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    Chemistry

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    Also known as: 13614-98-7, Minocycline hcl, Arestin, Solodyn, Minomycin, Minocin
    Molecular Formula
    C23H28ClN3O7
    Molecular Weight
    493.9  g/mol
    InChI Key
    WTJXVDPDEQKTCV-VQAITOIOSA-N
    FDA UNII
    0020414E5U
    Minocycline Hydrochloride
    A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections.
    1 2D Structure

    Minocycline Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride
    2.1.2 InChI
    InChI=1S/C23H27N3O7.ClH/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28;/h5-6,9,11,17,27-28,31,33H,7-8H2,1-4H3,(H2,24,32);1H/t9-,11-,17-,23-;/m0./s1
    2.1.3 InChI Key
    WTJXVDPDEQKTCV-VQAITOIOSA-N
    2.1.4 Canonical SMILES
    CN(C)C1C2CC3CC4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C.Cl
    2.1.5 Isomeric SMILES
    CN(C)[C@H]1[C@@H]2C[C@@H]3CC4=C(C=CC(=C4C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    0020414E5U
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Akamin

    2. Akne Puren

    3. Akne-puren

    4. Aknemin

    5. Aknin Mino

    6. Aknin-mino

    7. Aknosan

    8. Apo Minocycline

    9. Apo-minocycline

    10. Arestin

    11. Blemix

    12. Cyclomin

    13. Cyclops

    14. Dentomycin

    15. Dynacin

    16. Hydrochloride, Minocycline

    17. Icht Oral

    18. Icht-oral

    19. Klinomycin

    20. Lederderm

    21. Mestacine

    22. Minakne

    23. Mino Wolff

    24. Mino-wolff

    25. Minocin

    26. Minocin Mr

    27. Minoclir

    28. Minocycline

    29. Minocycline Monohydrochloride

    30. Minocycline, (4r-(4 Alpha,4a Beta,5a Beta,12a Beta))-isomer

    31. Minolis

    32. Minomycin

    33. Minoplus

    34. Minotab

    35. Minox 50

    36. Monohydrochloride, Minocycline

    37. Mynocine

    2.3.2 Depositor-Supplied Synonyms

    1. 13614-98-7

    2. Minocycline Hcl

    3. Arestin

    4. Solodyn

    5. Minomycin

    6. Minocin

    7. Dynacin

    8. Periocline

    9. Ximino

    10. Minocycline (hydrochloride)

    11. Vectrin

    12. Minomax

    13. (4s,4as,5ar,12as)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide Hydrochloride

    14. Mynocine Hydrochloride

    15. Minocycline (as Hydrochloride)

    16. Minocycline, Hydrochloride

    17. 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide Monohydrochloride

    18. 0020414e5u

    19. Tri-mino

    20. Nsc-141993

    21. Dsstox_cid_24545

    22. Dsstox_rid_80306

    23. Dsstox_gsid_44545

    24. (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide;hydrochloride

    25. [4s-(4alpha,4aalpha,5aalpha,12aalpha)]-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacene-2-carboxamide Monohydrochloride

    26. Lederderm

    27. Mynocine

    28. Acnez

    29. Minomycin Chloride

    30. Chebi:50697

    31. (4s-(4alpha,4aalpha,5aalpha,12aalpha))-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacene-2-carboxamide Monohydrochloride

    32. [4s-(4?,4a?,5a?,12a?)]-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a,tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide

    33. 2-naphthacenecarboxamide, 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, Hydrochloride (1:2), (4s,4as,5ar,12as)-

    34. Einecs 237-099-7

    35. Minocycline Hydrochloride (internal Use)

    36. C23h27n3o7.hcl

    37. Minocycline, Hcl

    38. Unii-0020414e5u

    39. Ncgc00096006-01

    40. Prestwick_626

    41. Arestin (tn)

    42. Dynacin (tn)

    43. Minocin (tn)

    44. Solodyn (tn)

    45. Minocycline Hydrochloride [usp:jan]

    46. 7-dimethylamino-6-demethyl-6-deoxytetracycline, Hcl

    47. Mfcd00083669

    48. Minocyclinhydrochlorid

    49. Amzeeq

    50. Minolira

    51. Zilxi

    52. Minomycin Hydrochloride

    53. Schembl2537

    54. Cas-13614-98-7

    55. 2-naphthacenecarboxamide, 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, Monohydrochloride, (4s-(4alpha,4aalpha,5aalpha,12aalpha))-

