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N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide

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30 API Suppliers, 3 USDMF, 8 EU WC, 4 KDMF, 3 NDC API, 25 Listed Suppliers, $ API Reference Price

30 API Suppliers
3 USDMF
8 EU WC
4 KDMF
3 NDC API
25 Listed Suppliers
$ API Reference Price

INTERMEDIATES

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25 FDF Dossiers, 17 Europe, 1 South Africa, 7 Listed Dossiers

25 FDF Dossiers
17 Europe
1 South Africa
7 Listed Dossiers

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14 Finished Drug Prices

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14 Finished Drug Prices

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ANALYTICAL

1 BioAnalytical Methods

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1 BioAnalytical Methods

Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: 138112-76-2, Thymanax, Valdoxan, N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide, N-(2-(7-methoxynaphthalen-1-yl)ethyl)acetamide, S20098

Molecular Formula

C₁₅H₁₇NO₂

Molecular Weight

243.30 g/mol

InChI Key

YJYPHIXNFHFHND-UHFFFAOYSA-N

FDA UNII

137R1N49AD

Agomelatine is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression. Agomelatine was developed in Europe by Servier Laboratories Ltd. and submitted to the European Medicines Agency (EMA) in 2005. The Committee for Medical Products for Human Use (CHMP) recommended refusal of marketing authorization on 27 July 2006. The major concern was that efficacy had not been sufficiently shown. In 2006 Servier sold the rights to develop Agomelatine in the US to Novartis. The development for the US market was discontinued in October 2011. It is currently sold in Australia under the Valdoxan trade name.

1 2D Structure

Agomelatine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide

2.1.2 InChI

InChI=1S/C15H17NO2/c1-11(17)16-9-8-13-5-3-4-12-6-7-14(18-2)10-15(12)13/h3-7,10H,8-9H2,1-2H3,(H,16,17)

2.1.3 InChI Key

YJYPHIXNFHFHND-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(=O)NCCC1=CC=CC2=C1C=C(C=C2)OC

