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    Muzolimine

    ACTIVE PHARMA INGREDIENTS

    PharmaCompass
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    2D Structure
    Also known as: 55294-15-0, Edrul, Muzolimina, Bay g 2821, Bay-g-2821, Bay-g 2821; edrul
    Molecular Formula
    C11H11Cl2N3O
    Molecular Weight
    272.13  g/mol
    InChI Key
    RLWRMIYXDPXIEX-UHFFFAOYSA-N
    FDA UNII
    07Z36289ZX
    A pyrazole diuretic with long duration and high capacity of action. It was proposed for kidney failure and hypertension but was withdrawn worldwide because of severe neurological effects.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-4H-pyrazol-3-one
    2.1.2 InChI
    InChI=1S/C11H11Cl2N3O/c1-6(16-11(17)5-10(14)15-16)7-2-3-8(12)9(13)4-7/h2-4,6H,5H2,1H3,(H2,14,15)
    2.1.3 InChI Key
    RLWRMIYXDPXIEX-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(C1=CC(=C(C=C1)Cl)Cl)N2C(=O)CC(=N2)N
    2.2 Other Identifiers
    2.2.1 UNII
    07Z36289ZX
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Bay G 2821

    2. G 2821, Bay

    2.3.2 Depositor-Supplied Synonyms

    1. 55294-15-0

    2. Edrul

    3. Muzolimina

    4. Bay G 2821

    5. Bay-g-2821

    6. Bay-g 2821; Edrul

    7. 3-amino-1-(1-(3,4-dichlorophenyl)ethyl)-1h-pyrazol-5(4h)-one

    8. Bay-g 2821

    9. 07z36289zx

    10. Muzolimina [spanish]

    11. 3h-pyrazol-3-one, 5-amino-2-(1-(3,4-dichlorophenyl)ethyl)-2,4-dihydro-

    12. 3h-pyrazol-3-one, 5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-2,4-dihydro-

    13. Muzoliminum

    14. Muzoliminum [inn-latin]

    15. Muzolimina [inn-spanish]

    16. Einecs 259-573-2

    17. Brn 0660881

    18. Muzolimine [usan:inn:ban]

    19. Unii-07z36289zx

    20. 5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-4h-pyrazol-3-one

    21. Muzolimine [mi]

    22. 3-amino-1-(3,4-dichloro-alpha-methylbenzyl)-2-pyrazolin-5-one

    23. Muzolimine [inn]

    24. Muzolimine (usan/inn)

    25. Muzolimine [usan]

    26. 3-amino-1-(3,4-dichloro-alpha-methylbenzyl)-4,5-dihydro-5-pyrazolon

    27. 3h-pyrazol-3-one, 2,4-dihydro-5-amino-2-(1-(3,4-dichlorophenyl)ethyl)-

    28. 5-amino-2-(1-(3,4-dichlorophenyl)-ethyl)-2,4-dihydro-3h-pyrazol-3-one

    29. Muzolimine [mart.]

    30. Muzolimine [who-dd]

    31. Schembl123392

    32. Chembl1697760

    33. Dtxsid50866476

    34. Chebi:135124

    35. 5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-2,4-dihydro-3h-pyrazol-3-one

    36. Db13801

    37. Da-04927

    38. Hy-106616

    39. Cs-0026158

    40. Ft-0759718

    41. D05093

    42. Q3868794

    43. 3-amino-1-(3,4-dichloro-a-methylbenzyl)-2-pyrazolin-5-one

    44. 3-amino-1-(3,4-dichloro-.alpha.-methylbenzyl)-2-pyrazolin-5-one

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 272.13 g/mol
    Molecular Formula C11H11Cl2N3O
    XLogP32
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count2
    Exact Mass271.0279174 g/mol
    Monoisotopic Mass271.0279174 g/mol
    Topological Polar Surface Area58.7 Ų
    Heavy Atom Count17
    Formal Charge0
    Complexity348
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    Diuretics

    Agents that promote the excretion of urine through their effects on kidney function. (See all compounds classified as Diuretics.)

    4.2 ATC Code

    C - Cardiovascular system

    C03 - Diuretics

    C03C - High-ceiling diuretics

    C03CD - Pyrazolone derivatives

    C03CD01 - Muzolimine