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Chemistry

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Also known as: 98418-47-4, Metroprolol succinate, Selozok, Toprol xl, Metoprolol (succinate), Seloken-zok
Molecular Formula
C34H56N2O10
Molecular Weight
652.8  g/mol
InChI Key
RGHAZVBIOOEVQX-UHFFFAOYSA-N
FDA UNII
TH25PD4CCB

Metoprolol Succinate
A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
1 2D Structure

Metoprolol Succinate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
butanedioic acid;1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol
2.1.2 InChI
InChI=1S/2C15H25NO3.C4H6O4/c2*1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3;5-3(6)1-2-4(7)8/h2*4-7,12,14,16-17H,8-11H2,1-3H3;1-2H2,(H,5,6)(H,7,8)
2.1.3 InChI Key
RGHAZVBIOOEVQX-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.C(CC(=O)O)C(=O)O
2.2 Other Identifiers
2.2.1 UNII
TH25PD4CCB
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Beloc Duriles

2. Beloc-duriles

3. Betaloc

4. Betaloc Astra

5. Betaloc-astra

6. Betalok

7. Cgp 2175

8. Cgp-2175

9. Cgp2175

10. H 93 26

11. H 93-26

12. H 9326

13. Lopressor

14. Metoprolol

15. Metoprolol Cr Xl

16. Metoprolol Cr-xl

17. Metoprolol Tartrate

18. Seloken

19. Spesicor

20. Spesikor

21. Toprol

22. Toprol Xl

23. Toprol-xl

2.3.2 Depositor-Supplied Synonyms

1. 98418-47-4

2. Metroprolol Succinate

3. Selozok

4. Toprol Xl

5. Metoprolol (succinate)

6. Seloken-zok

7. H 93/26 Succinate

8. Toprol-xl

9. Metoprolol Hemisuccinate

10. Butanedioic Acid;1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol

11. Th25pd4ccb

12. Spesicor Dos

13. Seloken Zoc

14. Beloc- Zok

15. 2-propanol, 1-(4-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-, (+-)-, Butanedioate (2:1) (salt)

16. Metoprolol Succinate [usan]

17. Unii-th25pd4ccb

18. Metoprololsuccinate

19. Metoprolol Succinate [usan:usp]

20. Toprol Xl (tn)

21. Metoprolol Succinate Extended-release Tablets

22. Metoprolol Succinate (usp)

23. (+-)-1-(isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propanol Succinate (2:1) (salt)

24. Dsstox_cid_28652

25. Dsstox_rid_82922

26. Dsstox_gsid_48726

27. Schembl40916

28. Chebi:6905

29. Chembl2356097

30. Dtxsid9048726

31. Metoprolol Succinate [mi]

32. Hms3886g21

33. Bcp02473

34. Metoprolol Succinate [vandf]

35. Tox21_113155

36. Hy-17503a

37. Metoprolol Succinate [mart.]

38. Mfcd23115896

39. S5341

40. Metoprolol Succinate [usp-rs]

41. Metoprolol Succinate [who-dd]

42. 1-(isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol; Succinic Acid

43. Akos015856332

44. Bcp9000922

45. Ccg-270331

46. Cs-3158

47. Ks-1241

48. Ac-26570

49. Metoprolol Succinate [ep Impurity]

50. Metoprolol Succinate [orange Book]

51. Metoprolol Succinate [ep Monograph]

52. Cas-98418-47-4

53. Metoprolol Succinate [usp Monograph]

54. Ft-0628933

55. Dutoprol Component Metoprolol Succinate

56. D00635

57. Metoprolol Succinate Component Of Dutoprol

58. 418m474

59. A845856

60. Q-201401

61. Q27289962

62. Metoprolol Succinate, United States Pharmacopeia (usp) Reference Standard

63. Bis(1-[4-(2-methoxyethyl)phenoxy]-3-[(propan-2-yl)amino]propan-2-ol); Butanedioic Acid

64. Butanedioic Acid,1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol

65. (+/-)-1-(isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propanol Succinate (2:1) (salt)

66. 123245-49-8

67. 2-propanol, 1-(4-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-, (+/-)-, Butanedioate (2:1) (salt)

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 652.8 g/mol
Molecular Formula C34H56N2O10
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count12
Rotatable Bond Count21
Exact Mass652.39349599 g/mol
Monoisotopic Mass652.39349599 g/mol
Topological Polar Surface Area176 Ų
Heavy Atom Count46
Formal Charge0
Complexity308
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameMetoprolol succinate
Drug LabelTOPROL-XL, metoprolol succinate, is a beta1-selective (cardioselective) adrenoceptor blocking agent, for oral administration, available as extended-release tablets. TOPROL-XL has been formulated to provide a controlled and predictable release of meto...
Active IngredientMetoprolol succinate
Dosage FormTablet, extended release
RouteOral
Strengtheq 25mg tartrate; eq 50mg tartrate; eq 200mg tartrate; eq 100mg tartrate
Market StatusPrescription
CompanyMylan Pharms; Wockhardt; Actavis Labs Fl; Reddys; Dr Reddys Labs