2.2 Other Identifiers

2.2.1 UNII

137R1N49AD

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Ago 178

2. Ago-178

3. Ago178

4. N-(2-(7-methoxy-1-naphthyl)ethyl)acetamide

5. S 20098

6. S-20098

7. S20098

8. Thymanax

9. Valdoxan

2.3.2 Depositor-Supplied Synonyms

1. 138112-76-2

2. Thymanax

3. Valdoxan

4. N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide

5. N-(2-(7-methoxynaphthalen-1-yl)ethyl)acetamide

6. S20098

7. S-20098

8. Agomelatine [inn]

9. Melitor

10. Ago-178

11. S 20098

12. Acetamide, N-[2-(7-methoxy-1-naphthalenyl)ethyl]-

13. N-(2-(7-methoxy-1-naphthyl)ethyl)acetamide

14. N-(2-(7-methoxynaphth-1-yl)ethyl)acetamide

15. N-(2-(7-methoxy-1-naphthalenyl)ethyl)acetamide

16. Chembl10878

17. 137r1n49ad

18. N-[2-(7-methoxy-1-naphthalenyl)ethyl]acetamide

19. Agomelatine (inn)

20. Ncgc00253646-01

21. N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide

22. Acetamide, N-(2-(7-methoxy-1-naphthalenyl)ethyl)-

23. N-[2-(7-methoxy-naphthalen-1-yl)-ethyl]-acetamide

24. Ago 178

25. Valdoxan (tn)

26. Unii-137r1n49ad

27. Ago178

28. N-[2-(7-methoxynaphth-1-yl)ethyl]acetamide

29. Sr-01000944938

30. Agomelatine [inn:ban]

31. Ago178c

32. Agomelatine-[d4]

33. Awy

34. Agomelatine- Bio-x

35. Mfcd00916659

36. Agomelatine [mi]

37. Agomelatine [mart.]

38. Dsstox_cid_31431

39. Dsstox_rid_97317

40. Dsstox_gsid_57642

41. Agomelatine [who-dd]

42. Gtpl198

43. Mls006011913

44. Schembl114476

45. Agomelatine [ema Epar]

46. Zinc5608

47. Dtxsid3057642

48. Agomelatine, >=98% (hplc)

49. Chebi:134990

50. Bcpp000421

51. Hms3604n09

52. Hms3648g18

53. Hms3654b07

54. Hms3884a07

55. Bcp02084

56. Tox21_113772

57. Bbl029084

58. Bdbm50035179

59. Pdsp1_001305

60. Pdsp1_001784

61. Pdsp2_001289

62. Pdsp2_001767

63. S1243

64. Stl237728

65. Akos005145681

66. Ac-3395

67. Bcp9000250

68. Ccg-221950

69. Cs-0740

70. Db06594

71. Ks-1247

72. Sb19508

73. Ncgc00253646-10

74. Ba167079

75. Hy-17038

76. Smr002530056

77. Am20090763

78. B2262

79. Cas-138112-76-2

80. Ft-0657383

81. Sw219177-1

82. A19445

83. D02578

84. Ab01274769-01

85. Ab01274769_02

86. 112a762

87. L000528

88. Q395229

89. Q-102507

90. Sr-01000944938-1

91. Sr-01000944938-3

92. F0001-2383

93. (4-chlorophenyl)-[(9h-fluoren-9-ylmethoxycarbonylamino)]-aceticacid

94. N-[2-(7-methoxy-naphthalen-1-yl)-ethyl]-acetamide(agomelatine)

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₁₅H₁₇NO₂
Molecular Weight	243.30 g/mol
XLogP3	2.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	4
Exact Mass	243.125928785 g/mol
Monoisotopic Mass	243.125928785 g/mol
Topological Polar Surface Area	38.3 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	280
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

Agomelatine is indicated to treat major depressive episodes in adults.

Treatment of major depressive episodes in adults.

Treatment of major depressive episodes

5 Pharmacology and Biochemistry

5.1 Pharmacology

Agomelatine resynchronises circadian rhythms in animal models of delayed sleep phase syndrome and other circadian rhythm disruptions. It increases noradrenaline and dopamine release specifically in the frontal cortex and has no influence on the extracellular levels of serotonin. Agomelatine has shown an antidepressant-like effect in animal depression models, (learned helplessness test, despair test, and chronic mild stress) circadian rhythm desynchronisation, and in stress and anxiety models. In humans, agomelatine has positive phase shifting properties; it induces a phase advance of sleep, body temperature decline and melatonin onset. Controlled studies in humans have shown that agomelatine is as effective as the SSRI antidepressants paroxetine and sertraline in the treatment of major depression

5.2 MeSH Pharmacological Classification

Hypnotics and Sedatives

Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. (See all compounds classified as Hypnotics and Sedatives.)

5.3 ATC Code

N06AX22

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

N - Nervous system

N06 - Psychoanaleptics

N06A - Antidepressants

N06AX - Other antidepressants

N06AX22 - Agomelatine

5.4 Absorption, Distribution and Excretion

Absorption

Bioavailability is less than 5%.

5.5 Metabolism/Metabolites

Hepatic (90% CYP1A2 and 10% CYP2C9).

5.6 Biological Half-Life

<2 hours

5.7 Mechanism of Action

The novel antidepressant agent, agomelatine, behaves as an agonist at melatonin receptors (MT1 and MT2) and as an antagonist at serotonin (5-HT)(2C) receptors.

API SUPPLIERS

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USDMF

01

Changzhou Pharmaceutical Factory

China

BioFlorida Conference

Not Confirmed

02

Changzhou Pharmaceutical Factory

China

BioFlorida Conference

Not Confirmed

03

Msn Pharmachem Private Ltd

India

BioFlorida Conference

Not Confirmed

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EU WC

01

Dr. Reddy's Laboratories

India

CPhI India 2024

Booth #RH.E02

DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

Contact Supplier

India

Virtual Booth

Digital Content

Agomelatine Phosphoric Acid IH

Date of Issue : 2022-06-17

Valid Till : 2025-07-07

Written Confirmation Number : WC-0067

Address of the Firm : Chemical Technical Operations Unit-VI, APIIC Industrial Estate, Pydibhimavaram V...

