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Chemistry

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Also known as: Pha-848125, 802539-81-7, Pha 848125, Milciclib [inn], Milciclib (pha-848125), Pha848125
Molecular Formula
C25H32N8O
Molecular Weight
460.6  g/mol
InChI Key
RXZMYLDMFYNEIM-UHFFFAOYSA-N
FDA UNII
688000M8S8

Milciclib
Milciclib is an orally bioavailable inhibitor of cyclin-dependent kinases (CDKs) and tropomyosin receptor kinase A (TRKA), with potential antineoplastic activity. CDK2/TRKA inhibitor PHA-848125 AC potently inhibits cyclin-dependent kinase 2 (CDK2) and exhibits activity against other CDKs including CDK1 and CDK4, in addition to TRKA. Inhibition of these kinases may result in cell cycle arrest and apoptosis of tumor cells that express these kinases. CDKs are serine/threonine kinases involved in regulation of the cell cycle and may be overexpressed in some cancer cell types. The neurotrophin receptor TRKA is mutated in a variety of cancer cell types.
1 2D Structure

Milciclib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N,1,4,4-tetramethyl-8-[4-(4-methylpiperazin-1-yl)anilino]-5H-pyrazolo[4,3-h]quinazoline-3-carboxamide
2.1.2 InChI
InChI=1S/C25H32N8O/c1-25(2)14-16-15-27-24(29-20(16)22-19(25)21(23(34)26-3)30-32(22)5)28-17-6-8-18(9-7-17)33-12-10-31(4)11-13-33/h6-9,15H,10-14H2,1-5H3,(H,26,34)(H,27,28,29)
2.1.3 InChI Key
RXZMYLDMFYNEIM-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1(CC2=CN=C(N=C2C3=C1C(=NN3C)C(=O)NC)NC4=CC=C(C=C4)N5CCN(CC5)C)C
2.2 Other Identifiers
2.2.1 UNII
688000M8S8
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Miliciclib

2. N,1,4,4-tetramethyl-8-((4-(4-methylpiperazin-1-yl)phenyl)amino)-4,5-dihydro-1h-pyrazolo(4,3-h)quinazoline-3-carboxamide

3. Pha 848125

4. Pha-848125

5. Pha-848125ac

6. Pha848125

2.3.2 Depositor-Supplied Synonyms

1. Pha-848125

2. 802539-81-7

3. Pha 848125

4. Milciclib [inn]

5. Milciclib (pha-848125)

6. Pha848125

7. 4,5-dihydro-n,1,4,4-tetramethyl-8-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide

8. Mmv676602

9. N,1,4,4-tetramethyl-8-[4-(4-methylpiperazin-1-yl)anilino]-5h-pyrazolo[4,3-h]quinazoline-3-carboxamide

10. 688000m8s8

11. 1h-pyrazolo(4,3-h)quinazoline-3-carboxamide, 4,5-dihydro-n,1,4,4-tetramethyl-8-((4-(4-methyl-1-piperazinyl)phenyl)amino)-

12. N,1,4,4-tetramethyl-8-((4-(4-methylpiperazin-1-yl)phenyl)amino)-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide

13. N,1,4,4-tetramethyl-8-((4-(4-methylpiperazin-1-yl)phenyl)amino)-4,5-dihydro-1h-pyrazolo(4,3-h)quinazoline-3-carboxamide

14. N,1,4,4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide

15. Unii-688000m8s8

16. 4,5-dihydro-n,1,4,4-tetramethyl-8-((4-(4-methyl-1-piperazinyl)phenyl)amino)-1h-pyrazolo(4,3-h)quinazoline-3-carboxamide

17. Milciclib; Pha 848125

18. Mls006011032

19. Schembl619139

20. Chembl564829

21. Gtpl7938

22. Pha-848125 - Milciclib

23. Bdbm31545

24. Dtxsid80230186

25. Bcpp000109

26. Hms3656p21

27. Bcp01918

28. Ex-a2135

29. Nsc800792

30. S2751

31. Zinc53119602

32. Akos030231455

33. Ccg-269340

34. Cs-0579

35. Nsc-800792

36. Sb16657

37. Ncgc00346673-01

38. Ncgc00346673-05

39. Ac-35945

40. As-56203

41. Hy-10424

42. Smr004700646

43. Db-075668

44. Ft-0732566

45. Sw219949-1

46. D82291

47. Pyrazolo[4,3-h]quinazoline-3-carboxamide, 28

48. Sr-05000022565

49. J-523919

50. Sr-05000022565-1

51. Pha-848125,cas:802539-81-7

52. Q27086363

53. 8-[4-(4-methyl-piperazin-1-yl)-phenylamino]-1,4,4-trimethyl-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxylic Acid Methylamide

54. N,1,4,4-tetramethyl-8-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-5h-pyrazolo[4,5-h]quinazoline-3-carboxamide

2.4 Create Date
2007-08-27
3 Chemical and Physical Properties
Molecular Weight 460.6 g/mol
Molecular Formula C25H32N8O
XLogP32.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass460.26990767 g/mol
Monoisotopic Mass460.26990767 g/mol
Topological Polar Surface Area91.2 Ų
Heavy Atom Count34
Formal Charge0
Complexity718
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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Looking for 802539-81-7 / Milciclib API manufacturers, exporters & distributors?

Milciclib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Milciclib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Milciclib manufacturer or Milciclib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Milciclib manufacturer or Milciclib supplier.

PharmaCompass also assists you with knowing the Milciclib API Price utilized in the formulation of products. Milciclib API Price is not always fixed or binding as the Milciclib Price is obtained through a variety of data sources. The Milciclib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Milciclib

Synonyms

Pha-848125, 802539-81-7, Pha 848125, Milciclib [inn], Milciclib (pha-848125), Pha848125

Cas Number

802539-81-7

Unique Ingredient Identifier (UNII)

688000M8S8

About Milciclib

Milciclib is an orally bioavailable inhibitor of cyclin-dependent kinases (CDKs) and tropomyosin receptor kinase A (TRKA), with potential antineoplastic activity. CDK2/TRKA inhibitor PHA-848125 AC potently inhibits cyclin-dependent kinase 2 (CDK2) and exhibits activity against other CDKs including CDK1 and CDK4, in addition to TRKA. Inhibition of these kinases may result in cell cycle arrest and apoptosis of tumor cells that express these kinases. CDKs are serine/threonine kinases involved in regulation of the cell cycle and may be overexpressed in some cancer cell types. The neurotrophin receptor TRKA is mutated in a variety of cancer cell types.

Milciclib Manufacturers

A Milciclib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Milciclib, including repackagers and relabelers. The FDA regulates Milciclib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Milciclib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Milciclib Suppliers

A Milciclib supplier is an individual or a company that provides Milciclib active pharmaceutical ingredient (API) or Milciclib finished formulations upon request. The Milciclib suppliers may include Milciclib API manufacturers, exporters, distributors and traders.

Milciclib GMP

Milciclib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Milciclib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Milciclib GMP manufacturer or Milciclib GMP API supplier for your needs.

Milciclib CoA

A Milciclib CoA (Certificate of Analysis) is a formal document that attests to Milciclib's compliance with Milciclib specifications and serves as a tool for batch-level quality control.

Milciclib CoA mostly includes findings from lab analyses of a specific batch. For each Milciclib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Milciclib may be tested according to a variety of international standards, such as European Pharmacopoeia (Milciclib EP), Milciclib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Milciclib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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