    56. Mls002548863

    57. Spectrum1500414

    58. Fxfm-244

    59. Chembl1200881

    60. Chembl4576719

    61. Dtxsid8044545

    62. Hms1568p12

    63. Pharmakon1600-01500414

    64. Bcp06597

    65. Tox21_111250

    66. Tox21_113183

    67. Tox21_301590

    68. Ccg-40107

    69. Nsc757120

    70. S4226

    71. Minocycline Hydrochloride [mi]

    72. Minocycline Hydrochloride, Crystalline

    73. Akos015951312

    74. Minocycline Hydrochloride (jp17/usp)

    75. Tox21_111250_1

    76. Cs-1256

    77. Minocycline Hydrochloride [jan]

    78. Nc00460

    79. Nsc-757120

    80. Minocycline Hydrochloride [mart.]

    81. Minocycline Hydrochloride [vandf]

    82. Ncgc00178854-03

    83. Ncgc00255988-01

    84. Ac-22362

    85. As-75306

    86. Hy-17412

    87. Minocycline Hydrochloride [usp-rs]

    88. Minocycline Hydrochloride [who-dd]

    89. Smr001906766

    90. M2288

    91. D00850

    92. Minocycline Hydrochloride [orange Book]

    93. Minocycline Hydrochloride [usp Monograph]

    94. 614m987

    95. Sr-01000075625

    96. Q-201407

    97. Sr-01000075625-1

    98. Q27104777

    99. Minocycline Hydrochloride, Antibiotic For Culture Media Use Only

    100. Minocycline Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    101. Minocycline Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

    102. Minocycline Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    103. (4s,12as,4as,5ar)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-4,5,6,12a,4a,5a-hexahydronaphthacene-2-carboxamide Hydrochloride

    104. (4s,4as,5ar,12as)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamidehydrochloride

    105. 2-naphthacenecarboxamide, 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, Monohydrochloride, (4s-(4.alpha.,4a.alpha.,5a.alpha.,12a.alpha.))-

    2.4 Create Date
    2011-12-26
    3 Chemical and Physical Properties
    Molecular Weight 493.9 g/mol
    Molecular Formula C23H28ClN3O7
    Hydrogen Bond Donor Count6
    Hydrogen Bond Acceptor Count9
    Rotatable Bond Count3
    Exact Mass493.1615779 g/mol
    Monoisotopic Mass493.1615779 g/mol
    Topological Polar Surface Area165 Ų
    Heavy Atom Count34
    Formal Charge0
    Complexity971
    Isotope Atom Count0
    Defined Atom Stereocenter Count4
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 10  
    Drug NameArestin
    PubMed HealthMinocycline
    Drug ClassesAmebicide, Intestinal, Antiacne, Antiacne Antibacterial, Antibiotic, Antiprotozoal, Tetracycline
    Drug LabelARESTIN (minocycline hydrochloride) Microspheres is a subgingival sustained-release product containing the antibiotic minocycline hydrochloride incorporated into a bioresorbable polymer, Poly (glycolide-co-dl-lactide) or PGLA, for professional subg...
    Active IngredientMinocycline hydrochloride
    Dosage FormPowder, extended release
    RouteDental
    Strengtheq 1mg base
    Market StatusPrescription
    CompanyOrapharma

    2 of 10  
    Drug NameDynacin
    Drug LabelMinocycline hydrochloride, is a semisynthetic derivative of tetracycline, 4,7-Bis(dimethylamino)1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1, 11-dioxo-2naphthacenecarboxamide monohydrochloride. Its structural formula is:C23H27N3O7...
    Active IngredientMinocycline hydrochloride
    Dosage FormCapsule
    RouteOral
    Strengtheq 100mg base; eq 75mg base
    Market StatusPrescription
    CompanyCnty Line Pharms

