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    Chemistry

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    Also known as: 2609-46-3, Amipramidin, Midamor, Guanamprazine, Amipramizid, Amipramizide
    Molecular Formula
    C6H8ClN7O
    Molecular Weight
    229.63  g/mol
    InChI Key
    XSDQTOBWRPYKKA-UHFFFAOYSA-N
    FDA UNII
    7DZO8EB0Z3
    Amiloride Hydrochloride
    A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
    Amiloride is a Potassium-sparing Diuretic. The physiologic effect of amiloride is by means of Decreased Renal K+ Excretion, and Increased Diuresis.
    1 2D Structure

    Amiloride Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide
    2.1.2 InChI
    InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)
    2.1.3 InChI Key
    XSDQTOBWRPYKKA-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N
    2.2 Other Identifiers
    2.2.1 UNII
    7DZO8EB0Z3
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Amidal

    2. Amiduret Trom

    3. Amiloberag

    4. Amiloride Hydrochloride

    5. Amiloride Hydrochloride, Anhydrous

    6. Anhydrous Amiloride Hydrochloride

    7. Hydrochloride, Amiloride

    8. Hydrochloride, Anhydrous Amiloride

    9. Kaluril

    10. Midamor

    11. Midoride

    12. Modamide

    13. Trom, Amiduret

    2.3.2 Depositor-Supplied Synonyms

    1. 2609-46-3

    2. Amipramidin

    3. Midamor

    4. Guanamprazine

    5. Amipramizid

    6. Amipramizide

    7. Guanamprazin

    8. Amilorida

    9. 3,5-diamino-n-carbamimidoyl-6-chloropyrazine-2-carboxamide

    10. Amiloridum

    11. Amyloride

    12. Amiloridum [inn-latin]

    13. Amilorida [inn-spanish]

    14. Amiclaran

    15. N-amidino-3,5-diamino-6-chloropyrazinecarboxamide

    16. N-amidino-3,5-diamino-6-chlorpyrazincarboxamid

    17. 3,5-diamino-6-chloro-n-(diaminomethylidene)pyrazine-2-carboxamide

    18. Amiloride (inn)

    19. Pyrazinecarboxamide, 3,5-diamino-n-(aminoiminomethyl)-6-chloro-

    20. 3,5-diamino-n-(aminoiminomethyl)-6-chloropyrazinecarboxamide

    21. Mk-870

    22. Chembl945

    23. 7dzo8eb0z3

    24. Chebi:2639

    25. 137053-86-2

    26. Ncgc00015089-08

    27. Amiloride [inn]

    28. Amiloride [inn:ban]

    29. Amipramidine

    30. Dsstox_cid_23853

    31. Dsstox_rid_80077

    32. Dsstox_gsid_43853

    33. Amiclaran (tn)

    34. Cas-2609-46-3

    35. Ccris 6545

    36. Einecs 220-024-7

    37. Unii-7dzo8eb0z3

    38. Amiloridehcl

    39. Amikal (hydrochloride Dihydrate)

    40. Midamor (hydrochloride Dihydrate)

    41. Mk-870 (hydrochloride Dihydrate)

    42. Amipramidin, Midamor

    43. N-amidino-3,5-diamino-6-chloro-2-pyrazinecarboxamide

    44. Spectrum_000034

    45. Tocris-0890

    46. 1f5l

    47. Amiloride [mi]

    48. Prestwick0_000007

    49. Prestwick1_000007

    50. Prestwick2_000007

    51. Prestwick3_000007

    52. Spectrum2_000118

    53. Spectrum3_000293

    54. Spectrum4_000132

    55. Spectrum5_000776

    56. Amiloride [vandf]

    57. Lopac-a-7410

    58. Amiloride [who-dd]

    59. Lopac0_000111

    60. Schembl27562

    61. Bspbio_000013

    62. Bspbio_001572

    63. Bspbio_001826

    64. Kbiogr_000292

    65. Kbiogr_000544

    66. Kbioss_000292

    67. Kbioss_000394

    68. Mls001060798

    69. Bidd:gt0466

    70. Divk1c_000182

    71. Spbio_000136

    72. Spbio_001934

    73. Bpbio1_000015

    74. Gtpl2421

    75. Dtxsid9043853

    76. Bcbcmap01_000101

    77. Bdbm16173

    78. Kbio1_000182

    79. Kbio2_000292

    80. Kbio2_000394

    81. Kbio2_002860

    82. Kbio2_002962

    83. Kbio2_005428

    84. Kbio2_005530

    85. Kbio3_000583

    86. Kbio3_000584

    87. Kbio3_001326

    88. Ninds_000182

    89. Bio1_000359

    90. Bio1_000848

    91. Bio1_001337

    92. Bio2_000292

    93. Bio2_000772

    94. Hms1791o14

    95. Hms1989o14

    96. Hms2089h05

    97. Hms2213e05

    98. Hms3355k04

    99. Act05635

    100. Act05652

    101. Bcp16815

    102. Hy-b0285

    103. Zinc4340269

    104. Tox21_110080

    105. 3,5-diamino-n-[amino(imino)methyl]-6-chloropyrazine-2-carboxamide

    106. Bbl028157

    107. Stl373007

    108. Akos015961348

    109. Tox21_110080_1

    110. Ccg-204206

    111. Db00594

    112. Sb74937

    113. Sdccgsbi-0050099.p005