2 of 4  
Drug NameToprol-xl
Drug LabelTOPROL-XL, metoprolol succinate, is a beta1-selective (cardioselective) adrenoceptor blocking agent, for oral administration, available as extended-release tablets. TOPROL-XL has been formulated to provide a controlled and predictable release of meto...
Active IngredientMetoprolol succinate
Dosage FormTablet, extended release
RouteOral
Strengtheq 25mg tartrate; eq 50mg tartrate; eq 200mg tartrate; eq 100mg tartrate
Market StatusPrescription
CompanyAstrazeneca

3 of 4  
Drug NameMetoprolol succinate
Drug LabelTOPROL-XL, metoprolol succinate, is a beta1-selective (cardioselective) adrenoceptor blocking agent, for oral administration, available as extended-release tablets. TOPROL-XL has been formulated to provide a controlled and predictable release of meto...
Active IngredientMetoprolol succinate
Dosage FormTablet, extended release
RouteOral
Strengtheq 25mg tartrate; eq 50mg tartrate; eq 200mg tartrate; eq 100mg tartrate
Market StatusPrescription
CompanyMylan Pharms; Wockhardt; Actavis Labs Fl; Reddys; Dr Reddys Labs

4 of 4  
Drug NameToprol-xl
Drug LabelTOPROL-XL, metoprolol succinate, is a beta1-selective (cardioselective) adrenoceptor blocking agent, for oral administration, available as extended-release tablets. TOPROL-XL has been formulated to provide a controlled and predictable release of meto...
Active IngredientMetoprolol succinate
Dosage FormTablet, extended release
RouteOral
Strengtheq 25mg tartrate; eq 50mg tartrate; eq 200mg tartrate; eq 100mg tartrate
Market StatusPrescription
CompanyAstrazeneca

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anti-Arrhythmia Agents

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)


Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)


Adrenergic beta-1 Receptor Antagonists

Drugs that bind to and block the activation of ADRENERGIC BETA-1 RECEPTORS. (See all compounds classified as Adrenergic beta-1 Receptor Antagonists.)


Sympatholytics

Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here. (See all compounds classified as Sympatholytics.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
beta-Adrenergic Blocker [EPC]; Adrenergic beta-Antagonists [MoA]

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MAHARASHTRA","supplier":"MOEHS IBERICA","supplierCountry":"SPAIN","foreign_port":"BARCELONA","customer":"ALKEM LABORATORIES","customerCountry":"INDIA","quantity":"112.20","actualQuantity":"112.2","unit":"KGS","unitRateFc":"57","totalValueFC":"6446.7","currency":"USD","unitRateINR":"4882.1","date":"17-Dec-2024","totalValueINR":"547766.01","totalValueInUsd":"6446.7","indian_port":"JNPT","hs_no":"29420090","bill_no":"7298091","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"BARCELONA","supplierAddress":"CESAR MARTINELL BRUNET, 08191 RUBI (BARCELONA) SDNF SPAIN","customerAddress":"ALKEM HOUSE, DEVASHISH ADJACENT TO"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1734373800,"product":"METOPROLOL SUCCINATE METOPROLOL SUCCINATE","address":"ALKEM HOUSE, DEVASHISH ADJACENT TO","city":"LOWER PAREL, MUMBAI. MAHARASHTRA","supplier":"MOEHS IBERICA","supplierCountry":"SPAIN","foreign_port":"BARCELONA","customer":"ALKEM LABORATORIES","customerCountry":"INDIA","quantity":"115.10","actualQuantity":"115.1","unit":"KGS","unitRateFc":"57","totalValueFC":"6613.3","currency":"USD","unitRateINR":"4882.1","date":"17-Dec-2024","totalValueINR":"561923.96","totalValueInUsd":"6613.3","indian_port":"JNPT","hs_no":"29420090","bill_no":"7298091","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"BARCELONA","supplierAddress":"CESAR MARTINELL BRUNET, 08191 RUBI (BARCELONA) SDNF SPAIN","customerAddress":"ALKEM HOUSE, DEVASHISH ADJACENT TO"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1734373800,"product":"METOPROLOL SUCCINATE METOPROLOL SUCCINATE","address":"ALKEM HOUSE, DEVASHISH ADJACENT TO","city":"LOWER PAREL, MUMBAI. MAHARASHTRA","supplier":"MOEHS IBERICA","supplierCountry":"SPAIN","foreign_port":"BARCELONA","customer":"ALKEM LABORATORIES","customerCountry":"INDIA","quantity":"586.50","actualQuantity":"586.5","unit":"KGS","unitRateFc":"57","totalValueFC":"33698.4","currency":"USD","unitRateINR":"4882.1","date":"17-Dec-2024","totalValueINR":"2863322.33","totalValueInUsd":"33698.4","indian_port":"JNPT","hs_no":"29420090","bill_no":"7298091","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"BARCELONA","supplierAddress":"CESAR MARTINELL BRUNET, 08191 RUBI (BARCELONA) SDNF SPAIN","customerAddress":"ALKEM HOUSE, DEVASHISH ADJACENT TO"}]
01-Jan-2021
23-Dec-2024
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Quantity (KGS) & Unit rate (USD/KGS) over time

