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Chemistry

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Also known as: 92623-85-3, Dextromilnacipran, Levomilnacipran, 96847-55-1, Milnacipranum [latin], Toledomin
Molecular Formula
C15H22N2O
Molecular Weight
246.35  g/mol
InChI Key
GJJFMKBJSRMPLA-HIFRSBDPSA-N
FDA UNII
G56VK1HF36

Milnacipran
A cyclopropanecarboxamide serotonin and norepinephrine reuptake inhibitor (SNRI) that is used in the treatment of FIBROMYALGIA.
Milnacipran is a Serotonin and Norepinephrine Reuptake Inhibitor. The mechanism of action of milnacipran is as a Norepinephrine Uptake Inhibitor, and Serotonin Uptake Inhibitor.
1 2D Structure

Milnacipran

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide
2.1.2 InChI
InChI=1S/C15H22N2O/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12/h5-9,13H,3-4,10-11,16H2,1-2H3/t13-,15+/m1/s1
2.1.3 InChI Key
GJJFMKBJSRMPLA-HIFRSBDPSA-N
2.1.4 Canonical SMILES
CCN(CC)C(=O)C1(CC1CN)C2=CC=CC=C2
2.1.5 Isomeric SMILES
CCN(CC)C(=O)[C@@]1(C[C@@H]1CN)C2=CC=CC=C2
2.2 Other Identifiers
2.2.1 UNII
G56VK1HF36
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1 Phenyl 1 Diethylaminocarbonyl 2 Aminomethylcyclopropane Hcl

2. 1-phenyl-1-diethylaminocarbonyl-2-aminomethylcyclopropane Hcl

3. F 2207

4. F-2207

5. F2207

6. Ixel

7. Midalcipran

8. Milnacipran Hydrochloride

9. Savella

2.3.2 Depositor-Supplied Synonyms

1. 92623-85-3

2. Dextromilnacipran

3. Levomilnacipran

4. 96847-55-1

5. Milnacipranum [latin]

6. Toledomin

7. Milnacipran [inn]

8. Ixel

9. (1r,2s)-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropane-1-carboxamide

10. Es1o38j3c4

11. G56vk1hf36

12. F2696

13. Milnacipran (inn)

14. (+-)-milnacipran

15. (1r,2s)-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropanecarboxamide

16. Impulsor

17. F2207

18. Milnacipranum

19. Milnace

20. (1r,2s)-2-(aminomethyl)-n,n-diethyl-1-phenyl-cyclopropane-1-carboxamide

21. Cyclopropanecarboxamide, 2-(aminomethyl)-n,n-diethyl-1-phenyl-,(1r,2s)-rel-

22. (-)-milnacipran

23. Milnacipran [inn:ban]

24. Unii-es1o38j3c4

25. Unii-g56vk1hf36

26. (?)-milnacipran

27. Milnacipran [mi]

28. Cyclopropanecarboxamide, 2-(aminomethyl)-n,n-diethyl-1-phenyl-, Cis-(+-)-

29. Milnacipran [vandf]

30. Schembl8099

31. Milnacipran [who-dd]

32. (1r,2s)-milnacipran

33. Milnacipran [ema Epar]

34. Chembl252923

35. Dtxsid3048287

36. Bdbm86420

37. Chebi:94468

38. Zinc14037

39. Dtxsid601025164

40. Hy-b0168

41. (+-)-cis-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropanecarboxamide

42. Ncgc00165825-01

43. Hy-14794

44. Milnacipran Pierre Fabre Medicament

45. Cas_92623-85-3

46. Cs-0003566

47. C16729

48. D08222

49. F-2696

50. Ab00640027_06

51. 623m853

52. Q421058

53. (1rs,2sr)-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropanecarboxamide

