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ACTIVE PHARMA INGREDIENTS

23 API Suppliers, 15 USDMF, 5 JDMF, 7 EU WC, 1 KDMF, 6 NDC API, 8 Listed Suppliers, $ API Reference Price

23 API Suppliers
15 USDMF
5 JDMF
7 EU WC
1 KDMF
6 NDC API
8 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

35 FDF Dossiers, 35 FDA Orange Book

35 FDF Dossiers
35 FDA Orange Book

DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - 100MG, TABLET;ORAL - 12.5MG, TABLET;ORAL - 25MG, TABLET;ORAL - 50MG

drugProductComposition
TABLET;ORAL - 100MG
TABLET;ORAL - 12.5MG
TABLET;ORAL - 25MG
TABLET;ORAL - 50MG

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2 Seqens, 3 DKSH, 2 Faran Shimi Pharmaceutical, 1 Boai NKY Pharmaceuticals Ltd, 2 Gangwal Healthcare, 1 Nanjing Well Pharmaceutical, 1 ACG Worldwide, 3 Actylis, 1 Aeon Procare, 3 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 18 BASF, 1 Clariant, 10 Corel Pharma Chem, 1 Finar, 6 Gangwal Chemicals, 6 Ideal Cures Pvt Ltd, 14 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 7 Microlex e.U, 2 Nomisma Healthcare, 3 Novo Excipients, 1 Pharmatrans-Sanaq, 2 Pluviaendo, 2 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 2 Roquette, 6 Seppic, 2 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 2 Sigachi Industries, 2 The Dow Chemical Company, 1 Vasa Pharmachem

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GLOBAL SALES INFORMATION

4 Finished Drug Prices

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4 Finished Drug Prices

PATENTS & EXCLUSIVITIES

4 US Patents

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4 US Patents

REF. STANDARDS & IMPURITIES

1 USP , 1 Others

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1 USP
1 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

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API REF. PRICE (USD/KG)

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Finished Drug Prices

118 RELATED EXCIPIENT COMPANIES

201EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Milnacipran hcl, Dalcipran, 101152-94-7, Savella, Toledomin, (1r-cis)-milnacipran hydrochloride

Molecular Formula

C₁₅H₂₃ClN₂O

Molecular Weight

282.81 g/mol

InChI Key

XNCDYJFPRPDERF-PBCQUBLHSA-N

FDA UNII

RNZ43O5WW5

A cyclopropanecarboxamide serotonin and norepinephrine reuptake inhibitor (SNRI) that is used in the treatment of FIBROMYALGIA.

1 2D Structure

Milnacipran Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide;hydrochloride

2.1.2 InChI

InChI=1S/C15H22N2O.ClH/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12;/h5-9,13H,3-4,10-11,16H2,1-2H3;1H/t13-,15+;/m1./s1

2.1.3 InChI Key

XNCDYJFPRPDERF-PBCQUBLHSA-N

2.1.4 Canonical SMILES

CCN(CC)C(=O)C1(CC1CN)C2=CC=CC=C2.Cl

2.1.5 Isomeric SMILES

CCN(CC)C(=O)[C@@]1(C[C@@H]1CN)C2=CC=CC=C2.Cl

2.2 Other Identifiers

2.2.1 UNII

RNZ43O5WW5

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 1 Phenyl 1 Diethylaminocarbonyl 2 Aminomethylcyclopropane Hcl

2. 1-phenyl-1-diethylaminocarbonyl-2-aminomethylcyclopropane Hcl

3. F 2207

4. F-2207

5. F2207

6. Ixel

7. Midalcipran

8. Milnacipran

9. Savella

2.3.2 Depositor-Supplied Synonyms

1. Milnacipran Hcl

2. Dalcipran

3. 101152-94-7

4. Savella

5. Toledomin

6. (1r-cis)-milnacipran Hydrochloride

7. Ixel

8. 175131-61-0

9. Milnacipran (hydrochloride)

10. F 2207

11. Milnacipran Hydrochloride [usan]

12. Rnz43o5ww5

13. Cyclopropanecarboxamide, 2-(aminomethyl)-n,n-diethyl-1-phenyl-, Monohydrochloride, (1r,2s)-rel-

14. Cis-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropanecarboxamide Hydrochloride

15. Z-2 Aminomethyl-1-phenyl-n,n-diethylcyclopropane-carboxamide Hydrochloride

16. (1rs,2sr)-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropanecarboxamide Hydrochloride

17. Smr000449266

18. Midalcipran Hydrochloride

19. Rac-milnacipran Hydrochloride

20. Unii-rnz43o5ww5

21. F2207

22. Toledomin (tn)

23. Savella (tn)

24. Ncgc00168780-01

25. 1-phenyl-1-(diethylaminocarbonyl)-2-(aminomethyl)cyclopropane Hydrochloride

26. Cis-(+-)-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropanecarboxamide Monohydrochloride

27. Dsstox_cid_26785

28. Dsstox_rid_81903

29. Dsstox_gsid_46785

30. Mls000758229

31. Mls001424149

32. Schembl161558

33. Chembl1237129

34. Dtxsid4046785

35. Chebi:31854

36. Hy-b0168a

37. Amy22199

38. Bcp05817

39. Tox21_112641

40. S3140

41. Milnacipran Hydrochloride (jan/usan)

42. Milnacipran Hydrochloride [mi]

43. Akos015950801

44. Ccg-101034

45. Cs-2010

46. Ks-1274

47. Milnacipran Hydrochloride [jan]

48. Nc00284

49. Nsc 759806

50. (1r,2s)-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropanecarboxamide Hydrochloride

