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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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API Suppliers

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USDMF

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CEP/COS

CEP/COS Certifications

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JDMF

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NDC API

NDC API

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NDC API

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REF. STANDARDS OR IMPURITIES

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Chemistry

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Also known as: 1802425-99-5, Milvexian [usan], Bms-986177, Jnj-70033093, 0w79ndq608, Milvexian (usan)
Molecular Formula
C28H23Cl2F2N9O2
Molecular Weight
626.4  g/mol
InChI Key
FSWFYCYPTDLKON-CMJOXMDJSA-N
FDA UNII
0W79NDQ608

Milvexian
Milvexian is under investigation in clinical trial NCT03766581 (A Study on BMS-986177 for the Prevention of a Stroke in Patients Receiving Aspirin and Clopidogrel).
1 2D Structure

Milvexian

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(9R,13S)-13-[4-[5-chloro-2-(4-chlorotriazol-1-yl)phenyl]-6-oxopyrimidin-1-yl]-3-(difluoromethyl)-9-methyl-3,4,7,15-tetrazatricyclo[12.3.1.02,6]octadeca-1(18),2(6),4,14,16-pentaen-8-one
2.1.2 InChI
InChI=1S/C28H23Cl2F2N9O2/c1-15-3-2-4-23(20-9-16(7-8-33-20)26-21(36-27(15)43)12-35-41(26)28(31)32)39-14-34-19(11-25(39)42)18-10-17(29)5-6-22(18)40-13-24(30)37-38-40/h5-15,23,28H,2-4H2,1H3,(H,36,43)/t15-,23+/m1/s1
2.1.3 InChI Key
FSWFYCYPTDLKON-CMJOXMDJSA-N
2.1.4 Canonical SMILES
CC1CCCC(C2=NC=CC(=C2)C3=C(C=NN3C(F)F)NC1=O)N4C=NC(=CC4=O)C5=C(C=CC(=C5)Cl)N6C=C(N=N6)Cl
2.1.5 Isomeric SMILES
C[C@@H]1CCC[C@@H](C2=NC=CC(=C2)C3=C(C=NN3C(F)F)NC1=O)N4C=NC(=CC4=O)C5=C(C=CC(=C5)Cl)N6C=C(N=N6)Cl
2.2 Other Identifiers
2.2.1 UNII
0W79NDQ608
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (9r,13s)-13-(4-(5-chloro-2-(4-chlorotriazol-1-yl)phenyl)-6-oxopyrimidin-1-yl)-3-(difluoromethyl)-9-methyl-3,4,7,15-tetrazatricyclo(12.3.1.02,6)octadeca-1(18),2(6),4,14,16-pentaen-8-one

2. Bms-986177

3. Jnj-70033093

2.3.2 Depositor-Supplied Synonyms

1. 1802425-99-5

2. Milvexian [usan]

3. Bms-986177

4. Jnj-70033093

5. 0w79ndq608

6. Milvexian (usan)

7. Bms 986177

8. (5r,9s)-9-(4-(5-chloro-2-(4-chloro-1h-1,2,3-triazol-1-yl)phenyl)-6-oxopyrimidin-1(6h)-yl)-21-(difluoromethyl)-5-methyl-21h-3-aza-1(4,2)-pyridina-2(5,4)-pyrazolacyclonaphan-4-one

9. (9r,13s)-13-[4-[5-chloro-2-(4-chlorotriazol-1-yl)phenyl]-6-oxopyrimidin-1-yl]-3-(difluoromethyl)-9-methyl-3,4,7,15-tetrazatricyclo[12.3.1.02,6]octadeca-1(18),2(6),4,14,16-pentaen-8-one

10. Milvexian [inn]

11. Unii-0w79ndq608

12. Chembl4112929

13. Schembl16982989

14. Gtpl11754

15. Ex-a6455

16. Bms986177

17. Who 11401

18. Jnj70033093

19. Compound 17 [pmid: 34494428]

20. Ac-36903

21. Hy-125856

22. Cs-0101887

23. D11802

24. (6r,10s)-10-{4-[5-chloro-2-(4-chloro-1h-1,2,3-triazol-1-yl)phenyl]-6-oxopyrimidin-1(6h)-yl}-1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-15,11-(metheno)pyrazolo[4,3-b][1,7]diazacyclotetradecin-5(6h)-one

25. (9r,13s)-13-{4-[5-chloro-2-(4-chloro-1h-1,2,3-triazol-1-yl)phenyl]-6-oxo-1,6-dihydropyrimidin-1-yl}-3-(difluoromethyl)-9-methyl-3,4,7,15-tetraazatricyclo[12.3.1.02,6]octadeca-1(18),2(6),4,14,16-pentaen-8-one

26. 11,15-metheno-15h-pyrazolo(4,3-b)(1,7)diazacyclotetradecin-5(6h)-one, 10-(4-(5-chloro-2-(4-chloro-1h-1,2,3-triazol-1-yl)phenyl)-6-oxo-1(6h)-pyrimidinyl)-1-(difluoromethyl)-1,4,7,8,9,10-hexahydro-6-methyl-, (6r,10s)-

27. 11,15-metheno-15h-pyrazolo(4,3-b)(1,7)diazacyclotetradecin-5(6h)-one, 10-(4-(5-chloro-2-(4-chloro-1h-1,2,3-triazol-1-yl)phenyl)-6-oxo-1(6h)-pyrimidinyl)-1-(difluoromethyl)-1,4,7,8,9,10-hexahydro-6-methyl-, (6r,10s)-2

28. Bms-986177; (6r,10s)-10-{4-[5-chloro-2-(4-chloro-1h-1,2,3-triazol-1-yl)phenyl]-6-oxopyrimidin-1(6h)-yl}-1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-15,11-(metheno)pyrazolo[4,3-b][1,7]diazacyclotetradecin-5(6h)-one

29. Yxg

2.4 Create Date
2016-02-23
3 Chemical and Physical Properties
Molecular Weight 626.4 g/mol
Molecular Formula C28H23Cl2F2N9O2
XLogP34
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count4
Exact Mass625.1319827 g/mol
Monoisotopic Mass625.1319827 g/mol
Topological Polar Surface Area123 Ų
Heavy Atom Count43
Formal Charge0
Complexity1100
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Milvexian Manufacturers

A Milvexian manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Milvexian, including repackagers and relabelers. The FDA regulates Milvexian manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Milvexian API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Milvexian Suppliers

A Milvexian supplier is an individual or a company that provides Milvexian active pharmaceutical ingredient (API) or Milvexian finished formulations upon request. The Milvexian suppliers may include Milvexian API manufacturers, exporters, distributors and traders.

Milvexian GMP

Milvexian Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Milvexian GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Milvexian GMP manufacturer or Milvexian GMP API supplier for your needs.

Milvexian CoA

A Milvexian CoA (Certificate of Analysis) is a formal document that attests to Milvexian's compliance with Milvexian specifications and serves as a tool for batch-level quality control.

Milvexian CoA mostly includes findings from lab analyses of a specific batch. For each Milvexian CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Milvexian may be tested according to a variety of international standards, such as European Pharmacopoeia (Milvexian EP), Milvexian JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Milvexian USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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