54. Cyclopropanecarboxamide, 2-(aminomethyl)-n,n-diethyl-1-phenyl-, (1r,2s)-

55. Cyclopropanecarboxamide, 2-(aminomethyl)-n,n-diethyl-1-phenyl-, (1r,2s)-rel-

56. Cyclopropanecarboxamide, 2-(aminomethyl)-n,n-diethyl-1-phenyl-, (1r-cis)-

57. F0f

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 246.35 g/mol
Molecular Formula C15H22N2O
XLogP31.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count5
Exact Mass246.173213330 g/mol
Monoisotopic Mass246.173213330 g/mol
Topological Polar Surface Area46.3 Ų
Heavy Atom Count18
Formal Charge0
Complexity295
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameSavella
PubMed HealthMilnacipran (By mouth)
Drug ClassesCentral Nervous System Agent
Drug LabelMilnacipran hydrochloride is a selective norepinephrine and serotonin reuptake inhibitor; it inhibits norepinephrine uptake with greater potency than serotonin. It is a racemic mixture with the chemical name: ()-[1R(S),2S(R)]-2-(aminomethyl)-N,N-di...
Active IngredientMilnacipran hydrochloride
Dosage FormTablet
RouteOral
Strength25mg; 100mg; 50mg; 12.5mg
Market StatusPrescription
CompanyCypress Bioscience

2 of 2  
Drug NameSavella
PubMed HealthMilnacipran (By mouth)
Drug ClassesCentral Nervous System Agent
Drug LabelMilnacipran hydrochloride is a selective norepinephrine and serotonin reuptake inhibitor; it inhibits norepinephrine uptake with greater potency than serotonin. It is a racemic mixture with the chemical name: ()-[1R(S),2S(R)]-2-(aminomethyl)-N,N-di...
Active IngredientMilnacipran hydrochloride
Dosage FormTablet
RouteOral
Strength25mg; 100mg; 50mg; 12.5mg
Market StatusPrescription
CompanyCypress Bioscience

4.2 Drug Indication

Treatment of stroke


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Analgesics, Non-Narcotic

A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS. (See all compounds classified as Analgesics, Non-Narcotic.)


Serotonin and Noradrenaline Reuptake Inhibitors

Drugs that selectively block or suppress the plasma membrane transport of SEROTONIN and NORADRENALINE into axon terminals and are used as ANTIDEPRESSIVE AGENTS. (See all compounds classified as Serotonin and Noradrenaline Reuptake Inhibitors.)


5.2 FDA Pharmacological Classification
5.2.1 Active Moiety
MILNACIPRAN
5.2.2 FDA UNII
G56VK1HF36
5.2.3 Pharmacological Classes
Serotonin Uptake Inhibitors [MoA]; Serotonin and Norepinephrine Reuptake Inhibitor [EPC]; Norepinephrine Uptake Inhibitors [MoA]
5.3 ATC Code

N06AX17

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


N - Nervous system

N06 - Psychoanaleptics

N06A - Antidepressants

N06AX - Other antidepressants

N06AX17 - Milnacipran


N - Nervous system

N06 - Psychoanaleptics

N06A - Antidepressants

N06AX - Other antidepressants

N06AX28 - Levomilnacipran


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Milnacipran

About the Company : HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It...

HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It offers services such as sourcing, manufacturing & supply, helping partners enter new markets worldwide. Its strong partnerships with major players in the pharma and food additive industries help HRV Global effectively promote projects and products. HRV Global represents over 30 large Indian drugmakers, primarily targeting Europe, the US & the Middle East markets. Headquartered in India, HRV Global has offices in the US, Switzerland, Dubai, Lithuania & Turkey.
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Milnacipran

About the Company : We are a Pharmaceutical Company aligned across two business verticals viz. Products and Services. Our Products business comprises manufacture and sale of APIs and Intermediates to ...

We are a Pharmaceutical Company aligned across two business verticals viz. Products and Services. Our Products business comprises manufacture and sale of APIs and Intermediates to innovator and generic pharmaceutical players in both Domestic and International markets including the regulated markets.
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Milnacipran

About the Company : Aspire group was established in the year 2000 with a motto of quality drug for better health of all. In its journey till date, aspire has developed enormous reputation, consistent ...

