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Chemistry

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Also known as: Melex, 31868-18-5, Cs-386, Chebi:31842, S5969b6237, 10-chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydro-3-methyloxazolo(3,2-d)(1,4)benzodiazepin-6(5h)-one
Molecular Formula
C18H16Cl2N2O2
Molecular Weight
363.2  g/mol
InChI Key
ANUCDXCTICZJRH-UHFFFAOYSA-N
FDA UNII
S5969B6237

Mexazolam
Mexazolam (CS-386) is a benzodiazepine indicated for the treatment of anxiety with or without psychoneurotic conditions. Mexazolam's structure is similar to that of other benzodiazepines such as [oxazolam] and [cloxazolam]. The use of benzodiazepines in the treatment of anxiety is generally a second line measure.
1 2D Structure

Mexazolam

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
10-chloro-11b-(2-chlorophenyl)-3-methyl-2,3,5,7-tetrahydro-[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6-one
2.1.2 InChI
InChI=1S/C18H16Cl2N2O2/c1-11-10-24-18(13-4-2-3-5-15(13)20)14-8-12(19)6-7-16(14)21-17(23)9-22(11)18/h2-8,11H,9-10H2,1H3,(H,21,23)
2.1.3 InChI Key
ANUCDXCTICZJRH-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1COC2(N1CC(=O)NC3=C2C=C(C=C3)Cl)C4=CC=CC=C4Cl
2.2 Other Identifiers
2.2.1 UNII
S5969B6237
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 10-chloro-2,3,7,11b-tetrahydro-3-methyl-11b-(2-chlorophenyl)oxazolo(3,2-d)(1,4)benzodiazepin-6(5h)-one

2. Cs 386

3. Cs-386

2.3.2 Depositor-Supplied Synonyms

1. Melex

2. 31868-18-5

3. Cs-386

4. Chebi:31842

5. S5969b6237

6. 10-chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydro-3-methyloxazolo(3,2-d)(1,4)benzodiazepin-6(5h)-one

7. 10-chloro-11b-(o-chlorophenyl)-2,3,7,11b-tetrahydro-3-methyloxazolo(3,2-d)(1,4)benzodiazepin-6(5h)-one

8. Mexazolamum

9. Mexazolam [inn:jan]

10. Mexazolamum [inn-latin]

11. Cs 386

12. 10-chloro-11b-(2-chlorophenyl)-3-methyl-2,3,7,11b-tetrahydrobenzo[f]oxazolo[3,2-d][1,4]diazepin-6(5h)-one

13. Brn 1091849

14. Sedoxil

15. Unii-s5969b6237

16. Melex (tn)

17. Mexazolam (jan/inn)

18. Mexazolam [inn]

19. Mexazolam [jan]

20. Mexazolam [mi]

21. Mexazolam [mart.]

22. Mexazolam [who-dd]

23. Dsstox_cid_31504

24. Dsstox_rid_97389

25. Dsstox_gsid_57715

26. 10-chloro-11b-(2-chlorophenyl)-3-methyl-2,3,5,7-tetrahydro-[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6-one

27. Schembl218453

28. Chembl1743261

29. Dtxsid9057715

30. Tox21_113740

31. Db15489

32. Ncgc00253606-01

33. Oxazolo(3,2-d)(1,4)benzodiazepin-6(5h)-one, 10-chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydro-3-methyl-

34. Cas-31868-18-5

35. D01316

36. Q6148446

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 363.2 g/mol
Molecular Formula C18H16Cl2N2O2
XLogP33.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass362.0588831 g/mol
Monoisotopic Mass362.0588831 g/mol
Topological Polar Surface Area41.6 Ų
Heavy Atom Count24
Formal Charge0
Complexity505
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Mexazolam is indicated for the treatment of anxiety with or without psychoneurotic conditions.


5 Pharmacology and Biochemistry
5.1 ATC Code

N - Nervous system

N05 - Psycholeptics

N05B - Anxiolytics

N05BA - Benzodiazepine derivatives

N05BA25 - Mexazolam


5.2 Absorption, Distribution and Excretion

Absorption

The active metabolite chloronordiazepam has a Tmax of 1-2h.


Route of Elimination

Mexazolam is mainly eliminated in the bile and feces, with <10% eliminated as metabolites in the urine. >50% of a dose of mexazolam is eliminated as the metabolite chloroxazepam.


5.3 Metabolism/Metabolites

Mexazolam is rapidly metabolized to the active metabolites chloronordiazepam and chloroxazepam.


5.4 Biological Half-Life

Mexazolam follows a 2 compartment model with a first half life of 1.4h and a second half life of 76h.


5.5 Mechanism of Action

Mexazolam is a benzodiazepine that binds to benzodiazepine-type receptors, inhibiting gamma-aminobutyric acid.


API Reference Price

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18-Oct-2021
20-Sep-2024
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Looking for 31868-18-5 / Mexazolam API manufacturers, exporters & distributors?

Mexazolam manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Mexazolam API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Mexazolam manufacturer or Mexazolam supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Mexazolam manufacturer or Mexazolam supplier.

PharmaCompass also assists you with knowing the Mexazolam API Price utilized in the formulation of products. Mexazolam API Price is not always fixed or binding as the Mexazolam Price is obtained through a variety of data sources. The Mexazolam Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Mexazolam

Synonyms

Melex, 31868-18-5, Cs-386, Chebi:31842, S5969b6237, 10-chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydro-3-methyloxazolo(3,2-d)(1,4)benzodiazepin-6(5h)-one

Cas Number

31868-18-5

Unique Ingredient Identifier (UNII)

S5969B6237

About Mexazolam

Mexazolam (CS-386) is a benzodiazepine indicated for the treatment of anxiety with or without psychoneurotic conditions. Mexazolam's structure is similar to that of other benzodiazepines such as [oxazolam] and [cloxazolam]. The use of benzodiazepines in the treatment of anxiety is generally a second line measure.

Mexazolam Manufacturers

A Mexazolam manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Mexazolam, including repackagers and relabelers. The FDA regulates Mexazolam manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Mexazolam API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Mexazolam manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Mexazolam Suppliers

A Mexazolam supplier is an individual or a company that provides Mexazolam active pharmaceutical ingredient (API) or Mexazolam finished formulations upon request. The Mexazolam suppliers may include Mexazolam API manufacturers, exporters, distributors and traders.

click here to find a list of Mexazolam suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Mexazolam GMP

Mexazolam Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Mexazolam GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Mexazolam GMP manufacturer or Mexazolam GMP API supplier for your needs.

Mexazolam CoA

A Mexazolam CoA (Certificate of Analysis) is a formal document that attests to Mexazolam's compliance with Mexazolam specifications and serves as a tool for batch-level quality control.

Mexazolam CoA mostly includes findings from lab analyses of a specific batch. For each Mexazolam CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Mexazolam may be tested according to a variety of international standards, such as European Pharmacopoeia (Mexazolam EP), Mexazolam JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Mexazolam USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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