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    Chemistry

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    Also known as: 65141-46-0, Ikorel, 2-nicotinamidoethyl nitrate, Sigmart, Sg-75, Dancor
    Molecular Formula
    C8H9N3O4
    Molecular Weight
    211.17  g/mol
    InChI Key
    LBHIOVVIQHSOQN-UHFFFAOYSA-N
    FDA UNII
    260456HAM0
    Nicorandil
    A derivative of the NIACINAMIDE that is structurally combined with an organic nitrate. It is a potassium-channel opener that causes vasodilatation of arterioles and large coronary arteries. Its nitrate-like properties produce venous vasodilation through stimulation of guanylate cyclase.
    1 2D Structure

    Nicorandil

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-(pyridine-3-carbonylamino)ethyl nitrate
    2.1.2 InChI
    InChI=1S/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,(H,10,12)
    2.1.3 InChI Key
    LBHIOVVIQHSOQN-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1=CC(=CN=C1)C(=O)NCCO[N+](=O)[O-]
    2.2 Other Identifiers
    2.2.1 UNII
    260456HAM0
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 2 Nicotinamidethyl Nitrate

    2. 2 Nicotinamidoethyl Nitrate

    3. 2-nicotinamidethyl Nitrate

    4. 2-nicotinamidoethyl Nitrate

    5. Adancor

    6. Dancor

    7. Ikorel

    8. Nitrate, 2-nicotinamidethyl

    9. Nitrate, 2-nicotinamidoethyl

    10. Sg 75

    11. Sg-75

    12. Sg75

    2.3.2 Depositor-Supplied Synonyms

    1. 65141-46-0

    2. Ikorel

    3. 2-nicotinamidoethyl Nitrate

    4. Sigmart

    5. Sg-75

    6. Dancor

    7. Nicorandilum

    8. Adancor

    9. 2-(pyridine-3-carbonylamino)ethyl Nitrate

    10. 2-(nicotinamido)ethyl Nitrate

    11. Sg 75

    12. N-(2-hydroxyethyl)nicotinamide Nitrate

    13. N-(2-hydroxyethyl)nicotinamide Nitrate (ester)

    14. Nicorandil (ikorel)

    15. Chebi:31905

    16. N-[2-(nitrooxy)ethyl]-3-pyridinecarboxamide

    17. 3-pyridinecarboxamide, N-(2-(nitroxy)ethyl)-

    18. 3-pyridinecarboxamide, N-[2-(nitrooxy)ethyl]-

    19. 260456ham0

    20. Ncgc00025357-01

    21. 2-(pyridin-3-ylformamido)ethyl Nitrate

    22. 3-pyridinecarboxamide, N-(2-(nitrooxy)ethyl)-

    23. Dsstox_cid_25692

    24. Dsstox_rid_81064

    25. Dsstox_gsid_45692

    26. Nicorandilum [inn-latin]

    27. 2-[(pyridin-3-ylcarbonyl)amino]ethyl Nitrate

    28. 2-(nicotinamido)ethyl Nitrat

    29. Smr000466365

    30. Sigmart (tn)

    31. Cas-65141-46-0

    32. Perisalol

    33. N-(2-(nitrooxy)ethyl)-3-pyridinecarboxamide

    34. Sr-01000597534

    35. Einecs 265-514-1

    36. Brn 0481451

    37. Nicorandilo

    38. Unii-260456ham0

    39. Nicorandil [usan:inn:ban:jan]

    40. Nicorandil- Bio-x

    41. Mfcd00186520

    42. 2-(pyridine-3-carboxamido)ethyl Nitrate

    43. Cpd000466365

    44. Rp-46417

    45. Nicorandil [mi]

    46. Nicorandil [inn]

    47. Nicorandil [jan]

    48. Nicorandil [usan]

    49. N-[2-(nitrooxy)ethyl]pyridine-3-carboxamide

    50. Nicorandil [mart.]

    51. Nicorandil [who-dd]

    52. Schembl34547

    53. Mls000759488

    54. Mls001424162

    55. Mls002222323

    56. Mls006010701

    57. Chembl284906

    58. Gtpl2411

    59. Dtxsid8045692

    60. Nicorandil (jp17/usan/inn)

    61. Nicorandil [ep Monograph]

    62. Hms2051n16

    63. Hms2089l12

    64. Hms2095e14

    65. Hms2232a06

    66. Hms3268l19

    67. Hms3371n18

    68. Hms3393n16

    69. Hms3413g17

    70. Hms3655p05

    71. Hms3677g17

    72. Hms3712e14

    73. Bcp09434

    74. Hy-b0341

    75. Zinc1533102

    76. Tox21_110968

    77. Bdbm50247908

    78. S1971

    79. Stl445540

    80. Akos001589705

    81. Akos015855406

    82. Akos025149378

    83. Tox21_110968_1

    84. Ab04467

    85. Ac-4690

    86. Ccg-101045

    87. Db09220

    88. Hs-0049

    89. Nc00295

    90. Ncgc00025357-02

    91. Ncgc00025357-04

    92. 2-(pyridine-3-carbylamino) Ethyl Nitrate

    93. Bn164649

    94. Ft-0602677

    95. N0837

    96. Sw197675-3

    97. D01810

    98. T72780

    99. Ab00639978-08

    100. Ab00639978-09

    101. Ab00639978_10

    102. Ab00639978_11

    103. A834984

    104. Q862989

    105. Sr-01000597534-1

    106. Sr-01000597534-5

    107. Brd-k97752965-001-01-6

    108. F0005-2298

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 211.17 g/mol
    Molecular Formula C8H9N3O4
    XLogP30.8
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count4
    Exact Mass211.05930578 g/mol
    Monoisotopic Mass211.05930578 g/mol
    Topological Polar Surface Area97 Ų
    Heavy Atom Count15
    Formal Charge0
    Complexity228
