Granules India Limited has high volume world-class facilities for APIs, PFIs, & FDFs, serving customers in over 80 countries.

Contact Supplier

Jai Radhe Sales is your partner for all your sourcing needs.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

DEVELOPMENTS

3 Drugs in Development

3 Drugs in Development

DIGITAL CONTENT

1 NEWS #PharmaBuzz

media
1 NEWS #PharmaBuzz

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

3DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: 944252-63-5, Murepavadin [inn], Pol7080, Ro7033877, 0d02gry87z, Ro-7033877

Molecular Formula

C₇₃H₁₁₂N₂₂O₁₆

Molecular Weight

1553.8 g/mol

InChI Key

RIDRXGOBXZLKHZ-NZUANIILSA-N

FDA UNII

0D02GRY87Z

Murepavadin is under investigation in clinical trial NCT02110459 (Pharmacokinetics and Safety of POL7080 in Patients With Renal Impairment).

1 2D Structure

Murepavadin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(3R,9S,12S,15S,18S,21S,24S,27R,30S,33S,36S,39S,42S,45S)-15,18,24,27,33-pentakis(2-aminoethyl)-30-(3-aminopropyl)-36-[(2S)-butan-2-yl]-42-[(1R)-1-hydroxyethyl]-9-(hydroxymethyl)-21,39-bis(1H-indol-3-ylmethyl)-12-methyl-1,7,10,13,16,19,22,25,28,31,34,37,40,43-tetradecazatricyclo[43.3.0.03,7]octatetracontane-2,8,11,14,17,20,23,26,29,32,35,38,41,44-tetradecone

2.1.2 InChI

InChI=1S/C73H112N22O16/c1-5-38(2)58-70(108)88-52(24-30-79)65(103)83-47(17-10-25-74)62(100)85-49(21-27-76)63(101)86-51(23-29-78)66(104)89-53(33-41-35-80-45-15-8-6-13-43(41)45)67(105)87-50(22-28-77)64(102)84-48(20-26-75)61(99)82-39(3)60(98)91-55(37-96)72(110)95-32-12-19-57(95)73(111)94-31-11-18-56(94)69(107)93-59(40(4)97)71(109)90-54(68(106)92-58)34-42-36-81-46-16-9-7-14-44(42)46/h6-9,13-16,35-36,38-40,47-59,80-81,96-97H,5,10-12,17-34,37,74-79H2,1-4H3,(H,82,99)(H,83,103)(H,84,102)(H,85,100)(H,86,101)(H,87,105)(H,88,108)(H,89,104)(H,90,109)(H,91,98)(H,92,106)(H,93,107)/t38-,39-,40+,47-,48-,49+,50-,51-,52-,53-,54-,55-,56-,57+,58-,59-/m0/s1

2.1.3 InChI Key

RIDRXGOBXZLKHZ-NZUANIILSA-N

2.1.4 Canonical SMILES

CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2CCCC2C(=O)N3CCCC3C(=O)NC(C(=O)NC(C(=O)N1)CC4=CNC5=CC=CC=C54)C(C)O)CO)C)CCN)CCN)CC6=CNC7=CC=CC=C76)CCN)CCN)CCCN)CCN

2.1.5 Isomeric SMILES

CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2CCC[C@@H]2C(=O)N3CCC[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC4=CNC5=CC=CC=C54)[C@@H](C)O)CO)C)CCN)CCN)CC6=CNC7=CC=CC=C76)CCN)CCN)CCCN)CCN

2.2 Other Identifiers

2.2.1 UNII

0D02GRY87Z

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Cyclo(-l-threonyl-l-tryptophanyl-l-isoleucyl-l-2,4-diaminobutyryl-l-ornithyl-d-2,4-diaminobutyryl-l-2,4-diaminobutyryl-l-tryptophanyl-l-2,4-diaminobutyryl-l-2,4-diaminobutyryl-l-alanyl-l-seryl-d-prolyl-l-prolyl), Acetate Salt

2. Pol7080

2.3.2 Depositor-Supplied Synonyms

1. 944252-63-5

2. Murepavadin [inn]

3. Pol7080

4. Ro7033877

5. 0d02gry87z

6. Ro-7033877

7. Pol-7080

8. Cyclo(l-alanyl-l-seryl-d-prolyl-l-prolyl-l-threonyl-l-tryptophyl-l-isoleucyl-(2s)-2,4-diaminobutanoyl-l-ornithyl-(2r)-2,4-diaminobutanoyl-(2s)-2,4-diaminobutanoyl-l-tryptophyl-(2s)-2,4-diaminobutanoyl-(2s)-2,4-diaminobutanoyl)

9. Unii-0d02gry87z

10. Murepavadin (usan/inn)

11. Murepavadin [usan:inn]

12. Murepavadin [usan]

13. Murepavadin [who-dd]

14. Chembl3946483

15. Gtpl10832

16. Ex-a4063

17. Rg7929

18. Akos037648482

19. Db14777

20. Rg-7929

21. Bs-14122

22. D10957

23. D80443

24. Q27236621

2.4 Create Date

2015-08-03

3 Chemical and Physical Properties

Molecular Formula	C₇₃H₁₁₂N₂₂O₁₆
Molecular Weight	1553.8 g/mol
XLogP3	-4.1
Hydrogen Bond Donor Count	22
Hydrogen Bond Acceptor Count	22
Rotatable Bond Count	21
Exact Mass	1552.86266557 g/mol
Monoisotopic Mass	1552.86266557 g/mol
Topological Polar Surface Area	618 Å²
Heavy Atom Count	111
Formal Charge	0
Complexity	3200
Isotope Atom Count	0
Defined Atom Stereocenter Count	16
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

Drugs in Development

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Digital Content

Create Content with PharmaCompass, ask us

NEWS #PharmaBuzz

ABOUT THIS PAGE

Find Murepavadin manufacturers, exporters & distributors on PharmaCompass

Murepavadin

ACCESS ALL DATA

Browse all information

CHEMISTRY

Discover Molecule Insights

DEVELOPMENTS

3 Drugs in Development

DIGITAL CONTENT

1 NEWS #PharmaBuzz

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

3DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

PATENTS & EXCLUSIVITIES

DIGITAL CONTENT

GLOBAL SALES INFORMATION

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

What are you looking for?