
    1 2D Structure

    Methylcobalamin

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    carbanide;cobalt(3+);[5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] 1-[3-[(4Z,9Z,14Z)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-21-id-3-yl]propanoylamino]propan-2-yl phosphate
    2.1.2 InChI
    InChI=1S/C62H90N13O14P.CH3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);1H3;/q;-1;+3/p-2
    2.1.3 InChI Key
    ZFLASALABLFSNM-UHFFFAOYSA-L
    2.1.4 Canonical SMILES
    [CH3-].CC1=CC2=C(C=C1C)N(C=N2)C3C(C(C(O3)CO)OP(=O)([O-])OC(C)CNC(=O)CCC4(C(C5C6(C(C(C(=N6)C(=C7C(C(C(=N7)C=C8C(C(C(=N8)C(=C4[N-]5)C)CCC(=O)N)(C)C)CCC(=O)N)(C)CC(=O)N)C)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[Co+3]
    2.1.5 Isomeric SMILES
    [CH3-].CC1=CC2=C(C=C1C)N(C=N2)C3C(C(C(O3)CO)OP(=O)([O-])OC(C)CNC(=O)CCC\4(C(C5C6(C(C(C(=N6)/C(=C\7/C(C(C(=N7)/C=C\8/C(C(C(=N8)/C(=C4\[N-]5)/C)CCC(=O)N)(C)C)CCC(=O)N)(C)CC(=O)N)/C)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[Co+3]
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Ch3-b12

    2. Mecobalamin

    3. Mecobalamin Monohydrate

    4. Mecobalamin, (13beta)-isomer

    5. Mecobalamin, 3h-labeled

    6. Mecobalamin, 57co-labeled

    7. Mecobalamin, Co-methyl-13c-labeled

    8. Mecobalamin, Co-methyl-14c-labeled

    9. Methylcobalamin

    10. Methylcobalamine

    11. Methylvitamin B12

    2.2.2 Depositor-Supplied Synonyms

    1. Methylcobalamin

    2. 13422-55-4

    2.3 Create Date
    2006-04-28
    3 Chemical and Physical Properties
    Molecular Weight 1344.4 g/mol
    Molecular Formula C63H91CoN13O14P
    Hydrogen Bond Donor Count9
    Hydrogen Bond Acceptor Count20
    Rotatable Bond Count26
    Exact Mass1343.587800 g/mol
    Monoisotopic Mass1343.587800 g/mol
    Topological Polar Surface Area452 Ų
    Heavy Atom Count92
    Formal Charge0
    Complexity3140
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count14
    Defined Bond Stereocenter Count3
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3

    API Reference Price

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    02-Jan-2021
    28-Feb-2025
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    Drugs in Development

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    • Development Update
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    Eisai Submits NDA in Japan for Ultrahigh-Dose Mecobalamin to Treat ALS

    Details:

    Methycobal (methylcobalamin) is the active form of vitamin B12. It is indicated for the treatment of peripheral neuropathies and megaloblastic anemia caused by vitamin B12 deficiency.


    Lead Product(s): Methylcobalamin

    Therapeutic Area: Neurology Brand Name: E0302

    Study Phase: Phase IIIProduct Type: Vitamins/Minerals/Inorganic Salts

    Sponsor: Inapplicable

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable January 26, 2024

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    01

    Eisai

    Japan
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    Drug Discovery Chemistry
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    Eisai

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    Lead Product(s) : Methylcobalamin

    Therapeutic Area : Neurology

    Highest Development Status : Phase III

    Partner/Sponsor/Collaborator : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Eisai Submits NDA in Japan for Ultrahigh-Dose Mecobalamin to Treat ALS

    Details : Methycobal (methylcobalamin) is the active form of vitamin B12. It is indicated for the treatment of peripheral neuropathies and megaloblastic anemia caused by vitamin B12 deficiency.

