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Milrinone

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ACTIVE PHARMA INGREDIENTS

22 API Suppliers, 10 USDMF, 3 JDMF, 5 NDC API, 14 Listed Suppliers, $ API Reference Price

22 API Suppliers
10 USDMF
3 JDMF
5 NDC API
14 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

3 Drugs in Development

3 Drugs in Development

INTERMEDIATES

1 Intermediates Suppliers

1 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

50 FDF Dossiers, 40 FDA Orange Book, 2 Europe, 2 Canada, 6 Listed Dossiers

50 FDF Dossiers
40 FDA Orange Book
2 Europe
2 Canada
6 Listed Dossiers

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EXCIPIENTS BY APPLICATIONS

2 Parenteral, 2 Fillers, Diluents & Binders

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2 Fillers, Diluents & Binders

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14 NEWS #PharmaBuzz

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GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions

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1 US Medicaid Prescriptions

MARKET PLACE

11 APIs, 4 FDF Dossiers

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11 APIs
4 FDF Dossiers

REF. STANDARDS & IMPURITIES

2 USP , 4 Others

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2 USP
4 Others

Chemwerth Milrinone

Synopsis

ACTIVE PHARMA INGREDIENTS

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USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

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API REF. PRICE (USD/KG)

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FDF

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FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

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REF. STANDARDS OR IMPURITIES

EDQM

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Others

PATENTS & EXCLUSIVITIES

US Patents

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GLOBAL SALES INFORMATION

US Medicaid (USD)

1,031,364

Annual Reports (USD Million)

Finished Drug Prices

4EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 100286-97-3, 9k8xr81mo8, 6-methyl-2-oxo-5-pyridin-4-yl-1h-pyridine-3-carbonitrile lactate, 2-hydroxypropanoic acid;6-methyl-2-oxo-5-pyridin-4-yl-1h-pyridine-3-carbonitrile, Chebi:34850, Unii-9k8xr81mo8

Molecular Formula

C₁₅H₁₅N₃O₄

Molecular Weight

301.30 g/mol

InChI Key

VWUPWEAFIOQCGF-UHFFFAOYSA-N

FDA UNII

9K8XR81MO8

A positive inotropic cardiotonic agent with vasodilator properties. It inhibits cAMP phosphodiesterase type 3 activity in myocardium and vascular smooth muscle. Milrinone is a derivative of amrinone and has 20-30 times the inotropic potency of amrinone.

1 2D Structure

Milrinone

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-hydroxypropanoic acid;6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile

2.1.2 InChI

InChI=1S/C12H9N3O.C3H6O3/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8;1-2(4)3(5)6/h2-6H,1H3,(H,15,16);2,4H,1H3,(H,5,6)

2.1.3 InChI Key

VWUPWEAFIOQCGF-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2.CC(C(=O)O)O

2.2 Other Identifiers

2.2.1 UNII

9K8XR81MO8

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Corotrop

2. Corotrope

3. Lactate, Milrinone

4. Milrinone

5. Primacor

6. Win 47203

7. Win-47203

8. Win47203

2.3.2 Depositor-Supplied Synonyms

1. 100286-97-3

2. 9k8xr81mo8

3. 6-methyl-2-oxo-5-pyridin-4-yl-1h-pyridine-3-carbonitrile Lactate

4. 2-hydroxypropanoic Acid;6-methyl-2-oxo-5-pyridin-4-yl-1h-pyridine-3-carbonitrile

5. Chebi:34850

6. Unii-9k8xr81mo8

7. Milrinonelactate

8. Milrinone Lactose In 5% Dextrose

9. Primacor (tn)

10. Primacor In Dextrose 5% In Plastic Container

11. Milrinone Lactate [mi]

12. Milrinone Lactate In 5% Dextrose In Plastic Container

13. Chembl1200977

14. Milrinone Lactate [vandf]

15. Milrinone Lactate [mart.]

16. Milrinone Lactate In Dextrose 5% In Plastic Container

17. Milrinone Lactate [who-dd]

18. Akos015917733

19. Milrinone Lactate [orange Book]

20. 1,6-dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile, Compd. With 2-hydroxypropionic Acid

21. Ls-14389

22. Ft-0739660

23. D02085

24. 286m973

25. A897507

26. Q27116295

27. 2-[(4-chlorobenzyl)sulfanyl]benzenecarboxylicacid

28. 1,6-dihydro-2-methyl-6-oxo[3,4'-bipyridine]-5-carbonitrile Lactate

29. 2-hydroxypropanoic Acid,6-methyl-2-oxo-5-pyridin-4-yl-1h-pyridine-3-carbonitrile

30. 6-methyl-2-oxo-5-pyridin-4-yl-1h-pyridine-3-carbonitrile 2-hydroxypropanoic Acid

31. Hydron;2-hydroxypropanoate;6-methyl-2-oxo-5-pyridin-4-yl-1h-pyridine-3-carbonitrile

32. Propanoic Acid, 2-hydroxy-, Compd. With 1,6-dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₅H₁₅N₃O₄
Molecular Weight	301.30 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	301.10625597 g/mol
Monoisotopic Mass	301.10625597 g/mol
Topological Polar Surface Area	123 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	478
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Milrinone lactate
Drug Label	Milrinone Lactate Injection is a member of a new class of bipyridine inotropic/vasodilator agents with phosphodiesterase inhibitor activity, distinct from digitalis glycosides or catecholamines. Milrinone lactate is designated chemically as 1,6-Dihyd...
Active Ingredient	Milrinone lactate
Dosage Form	Injectable
Route	injection; Injection
Strength	20mg/20ml; eq 1mg base/ml; eq 20mg /20ml (1mg/ml); eq 50mg /50ml (1mg/ml)
Market Status	Prescription
Company	Bedford; Hospira; Gland Pharma; Apotex; Hikma Farmaceutica; Fresenius Kabi Usa; Hikma Maple; Intl Medicated

2 of 2
Drug Name	Milrinone lactate
Drug Label	Milrinone Lactate Injection is a member of a new class of bipyridine inotropic/vasodilator agents with phosphodiesterase inhibitor activity, distinct from digitalis glycosides or catecholamines. Milrinone lactate is designated chemically as 1,6-Dihyd...
Active Ingredient	Milrinone lactate
Dosage Form	Injectable
Route	injection; Injection
Strength	20mg/20ml; eq 1mg base/ml; eq 20mg /20ml (1mg/ml); eq 50mg /50ml (1mg/ml)
Market Status	Prescription
Company	Bedford; Hospira; Gland Pharma; Apotex; Hikma Farmaceutica; Fresenius Kabi Usa; Hikma Maple; Intl Medicated

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Cardiotonic Agents

Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE). (See all compounds classified as Cardiotonic Agents.)

Phosphodiesterase 3 Inhibitors

Compounds that specifically inhibit PHOSPHODIESTERASE 3. (See all compounds classified as Phosphodiesterase 3 Inhibitors.)

Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

Platelet Aggregation Inhibitors

Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (See all compounds classified as Platelet Aggregation Inhibitors.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Phosphodiesterase 3 Inhibitors [MoA]; Phosphodiesterase 3 Inhibitor [EPC]

API SUPPLIERS

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USDMF

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JDMF

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NDC API

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API Reference Price

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