Find Motexafin Gadolinium manufacturers, exporters & distributors on PharmaCompass

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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: Motexafin gadolinium, Xcytrin, Gadolinium texaphyrin, 246252-06-2, 156436-89-4, Pci-0120
Molecular Formula
C52H74GdN5O14-
Molecular Weight
1150.4  g/mol
InChI Key
AARXZCZYLAFQQU-UHFFFAOYSA-N

Motexafin Gadolinium
1 2D Structure

Motexafin Gadolinium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
acetic acid;3-[4,5-diethyl-24-(3-hydroxypropyl)-16,17-bis[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-10,23-dimethyl-13,20,25,26-tetraza-27-azanidapentacyclo[20.2.1.13,6.18,11.014,19]heptacosa-1(25),2,4,6,8(26),9,11,13,15,17,19,21,23-tridecaen-9-yl]propan-1-ol;gadolinium
2.1.2 InChI
InChI=1S/C48H66N5O10.2C2H4O2.Gd/c1-7-35-36(8-2)40-28-42-38(12-10-14-55)34(4)46(53-42)32-50-44-30-48(63-26-24-61-22-20-59-18-16-57-6)47(62-25-23-60-21-19-58-17-15-56-5)29-43(44)49-31-45-33(3)37(11-9-13-54)41(52-45)27-39(35)51-40;2*1-2(3)4;/h27-32,54-55H,7-26H2,1-6H3;2*1H3,(H,3,4);/q-1;;;
2.1.3 InChI Key
AARXZCZYLAFQQU-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCC1=C(C2=CC3=NC(=CN=C4C=C(C(=CC4=NC=C5C(=C(C(=N5)C=C1[N-]2)CCCO)C)OCCOCCOCCOC)OCCOCCOCCOC)C(=C3CCCO)C)CC.CC(=O)O.CC(=O)O.[Gd]
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Gadolinium Texaphyrin

2. Gadolinium Texaphyrin Complex

3. Gd(iii) Texaphyrin

4. Motexafin Gadolinium

5. Pci-0120

6. Xcytrin

2.2.2 Depositor-Supplied Synonyms

1. Motexafin Gadolinium

2. Xcytrin

3. Gadolinium Texaphyrin

4. 246252-06-2

5. 156436-89-4

6. Pci-0120

7. Acetic Acid;3-[4,5-diethyl-24-(3-hydroxypropyl)-16,17-bis[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-10,23-dimethyl-13,20,25,26-tetraza-27-azanidapentacyclo[20.2.1.13,6.18,11.014,19]heptacosa-1(25),2,4,6,8(26),9,11,13,15,17,19,21,23-tridecaen-9-yl]propan-1-ol;gadolinium

8. Api-gp 3; Gd-tex; Gadolinium Texaphyrin; Gd Texaphyrin; Pci 0120; Xcytrin

9. 3-[4,5-diethyl-24-(3-hydroxypropyl)-16,17-bis[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-10,23-dimethyl-13,20,25,26-tetraza-27-azanidapentacyclo[20.2.1.13,6.18,11.014,19]heptacosa-1(25),2,4,6,8(26),9,11,13,15,17,19,21,23-tridecaen-9-yl]propan-1-ol;gadolinium(3+);diacetate

10. Gadolinium Diacetate (1z,7z,12e,20e)-4,5-diethyl-9,24-bis(3-hydroxypropyl)-16,17-bis{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}-10,23-dimethyl-13,20,25,26,27-pentaazapentacyclo[20.2.1.13,6.18,11.014,19]heptacosa-1,3,5,7,9,11(26),12,14,16,18,20,22(25),23-tridecaen-27-ide

11. Gdt2b2

12. Mgd

13. Dtxsid4037083

2.3 Create Date
2007-02-07
3 Chemical and Physical Properties
Molecular Weight 1150.4 g/mol
Molecular Formula C52H74GdN5O14-
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count19
Rotatable Bond Count28
Exact Mass1150.44734 g/mol
Monoisotopic Mass1150.44734 g/mol
Topological Polar Surface Area239 Ų
Heavy Atom Count72
Formal Charge-1
Complexity2080
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count4
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)


Contrast Media

Substances used to allow enhanced visualization of tissues. (See all compounds classified as Contrast Media.)


Photosensitizing Agents

Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms. (See all compounds classified as Photosensitizing Agents.)


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ABOUT THIS PAGE

Motexafin Gadolinium Manufacturers

A Motexafin Gadolinium manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Motexafin Gadolinium, including repackagers and relabelers. The FDA regulates Motexafin Gadolinium manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Motexafin Gadolinium API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Motexafin Gadolinium Suppliers

A Motexafin Gadolinium supplier is an individual or a company that provides Motexafin Gadolinium active pharmaceutical ingredient (API) or Motexafin Gadolinium finished formulations upon request. The Motexafin Gadolinium suppliers may include Motexafin Gadolinium API manufacturers, exporters, distributors and traders.

click here to find a list of Motexafin Gadolinium suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Motexafin Gadolinium USDMF

A Motexafin Gadolinium DMF (Drug Master File) is a document detailing the whole manufacturing process of Motexafin Gadolinium active pharmaceutical ingredient (API) in detail. Different forms of Motexafin Gadolinium DMFs exist exist since differing nations have different regulations, such as Motexafin Gadolinium USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Motexafin Gadolinium DMF submitted to regulatory agencies in the US is known as a USDMF. Motexafin Gadolinium USDMF includes data on Motexafin Gadolinium's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Motexafin Gadolinium USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Motexafin Gadolinium suppliers with USDMF on PharmaCompass.

Motexafin Gadolinium GMP

Motexafin Gadolinium Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Motexafin Gadolinium GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Motexafin Gadolinium GMP manufacturer or Motexafin Gadolinium GMP API supplier for your needs.

Motexafin Gadolinium CoA

A Motexafin Gadolinium CoA (Certificate of Analysis) is a formal document that attests to Motexafin Gadolinium's compliance with Motexafin Gadolinium specifications and serves as a tool for batch-level quality control.

Motexafin Gadolinium CoA mostly includes findings from lab analyses of a specific batch. For each Motexafin Gadolinium CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Motexafin Gadolinium may be tested according to a variety of international standards, such as European Pharmacopoeia (Motexafin Gadolinium EP), Motexafin Gadolinium JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Motexafin Gadolinium USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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