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 1...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 100MG TARTRATE

USFDA APPLICATION NUMBER - 19962

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 2...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 200MG TARTRATE

USFDA APPLICATION NUMBER - 19962

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 2...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 25MG TARTRATE

USFDA APPLICATION NUMBER - 19962

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 5...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 50MG TARTRATE

USFDA APPLICATION NUMBER - 19962

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DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ ...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ 100MG TARTRATE

USFDA APPLICATION NUMBER - 210428

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DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ ...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ 200MG TARTRATE

USFDA APPLICATION NUMBER - 210428

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DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ ...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ 25MG TARTRATE

USFDA APPLICATION NUMBER - 210428

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DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ ...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ 50MG TARTRATE

USFDA APPLICATION NUMBER - 210428

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 12.5...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 12.5MG;EQ 100MG TARTRATE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 21956

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 12.5...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 12.5MG;EQ 25MG TARTRATE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 21956

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 12.5...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 12.5MG;EQ 50MG TARTRATE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 21956

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ABOUT THIS PAGE

Metoprolol Succinate Manufacturers

A Metoprolol Succinate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Metoprolol Succinate, including repackagers and relabelers. The FDA regulates Metoprolol Succinate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Metoprolol Succinate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Metoprolol Succinate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Metoprolol Succinate Suppliers

A Metoprolol Succinate supplier is an individual or a company that provides Metoprolol Succinate active pharmaceutical ingredient (API) or Metoprolol Succinate finished formulations upon request. The Metoprolol Succinate suppliers may include Metoprolol Succinate API manufacturers, exporters, distributors and traders.

click here to find a list of Metoprolol Succinate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Metoprolol Succinate USDMF

A Metoprolol Succinate DMF (Drug Master File) is a document detailing the whole manufacturing process of Metoprolol Succinate active pharmaceutical ingredient (API) in detail. Different forms of Metoprolol Succinate DMFs exist exist since differing nations have different regulations, such as Metoprolol Succinate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Metoprolol Succinate DMF submitted to regulatory agencies in the US is known as a USDMF. Metoprolol Succinate USDMF includes data on Metoprolol Succinate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Metoprolol Succinate USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Metoprolol Succinate suppliers with USDMF on PharmaCompass.

Metoprolol Succinate CEP

A Metoprolol Succinate CEP of the European Pharmacopoeia monograph is often referred to as a Metoprolol Succinate Certificate of Suitability (COS). The purpose of a Metoprolol Succinate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Metoprolol Succinate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Metoprolol Succinate to their clients by showing that a Metoprolol Succinate CEP has been issued for it. The manufacturer submits a Metoprolol Succinate CEP (COS) as part of the market authorization procedure, and it takes on the role of a Metoprolol Succinate CEP holder for the record. Additionally, the data presented in the Metoprolol Succinate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Metoprolol Succinate DMF.

A Metoprolol Succinate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Metoprolol Succinate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Metoprolol Succinate suppliers with CEP (COS) on PharmaCompass.

Metoprolol Succinate WC

A Metoprolol Succinate written confirmation (Metoprolol Succinate WC) is an official document issued by a regulatory agency to a Metoprolol Succinate manufacturer, verifying that the manufacturing facility of a Metoprolol Succinate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Metoprolol Succinate APIs or Metoprolol Succinate finished pharmaceutical products to another nation, regulatory agencies frequently require a Metoprolol Succinate WC (written confirmation) as part of the regulatory process.

click here to find a list of Metoprolol Succinate suppliers with Written Confirmation (WC) on PharmaCompass.

Metoprolol Succinate NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Metoprolol Succinate as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Metoprolol Succinate API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Metoprolol Succinate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Metoprolol Succinate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Metoprolol Succinate NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Metoprolol Succinate suppliers with NDC on PharmaCompass.

Metoprolol Succinate GMP

Metoprolol Succinate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Metoprolol Succinate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Metoprolol Succinate GMP manufacturer or Metoprolol Succinate GMP API supplier for your needs.

Metoprolol Succinate CoA

A Metoprolol Succinate CoA (Certificate of Analysis) is a formal document that attests to Metoprolol Succinate's compliance with Metoprolol Succinate specifications and serves as a tool for batch-level quality control.

Metoprolol Succinate CoA mostly includes findings from lab analyses of a specific batch. For each Metoprolol Succinate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Metoprolol Succinate may be tested according to a variety of international standards, such as European Pharmacopoeia (Metoprolol Succinate EP), Metoprolol Succinate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Metoprolol Succinate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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