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    Chemistry

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    Also known as: 98418-47-4, Metroprolol succinate, Selozok, Toprol xl, Metoprolol (succinate), Seloken-zok
    Molecular Formula
    C34H56N2O10
    Molecular Weight
    652.8  g/mol
    InChI Key
    RGHAZVBIOOEVQX-UHFFFAOYSA-N
    FDA UNII
    TH25PD4CCB
    Metoprolol Succinate
    A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
    1 2D Structure

    Metoprolol Succinate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    butanedioic acid;1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol
    2.1.2 InChI
    InChI=1S/2C15H25NO3.C4H6O4/c2*1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3;5-3(6)1-2-4(7)8/h2*4-7,12,14,16-17H,8-11H2,1-3H3;1-2H2,(H,5,6)(H,7,8)
    2.1.3 InChI Key
    RGHAZVBIOOEVQX-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.C(CC(=O)O)C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    TH25PD4CCB
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Beloc Duriles

    2. Beloc-duriles

    3. Betaloc

    4. Betaloc Astra

    5. Betaloc-astra

    6. Betalok

    7. Cgp 2175

    8. Cgp-2175

    9. Cgp2175

    10. H 93 26

    11. H 93-26

    12. H 9326

    13. Lopressor

    14. Metoprolol

    15. Metoprolol Cr Xl

    16. Metoprolol Cr-xl

    17. Metoprolol Tartrate

    18. Seloken

    19. Spesicor

    20. Spesikor

    21. Toprol

    22. Toprol Xl

    23. Toprol-xl

    2.3.2 Depositor-Supplied Synonyms

    1. 98418-47-4

    2. Metroprolol Succinate

    3. Selozok

    4. Toprol Xl

    5. Metoprolol (succinate)

    6. Seloken-zok

    7. H 93/26 Succinate

    8. Toprol-xl

    9. Metoprolol Hemisuccinate

    10. Butanedioic Acid;1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol

    11. Th25pd4ccb

    12. Spesicor Dos

    13. Seloken Zoc

    14. Beloc- Zok

    15. 2-propanol, 1-(4-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-, (+-)-, Butanedioate (2:1) (salt)

    16. Metoprolol Succinate [usan]

    17. Unii-th25pd4ccb

    18. Metoprololsuccinate

    19. Metoprolol Succinate [usan:usp]

    20. Toprol Xl (tn)

    21. Metoprolol Succinate Extended-release Tablets

    22. Metoprolol Succinate (usp)

    23. (+-)-1-(isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propanol Succinate (2:1) (salt)

    24. Dsstox_cid_28652

    25. Dsstox_rid_82922

    26. Dsstox_gsid_48726

    27. Schembl40916

    28. Chebi:6905

    29. Chembl2356097

    30. Dtxsid9048726

    31. Metoprolol Succinate [mi]

    32. Hms3886g21

    33. Bcp02473

    34. Metoprolol Succinate [vandf]

    35. Tox21_113155

    36. Hy-17503a

    37. Metoprolol Succinate [mart.]

    38. Mfcd23115896

    39. S5341

    40. Metoprolol Succinate [usp-rs]

    41. Metoprolol Succinate [who-dd]

    42. 1-(isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol; Succinic Acid

    43. Akos015856332

    44. Bcp9000922

    45. Ccg-270331

    46. Cs-3158

    47. Ks-1241

    48. Ac-26570

    49. Metoprolol Succinate [ep Impurity]

    50. Metoprolol Succinate [orange Book]

    51. Metoprolol Succinate [ep Monograph]

    52. Cas-98418-47-4

    53. Metoprolol Succinate [usp Monograph]

    54. Ft-0628933

    55. Dutoprol Component Metoprolol Succinate

    56. D00635

    57. Metoprolol Succinate Component Of Dutoprol

    58. 418m474

    59. A845856

    60. Q-201401

    61. Q27289962

    62. Metoprolol Succinate, United States Pharmacopeia (usp) Reference Standard

    63. Bis(1-[4-(2-methoxyethyl)phenoxy]-3-[(propan-2-yl)amino]propan-2-ol); Butanedioic Acid

    64. Butanedioic Acid,1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol

    65. (+/-)-1-(isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propanol Succinate (2:1) (salt)

    66. 123245-49-8

    67. 2-propanol, 1-(4-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-, (+/-)-, Butanedioate (2:1) (salt)

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 652.8 g/mol
    Molecular Formula C34H56N2O10
    Hydrogen Bond Donor Count6
    Hydrogen Bond Acceptor Count12
    Rotatable Bond Count21
    Exact Mass652.39349599 g/mol
    Monoisotopic Mass652.39349599 g/mol
    Topological Polar Surface Area176 Ų
    Heavy Atom Count46
    Formal Charge0
    Complexity308
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count2
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameMetoprolol succinate
    Drug LabelTOPROL-XL, metoprolol succinate, is a beta1-selective (cardioselective) adrenoceptor blocking agent, for oral administration, available as extended-release tablets. TOPROL-XL has been formulated to provide a controlled and predictable release of meto...
    Active IngredientMetoprolol succinate
    Dosage FormTablet, extended release
    RouteOral
    Strengtheq 25mg tartrate; eq 50mg tartrate; eq 200mg tartrate; eq 100mg tartrate
    Market StatusPrescription
    CompanyMylan Pharms; Wockhardt; Actavis Labs Fl; Reddys; Dr Reddys Labs

