Seqens is an integrated global leader in pharmaceutical solutions & specialty ingredients & provides custom-made solutions.

Contact Supplier

AbbVie CDMO has been working with global companies to develop, manufacture & scale biopharmaceutical products.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

1 API Suppliers, 1 Listed Suppliers, $ API Reference Price

1 API Suppliers
1 Listed Suppliers
$ API Reference Price

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 21,040

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: Melex, 31868-18-5, Cs-386, Chebi:31842, S5969b6237, 10-chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydro-3-methyloxazolo(3,2-d)(1,4)benzodiazepin-6(5h)-one

Molecular Formula

C₁₈H₁₆Cl₂N₂O₂

Molecular Weight

363.2 g/mol

InChI Key

ANUCDXCTICZJRH-UHFFFAOYSA-N

FDA UNII

S5969B6237

Mexazolam (CS-386) is a benzodiazepine indicated for the treatment of anxiety with or without psychoneurotic conditions. Mexazolam's structure is similar to that of other benzodiazepines such as [oxazolam] and [cloxazolam]. The use of benzodiazepines in the treatment of anxiety is generally a second line measure.

1 2D Structure

Mexazolam

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

10-chloro-11b-(2-chlorophenyl)-3-methyl-2,3,5,7-tetrahydro-[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6-one

2.1.2 InChI

InChI=1S/C18H16Cl2N2O2/c1-11-10-24-18(13-4-2-3-5-15(13)20)14-8-12(19)6-7-16(14)21-17(23)9-22(11)18/h2-8,11H,9-10H2,1H3,(H,21,23)

2.1.3 InChI Key

ANUCDXCTICZJRH-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1COC2(N1CC(=O)NC3=C2C=C(C=C3)Cl)C4=CC=CC=C4Cl

2.2 Other Identifiers

2.2.1 UNII

S5969B6237

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 10-chloro-2,3,7,11b-tetrahydro-3-methyl-11b-(2-chlorophenyl)oxazolo(3,2-d)(1,4)benzodiazepin-6(5h)-one

2. Cs 386

3. Cs-386

2.3.2 Depositor-Supplied Synonyms

1. Melex

2. 31868-18-5

3. Cs-386

4. Chebi:31842

5. S5969b6237

6. 10-chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydro-3-methyloxazolo(3,2-d)(1,4)benzodiazepin-6(5h)-one

7. 10-chloro-11b-(o-chlorophenyl)-2,3,7,11b-tetrahydro-3-methyloxazolo(3,2-d)(1,4)benzodiazepin-6(5h)-one

8. Mexazolamum

9. Mexazolam [inn:jan]

10. Mexazolamum [inn-latin]

11. Cs 386

12. 10-chloro-11b-(2-chlorophenyl)-3-methyl-2,3,7,11b-tetrahydrobenzo[f]oxazolo[3,2-d][1,4]diazepin-6(5h)-one

13. Brn 1091849

14. Sedoxil

15. Unii-s5969b6237

16. Melex (tn)

17. Mexazolam (jan/inn)

18. Mexazolam [inn]

19. Mexazolam [jan]

20. Mexazolam [mi]

21. Mexazolam [mart.]

22. Mexazolam [who-dd]

23. Dsstox_cid_31504

24. Dsstox_rid_97389

25. Dsstox_gsid_57715

26. 10-chloro-11b-(2-chlorophenyl)-3-methyl-2,3,5,7-tetrahydro-[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6-one

27. Schembl218453

28. Chembl1743261

29. Dtxsid9057715

30. Tox21_113740

31. Db15489

32. Ncgc00253606-01

33. Oxazolo(3,2-d)(1,4)benzodiazepin-6(5h)-one, 10-chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydro-3-methyl-

34. Cas-31868-18-5

35. D01316

36. Q6148446

2.4 Create Date

2005-03-25

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₁₆Cl₂N₂O₂
Molecular Weight	363.2 g/mol
XLogP3	3.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	1
Exact Mass	362.0588831 g/mol
Monoisotopic Mass	362.0588831 g/mol
Topological Polar Surface Area	41.6 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	505
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

Mexazolam is indicated for the treatment of anxiety with or without psychoneurotic conditions.

5 Pharmacology and Biochemistry

5.1 ATC Code

N - Nervous system

N05 - Psycholeptics

N05B - Anxiolytics

N05BA - Benzodiazepine derivatives

N05BA25 - Mexazolam

5.2 Absorption, Distribution and Excretion

Absorption

The active metabolite chloronordiazepam has a T_max of 1-2h.

Route of Elimination

Mexazolam is mainly eliminated in the bile and feces, with <10% eliminated as metabolites in the urine. >50% of a dose of mexazolam is eliminated as the metabolite chloroxazepam.

5.3 Metabolism/Metabolites

Mexazolam is rapidly metabolized to the active metabolites chloronordiazepam and chloroxazepam.

5.4 Biological Half-Life

Mexazolam follows a 2 compartment model with a first half life of 1.4h and a second half life of 76h.

5.5 Mechanism of Action

Mexazolam is a benzodiazepine that binds to benzodiazepine-type receptors, inhibiting gamma-aminobutyric acid.