    3 of 10  
    Drug NameMinocin
    PubMed HealthMinocycline, Regular Release (By mouth)
    Drug ClassesAmebicide, Intestinal, Antiacne, Antibiotic, Antiprotozoal
    Drug LabelMINOCIN minocycline hydrochloride, is a semisynthetic derivative of tetracycline, 4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride.Its structural formula is:C23H27N...
    Active IngredientMinocycline hydrochloride
    Dosage FormCapsule; Injectable
    RouteInjection; Oral
    Strengtheq 100mg base; eq 50mg base; eq 100mg base/vial
    Market StatusPrescription
    CompanyRempex Pharms; Precision Dermat

    4 of 10  
    Drug NameMinocycline hydrochloride
    Drug LabelTo reduce the development of drug-resistant bacteria and maintain the effectiveness of minocycline hydrochloride capsules and other antibacterial drugs, minocycline hydrochloride capsules should be used only to treat or prevent infections that are pr...
    Active IngredientMinocycline hydrochloride
    Dosage FormTablet, extended release; Tablet; Capsule
    Routeoral; Oral
    Strength65mg; 115mg; eq 100mg base; eq 50mg base; eq 105mg base; eq 65mg base; eq 115mg base; eq 75mg base; eq 90mg base; eq 80mg base; 55mg; eq 45mg base; eq 55mg base; eq 135mg base
    Market StatusTentative Approval; Prescription
    CompanyMylan Pharms; Ranbaxy; Teva; Mylan Labs; Sun Pharm Inds; Aurobindo Pharma; Lupin; Barr Labs; Sandoz; Par Pharm; Watson Labs; Ranbaxy Labs; Dr Reddys Labs; Impax Labs

    5 of 10  
    Drug NameSolodyn
    PubMed HealthMinocycline
    Drug ClassesAmebicide, Intestinal, Antiacne, Antiacne Antibacterial, Antibiotic, Antiprotozoal, Tetracycline
    Drug LabelMinocycline hydrochloride, a semi synthetic derivative of tetracycline, is [4S-(4,4a,5a,12a)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide mono hydrochloride. The structura...
    Active IngredientMinocycline hydrochloride
    Dosage FormTablet, extended release
    RouteOral
    Strengtheq 105mg base; eq 65mg base; eq 115mg base; eq 80mg base; eq 55mg base
    Market StatusPrescription
    CompanyMedicis

    6 of 10  
    Drug NameArestin
    PubMed HealthMinocycline
    Drug ClassesAmebicide, Intestinal, Antiacne, Antiacne Antibacterial, Antibiotic, Antiprotozoal, Tetracycline
    Drug LabelARESTIN (minocycline hydrochloride) Microspheres is a subgingival sustained-release product containing the antibiotic minocycline hydrochloride incorporated into a bioresorbable polymer, Poly (glycolide-co-dl-lactide) or PGLA, for professional subg...
    Active IngredientMinocycline hydrochloride
    Dosage FormPowder, extended release
    RouteDental
    Strengtheq 1mg base
    Market StatusPrescription
    CompanyOrapharma

    7 of 10  
    Drug NameDynacin
    Drug LabelMinocycline hydrochloride, is a semisynthetic derivative of tetracycline, 4,7-Bis(dimethylamino)1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1, 11-dioxo-2naphthacenecarboxamide monohydrochloride. Its structural formula is:C23H27N3O7...
    Active IngredientMinocycline hydrochloride
    Dosage FormCapsule
    RouteOral
    Strengtheq 100mg base; eq 75mg base
    Market StatusPrescription
    CompanyCnty Line Pharms

    8 of 10  
    Drug NameMinocin
    PubMed HealthMinocycline, Regular Release (By mouth)
    Drug ClassesAmebicide, Intestinal, Antiacne, Antibiotic, Antiprotozoal
    Drug LabelMINOCIN minocycline hydrochloride, is a semisynthetic derivative of tetracycline, 4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride.Its structural formula is:C23H27N...
    Active IngredientMinocycline hydrochloride
    Dosage FormCapsule; Injectable
    RouteInjection; Oral
    Strengtheq 100mg base; eq 50mg base; eq 100mg base/vial
    Market StatusPrescription
    CompanyRempex Pharms; Precision Dermat

