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    Metoproferm

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    PharmaCompass
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    2D Structure
    Also known as: Beloc, Lopresor, Selopral, Betaloc, Prelis, 56392-17-7
    Molecular Formula
    C34H56N2O12
    Molecular Weight
    684.8  g/mol
    InChI Key
    YGULWPYYGQCFMP-CEAXSRTFSA-N
    FDA UNII
    W5S57Y3A5L
    A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (2R,3R)-2,3-dihydroxybutanedioic acid;1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol
    2.1.2 InChI
    InChI=1S/2C15H25NO3.C4H6O6/c2*1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3;5-1(3(7)8)2(6)4(9)10/h2*4-7,12,14,16-17H,8-11H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)/t;;1-,2-/m..1/s1
    2.1.3 InChI Key
    YGULWPYYGQCFMP-CEAXSRTFSA-N
    2.1.4 Canonical SMILES
    CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.C(C(C(=O)O)O)(C(=O)O)O
    2.1.5 Isomeric SMILES
    CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O
    2.2 Other Identifiers
    2.2.1 UNII
    W5S57Y3A5L
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Beloc Duriles

    2. Beloc-duriles

    3. Betaloc

    4. Betaloc Astra

    5. Betaloc-astra

    6. Betalok

    7. Cgp 2175

    8. Cgp-2175

    9. Cgp2175

    10. H 93 26

    11. H 93-26

    12. H 9326

    13. Lopressor

    14. Metoprolol

    15. Metoprolol Cr Xl

    16. Metoprolol Cr-xl

    17. Metoprolol Succinate

    18. Seloken

    19. Spesicor

    20. Spesikor

    21. Toprol

    22. Toprol Xl

    23. Toprol-xl

    2.3.2 Depositor-Supplied Synonyms

    1. Beloc

    2. Lopresor

    3. Selopral

    4. Betaloc

    5. Prelis

    6. 56392-17-7

    7. Metoprolol Hemitartrate

    8. Seloken

    9. Cgp 2175e

    10. W5s57y3a5l

    11. Cgp-2175e

    12. 1-isopropylamino-3-(p-(2-methoxyethyl)phenoxy)-2-propanol (2:1) Dextro-tartrate Salt

    13. Metoproferm

    14. Selectadril

    15. Arbralene

    16. Azumetop

    17. Beprolo

    18. Bloksan

    19. Cardoxone

    20. Jeprolol

    21. Kapodine

    22. Mepolol

    23. Metoberag

    24. Metoberta

    25. Metocard

    26. Metolol

    27. Metomerck

    28. Metoprolin

    29. Prolaken

    30. Ritmolol

    31. Sigaprolol

    32. Topromel

    33. Vasocardin

    34. Bloxan

    35. Lanoc

    36. Metop

    37. Metoprolol Acis

    38. Metoprolol-rpm

    39. Slow Lopresor

    40. Metoprolol Atid

    41. Metoprolol-wolf

    42. Apo-metoprolol

    43. Slow-lopresor

    44. Metoprolol Al

    45. Metoprolol Pb

    46. Metoprolol Stada

    47. Metoprolol Verla

    48. Metoprolol-gry

    49. Meto-isis

    50. Metoprolol Basics

    51. Proken M

    52. Metoprolol Heumann

    53. Meto Abz

    54. Dsstox_cid_17248

    55. Dsstox_rid_79315

    56. Dsstox_gsid_37248

    57. Metoprolol Apogepha

    58. Metropress

    59. Pms-metroprolol-b

    60. Metoprolol-radiopharm

    61. Metoprolol Tartrate (2:1)

    62. Einecs 260-148-9

    63. Unii-w5s57y3a5l

    64. Nsc-757105

    65. Ncgc00017119-01

    66. (2r,3r)-2,3-dihydroxybutanedioic Acid;1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol

    67. H 93/26

    68. Cas-56392-17-7

    69. Metoprolol Tartrate [usan:usp:jan]

    70. (+-)-1-(isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propanol Hemi-l-tartrate

    71. (+-)-1-(isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propanol L-(+)-tartrate (2:1) (salt)

