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Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

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ACTIVE PHARMA INGREDIENTS

13 API Suppliers, 5 CEP/COS, 1 EU WC, 6 NDC API, 7 VMF, 11 Listed Suppliers, $ API Reference Price

13 API Suppliers
5 CEP/COS
1 EU WC
6 NDC API
7 VMF
11 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

2 Drugs in Development

2 Drugs in Development

FINISHED DOSAGE FORMULATIONS

24 FDF Dossiers, 21 Canada, 3 Listed Dossiers

24 FDF Dossiers
21 Canada
3 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Minakem, 4 SPI Pharma, 2 DKSH, 1 Pharm-RX Chemical, 4 Faran Shimi Pharmaceutical, 11 Gangwal Healthcare, 3 Nanjing Well Pharmaceutical, 1 Pfanstiehl, 5 Actylis, 6 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 1 BASF, 5 DFE Pharma, 1 Finar, 5 Gangwal Chemicals, 1 Ideal Cures Pvt Ltd, 3 Ingredion Pharma Solutions, 19 Kerry, 9 Microlex e.U, 1 Pharmatrans-Sanaq, 5 Pluviaendo, 3 Prachin Chemical, 14 Roquette, 1 Seppic, 4 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 10 Sigachi Industries, 1 Valens Pharmachem, 3 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

52 Fillers, Diluents & Binders, 24 Direct Compression, 18 Disintegrants & Superdisintegrants, 16 Thickeners and Stabilizers, 13 Co-Processed Excipients, 11 Lubricants & Glidants, 11 Granulation, 9 Parenteral, 7 Taste Masking, 6 Controlled & Modified Release, 6 Coating Systems & Additives, 5 Chewable & Orodispersible Aids, 4 Topical, 4 Emulsifying Agents, 4 Film Formers & Plasticizers, 3 API Stability Enhancers, 2 Rheology Modifiers, 2 Solubilizers

excipientsByApplications
52 Fillers, Diluents & Binders
24 Direct Compression
18 Disintegrants & Superdisintegrants
16 Thickeners and Stabilizers
13 Co-Processed Excipients
11 Lubricants & Glidants
11 Granulation
9 Parenteral
7 Taste Masking
6 Controlled & Modified Release
6 Coating Systems & Additives
5 Chewable & Orodispersible Aids
4 Topical
4 Emulsifying Agents
4 Film Formers & Plasticizers
3 API Stability Enhancers
2 Rheology Modifiers
2 Solubilizers

DIGITAL CONTENT

1 NEWS #PharmaBuzz

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1 NEWS #PharmaBuzz

MARKET PLACE

9 APIs

marketPlace
9 APIs

PATENTS & EXCLUSIVITIES

5 Health Canada Patents

patents
5 Health Canada Patents

REF. STANDARDS & IMPURITIES

1 EDQM , 1 USP , 1 Others

otherSolutions
1 EDQM
1 USP
1 Others

Chemwerth Milbemycin Oxime

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 16,318

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

2DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

124 RELATED EXCIPIENT COMPANIES

197EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Milbemycin a, 5-oxime, Unii-0502pun0gt, Cga-179246, Schembl120526, 0502pun0gt, Hy-b0778

Molecular Formula

C₆₃H₈₈N₂O₁₄

Molecular Weight

1097.4 g/mol

InChI Key

CKVMAPHTVCTEMM-ALPQRHTBSA-N

1 2D Structure

Milbemycin Oxime

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(1R,4S,5'S,6R,6'R,8R,10E,13R,14E,16E,20R,21Z,24S)-6'-ethyl-24-hydroxy-21-hydroxyimino-5',11,13,22-tetramethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one;(1R,4S,5'S,6R,6'R,8R,10E,13R,14E,16E,20R,21Z,24S)-24-hydroxy-21-hydroxyimino-5',6',11,13,22-pentamethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one

2.1.2 InChI

InChI=1S/C32H45NO7.C31H43NO7/c1-6-27-21(4)12-13-31(40-27)17-25-16-24(39-31)11-10-20(3)14-19(2)8-7-9-23-18-37-29-28(33-36)22(5)15-26(30(34)38-25)32(23,29)35;1-18-7-6-8-23-17-36-28-27(32-35)21(4)14-26(31(23,28)34)29(33)37-25-15-24(10-9-19(2)13-18)39-30(16-25)12-11-20(3)22(5)38-30/h7-10,15,19,21,24-27,29,35-36H,6,11-14,16-18H2,1-5H3;6-9,14,18,20,22,24-26,28,34-35H,10-13,15-17H2,1-5H3/b8-7+,20-10+,23-9+,33-28-;7-6+,19-9+,23-8+,32-27-/t19-,21-,24+,25-,26-,27+,29+,31+,32+;18-,20-,22+,24+,25-,26-,28+,30-,31+/m00/s1

2.1.3 InChI Key

CKVMAPHTVCTEMM-ALPQRHTBSA-N

2.1.4 Canonical SMILES

CCC1C(CCC2(O1)CC3CC(O2)CC=C(CC(C=CC=C4COC5C4(C(C=C(C5=NO)C)C(=O)O3)O)C)C)C.CC1CCC2(CC3CC(O2)CC=C(CC(C=CC=C4COC5C4(C(C=C(C5=NO)C)C(=O)O3)O)C)C)OC1C

2.1.5 Isomeric SMILES

CC[C@@H]1[C@H](CC[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/C[C@H](/C=C/C=C/4\CO[C@H]\5[C@@]4([C@@H](C=C(/C5=N/O)C)C(=O)O3)O)C)\C)C.C[C@H]1CC[C@]2(C[C@@H]3C[C@H](O2)C/C=C(/C[C@H](/C=C/C=C/4\CO[C@H]\5[C@@]4([C@@H](C=C(/C5=N/O)C)C(=O)O3)O)C)\C)O[C@@H]1C

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Interceptor

2. Milbe Mite

3. Milbemycin A, 5-oxime

4. Milbemycin Oxime

2.2.2 Depositor-Supplied Synonyms

1. Milbemycin A, 5-oxime

2. Unii-0502pun0gt

3. Cga-179246

4. Schembl120526

5. 0502pun0gt

6. Hy-b0778

2.3 Create Date

2007-12-05

3 Chemical and Physical Properties

Molecular Formula	C₆₃H₈₈N₂O₁₄
Molecular Weight	1097.4 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	16
Rotatable Bond Count	1
Exact Mass	1096.62355549 g/mol
Monoisotopic Mass	1096.62355549 g/mol
Topological Polar Surface Area	214 Å²
Heavy Atom Count	79
Formal Charge	0
Complexity	2260
Isotope Atom Count	0
Defined Atom Stereocenter Count	18
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	8
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anthelmintics

Agents that kill parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal. (See all compounds classified as Anthelmintics.)

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API Reference Price

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