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Moricizine

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FINISHED DOSAGE FORMULATIONS

3 FDF Dossiers, 3 FDA Orange Book

3 FDF Dossiers
3 FDA Orange Book

REF. STANDARDS & IMPURITIES

1 USP , 1 Others

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1 USP
1 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

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CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

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$ 0

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Chemistry

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Also known as: 29560-58-5, Moracizine hydrochloride, Ethmozine, Ethmosine, Moricizine hcl, Moricizine (hydrochloride)

Molecular Formula

C₂₂H₂₆ClN₃O₄S

Molecular Weight

464.0 g/mol

InChI Key

GAQAKFHSULJNAK-UHFFFAOYSA-N

FDA UNII

71OK3Z1ESP

An antiarrhythmia agent used primarily for ventricular rhythm disturbances.

1 2D Structure

Moricizine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate;hydrochloride

2.1.2 InChI

InChI=1S/C22H25N3O4S.ClH/c1-2-29-22(27)23-16-7-8-20-18(15-16)25(17-5-3-4-6-19(17)30-20)21(26)9-10-24-11-13-28-14-12-24;/h3-8,15H,2,9-14H2,1H3,(H,23,27);1H

2.1.3 InChI Key

GAQAKFHSULJNAK-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCOC(=O)NC1=CC2=C(C=C1)SC3=CC=CC=C3N2C(=O)CCN4CCOCC4.Cl

2.2 Other Identifiers

2.2.1 UNII

71OK3Z1ESP

2.3 Synonyms

2.3.1 MeSH Synonyms

1. En 313

2. En-313

3. En313

4. Ethmozin

5. Ethmozine

6. Etmozin

7. Hydrochloride, Moricizine

8. Moracizin

9. Moracizine

10. Moricizine

2.3.2 Depositor-Supplied Synonyms

1. 29560-58-5

2. Moracizine Hydrochloride

3. Ethmozine

4. Ethmosine

5. Moricizine Hcl

6. Moricizine (hydrochloride)

7. Ethmozin

8. Etmozin

9. 71ok3z1esp

10. Mls000830274

11. Moricizine Hydrochloride [usp]

12. En 313; Ethmosine; Ethmozin

13. En 313

14. Ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate;hydrochloride

15. Moracizine Hcl

16. Smr000036736

17. Ethyl 10-(3-morpholinopropionyl)phenothiazine-2-carbamate, Hydrochloride

18. Dsstox_cid_27766

19. Dsstox_rid_82543

20. Dsstox_gsid_47786

21. Carbamic Acid, (10-(3-(4-morpholinyl)-l-oxopropyl)-10h-phenothiazin-2yl)-, Ethyl Ester, Hydrochloride

22. Moricizine Hydrochloride (usp)

23. Ethyl 10-(beta-n-morpholinylpropionyl)phenothiazine-2-carbamate Hydrochloride

24. Chebi:60937

25. Cas-29560-58-5

26. Ncgc00016809-01

27. Ncgc00016809-07

28. Unii-71ok3z1esp

29. Ethmozine (tn)

30. Opera_id_267

31. Ethyl 10-(3-morpholinopropionyl)phenothiazine-2-carbamate Hydrochloride

32. Cambridge Id 5229972

33. Ethyl Ether Of 10-(beta-morpholylpropionyl)phenthiazinecarbamino Acid Hydrochloride

34. Moracizinehydrochloride

35. Schembl41358

36. (10-(3-(4-morpholinyl)-1-oxopropyl)-10h-phenothiazin-2-yl)carbamic Acid, Ethyl Ester, Monohydrochloride

37. Mls000080120

38. Regid_for_cid_34632

39. Chembl1200334

40. Dtxsid1047786

41. Hy-b0615a

42. Hms1571c04

43. Ethyl 10-(3-morpholinopropanoyl)-

44. Tox21_110622

45. Moricizine Hydrochloride [mi]

46. Akos030506898

47. Tox21_110622_1

48. Ccg-221051

49. Moracizine Hydrochloride [mart.]

50. Moricizine Hydrochloride [vandf]

51. Phenothiazine-2-carbamic Acid, 10-(3-morpholinopropionyl)-, Ethyl Ester, Hydrochloride

52. Moracizine Hydrochloride [who-dd]

53. Moricizine Hydrochloride [usp-rs]

54. Ncgc00180924-01

55. Carbamic Acid, (10-(3-(4-morpholinyl)-1-oxopropyl)-10h-phenothiazin-2-yl)-, Ethyl Ester, Monohydrochloride

56. Db-047605

57. Cs-0013699

58. E-313

59. E-350

60. Ft-0630550

61. Moricizine Hydrochloride [orange Book]

62. D02087

63. Moricizine Hydrochloride [usp Impurity]

64. Sr-01000614327

65. Sr-01000614327-4

66. Q27130132

67. Ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate;hydron;chloride

68. Carbamic Acid, N-(10-(3-(4-morpholinyl)-1-oxopropyl)-10h-phenothiazin-2-yl)-, Ethyl Ester, Hydrochloride (1:1)

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₂H₂₆ClN₃O₄S
Molecular Weight	464.0 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Exact Mass	463.1332552 g/mol
Monoisotopic Mass	463.1332552 g/mol
Topological Polar Surface Area	96.4 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	601
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anti-Arrhythmia Agents

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

Voltage-Gated Sodium Channel Blockers

A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS. (See all compounds classified as Voltage-Gated Sodium Channel Blockers.)

FDF Dossiers