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Also known as: 654671-78-0, Sitagliptin (phosphate), Mk-0431, Chembl393336, 494p4635i6, Mk0431
Molecular Formula
C16H18F6N5O5P
Molecular Weight
505.31  g/mol
InChI Key
IQFYVLUXQXSJJN-SBSPUUFOSA-N
FDA UNII
494P4635I6

Sitagliptin Phosphate
A pyrazine-derived DIPEPTIDYL-PEPTIDASE IV INHIBITOR and HYPOGLYCEMIC AGENT that increases the levels of the INCRETIN hormones GLUCAGON-LIKE PEPTIDE-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). It is used in the treatment of TYPE 2 DIABETES.
1 2D Structure

Sitagliptin Phosphate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(3R)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;phosphoric acid
2.1.2 InChI
InChI=1S/C16H15F6N5O.H3O4P/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22;1-5(2,3)4/h4,6,9H,1-3,5,7,23H2;(H3,1,2,3,4)/t9-;/m1./s1
2.1.3 InChI Key
IQFYVLUXQXSJJN-SBSPUUFOSA-N
2.1.4 Canonical SMILES
C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)CC(CC3=CC(=C(C=C3F)F)F)N.OP(=O)(O)O
2.1.5 Isomeric SMILES
C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N.OP(=O)(O)O
2.2 Other Identifiers
2.2.1 UNII
494P4635I6
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 0431, Mk

2. 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo(4,3-a)pyrazin-7(8h)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine

3. Anhydrous, Sitagliptin Phosphate

4. Januvia

5. Mk 0431

6. Mk-0431

7. Mk0431

8. Monohydrate, Sitagliptin Monophosphate

9. Monohydrate, Sitagliptin Phosphate

10. Monophosphate Monohydrate, Sitagliptin

11. Phosphate Anhydrous, Sitagliptin

12. Phosphate Monohydrate, Sitagliptin

13. Phosphate, Sitagliptin

14. Sitagliptin

15. Sitagliptin Monophosphate Monohydrate

16. Sitagliptin Phosphate Anhydrous

17. Sitagliptin Phosphate Monohydrate

2.3.2 Depositor-Supplied Synonyms

1. 654671-78-0

2. Sitagliptin (phosphate)

3. Mk-0431

4. Chembl393336

5. 494p4635i6

6. Mk0431

7. (2r)-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo(4,3-a)pyrazin-7(8h)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine Phosphate Salt

8. (3r)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5h-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;phosphoric Acid

9. (r)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8h)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one Phosphate

10. 1-butanone, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8h)-yl]-4-(2,4,5-trifluorophenyl)-, (3r)-, Phosphate (1:1)

11. Sitagliptin Monophosphate

12. Sitagliptin Phosphate Anhydrous

13. (3r)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5h-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)-1-butanone; Phosphoric Acid

14. Mk 0431

15. Sr-05000001748

16. Unii-494p4635i6

17. (2r)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8h)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine Phosphate Salt

18. Mk 431

19. Mk-0431 Phosphate

20. Schembl877069

21. Dtxsid10215789

22. Hy-13749a

23. Mfcd09952339

24. Akos015896098

25. Sitagliptin Phosphate [who-dd]

26. Ks-1214

27. 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo(4,3-a)pyrazin-7(8h)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine Phosphate

28. Sitagliptin Monophosphate Anhydrous [mi]

29. 671s780

30. A835125

31. Sr-05000001748-2

32. Q27259224

33. Sitagliptin Phosphate Anhydrous Component Of Janumet

34. (3r)-3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8h)-yl]-4-(2,4,5-trifluorophenyl)-1-butanone Phosphate

35. (3r)-3-azanyl-1-[3-(trifluoromethyl)-6,8-dihydro-5h-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-[2,4,5-tris(fluoranyl)phenyl]butan-1-one; Phosphoric Acid

36. 1,2,4-triazolo(4,3-a)pyrazine, 7-((3r)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl)-5,6,7,8-tetrahydro-3-(trifluoromethyl)-, Phosphate (1:1)

37. 1269630-53-6

38. 7-((3r)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo(4,3-a)pyrazinemonophosphate