    114. Idi1_000182

    115. Idi1_034042

    116. Ncgc00015089-01

    117. Ncgc00015089-02

    118. Ncgc00015089-03

    119. Ncgc00015089-04

    120. Ncgc00015089-05

    121. Ncgc00015089-06

    122. Ncgc00015089-07

    123. Ncgc00015089-09

    124. Ncgc00015089-11

    125. Ncgc00015089-12

    126. Ncgc00015089-13

    127. Ncgc00015089-14

    128. Ncgc00015089-15

    129. Ncgc00015089-16

    130. Ncgc00015089-17

    131. Ncgc00015089-24

    132. Ncgc00024443-02

    133. Ncgc00024443-05

    134. Ncgc00024443-06

    135. Ncgc00024443-07

    136. Ncgc00024443-09

    137. Ac-13631

    138. Ls-13128

    139. Smr000486264

    140. (3,5-diamino-6-chloropyrazinoyl)guanidine

    141. Sbi-0050099.p004

    142. N-amidino-3,5-diamino-6-chloropyrazinamide

    143. Ab00053415

    144. Ft-0703177

    145. C06821

    146. D07447

    147. Ab00053415-24

    148. Ab00053415-25

    149. Ab00053415_26

    150. Ab00053415_27

    151. Ab00053415_28

    152. 609a463

    153. Q419995

    154. J-016249

    155. Brd-k97181089-003-02-3

    156. Brd-k97181089-310-03-0

    157. N-amidino 3,5-diamino-6-chloro-2-pyrazinecarboxamide

    158. F2173-0531

    159. N-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidine

    160. 3,5-diamino-n-carbamimidoyl-6-chloro-pyrazine-2-carboxamide

    161. 3,5-diamino-6-chloro-n-(diaminomethylene)pyrazinamide;hydrochloride

    2.3.3 Other Synonyms

    1. Amilorid Hydrochlorid-2-wasser

    2. Amiloride Hydrochloride Dihydrate

    2.4 Create Date
    2005-03-27
    3 Chemical and Physical Properties
    Molecular Weight 229.63 g/mol
    Molecular Formula C6H8ClN7O
    XLogP3-0.7
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count1
    Exact Mass229.0478856 g/mol
    Monoisotopic Mass229.0478856 g/mol
    Topological Polar Surface Area159 Ų
    Heavy Atom Count15
    Formal Charge0
    Complexity279
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameMidamor
    PubMed HealthAmiloride (By mouth)
    Drug ClassesCardiovascular Agent
    Drug LabelAmiloride HCl, an antikaliuretic-diuretic agent, is a pyrazine-carbonyl-guanidine that is unrelated chemically to other known antikaliuretic or diuretic agents. It is the salt of a moderately strong base (pKa 8.7). It is designated chemically as 3,5-...
    Active IngredientAmiloride hydrochloride
    Dosage FormTablet
    RouteOral
    Strength5mg
    Market StatusPrescription
    CompanyPaddock

    2 of 2  
    Drug NameMidamor
    PubMed HealthAmiloride (By mouth)
    Drug ClassesCardiovascular Agent
    Drug LabelAmiloride HCl, an antikaliuretic-diuretic agent, is a pyrazine-carbonyl-guanidine that is unrelated chemically to other known antikaliuretic or diuretic agents. It is the salt of a moderately strong base (pKa 8.7). It is designated chemically as 3,5-...
    Active IngredientAmiloride hydrochloride
    Dosage FormTablet
    RouteOral
    Strength5mg
    Market StatusPrescription
    CompanyPaddock

    4.2 Drug Indication

    For use as adjunctive treatment with thiazide diuretics or other kaliuretic-diuretic agents in congestive heart failure or hypertension.

    FDA Label

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Amiloride, an antikaliuretic-diuretic agent, is a pyrazine-carbonyl-guanidine that is unrelated chemically to other known antikaliuretic or diuretic agents. It is an antihypertensive, potassium-sparing diuretic that was first approved for use in 1967 and helps to treat hypertension and congestive heart failure. The drug is often used in conjunction with thiazide or loop diuretics. Due to its potassium-sparing capacities, hyperkalemia (high blood potassium levels) are occasionally observed in patients taking amiloride. The risk is high in concurrent use of ACE inhibitors or spironolactone. Patients are also advised not to use potassium-containing salt replacements.

    5.2 MeSH Pharmacological Classification

    Acid Sensing Ion Channel Blockers

    A subclass of sodium channel blockers that are specific for ACID-SENSING SODIUM CHANNELS. (See all compounds classified as Acid Sensing Ion Channel Blockers.)

    Diuretics

    Agents that promote the excretion of urine through their effects on kidney function. (See all compounds classified as Diuretics.)