    9 of 10  
    Drug NameMinocycline hydrochloride
    Drug LabelTo reduce the development of drug-resistant bacteria and maintain the effectiveness of minocycline hydrochloride capsules and other antibacterial drugs, minocycline hydrochloride capsules should be used only to treat or prevent infections that are pr...
    Active IngredientMinocycline hydrochloride
    Dosage FormTablet, extended release; Tablet; Capsule
    Routeoral; Oral
    Strength65mg; 115mg; eq 100mg base; eq 50mg base; eq 105mg base; eq 65mg base; eq 115mg base; eq 75mg base; eq 90mg base; eq 80mg base; 55mg; eq 45mg base; eq 55mg base; eq 135mg base
    Market StatusTentative Approval; Prescription
    CompanyMylan Pharms; Ranbaxy; Teva; Mylan Labs; Sun Pharm Inds; Aurobindo Pharma; Lupin; Barr Labs; Sandoz; Par Pharm; Watson Labs; Ranbaxy Labs; Dr Reddys Labs; Impax Labs

    10 of 10  
    Drug NameSolodyn
    PubMed HealthMinocycline
    Drug ClassesAmebicide, Intestinal, Antiacne, Antiacne Antibacterial, Antibiotic, Antiprotozoal, Tetracycline
    Drug LabelMinocycline hydrochloride, a semi synthetic derivative of tetracycline, is [4S-(4,4a,5a,12a)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide mono hydrochloride. The structura...
    Active IngredientMinocycline hydrochloride
    Dosage FormTablet, extended release
    RouteOral
    Strengtheq 105mg base; eq 65mg base; eq 115mg base; eq 80mg base; eq 55mg base
    Market StatusPrescription
    CompanyMedicis

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Bacterial Agents

    Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Tetracyclines [CS]; Tetracycline-class Drug [EPC]

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    About the Company : Guangzhou Topwork Chemical Co., Ltd. Specializes in manufacturing corticosteroid and relative intermediates. We provide high quality products and excellent service to our clients a...

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    Guangzhou Tosun Pharmaceutical

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    Guangzhou Tosun Pharmaceutical

    China
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    Minocycline Hydrochloride

    About the Company : Guangzhou Tosun Pharmaceutical was founded in 1999, which mainly focuses on importation & exportation of Active Pharmaceutical Ingrediants, Chemical Raw Materials, Intermediate, Ex...

    Guangzhou Tosun Pharmaceutical was founded in 1999, which mainly focuses on importation & exportation of Active Pharmaceutical Ingrediants, Chemical Raw Materials, Intermediate, Excipients, Herbal extracts, Formulation of Chinese & Western Medicine. With abundant economic strength, the group has successfully developed to a pharmaceutical group enterprise wich intergrets operation of medicine & related products, processing & manufacturing, and importation & exportation together.
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    06

    Hovione

    Portugal
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    Hovione

    Portugal
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    Minocycline

    About the Company : Hovione is an international company with over 60 years of experience as a Contract Development and Manufacturing Organization (CDMO) with a fully integrated offering of services fo...

    Hovione is an international company with over 60 years of experience as a Contract Development and Manufacturing Organization (CDMO) with a fully integrated offering of services for drug substance, drug product intermediate and drug product. The company has four FDA inspected sites. Hovione provides pharmaceutical customers services for the development and compliant manufacture of innovative drugs, including highly potent compounds, and customized product solution across the entire drug life cycle. In the inhalation area, Hovione offers a complete range of services, from API, formulation development and devices.
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    07

    Shenzhen Haorui

    China
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    Shenzhen Haorui

    China
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    Minocycline Hydrochloride

    About the Company : Haorui, established in 1997, is a manufacturer and supplier of APIs, intermediates, veterinary and food additives. Meanwhile, it is assisting global pharmaceutical companies to get...

    Haorui, established in 1997, is a manufacturer and supplier of APIs, intermediates, veterinary and food additives. Meanwhile, it is assisting global pharmaceutical companies to get the domestic registration of their finished dosage for their international expansion. Our USFDA approved products Flumazenil, Granisetron HCl, Granisetron Base, Docetaxel Anhydrous, Irinotecan HCl, Dasatinib Monohydrate, Oxaliplatin and Temozolomide have been recognized by our customers globally. In addition, our Amisulpride API acquired CEP, UK GMP & USDMF.
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    08

    Tecoland Corporation

    U.S.A
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    Tecoland Corporation

    U.S.A
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    Minocycline Hydrochloride

    About the Company : Established in 2002, Tecoland represents selected cGMP manufacturers with proven capabilities in organic synthesis, fermentation production as well as process and method developmen...