    Product Name : E0302

    Product Type : Vitamins/Minerals/Inorganic Salts

    Upfront Cash : Inapplicable

    January 26, 2024

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    Eisai Initiates Preparation for New Drug Application, Based on the Results of an Investigator-initiated Clinical Trial of Ultrahigh-dose Mecobalamin for...

    Details:

    An analysis of Study 761 suggested that ultrahigh-dose E0302 (methylcobalamin) prolonged survival period and suppressed progression in ALS patients who commenced treatment within 12 months of ALS onset.


    Lead Product(s): Methylcobalamin

    Therapeutic Area: Neurology Brand Name: E0302

    Study Phase: Phase IIIProduct Type: Vitamins/Minerals/Inorganic Salts

    Sponsor: Inapplicable

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable October 05, 2022

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    02

    Eisai

    Japan
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    Drug Discovery Chemistry
    Not Confirmed

    Eisai

    Japan
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    Drug Discovery Chemistry
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    Lead Product(s) : Methylcobalamin

    Therapeutic Area : Neurology

    Highest Development Status : Phase III

    Partner/Sponsor/Collaborator : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    Eisai Initiates Preparation for New Drug Application, Based on the Results of an Investigator-init...

    Details : An analysis of Study 761 suggested that ultrahigh-dose E0302 (methylcobalamin) prolonged survival period and suppressed progression in ALS patients who commenced treatment within 12 months of ALS onset.

    Product Name : E0302

    Product Type : Vitamins/Minerals/Inorganic Salts

    Upfront Cash : Inapplicable

    October 05, 2022

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    Ministry of Health, Labour and Welfare Grants Orphan Drug Designation in Japan to Mecobalamin Ultrahigh-Dose Formulation with Prospective Indication for...

    Details:

    Mecobalamin (generic name, development code: E0302) is approved and marketed as Methycobal®, a 500 µg injection of mecobalamin indicated for the treatment of peripheral neuropathies and megaloblastic anemia caused by vitamin B12 deficiency.


    Lead Product(s): Methylcobalamin

    Therapeutic Area: Neurology Brand Name: E0302

    Study Phase: Phase IIIProduct Type: Vitamins/Minerals/Inorganic Salts

    Sponsor: Inapplicable

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable May 27, 2022

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    03

    Eisai

    Japan
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    Drug Discovery Chemistry
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    Eisai

    Japan
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    Lead Product(s) : Methylcobalamin

    Therapeutic Area : Neurology

    Highest Development Status : Phase III

    Partner/Sponsor/Collaborator : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Ministry of Health, Labour and Welfare Grants Orphan Drug Designation in Japan to Mecobalamin Ultr...

    Details : Mecobalamin (generic name, development code: E0302) is approved and marketed as Methycobal®, a 500 µg injection of mecobalamin indicated for the treatment of peripheral neuropathies and megaloblastic anemia caused by vitamin B12 deficiency.

    Product Name : E0302

    Product Type : Vitamins/Minerals/Inorganic Salts

    Upfront Cash : Inapplicable

    May 27, 2022

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    Europe

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    01

    Nobel Ilac Sanayii Ve Ticaret A.S.

    Turkey
    Drug Discovery Chemistry
    Not Confirmed
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    Nobel Ilac Sanayii Ve Ticaret A.S.

    Turkey
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    Regulatory Info :

    Registration Country : Turkey

    Pregabalin; Cobamet

    Brand Name : Pagamax Plus

    Dosage Form :

    Dosage Strength : 75MG; 1MG

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    Registration Country : Turkey

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    Nobel Ilac Sanayii Ve Ticaret A.S.

    Turkey
    Drug Discovery Chemistry
    Not Confirmed
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    Nobel Ilac Sanayii Ve Ticaret A.S.

    Turkey
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    Regulatory Info :

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    Pregabalin; Cobamet

    Brand Name : Pagamax Plus

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    Dosage Strength : 150MG; 1MG

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    Registration Country : Turkey

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    03

    Nobel Ilac Sanayii Ve Ticaret A.S.