39. 7-(3r)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine Phosphate

2.4 Create Date
2006-04-29
3 Chemical and Physical Properties
Molecular Weight 505.31 g/mol
Molecular Formula C16H18F6N5O5P
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count14
Rotatable Bond Count4
Exact Mass505.09497466 g/mol
Monoisotopic Mass505.09497466 g/mol
Topological Polar Surface Area155 Ų
Heavy Atom Count33
Formal Charge0
Complexity616
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameJanuvia
PubMed HealthSitagliptin (By mouth)
Drug ClassesAntidiabetic
Drug LabelJANUVIA Tablets contain sitagliptin phosphate, an orally-active inhibitor of the dipeptidyl peptidase-4 (DPP-4) enzyme. Sitagliptin phosphate monohydrate is described chemically as 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahy...
Active IngredientSitagliptin phosphate
Dosage FormTablet
RouteOral
Strengtheq 100mg base; eq 50mg base; eq 25mg base
Market StatusPrescription
CompanyMerck Sharp Dohme

2 of 4  
Drug NameSitagliptin phosphate
Active IngredientSitagliptin phosphate
Dosage FormTablet
Routeoral; Oral
Strengtheq 100mg base; 25mg; eq 50mg base; 100mg; 50mg; eq 25mg base
Market StatusTentative Approval
CompanyMylan Pharms; Apotex; Sandoz; Sun Pharma Global; Watson Labs

3 of 4  
Drug NameJanuvia
PubMed HealthSitagliptin (By mouth)
Drug ClassesAntidiabetic
Drug LabelJANUVIA Tablets contain sitagliptin phosphate, an orally-active inhibitor of the dipeptidyl peptidase-4 (DPP-4) enzyme. Sitagliptin phosphate monohydrate is described chemically as 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahy...
Active IngredientSitagliptin phosphate
Dosage FormTablet
RouteOral
Strengtheq 100mg base; eq 50mg base; eq 25mg base
Market StatusPrescription
CompanyMerck Sharp Dohme

4 of 4  
Drug NameSitagliptin phosphate
Active IngredientSitagliptin phosphate
Dosage FormTablet
Routeoral; Oral
Strengtheq 100mg base; 25mg; eq 50mg base; 100mg; 50mg; eq 25mg base
Market StatusTentative Approval
CompanyMylan Pharms; Apotex; Sandoz; Sun Pharma Global; Watson Labs

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Hypoglycemic Agents

Substances which lower blood glucose levels. (See all compounds classified as Hypoglycemic Agents.)


Incretins

Peptides which stimulate INSULIN release from the PANCREATIC BETA CELLS following oral nutrient ingestion, or postprandially. (See all compounds classified as Incretins.)


Dipeptidyl-Peptidase IV Inhibitors

Compounds that suppress the degradation of INCRETINS by blocking the action of DIPEPTIDYL-PEPTIDASE IV. This helps to correct the defective INSULIN and GLUCAGON secretion characteristic of TYPE 2 DIABETES MELLITUS by stimulating insulin secretion and suppressing glucagon release. (See all compounds classified as Dipeptidyl-Peptidase IV Inhibitors.)