    Established in 2002, Tecoland represents selected cGMP manufacturers with proven capabilities in organic synthesis, fermentation production as well as process and method development. Tecoland provides high quality APIs to the pharmaceutical industry, with reliable technical and regulatory support such as USDMF, CEP, EDMF that are critical to the speedy approval of our customers’ regulatory filings.
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    09

    Unipex

    France
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    Unipex

    France
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    MINOCYCLINE HYDOCHLORIDE

    About the Company : Our work in the distribution sector starts and ends with the quality of human relations; first and foremost, it is trust that we want to build with you. The connections we build ar...

    Our work in the distribution sector starts and ends with the quality of human relations; first and foremost, it is trust that we want to build with you. The connections we build are made to last. They are built on professionalism, respect and transparency. This is how we work, and how we have been working for a long time now, with our client partners and constituents. Unipex has been operational for 50 years, and has always remained true to its core business: the distribution of specialities. This is also why we are independent and we intend to stay that way. Our structure is simple, our commitment is absolute: we work directly with you.
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    10

    Zhejiang Huida Biotech

    China
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    Zhejiang Huida Biotech

    China
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    Minocycline Hydrochloride

    About the Company : Zhejiang Huida Biotech Co., Ltd. is located in Hangzhou, Zhejiang Province. It was established in 2020 and is a holding subsidiary of Huadong Medicine Co., Ltd. The company focu...

    Zhejiang Huida Biotech Co., Ltd. is located in Hangzhou, Zhejiang Province. It was established in 2020 and is a holding subsidiary of Huadong Medicine Co., Ltd. The company focuses on the research and development of microbial active pharmaceutical substances (APIs), intermediates and large health products. It is a technologically innovative fermentation product research enterprise. With strong R&D strength, the company provides first-class technology, first-class service and first-class products to global customers by discovering and cultivating the most valuable microbial metabolites.
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    API Reference Price

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MAHARASHTRA","supplier":"SUANFARMA","supplierCountry":"PORTUGAL","foreign_port":"LISBON","customer":"ALKEM LABORATORIES","customerCountry":"INDIA","quantity":"10.62","actualQuantity":"10.62","unit":"KGS","unitRateFc":"1410","totalValueFC":"16564.4","currency":"EUR","unitRateINR":"131059.5","date":"22-Oct-2024","totalValueINR":"1391851.89","totalValueInUsd":"16564.4","indian_port":"Bombay Air","hs_no":"29419090","bill_no":"6271536","productDescription":"API","marketType":"REGULATED MARKET","country":"PORTUGAL","selfForZScoreResived":"Pharma Grade","supplierPort":"LISBON","supplierAddress":"C\/EINSTEIN 8 28108 ALCOBENDAS MADRI D SDNF SPAIN","customerAddress":"ALKEM HOUSE, DEVASHISH ADJACENT TO"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729535400,"product":"MINOCYCLINE HYDROCHLORIDE USP","address":"ALKEM HOUSE, DEVASHISH ADJACENT TO","city":"LOWER PAREL, MUMBAI. 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CHINA China","customerAddress":"PLOT NO.2, MAITRIVIHAR,"}]
    12-Jan-2021
    29-Oct-2024
    KGS
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

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    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    DOSAGE - INJECTABLE;INJECTION - EQ 100MG BASE...DOSAGE - INJECTABLE;INJECTION - EQ 100MG BASE/VIAL

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    DOSAGE - CAPSULE;ORAL - EQ 75MG BASE **Federa...DOSAGE - CAPSULE;ORAL - EQ 75MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 4...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 45MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 50808

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 5...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 55MG BASE

    USFDA APPLICATION NUMBER - 50808

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 6...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 65MG BASE

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 8...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 80MG BASE

    USFDA APPLICATION NUMBER - 50808

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 9...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 90MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

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