    2 of 4  
    Drug NameToprol-xl
    Drug LabelTOPROL-XL, metoprolol succinate, is a beta1-selective (cardioselective) adrenoceptor blocking agent, for oral administration, available as extended-release tablets. TOPROL-XL has been formulated to provide a controlled and predictable release of meto...
    Active IngredientMetoprolol succinate
    Dosage FormTablet, extended release
    RouteOral
    Strengtheq 25mg tartrate; eq 50mg tartrate; eq 200mg tartrate; eq 100mg tartrate
    Market StatusPrescription
    CompanyAstrazeneca

    3 of 4  
    Drug NameMetoprolol succinate
    Drug LabelTOPROL-XL, metoprolol succinate, is a beta1-selective (cardioselective) adrenoceptor blocking agent, for oral administration, available as extended-release tablets. TOPROL-XL has been formulated to provide a controlled and predictable release of meto...
    Active IngredientMetoprolol succinate
    Dosage FormTablet, extended release
    RouteOral
    Strengtheq 25mg tartrate; eq 50mg tartrate; eq 200mg tartrate; eq 100mg tartrate
    Market StatusPrescription
    CompanyMylan Pharms; Wockhardt; Actavis Labs Fl; Reddys; Dr Reddys Labs

    4 of 4  
    Drug NameToprol-xl
    Drug LabelTOPROL-XL, metoprolol succinate, is a beta1-selective (cardioselective) adrenoceptor blocking agent, for oral administration, available as extended-release tablets. TOPROL-XL has been formulated to provide a controlled and predictable release of meto...
    Active IngredientMetoprolol succinate
    Dosage FormTablet, extended release
    RouteOral
    Strengtheq 25mg tartrate; eq 50mg tartrate; eq 200mg tartrate; eq 100mg tartrate
    Market StatusPrescription
    CompanyAstrazeneca

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Arrhythmia Agents

    Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    Adrenergic beta-1 Receptor Antagonists

    Drugs that bind to and block the activation of ADRENERGIC BETA-1 RECEPTORS. (See all compounds classified as Adrenergic beta-1 Receptor Antagonists.)

    Sympatholytics

    Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here. (See all compounds classified as Sympatholytics.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    beta-Adrenergic Blocker [EPC]; Adrenergic beta-Antagonists [MoA]