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AP","supplier":"VERBEN S A","supplierCountry":"INDIA","foreign_port":"MUNICH","customer":"SMS PHARMACEUTICALS","customerCountry":"INDIA","quantity":"248.87","actualQuantity":"248.87","unit":"KGS","unitRateFc":"750","totalValueFC":"191007.4","currency":"USD","unitRateINR":"63974.2","date":"16-May-2024","totalValueINR":"15921259.93","totalValueInUsd":"191007.4","indian_port":"Hyderabad Air","hs_no":"29420090","bill_no":"3507838","productDescription":"Re-export","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"MUNICH","supplierAddress":"LUGANO BRANCHVIA F.PELLI 17P O BOX 6900 LUGANO CH","customerAddress":"PLOT NO.19-III, ROAD NO.71, OPP."},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1721154600,"product":"RE-IMPORT- SITAGLIPTIN PHOSPHATE (EXPORT INV NO:232410369 DT:30.03.2024 VIDE SB NO:8780352 DT: 30.03.2024 )","address":"26, VANDALUR - KELAMBAKKAM ROAD,","city":"CHENNAI. TAMIL NADU.","supplier":"DLS PHARMAG DMCC","supplierCountry":"INDIA","foreign_port":"DUBAI","customer":"VENKATA NARAYANA ACTIVE INGREDIENTS","customerCountry":"INDIA","quantity":"1000.00","actualQuantity":"1000","unit":"KGS","unitRateFc":"325","totalValueFC":"332033.3","currency":"USD","unitRateINR":"27755","date":"17-Jul-2024","totalValueINR":"27755020.31","totalValueInUsd":"332033.3","indian_port":"Madras Air","hs_no":"29420090","bill_no":"4545754","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"DUBAI","supplierAddress":"2208,1 LAKE PLAZAJUMEIRAH LAKES TOWERSP B 309045 DUBAI UNITED ARAB EMIRATES","customerAddress":"26, VANDALUR - KELAMBAKKAM ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1722450600,"product":"SITAGLIPTIN SYSTEM SUITABILITY MIXTURE (QTY: 1 X 0.2 G, VALUE USD: 31.39) (FOC)","address":"P.NO. D6 D8, SY.NO. 234\/2,234\/3,","city":"TURKAPALLY(V),SHAMEERPET, HYDERABAD","supplier":"UNITED STATES PHARMACOPEIAL","supplierCountry":"INDIA","foreign_port":"WASHINGTON, DULLES I","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.0002","unit":"KGS","unitRateFc":"156950","totalValueFC":"32.4","currency":"USD","unitRateINR":"13590900","date":"01-Aug-2024","totalValueINR":"2718.18","totalValueInUsd":"32.4","indian_port":"Hyderabad Air","hs_no":"29335990","bill_no":"4826736","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"WASHINGTON, DULLES I","supplierAddress":"7135 ENGLISH MUFFIN WAY FREDERICK,MD, US 21704, UNITED STATES OF AMERICA United States","customerAddress":"P.NO. D6 D8, SY.NO. 234\/2,234\/3,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1722450600,"product":"SITAGLIPTIN SYSTEM SUITABILITY MIXTURE (QTY: 3 X 0.05 G, VALUE USD: 17.60\/EACH) (FOC)","address":"P.NO. D6 D8, SY.NO. 234\/2,234\/3,","city":"TURKAPALLY(V),SHAMEERPET, HYDERABAD","supplier":"UNITED STATES PHARMACOPEIAL","supplierCountry":"INDIA","foreign_port":"WASHINGTON, DULLES I","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.00015","unit":"KGS","unitRateFc":"352000","totalValueFC":"54.5","currency":"USD","unitRateINR":"30481066.7","date":"01-Aug-2024","totalValueINR":"4572.16","totalValueInUsd":"54.5","indian_port":"Hyderabad Air","hs_no":"29335990","bill_no":"4826736","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"WASHINGTON, DULLES I","supplierAddress":"7135 ENGLISH MUFFIN WAY FREDERICK,MD, US 21704, UNITED STATES OF AMERICA United States","customerAddress":"P.NO. D6 D8, SY.NO. 234\/2,234\/3,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1723573800,"product":"SITAGLIPTIN PHOSPHATE ANHYDROUS","address":"ALKEM HOUSE, DEVASHISH ADJACENT T","city":"MUMBAI,MAHARASHTRA","supplier":"HONOUR LAB LTD","supplierCountry":"INDIA","foreign_port":"HIPL SEZ","customer":"ALKEM