Aspire group was established in the year 2000 with a motto of quality drug for better health of all. In its journey till date, aspire has developed enormous reputation, consistent growth, unique technologies and world class quality healthcare products. Aspire is pioneer in manufacturing and sourcing unique healthcare products. True to the statement, “Where the future started yesterday” with a foresight on the current trends in the healthcare market, Aspire has grown from strength combining its research strength, Human resources and well established quality systems. Aspire has crossed numerous milestones in a comparatively short period since its inception.
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Milnacipran

About the Company : We commit to be a customer focused business and acknowledge that to be successful we have to make the opportunity offered by our clients work for them and for the future prosperity...

We commit to be a customer focused business and acknowledge that to be successful we have to make the opportunity offered by our clients work for them and for the future prosperity of JRC. The opportunity within JRC is to promote an open environment to explore knowledge, share thoughts in a transparent manner and maintain our commitments to all the stakeholders at large. JRC’s strength over 5 years is in science and technology that includes synthetic organic chemistry, process research, and scale-up from laboratory to commercial-scale along with quality and regulatory support.
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AP","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1711477800,"product":"ACTIVE PHARMACEUTICALS INGREDIENTS (API)EXPORT INVOICE NUMBER:F32418005212 DT.23.03.2024 MILNACIPRAN HYDROCHLORIDE","address":"PLOT 170-172, CHANDRAMOULI,INDUSTR","city":"SOLAPUR,MAHARASHTRA","supplier":"GLENMARK PHARMACEUTICALS","supplierCountry":"INDIA","foreign_port":"OSAKA - KANSAI INT\\'L","customer":"TO THE ORDER","customerCountry":"JAPAN","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"1350","totalValueFC":"133015","currency":"USD","unitRateINR":110450.03779999999,"date":"27-Mar-2024","totalValueINR":"11045003.78","totalValueInUsd":"133015","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"8681002","productDescription":"API","marketType":"REGULATED MARKET","country":"JAPAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"PLOT 170-172, CHANDRAMOULI,INDUSTR, SOLAPUR,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1711477800,"product":"ACTIVE PHARMACEUTICALS INGREDIENTS (API)EXPORT INVOICE NUMBER:F32418005234 DT.26.03.2024 MILNACIPRAN HYDROCHLORIDE","address":"PLOT 170-172, CHANDRAMOULI,INDUSTR","city":"SOLAPUR,MAHARASHTRA","supplier":"GLENMARK PHARMACEUTICALS","supplierCountry":"INDIA","foreign_port":"TOKYO - NARITA","customer":"TO THE ORDER","customerCountry":"JAPAN","quantity":"0.75","actualQuantity":"0.75","unit":"KGS","unitRateFc":"1200","totalValueFC":"775.5","currency":"USD","unitRateINR":85853.653333333335,"date":"27-Mar-2024","totalValueINR":"64390.24","totalValueInUsd":"775.5","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"8680999","productDescription":"API","marketType":"REGULATED MARKET","country":"JAPAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"PLOT 170-172, CHANDRAMOULI,INDUSTR, SOLAPUR,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1719858600,"product":"MILNACIPRAN HYDROCHLORIDE IH","address":"HETERO CORPORATE, NO. 7-2-A2,","city":"HYDERABAD","supplier":"HETERO DRUGS","supplierCountry":"INDIA","foreign_port":"TAIPEI","customer":"TO THE ORDER OF","customerCountry":"TAIWAN","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"1100","totalValueFC":"106923.9","currency":"USD","unitRateINR":89378.867299999998,"date":"02-Jul-2024","totalValueINR":"8937886.73","totalValueInUsd":"106923.9","indian_port":"Hyderabad Air","hs_no":"29420090","bill_no":"2109872","productDescription":"API","marketType":"REGULATED MARKET","country":"TAIWAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"HETERO CORPORATE, NO. 7-2-A2,, HYDERABAD","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1726425000,"product":"MILNACIPRAN HYDROCHLORIDE IH","address":"HETERO HOUSE,H.NO.8-3-166\/7\/1ERRAGADDA","city":"HYDERABAD","supplier":"HETERO DRUGS","supplierCountry":"INDIA","foreign_port":"SEOUL - INCHEON INT\\'","customer":"MYUNG IN PHARM ","customerCountry":"REPUBLIC OF KOREA","quantity":"4.00","actualQuantity":"4","unit":"KGS","unitRateFc":"1500","totalValueFC":"5607.8","currency":"USD","unitRateINR":117484.22749999999,"date":"16-Sep-2024","totalValueINR":"469936.91","totalValueInUsd":"5607.8","indian_port":"Hyderabad Air","hs_no":"29420090","bill_no":"4035495","productDescription":"API","marketType":"REGULATED MARKET","country":"REPUBLIC OF KOREA","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"HETERO HOUSE,H.NO.8-3-166\/7\/1ERRAGADDA, HYDERABAD","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727375400,"product":"ACTIVE PHARMACEUTICALS INGREDIENTS (API) EXPORT INVOICE NUMBER : F32518002415 DT. 25.09.2024 MILNACIPRAN HYDROCHLORIDE","address":"PLOT 170-172, CHANDRAMOULI,INDUSTR","city":"SOLAPUR,MAHARASHTRA","supplier":"GLENMARK PHARMACEUTICALS","supplierCountry":"INDIA","foreign_port":"SEOUL - INCHEON INT\\'","customer":"TO THE ORDER","customerCountry":"REPUBLIC OF KOREA","quantity":"23.00","actualQuantity":"23","unit":"KGS","unitRateFc":"1600","totalValueFC":"36262.9","currency":"USD","unitRateINR":132125.04347826086,"date":"27-Sep-2024","totalValueINR":"3038876","totalValueInUsd":"36262.9","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"4402188","productDescription":"API","marketType":"REGULATED MARKET","country":"REPUBLIC OF KOREA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"PLOT 170-172, CHANDRAMOULI,INDUSTR, SOLAPUR,MAHARASHTRA","customerAddress":""}]
28-Jan-2021
27-Sep-2024
KGS
overview
Loading...

