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Chemistry

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Also known as: Mocravimod, Krp-203 free base, 509092-16-4, X71gcj0hli, 2-amino-2-(4-((3-(benzyloxy)phenyl)thio)-2-chlorophenethyl)propane-1,3-diol, 1,3-propanediol, 2-amino-2-(2-(2-chloro-4-((3-(phenylmethoxy)phenyl)thio)phenyl)ethyl)-
Molecular Formula
C24H26ClNO3S
Molecular Weight
444.0  g/mol
InChI Key
IINUNQPYJGJCJI-UHFFFAOYSA-N
FDA UNII
X71GCJ0HLI

Mocravimod
Mocravimod is a sphingosine 1-phosphate (S1P) receptor agonist, with potential immunosuppressive activity. Upon administration of mocravimod, this agent binds to S1P receptors on lymphocytes, which prevents binding of serum S1P to S1P receptors and leads to S1P receptor internalization. This reduces the number of circulating blood leukocytes and accelerates lymphocyte homing into peripheral lymph nodes, thereby preventing their infiltration into peripheral inflammatory sites. This agent also decreases the production of inflammatory cytokines by lymphocytes, such as interferon gamma (IFN-g), interleukin-12 (IL-12), and tumor necrosis factor (TNF).
1 2D Structure

Mocravimod

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-amino-2-[2-[2-chloro-4-(3-phenylmethoxyphenyl)sulfanylphenyl]ethyl]propane-1,3-diol
2.1.2 InChI
InChI=1S/C24H26ClNO3S/c25-23-14-22(10-9-19(23)11-12-24(26,16-27)17-28)30-21-8-4-7-20(13-21)29-15-18-5-2-1-3-6-18/h1-10,13-14,27-28H,11-12,15-17,26H2
2.1.3 InChI Key
IINUNQPYJGJCJI-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC=C(C=C1)COC2=CC(=CC=C2)SC3=CC(=C(C=C3)CCC(CO)(CO)N)Cl
2.2 Other Identifiers
2.2.1 UNII
X71GCJ0HLI
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Mocravimod

2. Krp-203 Free Base

3. 509092-16-4

4. X71gcj0hli

5. 2-amino-2-(4-((3-(benzyloxy)phenyl)thio)-2-chlorophenethyl)propane-1,3-diol

6. 1,3-propanediol, 2-amino-2-(2-(2-chloro-4-((3-(phenylmethoxy)phenyl)thio)phenyl)ethyl)-

7. Unii-x71gcj0hli

8. Mocravimod [inn]

9. Mocravimod [who-dd]

10. Schembl641641

11. Gtpl9727

12. Krp203

13. Chembl2137148

14. Dtxsid30965173

15. Zinc6744940

16. Compound 2 [pmid: 23124563]

17. Ncgc00250388-01

18. Q27293620

19. 2-amino-2-[2-(4-{[3-(benzyloxy)phenyl]sulfanyl}-2-chlorophenyl)ethyl]propane-1,3-diol

20. 2-amino-2-[2-[2-chloro-4-(3-phenylmethoxyphenyl)sulfanylphenyl]ethyl]propane-1,3-diol

21. 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl]-1,3-propanediol

2.4 Create Date
2006-10-26
3 Chemical and Physical Properties
Molecular Weight 444.0 g/mol
Molecular Formula C24H26ClNO3S
XLogP34.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count10
Exact Mass443.1321926 g/mol
Monoisotopic Mass443.1321926 g/mol
Topological Polar Surface Area101 Ų
Heavy Atom Count30
Formal Charge0
Complexity487
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Mocravimod Manufacturers

A Mocravimod manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Mocravimod, including repackagers and relabelers. The FDA regulates Mocravimod manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Mocravimod API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Mocravimod Suppliers

A Mocravimod supplier is an individual or a company that provides Mocravimod active pharmaceutical ingredient (API) or Mocravimod finished formulations upon request. The Mocravimod suppliers may include Mocravimod API manufacturers, exporters, distributors and traders.

Mocravimod GMP

Mocravimod Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Mocravimod GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Mocravimod GMP manufacturer or Mocravimod GMP API supplier for your needs.

Mocravimod CoA

A Mocravimod CoA (Certificate of Analysis) is a formal document that attests to Mocravimod's compliance with Mocravimod specifications and serves as a tool for batch-level quality control.

Mocravimod CoA mostly includes findings from lab analyses of a specific batch. For each Mocravimod CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Mocravimod may be tested according to a variety of international standards, such as European Pharmacopoeia (Mocravimod EP), Mocravimod JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Mocravimod USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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