API SUPPLIERS

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Listed Suppliers

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

API Reference Price

[{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1655058600,"product":"PHARMACEUTICAL BULK DRUG - MEXAZOLAM - B","address":"NO.C-10, 1ST CROSS,,KSSIDC INDUSTR IAL AREA, YELAHANKA","city":"BENGALURU,KARNATAKA","supplier":"R L FINE CHEM","supplierCountry":"INDIA","foreign_port":"SANTO DOMINGO","customer":"ACROMAX DOMINICANA S.A","customerCountry":"DOMINICAN REPUBLIC","quantity":"0.10","actualQuantity":"0.1","unit":"KGS","unitRateFc":"20000","totalValueFC":"1627.9","currency":"USD","unitRateINR":1270000,"date":"13-Jun-2022","totalValueINR":"127000","totalValueInUsd":"1627.9","indian_port":"BANGALORE AIR","hs_no":"29420090","bill_no":"2072349","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"DOMINICAN REPULIC","selfForZScoreResived":"Pharma Grade","supplierPort":"BANGALORE AIR","supplierAddress":"NO.C-10, 1ST CROSS,,KSSIDC INDUSTR IAL AREA, YELAHANKA, BENGALURU,KARNATAKA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1708453800,"product":"PHARMACEUTICAL BULK DRUG, MEXAZOLAM \/ IHBATCH NO: PDL\/MXZ\/24\/005","address":"RAY HOUSE, HIG 2000,,MOTHER DIARY","city":"BANGALORE,KARNATAKA","supplier":"R L FINE CHEM","supplierCountry":"INDIA","foreign_port":"SANTO DOMINGO","customer":"ACROMAX DOMINICANA SA","customerCountry":"DOMINICAN REPUBLIC","quantity":"0.25","actualQuantity":"0.25","unit":"KGS","unitRateFc":"17000","totalValueFC":"3989.6","currency":"USD","unitRateINR":1324116,"date":"21-Feb-2024","totalValueINR":"331029","totalValueInUsd":"3989.6","indian_port":"Bangalore Air","hs_no":"29420090","bill_no":"7712449","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"DOMINICAN REPULIC","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"RAY HOUSE, HIG 2000,,MOTHER DIARY, BANGALORE,KARNATAKA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1708626600,"product":"PHARMACEUTICAL BULK DRUG, MEXAZOLAM \/ IHBATCH NO: PDL\/MXZ\/24\/005","address":"RAY HOUSE, HIG 2000,,MOTHER DIARY","city":"BANGALORE,KARNATAKA","supplier":"R L FINE CHEM","supplierCountry":"INDIA","foreign_port":"GUATEMALA CITY","customer":"LABORATORIOS QUIMICO FARMACEUTICOS","customerCountry":"GUATEMALA","quantity":"0.10","actualQuantity":"0.1","unit":"KGS","unitRateFc":"40000","totalValueFC":"3768.6","currency":"USD","unitRateINR":3126980,"date":"23-Feb-2024","totalValueINR":"312698","totalValueInUsd":"3768.6","indian_port":"Bangalore Air","hs_no":"29420090","bill_no":"7781268","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"GAUTEMALA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"RAY HOUSE, HIG 2000,,MOTHER DIARY, BANGALORE,KARNATAKA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725993000,"product":"PHARMACEUTICAL BULK DRUG - MEXAZOLAM\/IH- BATCH NO: MXZ\/API\/WS\/02, MFG DT: FEB 2024, RETEST DT: FEB 2025","address":"RAY HOUSE, HIG 2000,,MOTHER DIARY","city":"BANGALORE,KARNATAKA","supplier":"R L FINE CHEM","supplierCountry":"INDIA","foreign_port":"GUATEMALA CITY","customer":"TO THE ORDER OF","customerCountry":"GUATEMALA","quantity":"0.00","actualQuantity":"0.004","unit":"KGS","unitRateFc":"1375000","totalValueFC":"5091.8","currency":"USD","unitRateINR":106674085,"date":"11-Sep-2024","totalValueINR":"426696.34","totalValueInUsd":"5091.8","indian_port":"Bangalore Air","hs_no":"29420090","bill_no":"3920417","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"GUATEMALA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"RAY HOUSE, HIG 2000,,MOTHER DIARY, BANGALORE,KARNATAKA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1726770600,"product":"PHARMACEUTICAL BULK DRUG MEXAZOLAM\/IH BATCH NUMBER-MXM\/224001, MFG.DATE-AUG 2024,RETEST DATE-JULY 2027","address":"RAY HOUSE, HIG 2000,,MOTHER DIARY","city":"BANGALORE,KARNATAKA","supplier":"R L FINE CHEM","supplierCountry":"INDIA","foreign_port":"SANTO DOMINGO","customer":"TO THE ORDER OF","customerCountry":"DOMINICAN REPUBLIC","quantity":"0.50","actualQuantity":"0.5","unit":"KGS","unitRateFc":"17500","totalValueFC":"8488.5","currency":"USD","unitRateINR":1422685.46,"date":"20-Sep-2024","totalValueINR":"711342.73","totalValueInUsd":"8488.5","indian_port":"Bangalore Air","hs_no":"29420090","bill_no":"4200898","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"DOMINICAN REPUBLIC","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"RAY HOUSE, HIG 2000,,MOTHER DIARY, BANGALORE,KARNATAKA","customerAddress":""}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

Upgrade, download data, analyse, strategize, subscribe with us contact

ABOUT THIS PAGE

Find Mexazolam manufacturers, exporters & distributors on PharmaCompass

Mexazolam

ACCESS ALL DATA

Browse all information

CHEMISTRY

Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

1 API Suppliers

1 Listed Suppliers

$ API Reference Price

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 21,040

MARKET PLACE

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

PATENTS & EXCLUSIVITIES

DIGITAL CONTENT

GLOBAL SALES INFORMATION

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

What are you looking for?