    Epithelial Sodium Channel Blockers

    A subclass of sodium channel blockers that are specific for EPITHELIAL SODIUM CHANNELS. (See all compounds classified as Epithelial Sodium Channel Blockers.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    AMILORIDE
    5.3.2 FDA UNII
    7DZO8EB0Z3
    5.3.3 Pharmacological Classes
    Established Pharmacologic Class [EPC] - Potassium-sparing Diuretic
    5.4 ATC Code

    C - Cardiovascular system

    C03 - Diuretics

    C03D - Aldosterone antagonists and other potassium-sparing agents

    C03DB - Other potassium-sparing agents

    C03DB01 - Amiloride

    5.5 Absorption, Distribution and Excretion

    Absorption

    Readily absorbed following oral administration.

    Route of Elimination

    Amiloride HCl is not metabolized by the liver but is excreted unchanged by the kidneys. About 50 percent of a 20 mg dose of amiloride HCl is excreted in the urine and 40 percent in the stool within 72 hours.

    5.6 Metabolism/Metabolites

    Amiloride is not metabolized by the liver but is excreted unchanged by the kidneys.

    5.7 Biological Half-Life

    Plasma half-life varies from 6 to 9 hours.

    5.8 Mechanism of Action

    Amiloride works by inhibiting sodium reabsorption in the distal convoluted tubules and collecting ducts in the kidneys by binding to the amiloride-sensitive sodium channels. This promotes the loss of sodium and water from the body, but without depleting potassium. Amiloride exerts its potassium sparing effect through the inhibition of sodium reabsorption at the distal convoluted tubule, cortical collecting tubule and collecting duct; this decreases the net negative potential of the tubular lumen and reduces both potassium and hydrogen secretion and their subsequent excretion. Amiloride is not an aldosterone antagonist and its effects are seen even in the absence of aldosterone.

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    ABOUT THIS PAGE

    Looking for 2016-88-8 / Amiloride API manufacturers, exporters & distributors?

    Amiloride manufacturers, exporters & distributors 1

    35

    PharmaCompass offers a list of Amiloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Amiloride manufacturer or Amiloride supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Amiloride manufacturer or Amiloride supplier.

    PharmaCompass also assists you with knowing the Amiloride API Price utilized in the formulation of products. Amiloride API Price is not always fixed or binding as the Amiloride Price is obtained through a variety of data sources. The Amiloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Amiloride

    Synonyms

    2609-46-3, Amipramidin, Midamor, Guanamprazine, Amipramizid, Amipramizide

    Cas Number

    2016-88-8

    Unique Ingredient Identifier (UNII)

    7DZO8EB0Z3

    About Amiloride

    A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)

    Modamide Manufacturers

    A Modamide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Modamide, including repackagers and relabelers. The FDA regulates Modamide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Modamide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Modamide manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Modamide Suppliers

    A Modamide supplier is an individual or a company that provides Modamide active pharmaceutical ingredient (API) or Modamide finished formulations upon request. The Modamide suppliers may include Modamide API manufacturers, exporters, distributors and traders.

    click here to find a list of Modamide suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Modamide USDMF

    A Modamide DMF (Drug Master File) is a document detailing the whole manufacturing process of Modamide active pharmaceutical ingredient (API) in detail. Different forms of Modamide DMFs exist exist since differing nations have different regulations, such as Modamide USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Modamide DMF submitted to regulatory agencies in the US is known as a USDMF. Modamide USDMF includes data on Modamide's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Modamide USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Modamide suppliers with USDMF on PharmaCompass.

    Modamide CEP

    A Modamide CEP of the European Pharmacopoeia monograph is often referred to as a Modamide Certificate of Suitability (COS). The purpose of a Modamide CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Modamide EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Modamide to their clients by showing that a Modamide CEP has been issued for it. The manufacturer submits a Modamide CEP (COS) as part of the market authorization procedure, and it takes on the role of a Modamide CEP holder for the record. Additionally, the data presented in the Modamide CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Modamide DMF.

    A Modamide CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Modamide CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Modamide suppliers with CEP (COS) on PharmaCompass.

    Modamide WC

    A Modamide written confirmation (Modamide WC) is an official document issued by a regulatory agency to a Modamide manufacturer, verifying that the manufacturing facility of a Modamide active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Modamide APIs or Modamide finished pharmaceutical products to another nation, regulatory agencies frequently require a Modamide WC (written confirmation) as part of the regulatory process.

    click here to find a list of Modamide suppliers with Written Confirmation (WC) on PharmaCompass.

    Modamide NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Modamide as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Modamide API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Modamide as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Modamide and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Modamide NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Modamide suppliers with NDC on PharmaCompass.

    Modamide GMP

    Modamide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Modamide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Modamide GMP manufacturer or Modamide GMP API supplier for your needs.

    Modamide CoA

    A Modamide CoA (Certificate of Analysis) is a formal document that attests to Modamide's compliance with Modamide specifications and serves as a tool for batch-level quality control.

    Modamide CoA mostly includes findings from lab analyses of a specific batch. For each Modamide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Modamide may be tested according to a variety of international standards, such as European Pharmacopoeia (Modamide EP), Modamide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Modamide USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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