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Chemistry

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Also known as: Metrizoate, 1949-45-7, Acide metrizoique, Acidum metrizoicum, 3-acetamido-2,4,6-triiodo-5-(n-methylacetamido)benzoic acid, Metrizoic acid [jan]
Molecular Formula
C12H11I3N2O4
Molecular Weight
627.94  g/mol
InChI Key
GGGDNPWHMNJRFN-UHFFFAOYSA-N
FDA UNII
CM1N99QR1M

Metrizoic Acid
A diagnostic radiopaque that usually occurs as the sodium salt.
Metrizoic acid is a Radiographic Contrast Agent. The mechanism of action of metrizoic acid is as a X-Ray Contrast Activity.
1 2D Structure

Metrizoic Acid

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-acetamido-5-[acetyl(methyl)amino]-2,4,6-triiodobenzoic acid
2.1.2 InChI
InChI=1S/C12H11I3N2O4/c1-4(18)16-10-7(13)6(12(20)21)8(14)11(9(10)15)17(3)5(2)19/h1-3H3,(H,16,18)(H,20,21)
2.1.3 InChI Key
GGGDNPWHMNJRFN-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(=O)NC1=C(C(=C(C(=C1I)C(=O)O)I)N(C)C(=O)C)I
2.2 Other Identifiers
2.2.1 UNII
CM1N99QR1M
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Benzoic Acid, 3-(acetylamino)-5-(acetylmethylamino)-2,4,6-triiodo-

2. Isopaque

3. Metrizoate

4. Metrizoate Sodium

5. Triosil

2.3.2 Depositor-Supplied Synonyms

1. Metrizoate

2. 1949-45-7

3. Acide Metrizoique

4. Acidum Metrizoicum

5. 3-acetamido-2,4,6-triiodo-5-(n-methylacetamido)benzoic Acid

6. Metrizoic Acid [jan]

7. Isopaque

8. Triosil

9. 3-acetamido-2,4,6-triiodo-5-n-methylacetamidobenzoic Acid

10. Benzoic Acid, 3-(acetylamino)-5-(acetylmethylamino)-2,4,6-triiodo-

11. 3-acetamido-5-[acetyl(methyl)amino]-2,4,6-triiodobenzoic Acid

12. 3-(acetylamino)-5-[acetyl(methyl)amino]-2,4,6-triiodobenzoic Acid

13. Cm1n99qr1m

14. Chebi:34847

15. 3-(acetylamino)-5-(acetylmethylamino)-2,4,6-triiodobenzoic Acid

16. V08aa02

17. Isopaque 440

18. Smr001550298

19. Nsc107431

20. Metrizoic Acid, Metrizoic Acid 610.4mg

21. Ncgc00181093-01

22. Einecs 217-761-1

23. Unii-cm1n99qr1m

24. Brn 2822724

25. Metrizoic-acid

26. 3-(acetylamino)-5-(acetyl(methyl)amino)-2,4,6-triiodobenzoic Acid

27. Benzoic Acid, 3-acetamido-2,4,6-triiodo-5-(n-methylacetamido)-

28. Sodium Metrizoate (usan)

29. Chembl1736

30. Metrizoic Acid [mi]

31. Schembl37641

32. Mls004773979

33. Mls006010899

34. Metrizoic Acid [mart.]

35. Dtxsid6023311

36. Metrizoic Acid [who-dd]

37. 3-acetamido-5-(n-methylacetamido)-2,4,6-triiodobenzoic Acid

38. 3-acetamido-5-[acetyl(methyl)amino]-2,4,6-triiodo-benzoic Acid

39. Hy-b1699

40. Zinc3831116

41. Metrizoic Acid [orange Book]

42. Mfcd00867964

43. Db09346

44. As-70791

45. Cs-0013692

46. Ft-0672392

47. M1363

48. D91491

49. Sr-01000939781

50. J-012629

51. Q6824400

52. Sr-01000939781-2

53. 3-acetamido-2,4, 6-triiodo-5-(n-methylacetamido)benzoate-

54. Sodium 3-acetamido-2,4, 6-triiodo-5-(n-methylacetamido)benzoate

55. 3-acetamido-2,4,6-tri-iodo-5-(n-methylacetamido)benzoic Acid

56. Benzoic Acid, 3-(acetylamino)-5-(acetylmethylamino)-2,4, 6-triiodo-, Monosodium Salt

57. Benzoic Acid, 3-acetamido-2,4, 6-triiodo-5-(n-methylacetamido)-, Monosodium Salt

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 627.94 g/mol
Molecular Formula C12H11I3N2O4
XLogP31.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass627.7853 g/mol
Monoisotopic Mass627.7853 g/mol
Topological Polar Surface Area86.7 Ų
Heavy Atom Count21
Formal Charge0
Complexity448
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

For use as a contrast medium.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Contrast Media

Substances used to allow enhanced visualization of tissues. (See all compounds classified as Contrast Media.)


5.2 FDA Pharmacological Classification
5.2.1 Active Moiety
METRIZOIC ACID
5.2.2 FDA UNII
CM1N99QR1M
5.2.3 Pharmacological Classes
Mechanisms of Action [MoA] - X-Ray Contrast Activity
5.3 ATC Code

V - Various

V08 - Contrast media

V08A - X-ray contrast media, iodinated

V08AA - Watersoluble, nephrotropic, high osmolar x-ray contrast media

V08AA02 - Metrizoic acid


5.4 Mechanism of Action

The mechanism of action of metrizoic acid is as an X-Ray contrast activity.


ABOUT THIS PAGE

Metrizoic Acid Manufacturers

A Metrizoic Acid manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Metrizoic Acid, including repackagers and relabelers. The FDA regulates Metrizoic Acid manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Metrizoic Acid API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Metrizoic Acid Suppliers

A Metrizoic Acid supplier is an individual or a company that provides Metrizoic Acid active pharmaceutical ingredient (API) or Metrizoic Acid finished formulations upon request. The Metrizoic Acid suppliers may include Metrizoic Acid API manufacturers, exporters, distributors and traders.

Metrizoic Acid GMP

Metrizoic Acid Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Metrizoic Acid GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Metrizoic Acid GMP manufacturer or Metrizoic Acid GMP API supplier for your needs.

Metrizoic Acid CoA

A Metrizoic Acid CoA (Certificate of Analysis) is a formal document that attests to Metrizoic Acid's compliance with Metrizoic Acid specifications and serves as a tool for batch-level quality control.

Metrizoic Acid CoA mostly includes findings from lab analyses of a specific batch. For each Metrizoic Acid CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Metrizoic Acid may be tested according to a variety of international standards, such as European Pharmacopoeia (Metrizoic Acid EP), Metrizoic Acid JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Metrizoic Acid USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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