02

Alembic Pharmaceuticals Limited

India

BioFlorida Conference

Not Confirmed

03

Alembic Pharmaceuticals Limited

India

BioFlorida Conference

Not Confirmed

04

Mehta API

India

BioFlorida Conference

Not Confirmed

05

MSN Laboratories

BioFlorida Conference

Not Confirmed

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API Reference Price

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PHARMASYNTEZ","customerCountry":"RUSSIA","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"3200","totalValueFC":"78151","currency":"USD","unitRateINR":232800,"date":"23-Nov-2021","totalValueINR":"5820000","totalValueInUsd":"78151","indian_port":"HYDERABAD AIR","hs_no":"29339990","bill_no":"6206687","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"RUSSIA","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"8-3-166\/6&7, IIND FLOOR,SREE ARCADEERRAGADDA, HYDERABAD-AP","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1663525800,"product":"AGOMELATINE (AS PER INV)","address":"MSN HOUSE ,PLOT NO. C-24, INDUSTRIAL ESTATE,SANATHNAGAR,HYDER","city":"HYDERABAD","supplier":"MSN LABORATORIES","supplierCountry":"INDIA","foreign_port":"SHANGHAI - PU DONG","customer":"TO THE ORDER OF.,","customerCountry":"CHINA","quantity":"4.00","actualQuantity":"4","unit":"KGS","unitRateFc":"4500","totalValueFC":"17581.5","currency":"USD","unitRateINR":352250,"date":"19-Sep-2022","totalValueINR":"1409000","totalValueInUsd":"17581.5","indian_port":"HYDERABAD AIR","hs_no":"29141990","bill_no":"4273786","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"MSN HOUSE ,PLOT NO. C-24, INDUSTRIAL ESTATE,SANATHNAGAR,HYDER, HYDERABAD","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1663698600,"product":"AGOMELATINE (TAX INVOICE NO:22-23\/EXP-53","address":"H.NO. 8-2-293\/174\/3, ROAD NO. 14,, B.N. REDDY COLONY, BANJARA HILLS,","city":"HYDERABAD,TELANGANA","supplier":"SYMED LABS","supplierCountry":"INDIA","foreign_port":"BASLE","customer":"AIRPHARM","customerCountry":"SWITZERLAND","quantity":"6.00","actualQuantity":"6","unit":"KGS","unitRateFc":"5222.3","totalValueFC":"30296.6","currency":"USD","unitRateINR":404666.66666666669,"date":"21-Sep-2022","totalValueINR":"2428000","totalValueInUsd":"30296.6","indian_port":"HYDERABAD AIR","hs_no":"29339990","bill_no":"4334313","productDescription":"API","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"H.NO. 8-2-293\/174\/3, ROAD NO. 14,, B.N. REDDY COLONY, BANJARA HILLS,, HYDERABAD,TELANGANA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1664476200,"product":"AGOMELATINE","address":"209, JHALAWAR,,PATANWALA ESTATE, L.B.S.MARG, GHATKOPAR(WEST)","city":"MUMBAI,MAHARASHTRA","supplier":"PRECISE BIO PHARMA PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"GUARULHOS","customer":"GAMMA COMERCIO IMPORTACAO &","customerCountry":"BRAZIL","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"1350","totalValueFC":"2433.2","currency":"USD","unitRateINR":97500,"date":"30-Sep-2022","totalValueINR":"195000","totalValueInUsd":"2433.2","indian_port":"BOMBAY AIR","hs_no":"29214190","bill_no":"4546404","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BRAZIL","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"209, JHALAWAR,,PATANWALA