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    Chemistry

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    Also known as: 7232-21-5, Maxolon, Metoclopramide hcl, Metoclopramide monohydrochloride, Cerucal, Paspertin
    Molecular Formula
    C14H23Cl2N3O2
    Molecular Weight
    336.3  g/mol
    InChI Key
    RVFUNJWWXKCWNS-UHFFFAOYSA-N
    FDA UNII
    7B1QZY5SWZ
    Metoclopramide Hydrochloride
    A dopamine D2 antagonist that is used as an antiemetic.
    1 2D Structure

    Metoclopramide Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide;hydrochloride
    2.1.2 InChI
    InChI=1S/C14H22ClN3O2.ClH/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3;/h8-9H,4-7,16H2,1-3H3,(H,17,19);1H
    2.1.3 InChI Key
    RVFUNJWWXKCWNS-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCN(CC)CCNC(=O)C1=CC(=C(C=C1OC)N)Cl.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    7B1QZY5SWZ
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 4-amino-5-chloro-n-(2-(diethylamino)ethyl)-2-methoxybenzamide

    2. Cerucal

    3. Dihydrochloride, Metoclopramide

    4. Hydrochloride, Metoclopramide

    5. Maxolon

    6. Metaclopramide

    7. Metoclopramide

    8. Metoclopramide Dihydrochloride

    9. Metoclopramide Monohydrochloride

    10. Metoclopramide Monohydrochloride, Monohydrate

    11. Monohydrochloride, Metoclopramide

    12. Primperan

    13. Reglan

    14. Rimetin

    2.3.2 Depositor-Supplied Synonyms

    1. 7232-21-5

    2. Maxolon

    3. Metoclopramide Hcl

    4. Metoclopramide Monohydrochloride

    5. Cerucal

    6. Paspertin

    7. Clopra

    8. Reglan

    9. 4-amino-5-chloro-n-(2-(diethylamino)ethyl)-2-methoxybenzamide Hydrochloride

    10. Metozolv

    11. Metozolv Odt

    12. Metoclopramide Hydrochloride Anhydrous

    13. 7b1qzy5swz

    14. Metoclopramide (hydrochloride)

    15. Mls000069667

    16. 4-amino-5-chloro-n-[2-(diethylamino)ethyl]-2-methoxybenzamide;hydrochloride

    17. Benzamide, 4-amino-5-chloro-n-(2-(diethylamino)ethyl)-2-methoxy-, Monohydrochloride

    18. Nsc-354467

    19. Rimetin

    20. Smr000058471

    21. 4-amino-5-chloro-n-(2-(diethylamino)ethyl)-o-anisamide Hydrochloride

    22. Primperan (tablet)

    23. Metoclopramide Hydrochloride 100 Microg/ml In Acetonitrile

    24. Metoclopramide Intensol

    25. Reglan Odt

    26. Ccris 7142

    27. Sr-01000000165

    28. Einecs 230-634-5

    29. Unii-7b1qzy5swz

    30. Nsc 354467

    31. 4-amino-5-chloro-n-[2-(diethylamino)ethyl]-o-anisamide Hydrochloride

    32. Prestwick_332

    33. 4-amino-5-chloro-n-(2-diethylaminoethyl)-2-methoxy-benzamide

    34. Mfcd00058011

    35. Metoclopramidehcl

    36. Opera_id_1671

    37. Mls001074186

    38. Mls002222202

    39. O-anisamide, Monohydrochloride

    40. Schembl205200

    41. Spectrum1500410

    42. Chembl1256771

    43. Dtxsid10964306

    44. Hms1568j19

    45. Hms1920n15

    46. Metoclopramide Hydrochloride, Solid

    47. Pharmakon1600-01500410

    48. Bcp28471

    49. Tox21_500762

    50. Nsc354467

    51. Nsc757117

    52. 4-amino-5-chloro-n-(2-diethylaminoethyl)-2-methoxybenzamide Hydrochloride

    53. Akos015889947

    54. O-anisamide, 4-amino-5-chloro-n-(2-(diethylamino)ethyl)-, Monohydrochloride

    55. Ccg-212697

    56. Hs-0006

    57. Lp00762

    58. Nc00519

    59. 4-amino-5-chloro-n-(2-(diethylamino)ethyl)-2-methoxybenzamide Monohydrochloride