51. (1r,2s)-rel-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropanecarboxamide Monohydrochloride

52. Cyclopropanecarboxamide, 2-(aminomethyl)-n,n-diethyl-1-phenyl-, Monohydrochloride, Cis-(+-)-

53. Milnacipran Hydrochloride [mart.]

54. Milnacipran Hydrochloride [vandf]

55. Cyclopropanecarboxamide, 2-(aminomethyl)-n,n-diethyl-1-phenyl-, Hydrochloride (1:1), (1r,2s)-rel-

56. Milnacipran Hydrochloride [usp-rs]

57. Milnacipran Hydrochloride [who-dd]

58. Cas-101152-94-7

59. Sw197664-2

60. D01107

61. Milnacipran Hydrochloride [orange Book]

62. Milnacipran Hydrochloride, >=98% (hplc), Solid

63. J-011063

64. Q27288221

65. Milnacipran Hydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₅H₂₃ClN₂O
Molecular Weight	282.81 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	5
Exact Mass	282.1498911 g/mol
Monoisotopic Mass	282.1498911 g/mol
Topological Polar Surface Area	46.3 Å²
Heavy Atom Count	19
Formal Charge	0
Complexity	295
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Savella
PubMed Health	Milnacipran (By mouth)
Drug Classes	Central Nervous System Agent
Drug Label	Milnacipran hydrochloride is a selective norepinephrine and serotonin reuptake inhibitor; it inhibits norepinephrine uptake with greater potency than serotonin. It is a racemic mixture with the chemical name: ()-[1R(S),2S(R)]-2-(aminomethyl)-N,N-di...
Active Ingredient	Milnacipran hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	25mg; 100mg; 50mg; 12.5mg
Market Status	Prescription
Company	Cypress Bioscience

2 of 2
Drug Name	Savella
PubMed Health	Milnacipran (By mouth)
Drug Classes	Central Nervous System Agent
Drug Label	Milnacipran hydrochloride is a selective norepinephrine and serotonin reuptake inhibitor; it inhibits norepinephrine uptake with greater potency than serotonin. It is a racemic mixture with the chemical name: ()-[1R(S),2S(R)]-2-(aminomethyl)-N,N-di...
Active Ingredient	Milnacipran hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	25mg; 100mg; 50mg; 12.5mg
Market Status	Prescription
Company	Cypress Bioscience

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Analgesics, Non-Narcotic

A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS. (See all compounds classified as Analgesics, Non-Narcotic.)

Serotonin and Noradrenaline Reuptake Inhibitors

Drugs that selectively block or suppress the plasma membrane transport of SEROTONIN and NORADRENALINE into axon terminals and are used as ANTIDEPRESSIVE AGENTS. (See all compounds classified as Serotonin and Noradrenaline Reuptake Inhibitors.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Serotonin Uptake Inhibitors [MoA]; Serotonin and Norepinephrine Reuptake Inhibitor [EPC]; Norepinephrine Uptake Inhibitors [MoA]

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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DOSAGE - TABLET;ORAL - 100MG

USFDA APPLICATION NUMBER - 22256

DOSAGE - TABLET;ORAL - 12.5MG

USFDA APPLICATION NUMBER - 22256

DOSAGE - TABLET;ORAL - 25MG

USFDA APPLICATION NUMBER - 22256

DOSAGE - TABLET;ORAL - 50MG

USFDA APPLICATION NUMBER - 22256

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Milnacipran Hydrochloride

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

23 API Suppliers

15 USDMF

5 JDMF

7 EU WC

1 KDMF

6 NDC API

8 Listed Suppliers

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FINISHED DOSAGE FORMULATIONS

35 FDF Dossiers

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DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - 100MG

TABLET;ORAL - 12.5MG

TABLET;ORAL - 25MG

TABLET;ORAL - 50MG

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EXCIPIENTS BY APPLICATIONS

50 Coating Systems & Additives

28 Controlled & Modified Release

18 Fillers, Diluents & Binders

12 Lubricants & Glidants

11 Solubilizers

9 Film Formers & Plasticizers

9 Topical

9 Thickeners and Stabilizers

8 Granulation

7 Direct Compression

6 Parenteral

5 Empty Capsules

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4 Disintegrants & Superdisintegrants

4 Vegetarian Capsules

4 Coloring Agents

4 Emulsifying Agents

2 Co-Processed Excipients

2 Taste Masking

2 Rheology Modifiers

1 Surfactant & Foaming Agents

1 Chewable & Orodispersible Aids