    Turkey
    Drug Discovery Chemistry
    Not Confirmed
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    Nobel Ilac Sanayii Ve Ticaret A.S.

    Turkey
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    Regulatory Info :

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    Pregabalin; Cobamet

    Brand Name : Pagamax Plus

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    Dosage Strength : 300MG; 1MG

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    Registration Country : Turkey

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    World Medicine Ilac San ve tic LTD STl

    Turkey
    Drug Discovery Chemistry
    Not Confirmed
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    Turkey
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    Regulatory Info : Generic

    Registration Country : Turkey

    Diclofenac Sodium; Thiamine; Pyridoxine; Cobamet

    Brand Name :

    Dosage Form : CAPSULE

    Dosage Strength : 50MG; 50MG; 50MG; 0.25MG

    Packaging : 20 Capsules

    Approval Date :

    Application Number :

    Regulatory Info : Generic

    Registration Country : Turkey

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    01

    Cooper Pharma Limited

    India
    Drug Discovery Chemistry
    Not Confirmed
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    Cooper Pharma Limited

    India
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    Drug Discovery Chemistry
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    Regulatory Info :

    Registration Country : India

    Methylcobalamin

    Brand Name :

    Dosage Form : Injection

    Dosage Strength : 500MCG/ML

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    Application Number :

    Regulatory Info :

    Registration Country : India

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    01

    Cooper Pharma Limited

    India
    Drug Discovery Chemistry
    Not Confirmed
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    India
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    Packaging :

    Regulatory Info :

    Methylcobalamin

    Dosage : Injection

    Dosage Strength : 500MCG/ML

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    Approval Date :

    Application Number :

    Registration Country : India

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    02

    Ind Swift Laboratories Limited

    India
    Drug Discovery Chemistry
    Not Confirmed
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    Ind Swift Laboratories Limited

    India
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    Drug Discovery Chemistry
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    Regulatory Info : Generic

    Registration Country : India

    Cobamet

    Brand Name : Renerve 250

    Dosage Form : TABLET

    Dosage Strength : 250MCG

    Packaging : 10x1x10 Alu-Alu

    Approval Date :

    Application Number :

    Regulatory Info : Generic

    Registration Country : India

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    02

    Ind Swift Laboratories Limited

    India
    Drug Discovery Chemistry
    Not Confirmed
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    Ind Swift Laboratories Limited

    India
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    Packaging : 10x1x10 Alu-Alu

    Regulatory Info : Generic

    Cobamet

    Dosage : TABLET

    Dosage Strength : 250MCG

    Brand Name : Renerve 250

    Approval Date :

    Application Number :

    Registration Country : India

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    03

    Inventia Healthcare Limited

    India
    Drug Discovery Chemistry
    Not Confirmed
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    India
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    Regulatory Info : Commercialized In: India (2008...

    Registration Country : India

    Pregabalin; Cobamet

    Brand Name :

    Dosage Form : Sustained Release Tabl...

    Dosage Strength : 150MG; 1500MCG

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    Regulatory Info : Commercialized In: India (2008...

    Registration Country : India

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    03

    Inventia Healthcare Limited

    India
    Drug Discovery Chemistry
    Not Confirmed
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    India
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    Packaging :

    Regulatory Info : Commercialized In: India (2008...

    Pregabalin; Cobamet

    Dosage : Sustained Release Tabl...

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    04

    Madras Pharmaceuticals

    India
    Drug Discovery Chemistry
    Not Confirmed
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    India
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    Registration Country : India

    Benfotiamine; Methylcobalamin; alpha-Lipoic Acid; Inositol; Folic Acid; Pyridoxine Hydrochloride

    Brand Name :

    Dosage Form : Softgelatin Capsule

    Dosage Strength : 100MG; 1000MCG; 200MCG...