    60. Ncgc00094102-01

    61. Ncgc00094102-02

    62. Ncgc00094102-03

    63. Ncgc00094102-04

    64. Ncgc00094102-05

    65. Ncgc00261447-01

    66. Wln: 2n2&2mvr Dz Cg Fo1 &gh

    67. Eu-0100762

    68. Ft-0657870

    69. Ft-0672375

    70. S4289

    71. Sw196611-3

    72. Vu0239518-5

    73. A14247

    74. M 0763

    75. A923754

    76. Sr-01000000165-2

    77. Sr-01000000165-7

    78. Q27267998

    79. 4-amino-5-chloro-n-(2-diethylaminoethyl)-2-methoxybenzamide Hcl

    80. 4-amino-5-chloro-n-(2-(diethylamino)ethyl)-o-anisamidmonohydrochloride

    81. 4-amino-5-chloro-n-(2-(diethylamino)ethyl)-o-anisamide Monohydrochloride

    82. Benzamide, 4-amino-5-chloro-n-(2-(diethylamino)ethyl)-2-methoxy-, Monohydrochloride (9ci)

    83. Benzamide, 4-amino-5-chloro-n-[2-(diethylamino)ethyl]-2-methoxy-, Hydrochloride (1:1)

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 336.3 g/mol
    Molecular Formula C14H23Cl2N3O2
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count7
    Exact Mass335.1167324 g/mol
    Monoisotopic Mass335.1167324 g/mol
    Topological Polar Surface Area67.6 Ų
    Heavy Atom Count21
    Formal Charge0
    Complexity300
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameMetoclopramide hydrochloride
    Drug LabelMetoclopramide hydrochloride is a white or practically white, crystalline, odorless or practically odorless powder. It is very soluble in water, freely soluble in alcohol, sparingly soluble in chloroform, practically insoluble in ether. Chemically it...
    Active IngredientMetoclopramide hydrochloride
    Dosage FormTablet; Injectable; Tablet, orally disintegrating; Solution
    RouteInjection; Oral
    Strengtheq 5mg base; eq 5mg base/5ml; eq 5mg base/ml; eq 10mg base
    Market StatusPrescription
    CompanyVintage Pharms; Wockhardt; Silarx; Ani Pharms; Hospira; Teva; Pharm Assoc; Teva Pharms Usa; Northstar Hlthcare; Par Pharm; Novel Labs; Watson Labs; Vistapharm; Ipca Labs; Mutual Pharm; Bd Rx

    2 of 4  
    Drug NameMetozolv odt
    PubMed HealthMetoclopramide
    Drug ClassesAntiemetic, Diagnostic Agent, Stimulant, Gastrointestinal
    Drug LabelMETOZOLV ODT is an orally disintegrating tablet formulation of metoclopramide hydrochloride. The 5 mg strength is a round white tablet debossed on one side with a 5 and plain on the other side; it is comprised of 5 mg metoclopramide (as 5.91...
    Active IngredientMetoclopramide hydrochloride
    Dosage FormTablet, orally disintegrating
    RouteOral
    Strengtheq 5mg base
    Market StatusPrescription
    CompanySalix Pharms

    3 of 4  
    Drug NameMetoclopramide hydrochloride
    Drug LabelMetoclopramide hydrochloride is a white or practically white, crystalline, odorless or practically odorless powder. It is very soluble in water, freely soluble in alcohol, sparingly soluble in chloroform, practically insoluble in ether. Chemically it...
    Active IngredientMetoclopramide hydrochloride
    Dosage FormTablet; Injectable; Tablet, orally disintegrating; Solution
    RouteInjection; Oral
    Strengtheq 5mg base; eq 5mg base/5ml; eq 5mg base/ml; eq 10mg base
    Market StatusPrescription
    CompanyVintage Pharms; Wockhardt; Silarx; Ani Pharms; Hospira; Teva; Pharm Assoc; Teva Pharms Usa; Northstar Hlthcare; Par Pharm; Novel Labs; Watson Labs; Vistapharm; Ipca Labs; Mutual Pharm; Bd Rx

    4 of 4  
    Drug NameMetozolv odt
    PubMed HealthMetoclopramide
    Drug ClassesAntiemetic, Diagnostic Agent, Stimulant, Gastrointestinal
    Drug LabelMETOZOLV ODT is an orally disintegrating tablet formulation of metoclopramide hydrochloride. The 5 mg strength is a round white tablet debossed on one side with a 5 and plain on the other side; it is comprised of 5 mg metoclopramide (as 5.91...
    Active IngredientMetoclopramide hydrochloride
    Dosage FormTablet, orally disintegrating
    RouteOral
    Strengtheq 5mg base
    Market StatusPrescription
    CompanySalix Pharms

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Dopamine D2 Receptor Antagonists

    Compounds and drugs that bind to and inhibit or block the activation of DOPAMINE D2 RECEPTORS. (See all compounds classified as Dopamine D2 Receptor Antagonists.)

    Antiemetics

    Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Dopamine-2 Receptor Antagonist [EPC]; Dopamine D2 Antagonists [MoA]

    API Reference Price

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    04-Jan-2021
    27-Dec-2024
    KGS
    overview
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    Average Price (USD/KGS)

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    (USD/KGS)    		 Number of Transactions

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    DOSAGE - INJECTABLE;INJECTION - EQ 5MG BASE/M...DOSAGE - INJECTABLE;INJECTION - EQ 5MG BASE/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 17862

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    DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL -...DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL - EQ 10MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 22246

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    DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL -...DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL - EQ 5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 22246

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    Looking for 7232-21-5 / Metoclopramide Hydrochloride API manufacturers, exporters & distributors?

