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1. 10-chloro-2,3,7,11b-tetrahydro-3-methyl-11b-(2-chlorophenyl)oxazolo(3,2-d)(1,4)benzodiazepin-6(5h)-one
2. Cs 386
3. Cs-386
1. Melex
2. 31868-18-5
3. Cs-386
4. Chebi:31842
5. S5969b6237
6. 10-chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydro-3-methyloxazolo(3,2-d)(1,4)benzodiazepin-6(5h)-one
7. 10-chloro-11b-(o-chlorophenyl)-2,3,7,11b-tetrahydro-3-methyloxazolo(3,2-d)(1,4)benzodiazepin-6(5h)-one
8. Mexazolamum
9. Mexazolam [inn:jan]
10. Mexazolamum [inn-latin]
11. Cs 386
12. 10-chloro-11b-(2-chlorophenyl)-3-methyl-2,3,7,11b-tetrahydrobenzo[f]oxazolo[3,2-d][1,4]diazepin-6(5h)-one
13. Brn 1091849
14. Sedoxil
15. Unii-s5969b6237
16. Melex (tn)
17. Mexazolam (jan/inn)
18. Mexazolam [inn]
19. Mexazolam [jan]
20. Mexazolam [mi]
21. Mexazolam [mart.]
22. Mexazolam [who-dd]
23. Dsstox_cid_31504
24. Dsstox_rid_97389
25. Dsstox_gsid_57715
26. 10-chloro-11b-(2-chlorophenyl)-3-methyl-2,3,5,7-tetrahydro-[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6-one
27. Schembl218453
28. Chembl1743261
29. Dtxsid9057715
30. Tox21_113740
31. Db15489
32. Ncgc00253606-01
33. Oxazolo(3,2-d)(1,4)benzodiazepin-6(5h)-one, 10-chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydro-3-methyl-
34. Cas-31868-18-5
35. D01316
36. Q6148446
Molecular Weight | 363.2 g/mol |
---|---|
Molecular Formula | C18H16Cl2N2O2 |
XLogP3 | 3.7 |
Hydrogen Bond Donor Count | 1 |
Hydrogen Bond Acceptor Count | 3 |
Rotatable Bond Count | 1 |
Exact Mass | 362.0588831 g/mol |
Monoisotopic Mass | 362.0588831 g/mol |
Topological Polar Surface Area | 41.6 Ų |
Heavy Atom Count | 24 |
Formal Charge | 0 |
Complexity | 505 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 2 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently Bonded Unit Count | 1 |
Mexazolam is indicated for the treatment of anxiety with or without psychoneurotic conditions.
N - Nervous system
N05 - Psycholeptics
N05B - Anxiolytics
N05BA - Benzodiazepine derivatives
N05BA25 - Mexazolam
Absorption
The active metabolite chloronordiazepam has a Tmax of 1-2h.
Route of Elimination
Mexazolam is mainly eliminated in the bile and feces, with <10% eliminated as metabolites in the urine. >50% of a dose of mexazolam is eliminated as the metabolite chloroxazepam.
Mexazolam is rapidly metabolized to the active metabolites chloronordiazepam and chloroxazepam.
Mexazolam follows a 2 compartment model with a first half life of 1.4h and a second half life of 76h.
Mexazolam is a benzodiazepine that binds to benzodiazepine-type receptors, inhibiting gamma-aminobutyric acid.