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    Chemistry

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    Also known as: 23828-92-4, Ambroxol hcl, Mucoangin, Mucosolvan, Ambroxolhydrochloride, 1384955-66-1
    Molecular Formula
    C13H19Br2ClN2O
    Molecular Weight
    414.56  g/mol
    InChI Key
    QNVKOSLOVOTXKF-UHFFFAOYSA-N
    FDA UNII
    R3593UZ7HS
    Ambroxol Hydrochloride
    A metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.
    1 2D Structure

    Ambroxol Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol;hydrochloride
    2.1.2 InChI
    InChI=1S/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10;/h5-6,10-11,17-18H,1-4,7,16H2;1H
    2.1.3 InChI Key
    QNVKOSLOVOTXKF-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CC(CCC1NCC2=C(C(=CC(=C2)Br)Br)N)O.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    R3593UZ7HS
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 4-(((2-amino-3,5-dibromophenyl)methyl)amino)cyclohexanol

    2. Abrohexal

    3. Am, Bisolvon

    4. Ambril

    5. Ambro Puren

    6. Ambro-puren

    7. Ambrobeta

    8. Ambrofur

    9. Ambrohexal

    10. Ambrols

    11. Ambrolitic

    12. Ambropp

    13. Ambropuren

    14. Ambroten

    15. Ambroxin

    16. Ambroxocompren

    17. Ambroxol

    18. Bisolvon Am

    19. Bromhexine Metabolite Viii

    20. Bronchopront

    21. Bronchowern

    22. Broxol

    23. Contac Husten Trunk

    24. Contac Husten-trunk

    25. Contac Hustentrunk

    26. Dinobroxol

    27. Duramucal

    28. Ebromin

    29. Expeflen

    30. Expit

    31. Farmabroxol

    32. Flavamed

    33. Frenopect

    34. Gelopol

    35. Hustenlser, Pect

    36. Hustenlser, Therapin

    37. Larylin Husten Lser

    38. Larylin Husten-lser

    39. Larylin Hustenlser

    40. Lasolvan

    41. Metabolite Viii, Bromhexine

    42. Mibrox

    43. Motosol

    44. Muco Fips

    45. Muco-fips

    46. Mucofips

    47. Mucosolvan

    48. Mucotablin

    49. Na 872

    50. Na-872

    51. Na872

    52. Pdiamuc

    53. Pect Hustenlser

    54. Pulmonal S

    55. Pulmonal, Ringelheimer

    56. Ringelheimer Pulmonal

    57. Sekretovit

    58. Stas Hustenlser

    59. Stas-hustenlser

    60. Stashustenlser

    61. Surbronc

    62. Therapin Hustenlser

    2.3.2 Depositor-Supplied Synonyms

    1. 23828-92-4

    2. Ambroxol Hcl

    3. Mucoangin

    4. Mucosolvan

    5. Ambroxolhydrochloride

    6. 1384955-66-1

    7. 1146648-86-3

    8. Lasolvan

    9. 15942-05-9

    10. Trans-4-((2-amino-3,5-dibromobenzyl)amino)cyclohexanol Hydrochloride

    11. Ambroxol Impurity D Hcl

    12. 4-((2-amino-3,5-dibromobenzyl)amino)cyclohexan-1-ol Hydrochloride

    13. Cis-4-((2-amino-3,5-dibromobenzyl)amino)cyclohexanol Hydrochloride

    14. Ambroxol Hydrochloride [jan]

    15. Ambroxol Hydrochloride

    16. Ambroxol (hydrochloride)

    17. Ambroxol Hydrochloride, Cis-

    18. 4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol;hydrochloride

    19. Cc995zmv90

    20. R3593uz7hs

    21. Ambroxol Impurity D Hydrochloride

    22. Na-872

    23. Mfcd00078932

    24. Nsc-758224

    25. Ambroxol Hydrochloride (jan)

    26. Ambroxol Hydrochloride 100 Microg/ml In Acetonitrile

    27. Mucolear

    28. Ambroxol Lozenge

    29. Cis-4-[(2-amino-3,5-dibromobenzyl)amino]cyclohexanol Hydrochloride

    30. Cyclohexanol, 4-(((2-amino-3,5-dibromophenyl)methyl)amino)-, Hydrochloride (1:1), Cis-

    31. Smr000875269

    32. Na 872 Hydrochloride

    33. Ncgc00016781-04

    34. Cas-23828-92-4

    35. Unii-cc995zmv90

    36. Lazolvan

    37. Ponophen

    38. 4-(2-amino-3,5-dibromobenzylamino)cyclohexanol Hydrochloride

    39. Ccris 8686

    40. Mucosolvan-l

    41. Sr-05000001463

    42. Mucosal-l

    43. Trans-4-[(2-amino-3,5-dibromobenzyl)amino]cyclohexanol Hydrochloride

    44. Hustless (tn)

    45. Prestwick_717

    46. Einecs 245-899-2