LABORATORIES","customerCountry":"INDIA","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"544.2","totalValueFC":"2744.5","currency":"USD","unitRateINR":"46040.5","date":"14-Aug-2024","totalValueINR":"230202.5","totalValueInUsd":"2744.5","indian_port":"Vizag-HIPL SEZ","hs_no":"29321990","bill_no":"5041630","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"HIPL SEZ","supplierAddress":"HETERO INFRASTRUCTURE SEZ LTD N.NARASAPURAM VILLAGE, NAKKAPALLY M SDNF India","customerAddress":"ALKEM HOUSE, DEVASHISH ADJACENT T"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729881000,"product":"SITAGLIPTIN PHOSPHATE ANH(SNP)CO USP(BR)","address":"564\/A\/22, ROAD NO.92","city":"HYDERABAD,ANDHRA PRADESH","supplier":"MYLAN LABORATORIES LIMITED FDF UNIT-3","supplierCountry":"INDIA","foreign_port":"NASIK","customer":"VIATRIS","customerCountry":"INDIA","quantity":"446.15","actualQuantity":"446.152","unit":"KGS","unitRateFc":"638.1","totalValueFC":"287835.8","currency":"USD","unitRateINR":"54209.9","date":"26-Oct-2024","totalValueINR":"24185846.38","totalValueInUsd":"287835.8","indian_port":"Indore-EPZ\/SEZ","hs_no":"29339990","bill_no":"6350764","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NASIK","supplierAddress":"IPlot No 11,12 & 13, SEZ Phase II SEZ, Sector 3, Pithampur, Dist Dhar SDNF India","customerAddress":"564\/A\/22, ROAD NO.92"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730917800,"product":"SITAGLIPTIN PHOSPHATE ANHYDROUS","address":"SANDOZ HOUSE","city":"MUMBAI ,MAHARASHTRA","supplier":"HONOUR LAB LTD","supplierCountry":"INDIA","foreign_port":"HIPL SEZ","customer":"SANDOZ B2B","customerCountry":"INDIA","quantity":"171.00","actualQuantity":"171","unit":"KGS","unitRateFc":"1029","totalValueFC":"177128.3","currency":"USD","unitRateINR":"87412.5","date":"07-Nov-2024","totalValueINR":"14947537.5","totalValueInUsd":"177128.3","indian_port":"Vizag-HIPL SEZ","hs_no":"29335950","bill_no":"6547337","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"HIPL SEZ","supplierAddress":"HETERO INFRASTRUCTURE SEZ LTD N.NARASAPURAM VILLAGE,NAKKAPALLY MA SDNF India","customerAddress":"SANDOZ HOUSE"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1737916200,"product":"SITAGLIPTIN PHOSPHATE MONOHYDRATE IP OVERSULFATED CHONDROITIN SULFATE","address":"CORONA HOUSE, C-MONDEAL BUSINESS","city":"THALTEJ, AHMEDABAD , GUJARAT","supplier":"SINOBRIGHT PHARMACEUTICAL COMPANY LTD","supplierCountry":"CHINA","foreign_port":"HANGCHOW (HANGZHOU)","customer":"CORONA REMEDIES LIMITED","customerCountry":"INDIA","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"155","totalValueFC":"313.1","currency":"N\/A","unitRateINR":"13500.5","date":"27-Jan-2025","totalValueINR":"27001","totalValueInUsd":"313.1","indian_port":"Ahmedabad Air","hs_no":"29335990","bill_no":"8032933","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HANGCHOW (HANGZHOU)","supplierAddress":"OFFICE F, 32\/F, PLAZA 88 NO.88 YEUNG UK ROAD, TSUEN WAN, NT, HONG KONG, CHINA","customerAddress":"CORONA HOUSE, C-MONDEAL BUSINESS"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1743100200,"product":"SITAGLIPTIN HYDROCHLORIDE","address":"SANDOZ HOUSE","city":"MUMBAI ,MAHARASHTRA","supplier":"BIOCON LIMITED SEZ UNIT","supplierCountry":"INDIA","foreign_port":"BIOCON SEZ BANGALORE","customer":"SANDOZ B2B","customerCountry":"INDIA","quantity":"211.30","actualQuantity":"211.3","unit":"KGS","unitRateFc":"676.1","totalValueFC":"143979.3","currency":"USD","unitRateINR":"59021","date":"28-Mar-2025","totalValueINR":"12471137.3","totalValueInUsd":"143979.3","indian_port":"Biocon-SEZ","hs_no":"29420090","bill_no":"9168184","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"BIOCON SEZ BANGALORE","supplierAddress":"PLOT NOS. 2,3,4 & 5, PHASE - IV, BOMMASANDRA-JIGANI LINK ROAD, BOMMA SDNF India","customerAddress":"SANDOZ HOUSE"}]
05-Jan-2021
31-Mar-2025
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INTERMEDIATE SUPPLIERS

