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Muzolimine

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ACTIVE PHARMA INGREDIENTS

2 API Suppliers, 2 USDMF

2 API Suppliers
2 USDMF

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

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PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

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GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 55294-15-0, Edrul, Muzolimina, Bay g 2821, Bay-g-2821, Bay-g 2821; edrul

Molecular Formula

C₁₁H₁₁Cl₂N₃O

Molecular Weight

272.13 g/mol

InChI Key

RLWRMIYXDPXIEX-UHFFFAOYSA-N

FDA UNII

07Z36289ZX

A pyrazole diuretic with long duration and high capacity of action. It was proposed for kidney failure and hypertension but was withdrawn worldwide because of severe neurological effects.

1 2D Structure

Muzolimine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-4H-pyrazol-3-one

2.1.2 InChI

InChI=1S/C11H11Cl2N3O/c1-6(16-11(17)5-10(14)15-16)7-2-3-8(12)9(13)4-7/h2-4,6H,5H2,1H3,(H2,14,15)

2.1.3 InChI Key

RLWRMIYXDPXIEX-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(C1=CC(=C(C=C1)Cl)Cl)N2C(=O)CC(=N2)N

2.2 Other Identifiers

2.2.1 UNII

07Z36289ZX

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Bay G 2821

2. G 2821, Bay

2.3.2 Depositor-Supplied Synonyms

1. 55294-15-0

2. Edrul

3. Muzolimina

4. Bay G 2821

5. Bay-g-2821

6. Bay-g 2821; Edrul

7. 3-amino-1-(1-(3,4-dichlorophenyl)ethyl)-1h-pyrazol-5(4h)-one

8. Bay-g 2821

9. 07z36289zx

10. Muzolimina [spanish]

11. 3h-pyrazol-3-one, 5-amino-2-(1-(3,4-dichlorophenyl)ethyl)-2,4-dihydro-

12. 3h-pyrazol-3-one, 5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-2,4-dihydro-

13. Muzoliminum

14. Muzoliminum [inn-latin]

15. Muzolimina [inn-spanish]

16. Einecs 259-573-2

17. Brn 0660881

18. Muzolimine [usan:inn:ban]

19. Unii-07z36289zx

20. 5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-4h-pyrazol-3-one

21. Muzolimine [mi]

22. 3-amino-1-(3,4-dichloro-alpha-methylbenzyl)-2-pyrazolin-5-one

23. Muzolimine [inn]

24. Muzolimine (usan/inn)

25. Muzolimine [usan]

26. 3-amino-1-(3,4-dichloro-alpha-methylbenzyl)-4,5-dihydro-5-pyrazolon

27. 3h-pyrazol-3-one, 2,4-dihydro-5-amino-2-(1-(3,4-dichlorophenyl)ethyl)-

28. 5-amino-2-(1-(3,4-dichlorophenyl)-ethyl)-2,4-dihydro-3h-pyrazol-3-one

29. Muzolimine [mart.]

30. Muzolimine [who-dd]

31. Schembl123392

32. Chembl1697760

33. Dtxsid50866476

34. Chebi:135124

35. 5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-2,4-dihydro-3h-pyrazol-3-one

36. Db13801

37. Da-04927

38. Hy-106616

39. Cs-0026158

40. Ft-0759718

41. D05093

42. Q3868794

43. 3-amino-1-(3,4-dichloro-a-methylbenzyl)-2-pyrazolin-5-one

44. 3-amino-1-(3,4-dichloro-.alpha.-methylbenzyl)-2-pyrazolin-5-one

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₁₁H₁₁Cl₂N₃O
Molecular Weight	272.13 g/mol
XLogP3	2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Exact Mass	271.0279174 g/mol
Monoisotopic Mass	271.0279174 g/mol
Topological Polar Surface Area	58.7 Å²
Heavy Atom Count	17
Formal Charge	0
Complexity	348
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

Diuretics

Agents that promote the excretion of urine through their effects on kidney function. (See all compounds classified as Diuretics.)

4.2 ATC Code

C - Cardiovascular system

C03 - Diuretics

C03C - High-ceiling diuretics

C03CD - Pyrazolone derivatives

C03CD01 - Muzolimine

API SUPPLIERS

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USDMF

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ABOUT THIS PAGE

Muzolimine Manufacturers

A Muzolimine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Muzolimine, including repackagers and relabelers. The FDA regulates Muzolimine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Muzolimine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Muzolimine Suppliers

A Muzolimine supplier is an individual or a company that provides Muzolimine active pharmaceutical ingredient (API) or Muzolimine finished formulations upon request. The Muzolimine suppliers may include Muzolimine API manufacturers, exporters, distributors and traders.

click here to find a list of Muzolimine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Muzolimine USDMF

A Muzolimine DMF (Drug Master File) is a document detailing the whole manufacturing process of Muzolimine active pharmaceutical ingredient (API) in detail. Different forms of Muzolimine DMFs exist exist since differing nations have different regulations, such as Muzolimine USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Muzolimine DMF submitted to regulatory agencies in the US is known as a USDMF. Muzolimine USDMF includes data on Muzolimine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Muzolimine USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Muzolimine suppliers with USDMF on PharmaCompass.

Muzolimine GMP

Muzolimine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Muzolimine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Muzolimine GMP manufacturer or Muzolimine GMP API supplier for your needs.

Muzolimine CoA

A Muzolimine CoA (Certificate of Analysis) is a formal document that attests to Muzolimine's compliance with Muzolimine specifications and serves as a tool for batch-level quality control.

Muzolimine CoA mostly includes findings from lab analyses of a specific batch. For each Muzolimine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Muzolimine may be tested according to a variety of international standards, such as European Pharmacopoeia (Muzolimine EP), Muzolimine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Muzolimine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.