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Chemistry

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Also known as: Cantor, 25905-77-5, Minaprinum, Minaprina, Minaprinum [inn-latin], Minaprina [inn-spanish]
Molecular Formula
C17H22N4O
Molecular Weight
298.4  g/mol
InChI Key
LDMWSLGGVTVJPG-UHFFFAOYSA-N
FDA UNII
00U7GX0NLM

Minaprine
Minaprine is a psychotropic drug which has proved to be effective in the treatment of various depressive states. Like most antidepressants minaprine antagonizes behavioral despair. Minaprine is an amino-phenylpyridazine antidepressant reported to be relatively free of cardiotoxicity, drowsiness, and weight gain.
1 2D Structure

Minaprine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-methyl-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine
2.1.2 InChI
InChI=1S/C17H22N4O/c1-14-13-16(15-5-3-2-4-6-15)19-20-17(14)18-7-8-21-9-11-22-12-10-21/h2-6,13H,7-12H2,1H3,(H,18,20)
2.1.3 InChI Key
LDMWSLGGVTVJPG-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=CC(=NN=C1NCCN2CCOCC2)C3=CC=CC=C3
2.2 Other Identifiers
2.2.1 UNII
00U7GX0NLM
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3-(2-morpholino-ethylamino)-4-methyl-6-phenyl Pyridazine, Dihydrochloride

2. 3-(morpholinoethyl)amino-4-methyl-6-phenylpyridazine

3. Agr 1240

4. Cantor

5. Minaprine Dihydrochloride

6. Minaprine Hydrochloride

2.3.2 Depositor-Supplied Synonyms

1. Cantor

2. 25905-77-5

3. Minaprinum

4. Minaprina

5. Minaprinum [inn-latin]

6. Minaprina [inn-spanish]

7. Agr 1240

8. N-(4-methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine

9. 4-morpholineethanamine, N-(4-methyl-6-phenyl-3-pyridazinyl)-

10. 4-(2-((4-methyl-6-phenyl-3-pyridazinyl)amino)ethyl)morpholine

11. 4-methyl-3-(2-morpholinoethylamino)-6-phenylpyridazin

12. Agr-1240

13. 4-methyl-n-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine

14. 00u7gx0nlm

15. Cb-30038

16. 4-methyl-n-(2-morpholinoethyl)-6-phenylpyridazin-3-amine

17. Chembl278819

18. Chebi:51038

19. 25905-77-5 (free Base)