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01

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothIOL Chemicals is an innovation-driven bulk drug, Intermediate and Specialty Chemicals company.

CAS Number : 762240-92-6

End Use API : Sitagliptin Phosphate

About The Company : With a history spanning over three decades, IOL Chemicals and Pharmaceuticals Limited is an innovation-driven company that specializes in bulk drugs, intermedia...

IOL Chemicals

02

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothIOL Chemicals is an innovation-driven bulk drug, Intermediate and Specialty Chemicals company.

CAS Number : 764667-65-4

End Use API : Sitagliptin Phosphate

About The Company : With a history spanning over three decades, IOL Chemicals and Pharmaceuticals Limited is an innovation-driven company that specializes in bulk drugs, intermedia...

IOL Chemicals

03

AACR Annual meeting
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AACR Annual meeting
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CAS Number : 762240-92-6

End Use API : Sitagliptin Phosphate

About The Company : Actis Generics Pvt Ltd is a fast emerging APIs (Active Pharmaceutical Ingredients) & Intermediates manufacturer & supplier in India set up by a group of young p...

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04

AACR Annual meeting
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AACR Annual meeting
Not Confirmed
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CAS Number : 764667-65-4

End Use API : Sitagliptin Phosphate

About The Company : Actis Generics Pvt Ltd is a fast emerging APIs (Active Pharmaceutical Ingredients) & Intermediates manufacturer & supplier in India set up by a group of young p...

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05

AACR Annual meeting
Not Confirmed
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AACR Annual meeting
Not Confirmed
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CAS Number : 486460-32-6

End Use API : Sitagliptin Phosphate

About The Company : Actis Generics Pvt Ltd is a fast emerging APIs (Active Pharmaceutical Ingredients) & Intermediates manufacturer & supplier in India set up by a group of young p...

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06

Almelo

India
AACR Annual meeting
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Almelo

India
AACR Annual meeting
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CAS Number : CAS-762240-92-6

End Use API : Sitagliptin Phosphate

About The Company : Almelo are the industry leaders in manufacturing advanced intermediates, Active Pharmaceutical Ingredients (APIs) and specialty fine chemicals. With a diverse p...

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07

Almelo

India
AACR Annual meeting
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Almelo

India
AACR Annual meeting
Not Confirmed
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CAS Number : CAS-764667-65-4

End Use API : Sitagliptin Phosphate

About The Company : Almelo are the industry leaders in manufacturing advanced intermediates, Active Pharmaceutical Ingredients (APIs) and specialty fine chemicals. With a diverse p...

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08

AACR Annual meeting
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AACR Annual meeting
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CAS Number : 2033-24-1

End Use API : Sitagliptin Phosphate

About The Company : Founded with a mission to transform strategic capital into specialty chemicals, Ami Group focuses on Agrochemicals, Cosmetics, and Polymers. Ami Organics Ltd. i...

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09

AACR Annual meeting
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AACR Annual meeting
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CAS Number : 486460-00-8

End Use API : Sitagliptin Phosphate

About The Company : Anhui Haikang Pharmaceutical Co., Ltd. was established in 2009 and located in a High-tech industry park, Anqing City, Anhui Province---a famous historical and c...

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10

AACR Annual meeting
Not Confirmed
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AACR Annual meeting
Not Confirmed
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CAS Number : 762240-92-6

End Use API : Sitagliptin Phosphate

About The Company : Anhui Haikang Pharmaceutical Co., Ltd. was established in 2009 and located in a High-tech industry park, Anqing City, Anhui Province---a famous historical and c...

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - TABLET;ORAL - EQ 100MG BASE

USFDA APPLICATION NUMBER - 21995

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DOSAGE - TABLET;ORAL - EQ 25MG BASE

USFDA APPLICATION NUMBER - 21995

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DOSAGE - TABLET;ORAL - EQ 50MG BASE

USFDA APPLICATION NUMBER - 21995

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DOSAGE - TABLET;ORAL - 1GM;EQ 50MG BASE

USFDA APPLICATION NUMBER - 22044

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DOSAGE - TABLET;ORAL - 500MG;EQ 50MG BASE

USFDA APPLICATION NUMBER - 22044

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ABOUT THIS PAGE

Looking for 1269630-53-6 / Sitagliptin Phosphate API manufacturers, exporters & distributors?

Sitagliptin Phosphate manufacturers, exporters & distributors 1

22

PharmaCompass offers a list of Sitagliptin Phosphate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Sitagliptin Phosphate manufacturer or Sitagliptin Phosphate supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Sitagliptin Phosphate manufacturer or Sitagliptin Phosphate supplier.

PharmaCompass also assists you with knowing the Sitagliptin Phosphate API Price utilized in the formulation of products. Sitagliptin Phosphate API Price is not always fixed or binding as the Sitagliptin Phosphate Price is obtained through a variety of data sources. The Sitagliptin Phosphate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Sitagliptin Phosphate

Synonyms

654671-78-0, Sitagliptin (phosphate), Mk-0431, Chembl393336, 494p4635i6, Mk0431

Cas Number

1269630-53-6

Unique Ingredient Identifier (UNII)

494P4635I6

About Sitagliptin Phosphate

A pyrazine-derived DIPEPTIDYL-PEPTIDASE IV INHIBITOR and HYPOGLYCEMIC AGENT that increases the levels of the INCRETIN hormones GLUCAGON-LIKE PEPTIDE-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). It is used in the treatment of TYPE 2 DIABETES.