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    Registration Country : India

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    Madras Pharmaceuticals

    India
    Drug Discovery Chemistry
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    Packaging :

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    Benfotiamine; Methylcobalamin; alpha-Lipoic Acid; Inositol; Folic Acid; Pyridoxine Hydrochloride

    Dosage : Softgelatin Capsule

    Dosage Strength : 100MG; 1000MCG; 200MCG...

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    Registration Country : India

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    Madras Pharmaceuticals

    India
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    Pyridoxal Phosphate; Methylcobalamin

    Brand Name :

    Dosage Form : Softgelatin Capsule

    Dosage Strength : 500MCG; 1500MCG

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    Madras Pharmaceuticals

    India
    Drug Discovery Chemistry
    Not Confirmed
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    India
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    Pyridoxal Phosphate; Methylcobalamin

    Dosage : Softgelatin Capsule

    Dosage Strength : 500MCG; 1500MCG

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    Approval Date :

    Application Number :

    Registration Country : India

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    06

    Meenaxy Pharma Pvt. Ltd

    India
    Drug Discovery Chemistry
    Not Confirmed
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    Meenaxy Pharma Pvt. Ltd

    India
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    Drug Discovery Chemistry
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    Registration Country : India

    Cobamet; Pregabalin

    Brand Name : Menerve

    Dosage Form : Capsule

    Dosage Strength : 750MCG; 75MG

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    Registration Country : India

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    Meenaxy Pharma Pvt. Ltd

    India
    Drug Discovery Chemistry
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    India
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    Cobamet; Pregabalin

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    Dosage Strength : 750MCG; 75MG

    Brand Name : Menerve

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    Registration Country : India

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    Meenaxy Pharma Pvt. Ltd

    India
    Drug Discovery Chemistry
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    India
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    Regulatory Info :

    Registration Country : India

    Cobamet

    Brand Name : Mepex

    Dosage Form : Capsule

    Dosage Strength : 750MG

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    Application Number :

    Regulatory Info :

    Registration Country : India

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    07

    Meenaxy Pharma Pvt. Ltd

    India
    Drug Discovery Chemistry
    Not Confirmed
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    Meenaxy Pharma Pvt. Ltd

    India
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    Packaging :

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    Cobamet

    Dosage : Capsule

    Dosage Strength : 750MG

    Brand Name : Mepex

    Approval Date :

    Application Number :

    Registration Country : India

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    08

    RELIANCE FORMULATION PVT. LTD

    India
    Drug Discovery Chemistry
    Not Confirmed
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    RELIANCE FORMULATION PVT. LTD

    India
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    Drug Discovery Chemistry
    Not Confirmed
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    Regulatory Info :

    Registration Country : India

    Pregabalin; Cobamet

    Brand Name : NUROVITA P

    Dosage Form : Capsule

    Dosage Strength : 75MG; 750MCG

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : India

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    08

    RELIANCE FORMULATION PVT. LTD

    India
    Drug Discovery Chemistry
    Not Confirmed
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    RELIANCE FORMULATION PVT. LTD

    India
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    Packaging :

    Regulatory Info :

    Pregabalin; Cobamet

    Dosage : Capsule

    Dosage Strength : 75MG; 750MCG

    Brand Name : NUROVITA P

    Approval Date :

    Application Number :

    Registration Country : India

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    09

    SkyEc Drugs and Pharmaceuticals

    India
    Drug Discovery Chemistry
    Not Confirmed
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    SkyEc Drugs and Pharmaceuticals

    India
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    Drug Discovery Chemistry
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    Regulatory Info :

    Registration Country : India

    Ferrous Ascorbate; Folic Acid; Vitamin B6; Zinc; Mecobalamin; AMINO ACIDS

    Brand Name : Nicefer

    Dosage Form : Tablet

    Dosage Strength :

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    Registration Country : India