    Metoclopramide Hydrochloride manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Metoclopramide Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Metoclopramide Hydrochloride manufacturer or Metoclopramide Hydrochloride supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Metoclopramide Hydrochloride manufacturer or Metoclopramide Hydrochloride supplier.

    PharmaCompass also assists you with knowing the Metoclopramide Hydrochloride API Price utilized in the formulation of products. Metoclopramide Hydrochloride API Price is not always fixed or binding as the Metoclopramide Hydrochloride Price is obtained through a variety of data sources. The Metoclopramide Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Metoclopramide Hydrochloride

    Synonyms

    7232-21-5, Maxolon, Metoclopramide hcl, Metoclopramide monohydrochloride, Cerucal, Paspertin

    Cas Number

    7232-21-5

    Unique Ingredient Identifier (UNII)

    7B1QZY5SWZ

    About Metoclopramide Hydrochloride

    A dopamine D2 antagonist that is used as an antiemetic.

    Metoclopramide Hydrochloride Manufacturers

    A Metoclopramide Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Metoclopramide Hydrochloride, including repackagers and relabelers. The FDA regulates Metoclopramide Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Metoclopramide Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Metoclopramide Hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Metoclopramide Hydrochloride Suppliers

    A Metoclopramide Hydrochloride supplier is an individual or a company that provides Metoclopramide Hydrochloride active pharmaceutical ingredient (API) or Metoclopramide Hydrochloride finished formulations upon request. The Metoclopramide Hydrochloride suppliers may include Metoclopramide Hydrochloride API manufacturers, exporters, distributors and traders.

    click here to find a list of Metoclopramide Hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Metoclopramide Hydrochloride USDMF

    A Metoclopramide Hydrochloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Metoclopramide Hydrochloride active pharmaceutical ingredient (API) in detail. Different forms of Metoclopramide Hydrochloride DMFs exist exist since differing nations have different regulations, such as Metoclopramide Hydrochloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Metoclopramide Hydrochloride DMF submitted to regulatory agencies in the US is known as a USDMF. Metoclopramide Hydrochloride USDMF includes data on Metoclopramide Hydrochloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Metoclopramide Hydrochloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Metoclopramide Hydrochloride suppliers with USDMF on PharmaCompass.

    Metoclopramide Hydrochloride JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Metoclopramide Hydrochloride Drug Master File in Japan (Metoclopramide Hydrochloride JDMF) empowers Metoclopramide Hydrochloride API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Metoclopramide Hydrochloride JDMF during the approval evaluation for pharmaceutical products. At the time of Metoclopramide Hydrochloride JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Metoclopramide Hydrochloride suppliers with JDMF on PharmaCompass.

    Metoclopramide Hydrochloride CEP

    A Metoclopramide Hydrochloride CEP of the European Pharmacopoeia monograph is often referred to as a Metoclopramide Hydrochloride Certificate of Suitability (COS). The purpose of a Metoclopramide Hydrochloride CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Metoclopramide Hydrochloride EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Metoclopramide Hydrochloride to their clients by showing that a Metoclopramide Hydrochloride CEP has been issued for it. The manufacturer submits a Metoclopramide Hydrochloride CEP (COS) as part of the market authorization procedure, and it takes on the role of a Metoclopramide Hydrochloride CEP holder for the record. Additionally, the data presented in the Metoclopramide Hydrochloride CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Metoclopramide Hydrochloride DMF.

    A Metoclopramide Hydrochloride CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Metoclopramide Hydrochloride CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Metoclopramide Hydrochloride suppliers with CEP (COS) on PharmaCompass.

    Metoclopramide Hydrochloride WC

    A Metoclopramide Hydrochloride written confirmation (Metoclopramide Hydrochloride WC) is an official document issued by a regulatory agency to a Metoclopramide Hydrochloride manufacturer, verifying that the manufacturing facility of a Metoclopramide Hydrochloride active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Metoclopramide Hydrochloride APIs or Metoclopramide Hydrochloride finished pharmaceutical products to another nation, regulatory agencies frequently require a Metoclopramide Hydrochloride WC (written confirmation) as part of the regulatory process.

    click here to find a list of Metoclopramide Hydrochloride suppliers with Written Confirmation (WC) on PharmaCompass.

    Metoclopramide Hydrochloride NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Metoclopramide Hydrochloride as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Metoclopramide Hydrochloride API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Metoclopramide Hydrochloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Metoclopramide Hydrochloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Metoclopramide Hydrochloride NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Metoclopramide Hydrochloride suppliers with NDC on PharmaCompass.

    Metoclopramide Hydrochloride GMP

    Metoclopramide Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Metoclopramide Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Metoclopramide Hydrochloride GMP manufacturer or Metoclopramide Hydrochloride GMP API supplier for your needs.

    Metoclopramide Hydrochloride CoA

    A Metoclopramide Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Metoclopramide Hydrochloride's compliance with Metoclopramide Hydrochloride specifications and serves as a tool for batch-level quality control.

    Metoclopramide Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Metoclopramide Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Metoclopramide Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Metoclopramide Hydrochloride EP), Metoclopramide Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Metoclopramide Hydrochloride USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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