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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: Tak-659, 1312691-33-0, Tak-659 free base, Mivavotinib [usan], Tak-659f, Tak659
Molecular Formula
C17H21FN6O
Molecular Weight
344.4  g/mol
InChI Key
MJHOMTRKVMKCNE-NWDGAFQWSA-N
FDA UNII
8QR88H79VX

Mivavotinib
Mivavotinib is an inhibitor of spleen tyrosine kinase (syk), with potential anti-inflammatory, immunomodulating, and antineoplastic activities. Upon administration, mivavotinib may inhibit the activity of syk, which abrogates downstream B-cell receptor (BCR) signaling and leads to an inhibition of B-cell activation, chemotaxis, adhesion and proliferation. Syk, a BCR-associated non-receptor tyrosine kinase that mediates diverse cellular responses, including proliferation, differentiation, and phagocytosis, is expressed in hematopoietic tissues and is often overexpressed in hematopoietic malignancies.
1 2D Structure

Mivavotinib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
6-[[(1R,2S)-2-aminocyclohexyl]amino]-7-fluoro-4-(1-methylpyrazol-4-yl)-1,2-dihydropyrrolo[3,4-c]pyridin-3-one
2.1.2 InChI
InChI=1S/C17H21FN6O/c1-24-8-9(6-21-24)15-13-10(7-20-17(13)25)14(18)16(23-15)22-12-5-3-2-4-11(12)19/h6,8,11-12H,2-5,7,19H2,1H3,(H,20,25)(H,22,23)/t11-,12+/m0/s1
2.1.3 InChI Key
MJHOMTRKVMKCNE-NWDGAFQWSA-N
2.1.4 Canonical SMILES
CN1C=C(C=N1)C2=NC(=C(C3=C2C(=O)NC3)F)NC4CCCCC4N
2.1.5 Isomeric SMILES
CN1C=C(C=N1)C2=NC(=C(C3=C2C(=O)NC3)F)N[C@@H]4CCCC[C@@H]4N
2.2 Other Identifiers
2.2.1 UNII
8QR88H79VX
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Tak-659

2.3.2 Depositor-Supplied Synonyms

1. Tak-659

2. 1312691-33-0

3. Tak-659 Free Base

4. Mivavotinib [usan]

5. Tak-659f

6. Tak659

7. 8qr88h79vx

8. Chembl3979920

9. 6-[[(1r,2s)-2-aminocyclohexyl]amino]-7-fluoro-4-(1-methylpyrazol-4-yl)-1,2-dihydropyrrolo[3,4-c]pyridin-3-one

10. 3h-pyrrolo(3,4-c)pyridin-3-one, 6-(((1r,2s)-2-aminocyclohexyl)amino)-7-fluoro-1,2-dihydro-4-(1-methyl-1h-pyrazol-4-yl)-

11. 3h-pyrrolo[3,4-c]pyridin-3-one, 6-[[(1r,2s)-2-aminocyclohexyl]amino]-7-fluoro-1,2-dihydro-4-(1-methyl-1h-pyrazol-4-yl)-

12. 6-(((1r,2s)-2-aminocyclohexyl)amino)-7-fluoro-4-(1-methyl-1h-pyrazol-4-yl)-1,2-dihydro-3h-pyrrolo[3,4-c]pyridin-3-one

13. 6-((1r,2s)-2-aminocyclohexylamino)-7-fluoro-4-(1-methyl-1h-pyrazol-4-yl)-1h-pyrrolo(3,4-c)pyridin-3(2h)-one

14. 6-((1r,2s)-2-aminocyclohexylamino)-7-fluoro-4-(1-methyl-1h-pyrazol-4-yl)-1h-pyrrolo[3,4-c]pyridin-3(2h)-one

15. 6-{[(1r,2s)-2-aminocyclohexyl]amino}-7-fluoro-4-(1-methyl-1h-pyrazol-4-yl)-1,2-dihydro-3h-pyrrolo[3,4-c]pyridin-3-one

16. Mivavotinib [inn]

17. Mivavotinib (usan/inn)

18. Tak659 2hcl

19. Unii-8qr88h79vx

20. Mivavotinib [who-dd]

21. Tak-659 2hcl

22. Gtpl9600

23. Schembl1987799

24. Tak-659 Free Base(mivavotinib)

25. Bcp28883

26. Ex-a1401

27. Bdbm50204290

28. Cb-659

29. Nsc791967

30. Nsc791968

31. Who 10836

32. Nsc-791967

33. Nsc-791968

34. Compound 3b [pmid: 27839918]

35. Ac-35463

36. Hy-100867

37. Cs-0020533

38. D11789

39. 1312691-41-0

40. Cis-6-(2-aminocyclohexylamino)-7-fluoro-4-(1-methyl-1h-pyrazol-4-yl)-1h-pyrrolo[3,4-c]pyridin-3(2h)-one

2.4 Create Date
2011-07-25
3 Chemical and Physical Properties
Molecular Weight 344.4 g/mol
Molecular Formula C17H21FN6O
XLogP30.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass344.17608748 g/mol
Monoisotopic Mass344.17608748 g/mol
Topological Polar Surface Area97.9 Ų
Heavy Atom Count25
Formal Charge0
Complexity508
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Looking for 1312691-33-0 / Mivavotinib API manufacturers, exporters & distributors?

Mivavotinib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Mivavotinib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Mivavotinib manufacturer or Mivavotinib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Mivavotinib manufacturer or Mivavotinib supplier.

PharmaCompass also assists you with knowing the Mivavotinib API Price utilized in the formulation of products. Mivavotinib API Price is not always fixed or binding as the Mivavotinib Price is obtained through a variety of data sources. The Mivavotinib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Mivavotinib

Synonyms

Tak-659, 1312691-33-0, Tak-659 free base, Mivavotinib [usan], Tak-659f, Tak659

Cas Number

1312691-33-0

Unique Ingredient Identifier (UNII)

8QR88H79VX

About Mivavotinib

Mivavotinib is an inhibitor of spleen tyrosine kinase (syk), with potential anti-inflammatory, immunomodulating, and antineoplastic activities. Upon administration, mivavotinib may inhibit the activity of syk, which abrogates downstream B-cell receptor (BCR) signaling and leads to an inhibition of B-cell activation, chemotaxis, adhesion and proliferation. Syk, a BCR-associated non-receptor tyrosine kinase that mediates diverse cellular responses, including proliferation, differentiation, and phagocytosis, is expressed in hematopoietic tissues and is often overexpressed in hematopoietic malignancies.

Mivavotinib Manufacturers

A Mivavotinib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Mivavotinib, including repackagers and relabelers. The FDA regulates Mivavotinib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Mivavotinib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Mivavotinib Suppliers

A Mivavotinib supplier is an individual or a company that provides Mivavotinib active pharmaceutical ingredient (API) or Mivavotinib finished formulations upon request. The Mivavotinib suppliers may include Mivavotinib API manufacturers, exporters, distributors and traders.

Mivavotinib GMP

Mivavotinib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Mivavotinib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Mivavotinib GMP manufacturer or Mivavotinib GMP API supplier for your needs.

Mivavotinib CoA

A Mivavotinib CoA (Certificate of Analysis) is a formal document that attests to Mivavotinib's compliance with Mivavotinib specifications and serves as a tool for batch-level quality control.

Mivavotinib CoA mostly includes findings from lab analyses of a specific batch. For each Mivavotinib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Mivavotinib may be tested according to a variety of international standards, such as European Pharmacopoeia (Mivavotinib EP), Mivavotinib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Mivavotinib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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