ESTATE, L.B.S.MARG, GHATKOPAR(WEST), MUMBAI,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1676226600,"product":"AGOMELATINE (TAX INVOICE NO:22-23\/EXP-10","address":"H.NO. 8-2-293\/174\/3, ROAD NO. 14,, B.N. REDDY COLONY, BANJARA HILLS,","city":"HYDERABAD,TELANGANA","supplier":"SYMED LABS","supplierCountry":"INDIA","foreign_port":"BASLE","customer":"TO THE ORDER OF","customerCountry":"SWITZERLAND","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"5148","totalValueFC":"49897.1","currency":"USD","unitRateINR":412100,"date":"13-Feb-2023","totalValueINR":"4121000","totalValueInUsd":"49897.1","indian_port":"HYDERABAD AIR","hs_no":"29339990","bill_no":"7758367","productDescription":"API","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"H.NO. 8-2-293\/174\/3, ROAD NO. 14,, B.N. REDDY COLONY, BANJARA HILLS,, HYDERABAD,TELANGANA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1677522600,"product":"AGOMELATINE (TAX INVOICE NO:22-23\/EXP-10","address":"H.NO. 8-2-293\/174\/3, ROAD NO. 14,, B.N. REDDY COLONY, BANJARA HILLS,","city":"HYDERABAD,TELANGANA","supplier":"SYMED LABS","supplierCountry":"INDIA","foreign_port":"CHONGQING","customer":"TO THE ORDER OF","customerCountry":"CHINA","quantity":"3.00","actualQuantity":"3","unit":"KGS","unitRateFc":"2500","totalValueFC":"7385.9","currency":"USD","unitRateINR":203333.33333333334,"date":"28-Feb-2023","totalValueINR":"610000","totalValueInUsd":"7385.9","indian_port":"HYDERABAD AIR","hs_no":"29339990","bill_no":"8127564","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"H.NO. 8-2-293\/174\/3, ROAD NO. 14,, B.N. REDDY COLONY, BANJARA HILLS,, HYDERABAD,TELANGANA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1681324200,"product":"PHARMA INGREDIENTS IN AGOMELATINE","address":"30, AROHI VILLA, S.P. RING ROAD, BOPAL,","city":"AHMEDABAD","supplier":"GREENCROSS EXPORT PRIVATE ","supplierCountry":"INDIA","foreign_port":"MOSCOW","customer":"TO THE ORDER","customerCountry":"RUSSIA","quantity":"22.00","actualQuantity":"22","unit":"KGS","unitRateFc":"5200","totalValueFC":"113198","currency":"USD","unitRateINR":421681.81818181818,"date":"13-Apr-2023","totalValueINR":"9277000","totalValueInUsd":"113198","indian_port":"HYDERABAD AIR","hs_no":"29141990","bill_no":"9272646","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"RUSSIA","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"30, AROHI VILLA, S.P. RING ROAD, BOPAL,, AHMEDABAD","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1683570600,"product":"AGOMELATINE TAX INVOICE NO 23 24 EXP 88DT 29 04 2023","address":"H.NO. 8-2-293\/174\/3, ROAD NO. 14,, B.N. REDDY COLONY, BANJARA HILLS,","city":"HYDERABAD,TELANGANA","supplier":"SYMED LABS","supplierCountry":"INDIA","foreign_port":"MOSCOW","customer":"TO THE ORDER","customerCountry":"RUSSIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"5000","totalValueFC":"4569.5","currency":"USD","unitRateINR":376000,"date":"09-May-2023","totalValueINR":"376000","totalValueInUsd":"4569.5","indian_port":"HYDERABAD AIR","hs_no":"29339990","bill_no":"0","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"RUSSIA","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"H.NO. 8-2-293\/174\/3, ROAD NO. 14,, B.N. REDDY