Average Price (USD/KGS)

1.1k

Number of Transactions

11 - 50

Total Quantity (KGS)

1.2k

Total Value (USD)

1.4M

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
(KGS)
Average Price
(USD/KGS)
Number of Transactions
JAPAN501.111,327.5<10
CANADA112.901,515.3<10
CHINA37.00878.2<10
VIETNAM, DEMOCRATIC REP. OF26.50367.9<10
EGYPT90.00476.1<10
GERMANY301.26787.1<10
REPUBLIC OF KOREA27.001,550.8<10
HONG KONG2.001,435.0<10
SWITZERLAND38.00981.0<10

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REF. STANDARDS & IMPURITIES

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USP

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01

USP

U.S.A
arrow
CPHI Middle east
Not Confirmed

Others

read-more
read-more

01

CPHI Middle east
Not Confirmed

02

USP

U.S.A
arrow
CPHI Middle east
Not Confirmed

USP

U.S.A
arrow
CPHI Middle east
Not Confirmed

Milnacipran Related Compound C (25 mg) ((1RS ...

CAS Number : 105310-75-6

Quantity Per Vial : 25

Sale Unit : mg

Price : $730.00

Details : Material Origin- Chemical Synthesis; USMCA- N...

Monograph :

Storage :

Code/Batch No : Catalog #1443680 / F075R0

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03

USP

U.S.A
arrow
CPHI Middle east
Not Confirmed

USP

U.S.A
arrow
CPHI Middle east
Not Confirmed

Milnacipran Related Compound B (25 mg) (1-Phe...

CAS Number : 153275-06-0

Quantity Per Vial : 25

Sale Unit : mg

Price : $730.00

Details : Material Origin- Chemical Synthesis; USMCA- N...

Monograph :

Storage :

Code/Batch No : Catalog #1443679 / F075Q0

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04

USP

U.S.A
arrow
CPHI Middle east
Not Confirmed

USP

U.S.A
arrow
CPHI Middle east
Not Confirmed

Milnacipran Related Compound A (25 mg) (2-(Am...

CAS Number : 871100-19-5 (free base)

Quantity Per Vial : 25

Sale Unit : mg

Price : $730.00

Details : Material Origin- Chemical Synthesis; USMCA- N...

Monograph :

Storage :

Code/Batch No : Catalog #1443668 / F075P0

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