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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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API Suppliers

API Suppliers

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USDMF

US DMFs Filed

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CEP/COS

CEP/COS Certifications

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JDMF

JDMFs Filed

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EU WC

EU WC

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KDMF

KDMF

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NDC API

NDC API

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VMF

NDC API

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Listed Suppliers

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API REF. PRICE (USD/KG)

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MARKET PLACE

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API

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FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

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FDF Dossiers

FDF Dossiers

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FDA Orange Book

FDA (Orange Book)

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Europe

Europe

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Canada

Canada

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Australia

Australia

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South Africa

South Africa

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Listed Dossiers

Listed Dossiers

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

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EDQM

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USP

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JP

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PATENTS & EXCLUSIVITIES

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Health Canada Patents

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Data Compilation #PharmaFlow

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GLOBAL SALES INFORMATION

US Medicaid

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Finished Drug Prices

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Chemistry

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Also known as: 944252-63-5, Murepavadin [inn], Pol7080, Ro7033877, 0d02gry87z, Ro-7033877
Molecular Formula
C73H112N22O16
Molecular Weight
1553.8  g/mol
InChI Key
RIDRXGOBXZLKHZ-NZUANIILSA-N
FDA UNII
0D02GRY87Z

Murepavadin
Murepavadin is under investigation in clinical trial NCT02110459 (Pharmacokinetics and Safety of POL7080 in Patients With Renal Impairment).
1 2D Structure

Murepavadin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(3R,9S,12S,15S,18S,21S,24S,27R,30S,33S,36S,39S,42S,45S)-15,18,24,27,33-pentakis(2-aminoethyl)-30-(3-aminopropyl)-36-[(2S)-butan-2-yl]-42-[(1R)-1-hydroxyethyl]-9-(hydroxymethyl)-21,39-bis(1H-indol-3-ylmethyl)-12-methyl-1,7,10,13,16,19,22,25,28,31,34,37,40,43-tetradecazatricyclo[43.3.0.03,7]octatetracontane-2,8,11,14,17,20,23,26,29,32,35,38,41,44-tetradecone
2.1.2 InChI
InChI=1S/C73H112N22O16/c1-5-38(2)58-70(108)88-52(24-30-79)65(103)83-47(17-10-25-74)62(100)85-49(21-27-76)63(101)86-51(23-29-78)66(104)89-53(33-41-35-80-45-15-8-6-13-43(41)45)67(105)87-50(22-28-77)64(102)84-48(20-26-75)61(99)82-39(3)60(98)91-55(37-96)72(110)95-32-12-19-57(95)73(111)94-31-11-18-56(94)69(107)93-59(40(4)97)71(109)90-54(68(106)92-58)34-42-36-81-46-16-9-7-14-44(42)46/h6-9,13-16,35-36,38-40,47-59,80-81,96-97H,5,10-12,17-34,37,74-79H2,1-4H3,(H,82,99)(H,83,103)(H,84,102)(H,85,100)(H,86,101)(H,87,105)(H,88,108)(H,89,104)(H,90,109)(H,91,98)(H,92,106)(H,93,107)/t38-,39-,40+,47-,48-,49+,50-,51-,52-,53-,54-,55-,56-,57+,58-,59-/m0/s1
2.1.3 InChI Key
RIDRXGOBXZLKHZ-NZUANIILSA-N
2.1.4 Canonical SMILES
CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2CCCC2C(=O)N3CCCC3C(=O)NC(C(=O)NC(C(=O)N1)CC4=CNC5=CC=CC=C54)C(C)O)CO)C)CCN)CCN)CC6=CNC7=CC=CC=C76)CCN)CCN)CCCN)CCN
2.1.5 Isomeric SMILES
CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2CCC[C@@H]2C(=O)N3CCC[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC4=CNC5=CC=CC=C54)[C@@H](C)O)CO)C)CCN)CCN)CC6=CNC7=CC=CC=C76)CCN)CCN)CCCN)CCN
2.2 Other Identifiers
2.2.1 UNII
0D02GRY87Z
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Cyclo(-l-threonyl-l-tryptophanyl-l-isoleucyl-l-2,4-diaminobutyryl-l-ornithyl-d-2,4-diaminobutyryl-l-2,4-diaminobutyryl-l-tryptophanyl-l-2,4-diaminobutyryl-l-2,4-diaminobutyryl-l-alanyl-l-seryl-d-prolyl-l-prolyl), Acetate Salt

2. Pol7080

2.3.2 Depositor-Supplied Synonyms

1. 944252-63-5

2. Murepavadin [inn]

3. Pol7080

4. Ro7033877

5. 0d02gry87z

6. Ro-7033877

7. Pol-7080

8. Cyclo(l-alanyl-l-seryl-d-prolyl-l-prolyl-l-threonyl-l-tryptophyl-l-isoleucyl-(2s)-2,4-diaminobutanoyl-l-ornithyl-(2r)-2,4-diaminobutanoyl-(2s)-2,4-diaminobutanoyl-l-tryptophyl-(2s)-2,4-diaminobutanoyl-(2s)-2,4-diaminobutanoyl)

9. Unii-0d02gry87z

10. Murepavadin (usan/inn)

11. Murepavadin [usan:inn]

12. Murepavadin [usan]

13. Murepavadin [who-dd]

14. Chembl3946483

15. Gtpl10832

16. Ex-a4063

17. Rg7929

18. Akos037648482

19. Db14777

20. Rg-7929

21. Bs-14122

22. D10957

23. D80443

24. Q27236621

2.4 Create Date
2015-08-03
3 Chemical and Physical Properties
Molecular Weight 1553.8 g/mol
Molecular Formula C73H112N22O16
XLogP3-4.1
Hydrogen Bond Donor Count22
Hydrogen Bond Acceptor Count22
Rotatable Bond Count21
Exact Mass1552.86266557 g/mol
Monoisotopic Mass1552.86266557 g/mol
Topological Polar Surface Area618 Ų
Heavy Atom Count111
Formal Charge0
Complexity3200
Isotope Atom Count0
Defined Atom Stereocenter Count16
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


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ABOUT THIS PAGE

Murepavadin Manufacturers

A Murepavadin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Murepavadin, including repackagers and relabelers. The FDA regulates Murepavadin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Murepavadin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Murepavadin Suppliers

A Murepavadin supplier is an individual or a company that provides Murepavadin active pharmaceutical ingredient (API) or Murepavadin finished formulations upon request. The Murepavadin suppliers may include Murepavadin API manufacturers, exporters, distributors and traders.

Murepavadin GMP

Murepavadin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Murepavadin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Murepavadin GMP manufacturer or Murepavadin GMP API supplier for your needs.

Murepavadin CoA

A Murepavadin CoA (Certificate of Analysis) is a formal document that attests to Murepavadin's compliance with Murepavadin specifications and serves as a tool for batch-level quality control.

Murepavadin CoA mostly includes findings from lab analyses of a specific batch. For each Murepavadin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Murepavadin may be tested according to a variety of international standards, such as European Pharmacopoeia (Murepavadin EP), Murepavadin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Murepavadin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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