COLONY, BANJARA HILLS,, HYDERABAD,TELANGANA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1693593000,"product":"PHARMACEUTICAL RAW MATERIAL-BULK DRUG FOR USE IN PHARMACEUTICAL INDUSTRIES AGOMELATINE IH","address":"708, TIMES SQUARE ARCADE,","city":"AHMEDABAD","supplier":"SKJ HEALTHCARE PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"BEIRUT","customer":"TO THE ORDER OF","customerCountry":"LEBANON","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"1015","totalValueFC":"9770.1","currency":"USD","unitRateINR":81100,"date":"02-Sep-2023","totalValueINR":"811000","totalValueInUsd":"9770.1","indian_port":"Ahmedabad Air","hs_no":"29242990","bill_no":"3660611","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"LEBANON","selfForZScoreResived":"Pharma Grade","supplierPort":"Ahmedabad Air","supplierAddress":"708, TIMES SQUARE ARCADE,, AHMEDABAD","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1693852200,"product":"PHARMACEUTICAL RAW MATERIAL-BULK DRUG FOR USE IN PHARMACEUTICAL INDUSTRIES AGOMELATINE IH","address":"708, TIMES SQUARE ARCADE,","city":"AHMEDABAD","supplier":"SKJ HEALTHCARE PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"BEIRUT","customer":"TO THE ORDER OF","customerCountry":"LEBANON","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"1015","totalValueFC":"9770.1","currency":"USD","unitRateINR":81100,"date":"05-Sep-2023","totalValueINR":"811000","totalValueInUsd":"9770.1","indian_port":"Ahmedabad Air","hs_no":"29242990","bill_no":"3720387","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"LEBANON","selfForZScoreResived":"Pharma Grade","supplierPort":"Ahmedabad Air","supplierAddress":"708, TIMES SQUARE ARCADE,, AHMEDABAD","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1694629800,"product":"AGOMELATINE","address":"PLOT NO. C-24, INDUSTRIAL ESTATE,","city":"HYDERABAD. AP","supplier":"MSN LABORATORIES","supplierCountry":"INDIA","foreign_port":"TAIPEI","customer":"TO THE ORDER OF","customerCountry":"TAIWAN","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"3000","totalValueFC":"5830.7","currency":"USD","unitRateINR":242000,"date":"14-Sep-2023","totalValueINR":"484000","totalValueInUsd":"5830.7","indian_port":"Hyderabad Air","hs_no":"29141990","bill_no":"3935881","productDescription":"API","marketType":"REGULATED MARKET","country":"TAIWAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"PLOT NO. C-24, INDUSTRIAL ESTATE,, HYDERABAD. AP","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1697049000,"product":"AGOMELATINE (TAX INVOICE NO:23-24\/EXP-583 DT:06\/10\/2023)","address":"8-3-166\/6 7, IIND FLOOR,SREE ARCADE","city":"HYDERABAD-AP","supplier":"SYMED LABS","supplierCountry":"INDIA","foreign_port":"MOSCOW","customer":"TO THE ORDER OF","customerCountry":"RUSSIA","quantity":"15.00","actualQuantity":"15","unit":"KGS","unitRateFc":"303400","totalValueFC":"53490.8","currency":"INR","unitRateINR":296800,"date":"12-Oct-2023","totalValueINR":"4452000","totalValueInUsd":"53490.8","indian_port":"Hyderabad Air","hs_no":"29339990","bill_no":"4569371","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"RUSSIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"8-3-166\/6 7, IIND FLOOR,SREE