20. Brantur

21. 4-methyl-n-[2-(morpholin-4-yl)ethyl]-6-phenylpyridazin-3-amine

22. 4-[2-[(4-methyl-6-phenyl-3-pyridazinyl)amino]ethyl]morpholine

23. Minaprin Dihydrochloride

24. Chembl536932

25. Cantor (tn)

26. Cb 30038

27. Minaprine (usan/inn)

28. Einecs 247-329-8

29. Cas-25953-17-7

30. Unii-00u7gx0nlm

31. Minaprine [usan:inn:ban]

32. Spectrum_001334

33. Minaprine [inn]

34. Minaprine [mi]

35. Minaprine [usan]

36. Prestwick0_000066

37. Prestwick1_000066

38. Prestwick2_000066

39. Prestwick3_000066

40. Spectrum2_001407

41. Spectrum3_001445

42. Spectrum4_000418

43. Spectrum5_001593

44. Minaprine [who-dd]

45. Schembl49371

46. Bspbio_000251

47. Bspbio_002909

48. Kbiogr_000716

49. Kbioss_001814

50. Divk1c_000063

51. Spbio_001454

52. Spbio_002172

53. Bpbio1_000277

54. Dtxsid5048477

55. Kbio1_000063

56. Kbio2_001814

57. Kbio2_004382

58. Kbio2_006950

59. Kbio3_002409

60. Ninds_000063

61. Hy-b0884

62. (r)-benzyl2-oxooxetan-3-ylcarbamate

63. Bdbm50074289

64. Zinc19796082

65. Akos024287006

66. Cs-4346

67. Db00805

68. Idi1_000063

69. Ncgc00016795-01

70. Ncgc00016795-02

71. Ncgc00016795-03

72. Ncgc00016795-04

73. Sbi-0051647.p002

74. Db-046791

75. Ab00053599

76. Ft-0630519

77. D05039

78. Ab00053599_13

79. L001202

80. Q6863173

81. Brd-k02867583-300-05-5

82. Brd-k02867583-300-06-3

83. 3-(2-morpholinoethylamino)-4-methyl-6-phenylpyridazine

84. 4-methyl-n-[2-(4-morpholinyl)ethyl]-6-phenyl-3-pyridazinamine #

85. (4-methyl-6-phenyl-pyridazin-3-yl)-(2-morpholin-4-yl-ethyl)-amine; Hydrochloride

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 298.4 g/mol
Molecular Formula C17H22N4O
XLogP32
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass298.17936134 g/mol
Monoisotopic Mass298.17936134 g/mol
Topological Polar Surface Area50.3 Ų
Heavy Atom Count22
Formal Charge0
Complexity316
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

For the treatment of depression


5 Pharmacology and Biochemistry
5.1 Pharmacology

Minaprine is an amino-phenylpyridazine antidepressant reported to be relatively free of cardiotoxicity, drowsiness, and weight gain. Similar to other antidepressant treatments, minaprine attenuates the beta-adrenergic receptor function. Studies have also shown that minaprine improves memory consolidation and that repeated drug administration leads to potentiation of this effect. Moreover, the effects of minaprine on memory consolidation are related to its dopaminergic action.


5.2 MeSH Pharmacological Classification

Antidepressive Agents

Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems. (See all compounds classified as Antidepressive Agents.)


5.3 ATC Code

N - Nervous system

N06 - Psychoanaleptics

N06A - Antidepressants

N06AX - Other antidepressants

N06AX07 - Minaprine


5.4 Metabolism/Metabolites

Hepatic. Cytochrome P4502D is responsible for the 4-hydroxylation of minaprine to 4-hydroxyminaprine.


Minaprine has known human metabolites that include 4-Hydroxyminaprine.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560


5.5 Mechanism of Action

Minaprine binds to serotonin type 2 receptors and to dopamine D1 and D2 type receptors. It also binds to the serotonin reuptake pump. Therefore, minaprine blocks the reuptake of both dopamine and serotonin. It is also, to a slight degree, cholinomimetic. Thus it may exhibit both mood-brightening and nootropic properties. It also acts as a reversible inhibitor of MAO-A (RIMA).It has also been found to inhibit acetylcholinesterase.


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ABOUT THIS PAGE

Minaprine Manufacturers

A Minaprine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Minaprine, including repackagers and relabelers. The FDA regulates Minaprine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Minaprine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Minaprine Suppliers

A Minaprine supplier is an individual or a company that provides Minaprine active pharmaceutical ingredient (API) or Minaprine finished formulations upon request. The Minaprine suppliers may include Minaprine API manufacturers, exporters, distributors and traders.

click here to find a list of Minaprine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Minaprine USDMF

A Minaprine DMF (Drug Master File) is a document detailing the whole manufacturing process of Minaprine active pharmaceutical ingredient (API) in detail. Different forms of Minaprine DMFs exist exist since differing nations have different regulations, such as Minaprine USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Minaprine DMF submitted to regulatory agencies in the US is known as a USDMF. Minaprine USDMF includes data on Minaprine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Minaprine USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Minaprine suppliers with USDMF on PharmaCompass.

Minaprine GMP

Minaprine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Minaprine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Minaprine GMP manufacturer or Minaprine GMP API supplier for your needs.

Minaprine CoA

A Minaprine CoA (Certificate of Analysis) is a formal document that attests to Minaprine's compliance with Minaprine specifications and serves as a tool for batch-level quality control.

Minaprine CoA mostly includes findings from lab analyses of a specific batch. For each Minaprine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Minaprine may be tested according to a variety of international standards, such as European Pharmacopoeia (Minaprine EP), Minaprine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Minaprine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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