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    SkyEc Drugs and Pharmaceuticals

    India
    Drug Discovery Chemistry
    Not Confirmed
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    SkyEc Drugs and Pharmaceuticals

    India
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    Packaging :

    Regulatory Info :

    Ferrous Ascorbate; Folic Acid; Vitamin B6; Zinc; Mecobalamin; AMINO ACIDS

    Dosage : Tablet

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    Brand Name : Nicefer

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    Registration Country : India

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    10

    ZRS LABS

    India
    Drug Discovery Chemistry
    Not Confirmed
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    India
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    Regulatory Info :

    Registration Country : India

    methylcobalamin; Folic Acid; Pyridoxine Hydrochloride; Thioctic Acid; Thiamine Hydrochloride

    Brand Name :

    Dosage Form : Capsule

    Dosage Strength : 500MCG; 1.5MG; 3MG; 10...

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    Regulatory Info :

    Registration Country : India

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    ZRS LABS

    India
    Drug Discovery Chemistry
    Not Confirmed
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    India
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    Packaging :

    Regulatory Info :

    methylcobalamin; Folic Acid; Pyridoxine Hydrochloride; Thioctic Acid; Thiamine Hydrochloride

    Dosage : Capsule

    Dosage Strength : 500MCG; 1.5MG; 3MG; 10...

    Brand Name :

    Approval Date :

    Application Number :

    Registration Country : India

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    Methylcobalamin API needed in India [ENA21963]
    A company that focuses on research, development & manufacturing of pellets, micro-pellets and granules is looking for suppliers of Methylcobalamin API for development purposes. The suppliers must support this enquiry with USDMF & CoA.
    04 Feb 2025

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    04 Feb 2025

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    04 Feb 2025

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    BP Grade Methylcobalamin (200 g) API needed in India [ENA20354]
    A company that specializes in manufacturing various finished formulations across various therapeutic areas is looking for suppliers of BP Grade Methylcobalamin (200 g) API for commercial purposes. The suppliers must support this enquiry with CoA.
    24 Aug 2024

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    24 Aug 2024

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    24 Aug 2024

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    Mecobalamin (1 kg) API needed in Pakistan [ENA18845]
    A company that focuses on sourcing pharmaceutical raw Materials specifically active pharmaceutical ingredients for pharmaceutical manufacturing industry is looking for suppliers of Mecobalamin (1 kg) API for commercial purposes. The suppliers must support this enquiry with GMP & CoA.
    02 Jan 2024

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    02 Jan 2024

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    02 Jan 2024

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    Methylcobalamin API (1kg) needed in India [ENA18809]
    A company that focuses on new product development & distribution of APIs is looking for suppliers of methylcobalamin (1kg) for commercial/R&D Purposes. The suppliers must support this inquiry with an active CoA.
    23 Dec 2023

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    23 Dec 2023

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    23 Dec 2023

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    Methylcobalamine (1 kg) API needed in India [ENA18565]
    A pharmaceutical manufacturing company that deals in beta-lactam, non beta-lactam and food supplements for both tablets and capsules is looking for suppliers of Methylcobalamine (1 kg) API for commercial purposes. The suppliers must support this enquiry with CoA.
    07 Nov 2023

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    07 Nov 2023

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    07 Nov 2023

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    Methylcobalamin (2 kg) API needed in India [ENA18531]
    A company that focuses on manufacturing of tablets, capsules, injections, syrups, drops, ointments & creams is looking for suppliers of Methylcobalamin (2 kg) API for commercial purposes. The suppliers must support this enquiry with CoA.
    03 Nov 2023

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    03 Nov 2023

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    03 Nov 2023

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    Injectable Grade Methylcobalamin API needed in India [ENA18477]
    A CMO that focuses on solid & liquid finished formulations in various therapeutic areas is looking for suppliers of Injectable Grade Methylcobalamin API for development purposes. The suppliers must support this enquiry with CoA.
    28 Oct 2023