MK 0431 phosphate Manufacturers

A MK 0431 phosphate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of MK 0431 phosphate, including repackagers and relabelers. The FDA regulates MK 0431 phosphate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. MK 0431 phosphate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of MK 0431 phosphate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

MK 0431 phosphate Suppliers

A MK 0431 phosphate supplier is an individual or a company that provides MK 0431 phosphate active pharmaceutical ingredient (API) or MK 0431 phosphate finished formulations upon request. The MK 0431 phosphate suppliers may include MK 0431 phosphate API manufacturers, exporters, distributors and traders.

click here to find a list of MK 0431 phosphate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

MK 0431 phosphate USDMF

A MK 0431 phosphate DMF (Drug Master File) is a document detailing the whole manufacturing process of MK 0431 phosphate active pharmaceutical ingredient (API) in detail. Different forms of MK 0431 phosphate DMFs exist exist since differing nations have different regulations, such as MK 0431 phosphate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A MK 0431 phosphate DMF submitted to regulatory agencies in the US is known as a USDMF. MK 0431 phosphate USDMF includes data on MK 0431 phosphate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The MK 0431 phosphate USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of MK 0431 phosphate suppliers with USDMF on PharmaCompass.

MK 0431 phosphate JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The MK 0431 phosphate Drug Master File in Japan (MK 0431 phosphate JDMF) empowers MK 0431 phosphate API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the MK 0431 phosphate JDMF during the approval evaluation for pharmaceutical products. At the time of MK 0431 phosphate JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of MK 0431 phosphate suppliers with JDMF on PharmaCompass.

MK 0431 phosphate KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a MK 0431 phosphate Drug Master File in Korea (MK 0431 phosphate KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of MK 0431 phosphate. The MFDS reviews the MK 0431 phosphate KDMF as part of the drug registration process and uses the information provided in the MK 0431 phosphate KDMF to evaluate the safety and efficacy of the drug.

After submitting a MK 0431 phosphate KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their MK 0431 phosphate API can apply through the Korea Drug Master File (KDMF).

click here to find a list of MK 0431 phosphate suppliers with KDMF on PharmaCompass.

MK 0431 phosphate CEP

A MK 0431 phosphate CEP of the European Pharmacopoeia monograph is often referred to as a MK 0431 phosphate Certificate of Suitability (COS). The purpose of a MK 0431 phosphate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of MK 0431 phosphate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of MK 0431 phosphate to their clients by showing that a MK 0431 phosphate CEP has been issued for it. The manufacturer submits a MK 0431 phosphate CEP (COS) as part of the market authorization procedure, and it takes on the role of a MK 0431 phosphate CEP holder for the record. Additionally, the data presented in the MK 0431 phosphate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the MK 0431 phosphate DMF.

A MK 0431 phosphate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. MK 0431 phosphate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of MK 0431 phosphate suppliers with CEP (COS) on PharmaCompass.

MK 0431 phosphate WC

A MK 0431 phosphate written confirmation (MK 0431 phosphate WC) is an official document issued by a regulatory agency to a MK 0431 phosphate manufacturer, verifying that the manufacturing facility of a MK 0431 phosphate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting MK 0431 phosphate APIs or MK 0431 phosphate finished pharmaceutical products to another nation, regulatory agencies frequently require a MK 0431 phosphate WC (written confirmation) as part of the regulatory process.

click here to find a list of MK 0431 phosphate suppliers with Written Confirmation (WC) on PharmaCompass.

MK 0431 phosphate NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing MK 0431 phosphate as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for MK 0431 phosphate API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture MK 0431 phosphate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain MK 0431 phosphate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a MK 0431 phosphate NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of MK 0431 phosphate suppliers with NDC on PharmaCompass.

MK 0431 phosphate GMP

MK 0431 phosphate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of MK 0431 phosphate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right MK 0431 phosphate GMP manufacturer or MK 0431 phosphate GMP API supplier for your needs.

MK 0431 phosphate CoA

A MK 0431 phosphate CoA (Certificate of Analysis) is a formal document that attests to MK 0431 phosphate's compliance with MK 0431 phosphate specifications and serves as a tool for batch-level quality control.

MK 0431 phosphate CoA mostly includes findings from lab analyses of a specific batch. For each MK 0431 phosphate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

MK 0431 phosphate may be tested according to a variety of international standards, such as European Pharmacopoeia (MK 0431 phosphate EP), MK 0431 phosphate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (MK 0431 phosphate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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