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    Also known as: Solu-medrone, Urbason solubile, M-6-p, Nsc-48989, Methylprednisolone sodium hemisuccinate, U 9088
    Molecular Formula
    C26H34NaO8+
    Molecular Weight
    497.5  g/mol
    InChI Key
    FQISKWAFAHGMGT-SGJOWKDISA-N
    Methylprednisolone Sodium Succinate
    A water-soluble ester of METHYLPREDNISOLONE used for cardiac, allergic, and hypoxic emergencies.
    1 2D Structure

    Methylprednisolone Sodium Succinate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;4-[2-[(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoic acid
    2.1.2 InChI
    InChI=1S/C26H34O8.Na/c1-14-10-16-17-7-9-26(33,20(29)13-34-22(32)5-4-21(30)31)25(17,3)12-19(28)23(16)24(2)8-6-15(27)11-18(14)24;/h6,8,11,14,16-17,19,23,28,33H,4-5,7,9-10,12-13H2,1-3H3,(H,30,31);/q;+1/t14-,16-,17-,19-,23+,24-,25-,26-;/m0./s1
    2.1.3 InChI Key
    FQISKWAFAHGMGT-SGJOWKDISA-N
    2.1.4 Canonical SMILES
    CC1CC2C3CCC(C3(CC(C2C4(C1=CC(=O)C=C4)C)O)C)(C(=O)COC(=O)CCC(=O)O)O.[Na+]
    2.1.5 Isomeric SMILES
    C[C@H]1C[C@H]2[C@@H]3CC[C@@]([C@]3(C[C@@H]([C@@H]2[C@@]4(C1=CC(=O)C=C4)C)O)C)(C(=O)COC(=O)CCC(=O)O)O.[Na+]
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. 6 Alpha-methylprednisolone Sodium Hemisuccinate

    2. A-methapred

    3. Hemisuccinate, Methylprednisolone

    4. Methylprednisolone Hemisuccinate

    5. Methylprednisolone Hemisuccinate Monosodium Salt

    6. Methylprednisolone Sodium Hemisuccinate

    7. Methylprednisolone Sodium Succinate

    8. Methylprednisolone Succinate

    9. Sodium Hemisuccinate, Methylprednisolone

    10. Sodium Succinate, Methylprednisolone

    11. Solumedrol

    12. Succinate, Methylprednisolone

    13. Urbason-soluble

    14. Urbasonsoluble

    2.2.2 Depositor-Supplied Synonyms

    1. Solu-medrone

    2. Urbason Solubile

    3. M-6-p

    4. Nsc-48989

    5. Methylprednisolone Sodium Hemisuccinate

    6. U 9088

    7. Urabason

    8. 2375-03-3

    9. Nsc48989

    10. Prednisolone, Succinate, Sodium Salt

    11. 6.alpha.-methylprednisolone Sodium Succinate

    12. 6.alpha.-methylprednisolone 21-sodium Succinate

    13. 6.alpha.-methylprednisolone Sodium Hemisuccinate

    14. 6.alpha.-methylpregnisolone 21-sodium Succinate

    15. 6.alpha.-methylprednisolone 21-sodium Hemisuccinate

    16. 6.alpha.-methylprednisolone 21-hemisuccinate Sodium Salt

    17. Pregna-1,20-dione, 11.beta.,17,21-trihydroxy-6.alpha.-methyl-, 21-(hydrogen Succinate), Monosodium Salt

    18. Pregna-1,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-, Monosodium Salt, (6.alpha.,11.beta.)-

    2.3 Create Date
    2011-12-19
    3 Chemical and Physical Properties
    Molecular Weight 497.5 g/mol
    Molecular Formula C26H34NaO8+
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count7
    Exact Mass497.21513732 g/mol
    Monoisotopic Mass497.21513732 g/mol
    Topological Polar Surface Area138 Ų
    Heavy Atom Count35
    Formal Charge1
    Complexity981
    Isotope Atom Count0
    Defined Atom Stereocenter Count8
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameMethylprednisolone sodium succinate
    Drug LabelSOLU-MEDROL Sterile Powder is an antiflammatory glucocorticoid, which contains methylprednisolone sodium succinate as the active ingredient. Methylprednisolone sodium succinate, USP, is the sodium succinate ester of methylprednisolone, and it occurs...
    Active IngredientMethylprednisolone sodium succinate
    Dosage FormInjectable
    RouteInjection
    Strengtheq 2gm base/vial; eq 40mg base/vial; eq 125mg base/vial; eq 500mg base/vial; eq 1gm base/vial
    Market StatusPrescription
    CompanyMustafa Nevsat; Fresenius Kabi Usa

    2 of 2  
    Drug NameMethylprednisolone sodium succinate
    Drug LabelSOLU-MEDROL Sterile Powder is an antiflammatory glucocorticoid, which contains methylprednisolone sodium succinate as the active ingredient. Methylprednisolone sodium succinate, USP, is the sodium succinate ester of methylprednisolone, and it occurs...
    Active IngredientMethylprednisolone sodium succinate
    Dosage FormInjectable
    RouteInjection
    Strengtheq 2gm base/vial; eq 40mg base/vial; eq 125mg base/vial; eq 500mg base/vial; eq 1gm base/vial
    Market StatusPrescription
    CompanyMustafa Nevsat; Fresenius Kabi Usa

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Inflammatory Agents

    Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)

    Antineoplastic Agents, Hormonal

    Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079) (See all compounds classified as Antineoplastic Agents, Hormonal.)

    Glucocorticoids

    A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (See all compounds classified as Glucocorticoids.)

    Neuroprotective Agents

    Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids. (See all compounds classified as Neuroprotective Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Corticosteroid [EPC]; Corticosteroid Hormone Receptor Agonists [MoA]

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    22-Jan-2021
    23-Oct-2024
    KGS
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    Average Price (USD/KGS)

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