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    28 Oct 2023

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    28 Oct 2023

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    Methylcobalamin (2 kg) API needed in India [ENA18351]
    A company that deals in various pharmaceutical products is looking for suppliers of Methylcobalamin (2 kg) API for commercial purposes. The suppliers must support this enquiry with CoA.
    16 Oct 2023

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    16 Oct 2023

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    16 Oct 2023

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    Various APIs needed in India [ENA17009]
    A company that focuses on the manufacturing of tablets and capsules is looking for suppliers of Various APIs for commercial purposes. The suppliers must support this enquiry with CoA. 1. Methylcobalamin (1 kg) API 2. IP Grade Methylparaben Sodium (5 kg) API
    01 May 2023

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    01 May 2023

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    01 May 2023

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    JP/ IP Grade Methylcobalamin (1 kg) API needed in India [ENA16874]
    A company that focuses on the manufacturing of tablets and capsules is looking for suppliers of JP/ IP Grade Methylcobalamin (1 kg) API for commercial purposes. The suppliers must support this enquiry with CoA.
    13 Apr 2023

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    13 Apr 2023

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    13 Apr 2023

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    Various Finished Dosage Formulations needed in Vietnam [ENA12884]
    A large pharmaceutical company based in India that deals in various segments such as gynaecology, cardiovascular, diabetology, asthma, paediatric, CNS, GI and NSAIDs is looking for suppliers of Various Finished Dosage Formulations for commercial purpose. 1. Amoxicillin (500 mg & 875 mg) and Potassium Clavulanate (125 mg) Tablets 2. Amoxicillin (600 mg & 400 mg) and Potassium Clavulanate (42.9 mg & 57 mg) Suspensions 3. Cefdinir (300 mg) Tablets 4. Progesterone (100 mg & 200 mg) Tablets 5. Methylcobalamin (500 mg) Injections 6. Methocarbamol (1000 mg) Injections
    04 Mar 2022

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    04 Mar 2022

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    Various Finished Dosage Formulations needed in Yemen [ENA11957]
    A company that deals in the distribution and marketing of pharmaceuticals and supplements is looking for suppliers of Various Finished Dosage Formulations for commercial purpose. The suppliers must support this enquiry with GMP. 1. Lincomycin HCl (600 mg/ 2 ml) Vials. The first order quantity is 500,000 units & annual requirement is 2.5 million units. 2. Ceftriaxone (1 g) Vials. The first order quantity is 200,000 units & annual requirement is 1 million units. 3. Methylcobalamin (500 mcg/ ml) Injections. The first order quantity is 100,000 units & annual requirement is 500,000 units. 4. IP Grade Dexamethasone Sodium Phosphate (8 mg/ ml) Injection. The first order quantity is 100,000 units & annual requirement is 500,000 units. 5. IP Grade Gentamicin (40 mg/ ml) Injection. The first order quantity is 50,000 units & annual requirement is 250,000 units.
    29 Nov 2021