    API Reference Price

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SOLA BRIDGE,,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1704997800,"product":"(N.C.V.)[MARKET COMPLAINT SAMPLE FOR EVALUATION PURPOSE] METOPROLOL SUCCINATE PH.EUR (METOPR OLOL SUCCINATE)[BATCH # B68","address":"48, KANDIVLI INDUSTRIAL ESTATE,","city":"MUMBAI, MAHARASHTRA.","supplier":"SALUTAS PHARMA GMBH","supplierCountry":"INDIA","foreign_port":"N\/A","customer":"IPCA LABORATORIES","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"0.01","unit":"KGS","unitRateFc":"1000","totalValueFC":"11.2","currency":"EUR","unitRateINR":"92700","date":"12-Jan-2024","totalValueINR":"927","totalValueInUsd":"11.2","indian_port":"Bombay Air","hs_no":"29225090","bill_no":"9646647","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"OTTO-VON-GUERICKE-ALLEE 1 39179 BRALEBEN","customerAddress":"48, KANDIVLI INDUSTRIAL ESTATE,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1706812200,"product":"METOPROLOL SUCCINATE (1-(4-(2-METHOXYETHYL)PHENOXY)-3-((1-METHYLETHYL)AMINO)PROPAN-2-OL) BUTANEDIOATE","address":"H.NO. 8-2-337,BESIDE TV9 OFFICE","city":"HYDERABAD ANDHRA PRADESH","supplier":"MOEHS IBERICA","supplierCountry":"SPAIN","foreign_port":"BARCELONA","customer":"DR. REDDY\\'S LABORATORIES","customerCountry":"INDIA","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"500","totalValueFC":"2529.4","currency":"USD","unitRateINR":"41975","date":"02-Feb-2024","totalValueINR":"209875","totalValueInUsd":"2529.4","indian_port":"Hyderabad Air","hs_no":"29221990","bill_no":"9946882","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"BARCELONA","supplierAddress":"C\/. CESAR MARTINELL I BRUNET, 12A ,08191 RUBI, BARCELONA , SPAINSDNF Spain","customerAddress":"H.NO. 8-2-337,BESIDE TV9 OFFICE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1717353000,"product":"METOPROLOL SUCCINATE","address":"HETERO CORPORATE, NO. 7-2-A2,","city":"HYDERABAD","supplier":"MOEHS IBERICA","supplierCountry":"SPAIN","foreign_port":"BARCELONA","customer":"HETERO DRUGS","customerCountry":"INDIA","quantity":"2250.00","actualQuantity":"2250","unit":"KGS","unitRateFc":"63.9","totalValueFC":"145206.2","currency":"USD","unitRateINR":"5387.4","date":"03-Jun-2024","totalValueINR":"12121727.63","totalValueInUsd":"145206.2","indian_port":"Madras Air","hs_no":"29221990","bill_no":"3808145","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"BARCELONA","supplierAddress":"C\/ CESAR MARTINELL I BRUNET12A 08191 RUBIBARCELONA SPAIN","customerAddress":"HETERO CORPORATE, NO. 7-2-A2,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1718821800,"product":"METOPROLOL SUCCINATE","address":"ALKEM HOUSE, DEVASHISH ADJACENT TO","city":"LOWER PAREL, MUMBAI. MAHARASHTRA","supplier":"MOEHS IBERICA","supplierCountry":"SPAIN","foreign_port":"BARCELONA","customer":"ALKEM LABORATORIES","customerCountry":"INDIA","quantity":"5375.00","actualQuantity":"5375","unit":"KGS","unitRateFc":"57","totalValueFC":"309386.6","currency":"USD","unitRateINR":"4805.1","date":"20-Jun-2024","totalValueINR":"25827412.5","totalValueInUsd":"309386.6","indian_port":"JNPT","hs_no":"29222190","bill_no":"4101659","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"BARCELONA","supplierAddress":"CESAR MARTINELL BRUNET,08191 RUBI (BARCELONA)SDNF SPAIN","customerAddress":"ALKEM HOUSE, DEVASHISH ADJACENT TO"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1723055400,"product":"METOPROLOL SUCCINATE","address":"ALKEM HOUSE, DEVASHISH ADJACENT TO","city":"LOWER PAREL, MUMBAI. MAHARASHTRA","supplier":"MOEHS IBERICA","supplierCountry":"SPAIN","foreign_port":"BARCELONA","customer":"ALKEM LABORATORIES","customerCountry":"INDIA","quantity":"5875.00","actualQuantity":"5875","unit":"KGS","unitRateFc":"57","totalValueFC":"337755.3","currency":"USD","unitRateINR":"4822.2","date":"08-Aug-2024","totalValueINR":"28330425","totalValueInUsd":"337755.3","indian_port":"JNPT","hs_no":"29222190","bill_no":"4954823","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"BARCELONA","supplierAddress":"CESAR MARTINELL BRUNET,08191 RUBI (BARCELONA)SDNF SPAIN","customerAddress":"ALKEM HOUSE, DEVASHISH ADJACENT TO"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727375400,"product":"METOPROLOL SUCCINATE","address":"2ND FLOOR, CHINUBHAI CENTRE,","city":"AHMEDABAD, GUJARAT","supplier":"MOEHS IBERICA","supplierCountry":"SPAIN","foreign_port":"BARCELONA","customer":"INTAS PHARMACEUTICALS","customerCountry":"INDIA","quantity":"5650.00","actualQuantity":"5650","unit":"KGS","unitRateFc":"57","totalValueFC":"325119.7","currency":"USD","unitRateINR":"4822.2","date":"27-Sep-2024","totalValueINR":"27245430","totalValueInUsd":"325119.7","indian_port":"JNPT","hs_no":"29420090","bill_no":"5833392","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"BARCELONA","supplierAddress":"C\/. Cesar Martinell i Brunet, 12A 08191 RUBI BARCELONA SDNF Spain","customerAddress":"2ND FLOOR, CHINUBHAI CENTRE,"}]
    18-Jan-2021
    08-Nov-2024
    KGS
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 1...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 100MG TARTRATE

    USFDA APPLICATION NUMBER - 19962

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 2...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 200MG TARTRATE

    USFDA APPLICATION NUMBER - 19962

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 2...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 25MG TARTRATE

    USFDA APPLICATION NUMBER - 19962

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 5...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 50MG TARTRATE

    USFDA APPLICATION NUMBER - 19962

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    DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ ...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ 100MG TARTRATE

    USFDA APPLICATION NUMBER - 210428

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    DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ ...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ 200MG TARTRATE

    USFDA APPLICATION NUMBER - 210428

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    DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ ...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ 25MG TARTRATE

    USFDA APPLICATION NUMBER - 210428

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    DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ ...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ 50MG TARTRATE

    USFDA APPLICATION NUMBER - 210428

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 12.5...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 12.5MG;EQ 100MG TARTRATE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 21956

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 12.5...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 12.5MG;EQ 25MG TARTRATE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 21956

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 12.5...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 12.5MG;EQ 50MG TARTRATE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 21956

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