ARCADE, HYDERABAD-AP","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1698949800,"product":"AGOMELATINE (TAX INVOICE NO:23-24\/EXP-637 DT:28\/10\/2023)","address":"8-3-166\/6 7, IIND FLOOR,SREE ARCADE","city":"HYDERABAD-AP","supplier":"SYMED LABS","supplierCountry":"INDIA","foreign_port":"CAIRO","customer":"TO THE ORDER OF","customerCountry":"EGYPT","quantity":"6.00","actualQuantity":"6","unit":"KGS","unitRateFc":"1480","totalValueFC":"8718.5","currency":"USD","unitRateINR":121000,"date":"03-Nov-2023","totalValueINR":"726000","totalValueInUsd":"8718.5","indian_port":"Hyderabad Air","hs_no":"29339990","bill_no":"5123777","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"EGYPT","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"8-3-166\/6 7, IIND FLOOR,SREE ARCADE, HYDERABAD-AP","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1698949800,"product":"AGOMELATINE (TAX INVOICE NO:23-24\/EXP-636, DT:28\/10\/2023)","address":"8-3-166\/6 7, IIND FLOOR,SREE ARCADE","city":"HYDERABAD-AP","supplier":"SYMED LABS","supplierCountry":"INDIA","foreign_port":"HAMBURG - FUHLSBUETT","customer":"TO THE ORDER OF","customerCountry":"GERMANY","quantity":"0.50","actualQuantity":"0.5","unit":"KGS","unitRateFc":"7000","totalValueFC":"3374.5","currency":"USD","unitRateINR":562000,"date":"03-Nov-2023","totalValueINR":"281000","totalValueInUsd":"3374.5","indian_port":"Hyderabad Air","hs_no":"29339990","bill_no":"5123760","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"8-3-166\/6 7, IIND FLOOR,SREE ARCADE, HYDERABAD-AP","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1718649000,"product":"AGOMELATINE","address":"PLOT NO. C-24, INDUSTRIAL ESTATE,","city":"HYDERABAD. AP","supplier":"MSN LABORATORIES","supplierCountry":"INDIA","foreign_port":"TAIPEI","customer":"TRADSHINE CO LTD","customerCountry":"TAIWAN","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"3000","totalValueFC":"29591.3","currency":"USD","unitRateINR":247026.70000000001,"date":"18-Jun-2024","totalValueINR":"2470267","totalValueInUsd":"29591.3","indian_port":"Hyderabad Air","hs_no":"29141990","bill_no":"1764703","productDescription":"API","marketType":"REGULATED MARKET","country":"TAIWAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"PLOT NO. C-24, INDUSTRIAL ESTATE,, HYDERABAD. AP","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728930600,"product":"AGOMELATINE IN-HOUSE (PHARMA INGREDIENTS","address":"30, AROHI VILLA, S.P. RING ROAD, BOPAL,","city":"AHMEDABAD","supplier":"GREENCROSS EXPORT PRIVATE ","supplierCountry":"INDIA","foreign_port":"MOSCOW DOMODEDOVO","customer":"OZON LLC (OOO OZON)","customerCountry":"RUSSIA","quantity":"8.00","actualQuantity":"8","unit":"KGS","unitRateFc":"4500","totalValueFC":"34322.5","currency":"USD","unitRateINR":360500,"date":"15-Oct-2024","totalValueINR":"2884000","totalValueInUsd":"34322.5","indian_port":"Hyderabad Air","hs_no":"29141990","bill_no":"4818284","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"RUSSIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"30, AROHI VILLA, S.P. RING ROAD, BOPAL,, AHMEDABAD","customerAddress":""}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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INTERMEDIATES SUPPLIERS