    72. (+-)-1-(isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propanol Tartrate (2:1)

    73. 2-propanol, 1-(4-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-, (+-)-, Tartrate (2:1)

    74. Chebi:6906

    75. Schembl1649321

    76. Chembl3186768

    77. Metoprolol Tartrate [mi]

    78. Metoprolol Tartrate [jan]

    79. Metoprolol Tartrate (jp17/usp)

    80. Hms2097c08

    81. Hms3714c08

    82. Hms3884o12

    83. Metoprolol Tartrate [usan]

    84. Metoprolol Tartrate [vandf]

    85. Metoprolol Tartrate [mart.]

    86. (?)-metoprolol (+)-tartrate Salt

    87. Tox21_110787

    88. Tox21_113528

    89. Metoprolol Tartrate [usp-rs]

    90. Metoprolol Tartrate [who-dd]

    91. S1856

    92. 1-(isopropylamino)-3-[4-(beta-methoxyethyl)phenoxy]-2-propanol (+)-tartrate

    93. Akos015961630

    94. Tox21_110787_1

    95. Ccg-220733

    96. Nsc 757105

    97. 2-propanol, 1-(isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-, (+-)-, Tartrate (2:1)

    98. Metoprolol Tartrate [orange Book]

    99. Ncgc00021148-08

    100. 2-propanol, 1-(4-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-, (+-)-, (r-(r*,r*))-2,3-dihydroxybutanedioate (2:1) (salt)

    101. As-10163

    102. Metoprolol Tartrate [ep Monograph]

    103. Metoprolol Tartrate [usp Monograph]

    104. Metoprolol Tartrat 100 Microg/ml In Water

    105. M2555

    106. Sw199199-2

    107. D00601

    108. D91610

    109. Lopressidone Component Metoprolol Tartrate

    110. Lopressor Hct Component Metoprolol Tartrate

    111. Sr-01000872674

    112. Metoprolol Tartrate Component Of Lopressidone

    113. Sr-01000872674-1

    114. Metoprolol Tartrate Component Of Lopressor Hct

    115. Q27292351

    116. (+/-)-metoprolol (+)-tartrate Salt, Analytical Standard

    117. Metoprolol Tartrate 1.0 Mg/ml In Methanol (as Free Base)

    118. (+/-)-metoprolol (+)-tartrate Salt, >=98% (titration), Powder

    119. Metoprolol Tartrate, British Pharmacopoeia (bp) Reference Standard

    120. Metoprolol Tartrate, European Pharmacopoeia (ep) Reference Standard

    121. Metoprolol Tartrate, United States Pharmacopeia (usp) Reference Standard

    122. 1-(isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propanol (2:1) Dextro-tartrate Salt

    123. 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)- Amino]-2-propanol Tartrate

    124. Metoprolol Tartrate, Pharmaceutical Secondary Standard; Certified Reference Material

    125. (+/-)-1-(isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propanol L-(+)-tartrate (2:1) (salt)

    126. 2-propanol, 1-(4-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-, (+/-)-, (r-(r*,r*))-2,3-dihydroxybutanedioate (2:1) (salt)

    127. Butanedioic Acid, 2,3-dihydroxy-, (2r,3r)-, Compd. With 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol (1:2)

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 684.8 g/mol
    Molecular Formula C34H56N2O12
    Hydrogen Bond Donor Count8
    Hydrogen Bond Acceptor Count14
    Rotatable Bond Count21
    Exact Mass684.38332523 g/mol
    Monoisotopic Mass684.38332523 g/mol
    Topological Polar Surface Area217 Ų
    Heavy Atom Count48
    Formal Charge0
    Complexity349
    Isotope Atom Count0
    Defined Atom Stereocenter Count2
    Undefined Atom Stereocenter Count2
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Arrhythmia Agents

    Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

    Adrenergic beta-1 Receptor Antagonists

    Drugs that bind to and block the activation of ADRENERGIC BETA-1 RECEPTORS. (See all compounds classified as Adrenergic beta-1 Receptor Antagonists.)

    Sympatholytics

    Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here. (See all compounds classified as Sympatholytics.)

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)