    47. Dsstox_cid_25442

    48. Dsstox_rid_80883

    49. Unii-r3593uz7hs

    50. Dsstox_gsid_45442

    51. Schembl99455

    52. Ambroxol Hydrochloride ,(s)

    53. Ambroxol Hydrochloride, 98%

    54. Mls001333105

    55. Mls001333106

    56. Mls002153788

    57. Spectrum1503080

    58. (e)-4-hdmb

    59. Na-872et

    60. Chembl1514634

    61. Dtxsid2045442

    62. Chebi:31198

    63. Hy-b1039a

    64. Dtxsid60936098

    65. Exr-202

    66. Hms1569i13

    67. Hms1922c19

    68. Pharmakon1600-01503080

    69. Ambroxol Hydrochloride [mi]

    70. 4-((2-amino-3,5-dibromobenzyl)amino)cyclohexanol Hydrochloride

    71. Bcp04490

    72. Tox21_110607

    73. Ac-024

    74. Ccg-39174

    75. Nsc758224

    76. S3064

    77. (1r,4r)-4-((2-amino-3,5-dibromobenzyl)amino)cyclohexanol Hydrochloride

    78. Akos015895175

    79. Akos015951294

    80. Akos024462505

    81. Ambroxol Hydrochloride [mart.]

    82. Ambroxol Hydrochloride [who-dd]

    83. Bcp9000284

    84. Ccg-220366

    85. Ks-5248

    86. Nsc 758224

    87. Ncgc00016781-03

    88. Ncgc00092387-01

    89. Ncgc00094999-01

    90. Ncgc00094999-02

    91. Ba166015

    92. Sy052506

    93. Ambroxol Hydrochloride, Analytical Standard

    94. Bcp0726000073

    95. Ambroxol Hydrochloride [ep Impurity]

    96. Ambroxol Hydrochloride [ep Monograph]

    97. B2267

    98. Cs-0013219

    99. Ft-0630506

    100. Sw198832-2

    101. A16398

    102. D01479

    103. H11915

    104. A816928

    105. Sr-01000837516

    106. Q-100980

    107. Sr-01000837516-3

    108. Sr-05000001463-2

    109. Q27275396

    110. Ambroxol Hydrochloride Pound Ep2001/cp2000 Pound(c)

    111. F1131-0002

    112. Ambroxol Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

    113. Trans-4-(2-amino-3,5-dibromobenzylamino)cyclohexanol Hydrochloride

    114. (1r,4r)-4-((2-amino-3,5-dibromobenzyl)amino)cyclohexan-1-ol Hydrochloride

    115. (1r,4r)-4-(2-amino-3,5-dibromobenzylamino)cyclohexanol Hydrochloride

    116. 4-[(2-amino-3,5-dibromobenzyl)amino]cyclohexanol Hydrochloride, Aldrichcpr

    117. Ambroxol Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    118. Cyclohexanol, 4-((2-amino-3,5-dibromobenzyl)amino)-, Hydrochloride, Trans-

    119. Cyclohexanol, 4-(n-(2-amino-3,5-dibromobenzyl)amino)-, Hydrochloride (e)-

    120. Cyclohexanol, 4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-, Hydrochloride

    121. Cyclohexanol,4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-,hydrochloride

    122. Trans-4-((2-amino-3,5-dibromobenzyl)-amino)cyclohexanol Hydrochloride

    123. 4-{[(2-amino-3,5-dibromophenyl)methyl]amino}cyclohexan-1-ol--hydrogen Chloride (1/1)

    124. Cyclohexanol, 4-(((2-amino-3,5-dibromophenyl)methyl)amino)-, Monohydrochloride, Trans-

    125. Cyclohexanol, 4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-, Hydrochloride (1:1), Trans-

    126. Imp. D (ep): Cis-4-[(2-amino-3,5-dibromobenzyl)amino]-cyclohexanol Hcl

    127. Trans-4-(((2-amino-3,5-dibromophenyl)methyl)amino)cyclohexan-1-ol Hydrochloride

    128. Trans-4-[[(2-amino-3,5-dibromo-phenyl)methyl]amino]-cyclohexanol Hydrochloride

    129. Trans-4-[[(2-amino-3,5-dibromophenyl)methyl]amino]cyclohexanol Hydrochloride

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 414.56 g/mol
    Molecular Formula C13H19Br2ClN2O
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count3
    Exact Mass413.95322 g/mol
    Monoisotopic Mass411.95527 g/mol
    Topological Polar Surface Area58.3 Ų
    Heavy Atom Count19
    Formal Charge0
    Complexity259
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Expectorants

    Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here. (See all compounds classified as Expectorants.)

    API Reference Price

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    01-Jan-2021
    23-Oct-2024
    KGS
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