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Metoproferm

Polfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

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FINISHED DOSAGE FORMULATIONS

1 FDF Dossiers, 1 Listed Dossiers

1 FDF Dossiers
1 Listed Dossiers

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

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API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

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Canada

Australia

South Africa

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Chemistry

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Also known as: Beloc, Lopresor, Selopral, Betaloc, Prelis, 56392-17-7

Molecular Formula

C₃₄H₅₆N₂O₁₂

Molecular Weight

684.8 g/mol

InChI Key

YGULWPYYGQCFMP-CEAXSRTFSA-N

FDA UNII

W5S57Y3A5L

A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.

1 2D Structure

Metoproferm

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2R,3R)-2,3-dihydroxybutanedioic acid;1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol

2.1.2 InChI

InChI=1S/2C15H25NO3.C4H6O6/c2*1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3;5-1(3(7)8)2(6)4(9)10/h2*4-7,12,14,16-17H,8-11H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)/t;;1-,2-/m..1/s1

2.1.3 InChI Key

YGULWPYYGQCFMP-CEAXSRTFSA-N

2.1.4 Canonical SMILES

CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.C(C(C(=O)O)O)(C(=O)O)O

2.1.5 Isomeric SMILES

CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O

2.2 Other Identifiers

2.2.1 UNII

W5S57Y3A5L

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Beloc Duriles

2. Beloc-duriles

3. Betaloc

4. Betaloc Astra

5. Betaloc-astra

6. Betalok

7. Cgp 2175

8. Cgp-2175

9. Cgp2175

10. H 93 26

11. H 93-26

12. H 9326

13. Lopressor

14. Metoprolol

15. Metoprolol Cr Xl

16. Metoprolol Cr-xl

17. Metoprolol Succinate

18. Seloken

19. Spesicor

20. Spesikor

21. Toprol

22. Toprol Xl

23. Toprol-xl

2.3.2 Depositor-Supplied Synonyms

1. Beloc

2. Lopresor

3. Selopral

4. Betaloc

5. Prelis

6. 56392-17-7

7. Metoprolol Hemitartrate

8. Seloken

9. Cgp 2175e

10. W5s57y3a5l

11. Cgp-2175e

12. 1-isopropylamino-3-(p-(2-methoxyethyl)phenoxy)-2-propanol (2:1) Dextro-tartrate Salt

13. Metoproferm

14. Selectadril

15. Arbralene

16. Azumetop

17. Beprolo

18. Bloksan

19. Cardoxone

20. Jeprolol

21. Kapodine

22. Mepolol

23. Metoberag

24. Metoberta

25. Metocard

26. Metolol

27. Metomerck

28. Metoprolin

29. Prolaken

30. Ritmolol

31. Sigaprolol

32. Topromel

33. Vasocardin

34. Bloxan

35. Lanoc

36. Metop

37. Metoprolol Acis

38. Metoprolol-rpm

39. Slow Lopresor

40. Metoprolol Atid

41. Metoprolol-wolf

42. Apo-metoprolol

43. Slow-lopresor

44. Metoprolol Al

45. Metoprolol Pb

46. Metoprolol Stada

47. Metoprolol Verla

48. Metoprolol-gry

49. Meto-isis

50. Metoprolol Basics

51. Proken M

52. Metoprolol Heumann

53. Meto Abz

54. Dsstox_cid_17248

55. Dsstox_rid_79315

56. Dsstox_gsid_37248

57. Metoprolol Apogepha

58. Metropress

59. Pms-metroprolol-b

60. Metoprolol-radiopharm

61. Metoprolol Tartrate (2:1)

62. Einecs 260-148-9

63. Unii-w5s57y3a5l

64. Nsc-757105

65. Ncgc00017119-01

66. (2r,3r)-2,3-dihydroxybutanedioic Acid;1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol

67. H 93/26

68. Cas-56392-17-7

69. Metoprolol Tartrate [usan:usp:jan]

70. (+-)-1-(isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propanol Hemi-l-tartrate

71. (+-)-1-(isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propanol L-(+)-tartrate (2:1) (salt)

72. (+-)-1-(isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propanol Tartrate (2:1)

73. 2-propanol, 1-(4-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-, (+-)-, Tartrate (2:1)