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    29 Nov 2021

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    29 Nov 2021

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    Various FDFs needed in the United Arab Emirates [ENA11199]
    A reputed pharmaceutical agent & distributor in the UAE having an account of ongoing business with plentiful healthcare customers since 1996 through a reliable marketing and sales team is looking for suppliers of Various FDFs. The required quantity is 20,000 units to 50,000 units for each. The suppliers must support this enquiy with Zone 4 stability studies. 1. Dexamethasone Sodium Phosphate (4 mg/ ml in 2 ml) Ampoules 2. Methylcobalamin (1000 mcg) + Thiamine Hydrochloride (100 mg) + Pyridoxine Hydrochloride (100 mg) + Riboflavin Sodium Phosphate (5 mg) + Niacinamide (100 mg) in 1 ml Ampoules 3. Dimetindene Maleate (1 mg/ ml in 20 ml) Drops in Glass Dropper Bottle 4. Triamcinolone Acetonide (0.1% in 15 gm) Oral Paste 5. Fusidic Acid (1% w/w in 5 g) Viscous Eye Drops 6. Betamethasone (0.1%) + Gentamicin Sulfate (0.1%) + Miconazole Nitrate (20%) and /or without Chlorocresol (0.1%) in 30 gm Cream 7. Hydroquinone (2% w/w) + Tretinoin (0.025% w/w) + Mometasone Furoate (0.1% w/w) in 30 gm Cream 8. Hydrocortisone (1% in 20 gm) Cream 9. Clotrimazole (1% w/w in 30 gm) Gel 10. Clotrimazole (1%) + Beclomethasone Dipropionate (0.025%) in 30 gm Cream 11. Mupirocin (1% in 30 gm) Cream
    24 Aug 2021

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    24 Aug 2021

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    24 Aug 2021

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    Various Finished Dosage Formulations needed in India [ENA10017]
    A company that deals in gluten and lactose-free foods, vitamins and supplements & unique healthcare concepts is looking for suppliers of Various Finished Dosage Formulations for commercial purposes. The required quantity is 1,000 units for each. 1. Ascorbic Acid (500 mg/ ml in 10 ml) Injections 2. Biotin (0.5 mg/ ml) Injections 3. Methylcobalamin (5 mg/ ml in 30 ml & 10 ml) Vials 4. Dexamethasone Sodium Phosphate (100 mg/ 10 ml) Injections 5. Dexpanthenol (250 mg/ ml in 30 ml) Injections 6. Glutathione (200 mg/ ml) Injections 7. Hydroxcabalamin (1 mg/ ml) Injections 8. Methylcobalamin (5 mg/ ml) Injections 9. Nicotinamide Adenine Dinucleotide (500 mg) Vials 10. Sodium Selenite (200 mcg/ ml) Injections 11. Taurine (50 mg/ ml) Injections 12. Zinc Chloride (0.5 mg/ ml) Injections 13. USP Grade Ondansetron (4 mg/ 2 ml) Injections
    22 Mar 2021

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    22 Mar 2021

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    22 Mar 2021

    Market Place
    Enquiry// Various finished formulations needed in Kenya [ENA00928]
    Taurus Medical is looking for Pharmacy & Poisons Board (PPB) approved manufacturer or suppliers for below listed products: 1. Ferrous ascorbate 30 mg + Folic acid 0.5 mg syrup 2. Multivitamin Syrup (Centrum combination) 3. Losartan 50 mg + Hydrochlorothiazide 12.5 mg tablets 4. Nebivolol tablets 5. Enalapril 2.5 mg, 5 mg & 10 mg tablets 6. Amlodipine 5 & 10 mg tablets 7. Sitagliptin 50 mg+ Metformin 500 mg tablets 8. Vildagliptin 50 mg + Metformin 500 mg tablets 9. Olmesartan tablets 10. Hydrochlorothiazide 25 mg & 50 mg 11. Esomeprazole 40 mg tablets 12. Amoxyclav 157 mg & 228 mg suspension 13. Amoxyclav 375 mg, 625 mg & 1 g Tablets 14. Amoxycillin 500 mg capsules 15. Amoxycillin 125 mg/5 ml & 250 mg/5 ml dry suspension 16. Flucloxacillin 500 mg capsules 17. Flucloxacillin 125 mg/5 ml suspension 18. Levofloxacin 750 mg tablets 19. Etoricoxib 60 mg, 90 mg & 120 mg 20. Linezolid 600 mg 21. Amoxy 250 DT tablets 22. Methylcobalamine + Gabapentin tablets 23. Aceclofenac 100 mg & 200 mg SR tablets 24. Esomeprazole 20 + Clarithromycin 500 + Amoxy 1000 mg 25. Pantoprazole 20 + Clarithromycin 500 + Amoxy 1000 mg 26. Azithromycin 200 mg/5 ml dry suspension 27. Azithromycin 500 mg + Secnidazole 1 g + Fluconazole 150 capsules 28. Losartan 100 mg + Hydrochlorothiazide 25 mg tablets Interested suppliers should contact Sanjeev Dagar via Email: taurus.epz@gmail.com or Tel: +254789843746.
    21 May 2018