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

FDF Dossiers

01

Sanofi

France

BioFlorida Conference

Not Confirmed

Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Contact Supplier

France

Virtual Booth

Digital Content

Regulatory Info :

Registration Country : Switzerland

Agomelatine

Brand Name : Agomelatin Zentiva

Dosage Form : Filmtabl

Dosage Strength : 25mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

Portfolio PDF

Product Web Link

02

Sanofi

France

BioFlorida Conference

Not Confirmed

Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Contact Supplier

France

Virtual Booth

Digital Content

Regulatory Info :

Registration Country : Switzerland

Agomelatine

Brand Name : Agomelatin Zentiva

Dosage Form : Filmtabl

Dosage Strength : 25mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

Portfolio PDF

Product Web Link

03

GL Pharma

Austria

BioFlorida Conference

Not Confirmed

04

GL Pharma

Austria

BioFlorida Conference

Not Confirmed

05

Indoco Remedies Limited

India

BioFlorida Conference

Not Confirmed

06

LES LABORATOIRES DU SAINT-LAURENT E...

Canada

France

BioFlorida Conference

Not Confirmed

10

Servier

France

BioFlorida Conference

Not Confirmed

Only 10 entries up to this point, click to access all

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Europe

01

Helvepharm AG

France

BioFlorida Conference

Not Confirmed

Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Contact Supplier

France

Virtual Booth

Digital Content

Regulatory Info :

Registration Country : Switzerland

Agomelatine

Brand Name : Agomelatin Zentiva

Dosage Form : Filmtabl

Dosage Strength : 25mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

Portfolio PDF

Product Web Link

02

Helvepharm AG

France

BioFlorida Conference

Not Confirmed

Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Contact Supplier

France

Virtual Booth

Digital Content

Regulatory Info :

Registration Country : Switzerland

Agomelatine

Brand Name : Agomelatin Zentiva

Dosage Form : Filmtabl

Dosage Strength : 25mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

Portfolio PDF

Product Web Link

Virtual Booth

Spirig HealthCare AG

Switzerland

BioFlorida Conference

Not Confirmed

09

World Medicine Ilac San ve tic LTD STl

Turkey

BioFlorida Conference

Not Confirmed

10

Servier (Ireland) Industries

Country

BioFlorida Conference

Not Confirmed

Only 10 entries up to this point, click to access all

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Whanin Pharmaceutical

South Korea

BioFlorida Conference

Not Confirmed

07

World Medicine

Turkey

BioFlorida Conference

Not Confirmed

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Global Sales Information

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Finished Drug Prices

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Market Place

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APIs

IP Grade Agomelatine (25 g) API needed in India [ENA11131]

A company that deals in the manufacturing of pharmaceutical formulations is looking for suppliers of IP Grade Agomelatine (25 g) API for the formulation of tablets. The suppliers must support this enquiry with CoA.

16 Aug 2021

Agomelatine API (10 kg) needed in Pakistan [ENA04294]

Al Syed Trade, a pharmaceutical company based in Pakistan is looking for suppliers of Agomelatine API (10 kg). Interested suppliers can contact them via Email: suffiyan@alsyedtrade.com.

29 May 2019

Agomelatine API needed in Korea [ENA03386]

One of the biggest active pharmaceutical ingredients company in Korea is looking for suppliers of Agomelatine API for domestic consumption. Suppliers must support the product with below information: 1) DMF availability 2) Price for 1 kg / 100 kg 3) Any contract with a Korean company 4) GMP certificate 5) Production/year 6) COA

08 Feb 2019

Agomeatine API (1kg) needed in Uruguay [ENA01998]

A fast-growing and developing Polish pharmaceutical company is looking for suppliers of Agomelatine API (1kg). Interested suppliers must support this enquiry with Certificate of Analysis (COA).

19 Sep 2018

Enquiry// Agomelatine, Dexlansoprazole, Tenofovir alafenamide and various other API samples needed in Vietnam [ENA00525]

A pharmaceutical company founded in 1959 in Vietnam having WHO GMP manufacturing plant is searching for suppliers of following API samples for developmental purposes: 1. Agomelatine 2. Dexlansoprazole 3. Tenofovir alafenamide 4. Dabigatran 5. Rifaximin The suppliers must support the product with GMP certificate.

25 Oct 2017

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REF. STANDARDS & IMPURITIES

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Others

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ANALYTICAL

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BioAnalytical Methods

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

30 API Suppliers

3 USDMF

8 EU WC

4 KDMF

3 NDC API

25 Listed Suppliers

$ API Reference Price

INTERMEDIATES

11 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

25 FDF Dossiers

17 Europe

1 South Africa

7 Listed Dossiers

GLOBAL SALES INFORMATION

14 Finished Drug Prices

MARKET PLACE

5 APIs

REF. STANDARDS & IMPURITIES

5 Others

ANALYTICAL

1 BioAnalytical Methods

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 3,161

MARKET PLACE

FINISHED DOSAGE FORMULATIONS

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

PATENTS & EXCLUSIVITIES

DIGITAL CONTENT

GLOBAL SALES INFORMATION

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

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