74. Chebi:6906

75. Schembl1649321

76. Chembl3186768

77. Metoprolol Tartrate [mi]

78. Metoprolol Tartrate [jan]

79. Metoprolol Tartrate (jp17/usp)

80. Hms2097c08

81. Hms3714c08

82. Hms3884o12

83. Metoprolol Tartrate [usan]

84. Metoprolol Tartrate [vandf]

85. Metoprolol Tartrate [mart.]

86. (?)-metoprolol (+)-tartrate Salt

87. Tox21_110787

88. Tox21_113528

89. Metoprolol Tartrate [usp-rs]

90. Metoprolol Tartrate [who-dd]

91. S1856

92. 1-(isopropylamino)-3-[4-(beta-methoxyethyl)phenoxy]-2-propanol (+)-tartrate

93. Akos015961630

94. Tox21_110787_1

95. Ccg-220733

96. Nsc 757105

97. 2-propanol, 1-(isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-, (+-)-, Tartrate (2:1)

98. Metoprolol Tartrate [orange Book]

99. Ncgc00021148-08

100. 2-propanol, 1-(4-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-, (+-)-, (r-(r*,r*))-2,3-dihydroxybutanedioate (2:1) (salt)

101. As-10163

102. Metoprolol Tartrate [ep Monograph]

103. Metoprolol Tartrate [usp Monograph]

104. Metoprolol Tartrat 100 Microg/ml In Water

105. M2555

106. Sw199199-2

107. D00601

108. D91610

109. Lopressidone Component Metoprolol Tartrate

110. Lopressor Hct Component Metoprolol Tartrate

111. Sr-01000872674

112. Metoprolol Tartrate Component Of Lopressidone

113. Sr-01000872674-1

114. Metoprolol Tartrate Component Of Lopressor Hct

115. Q27292351

116. (+/-)-metoprolol (+)-tartrate Salt, Analytical Standard

117. Metoprolol Tartrate 1.0 Mg/ml In Methanol (as Free Base)

118. (+/-)-metoprolol (+)-tartrate Salt, >=98% (titration), Powder

119. Metoprolol Tartrate, British Pharmacopoeia (bp) Reference Standard

120. Metoprolol Tartrate, European Pharmacopoeia (ep) Reference Standard

121. Metoprolol Tartrate, United States Pharmacopeia (usp) Reference Standard

122. 1-(isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propanol (2:1) Dextro-tartrate Salt

123. 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)- Amino]-2-propanol Tartrate

124. Metoprolol Tartrate, Pharmaceutical Secondary Standard; Certified Reference Material

125. (+/-)-1-(isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propanol L-(+)-tartrate (2:1) (salt)

126. 2-propanol, 1-(4-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-, (+/-)-, (r-(r*,r*))-2,3-dihydroxybutanedioate (2:1) (salt)

127. Butanedioic Acid, 2,3-dihydroxy-, (2r,3r)-, Compd. With 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol (1:2)

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₃₄H₅₆N₂O₁₂
Molecular Weight	684.8 g/mol
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	14
Rotatable Bond Count	21
Exact Mass	684.38332523 g/mol
Monoisotopic Mass	684.38332523 g/mol
Topological Polar Surface Area	217 Å²
Heavy Atom Count	48
Formal Charge	0
Complexity	349
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anti-Arrhythmia Agents

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

Adrenergic beta-1 Receptor Antagonists

Drugs that bind to and block the activation of ADRENERGIC BETA-1 RECEPTORS. (See all compounds classified as Adrenergic beta-1 Receptor Antagonists.)

Sympatholytics

Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here. (See all compounds classified as Sympatholytics.)

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

FDF Dossiers

01

Verve Human Care Laboratories

India

Pharma, Lab & Chemical Expo

Not Confirmed

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ABOUT THIS PAGE

Metoproferm Manufacturers

A Metoproferm manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Metoproferm, including repackagers and relabelers. The FDA regulates Metoproferm manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Metoproferm API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Metoproferm Suppliers

A Metoproferm supplier is an individual or a company that provides Metoproferm active pharmaceutical ingredient (API) or Metoproferm finished formulations upon request. The Metoproferm suppliers may include Metoproferm API manufacturers, exporters, distributors and traders.

Metoproferm GMP

Metoproferm Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Metoproferm GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Metoproferm GMP manufacturer or Metoproferm GMP API supplier for your needs.

Metoproferm CoA

A Metoproferm CoA (Certificate of Analysis) is a formal document that attests to Metoproferm's compliance with Metoproferm specifications and serves as a tool for batch-level quality control.

Metoproferm CoA mostly includes findings from lab analyses of a specific batch. For each Metoproferm CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Metoproferm may be tested according to a variety of international standards, such as European Pharmacopoeia (Metoproferm EP), Metoproferm JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Metoproferm USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.