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    21 May 2018

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    21 May 2018

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    ABOUT THIS PAGE

    Looking for 13422-55-4 / Methylcobalamin API manufacturers, exporters & distributors?

    Methylcobalamin manufacturers, exporters & distributors 1

    34

    PharmaCompass offers a list of Methylcobalamin API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Methylcobalamin manufacturer or Methylcobalamin supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Methylcobalamin manufacturer or Methylcobalamin supplier.

    PharmaCompass also assists you with knowing the Methylcobalamin API Price utilized in the formulation of products. Methylcobalamin API Price is not always fixed or binding as the Methylcobalamin Price is obtained through a variety of data sources. The Methylcobalamin Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Methylcobalamin

    Synonyms

    13422-55-4

    Cas Number

    13422-55-4

    Methycobal Manufacturers

    A Methycobal manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Methycobal, including repackagers and relabelers. The FDA regulates Methycobal manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Methycobal API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Methycobal manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Methycobal Suppliers

    A Methycobal supplier is an individual or a company that provides Methycobal active pharmaceutical ingredient (API) or Methycobal finished formulations upon request. The Methycobal suppliers may include Methycobal API manufacturers, exporters, distributors and traders.

    click here to find a list of Methycobal suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Methycobal USDMF

    A Methycobal DMF (Drug Master File) is a document detailing the whole manufacturing process of Methycobal active pharmaceutical ingredient (API) in detail. Different forms of Methycobal DMFs exist exist since differing nations have different regulations, such as Methycobal USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Methycobal DMF submitted to regulatory agencies in the US is known as a USDMF. Methycobal USDMF includes data on Methycobal's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Methycobal USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Methycobal suppliers with USDMF on PharmaCompass.

    Methycobal JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Methycobal Drug Master File in Japan (Methycobal JDMF) empowers Methycobal API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Methycobal JDMF during the approval evaluation for pharmaceutical products. At the time of Methycobal JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Methycobal suppliers with JDMF on PharmaCompass.

    Methycobal KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Methycobal Drug Master File in Korea (Methycobal KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Methycobal. The MFDS reviews the Methycobal KDMF as part of the drug registration process and uses the information provided in the Methycobal KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Methycobal KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Methycobal API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Methycobal suppliers with KDMF on PharmaCompass.

    Methycobal WC

    A Methycobal written confirmation (Methycobal WC) is an official document issued by a regulatory agency to a Methycobal manufacturer, verifying that the manufacturing facility of a Methycobal active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Methycobal APIs or Methycobal finished pharmaceutical products to another nation, regulatory agencies frequently require a Methycobal WC (written confirmation) as part of the regulatory process.

    click here to find a list of Methycobal suppliers with Written Confirmation (WC) on PharmaCompass.

    Methycobal NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Methycobal as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Methycobal API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Methycobal as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Methycobal and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Methycobal NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Methycobal suppliers with NDC on PharmaCompass.

    Methycobal GMP

    Methycobal Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Methycobal GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Methycobal GMP manufacturer or Methycobal GMP API supplier for your needs.

    Methycobal CoA

    A Methycobal CoA (Certificate of Analysis) is a formal document that attests to Methycobal's compliance with Methycobal specifications and serves as a tool for batch-level quality control.

    Methycobal CoA mostly includes findings from lab analyses of a specific batch. For each Methycobal CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Methycobal may be tested according to a variety of international standards, such as European Pharmacopoeia (Methycobal EP), Methycobal JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Methycobal USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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