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Indicated for the prevention and treatment of chronic stable angina pectoris and reduction in the risk of acute coronary syndromes.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Nicorandil is a potassium channel opener with nitrovasodilator (NO donor) actions, making it both an arterial and a venous dilator. It causes sustained dilation of both the arterial resistance and conductive vessels that increases coronary blood flow, however the effect of the drug on coronary arteries does not involve the coronary steal phenomenon. Activation of potassium channels lead to hyperpolarization of the smooth muscle cells, followed by arterial dilation and afterload reduction. Nicorandil is shown to increase pooling in the capacitance vessels with a decrease in preload through relaxing the venous vascular system. Overall, improved blood flow and reduced infarct size are achieved through reduction of end-diastolix pressure and decreased extravascular component of vascular resistance. Open studies showed the effectiveness of nicorandil treatment on various types of angina pectoris.

    5.2 MeSH Pharmacological Classification

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    Vasodilator Agents

    Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

    Vitamin B Complex

    A group of water-soluble vitamins, some of which are COENZYMES. (See all compounds classified as Vitamin B Complex.)

    Anti-Arrhythmia Agents

    Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

    5.3 ATC Code

    C - Cardiovascular system

    C01 - Cardiac therapy

    C01D - Vasodilators used in cardiac diseases

    C01DX - Other vasodilators used in cardiac diseases

    C01DX16 - Nicorandil

    5.4 Absorption, Distribution and Excretion

    Absorption

    Following oral administration, nicorandil is well absorbed from the gastrointestinal tract with the oral bioavailability of 75% with the maximum peak plasma concentration (Cmax) reached within 30-60 minutes. The mean Cmax is Cmax then is approximately 300 ng/ml. Steady-state plasma concentrations of nicorandil usually are reached within approximately 96-120 h after twice daily dosing (10 or 20mg).

    Route of Elimination

    The main route of elimination is the kidney with more than 60% of the administered dose was eliminated in the urine 24 hours after dosing. Only approximately 1% of nicorandil is excreted unchanged in the urine, and the remaining compounds are mainly the denitrated metabolite (9%) and its derivatives (e.g. nicotinuric acid 6%, nicotinamide 1%, N-methylnicotinamide < 1% and nicotinic acid < 1%). Less than 2% of administered dose is excreted through the biliary system.

    Volume of Distribution

    After oral (and i.v.) administration of the drug, the apparent volume of distribution is approximately 1.0-1.4 L/kg body weight.

    Clearance

    The total body clearance is approximately 1.15 L/min.

    5.5 Metabolism/Metabolites

    Nicorandil undergoes extensive hepatic metabolism. The main biotransformation pathways of nicorandil are denitration, followed by subsequent nicotinamide metabolism. The main pharmacologically inactive denitrated metabolite 2-nicotinamidoethanol can be detected in the urine. The derivatives formed from the nicotinamide metabolism of denitrated products are nicotinuric acid, nicotinamide, N-methylnicotinamide and nicotinic acid.

    5.6 Biological Half-Life

    The elimination half life is approximately 1 hour.

    5.7 Mechanism of Action

    Nicorandil mediates its therapeutic efficacy via two main mechanisms. Nicorandil is an activator and opener of ATP-sensitive (ATP-dependent) potassium channels (KATP channels) that are composed of Kir6.x-type subunits and sulfonylurea receptor (SUR) subunits. Nicorandil binding sites are located in the sulfonylurea receptor 2 (SUR2) in the ATP-sensitive potassium channel, which are regulatory subunits of the channel that exhibit an ATPase activitiy. There are 2 types of SUR2 subunits (2A/2B) that have identical nucleotide binding domains (NBD), where SUR2A is more predominantly expressed in skeletal and cardiac myocytes and SUR2B in smooth muscle cells. Nicorandil more potently activates SUR2B/Kir6.2 than SUR2A/Kir6.2 channels to cause hyperpolarization. ATP-NBD1 interaction influences the channel signalling by nicorandil, and the response of the channel to nicorandil is also facilitated and heightened by the interaction of ATP or ADP with NBD2. Potentiated activity of ATP-sensitive channels have cardioprotective role by limiting the duration of action potentials and preventing intraceullar calcium overload. This attenuates cellular injury by preserving cellular energetics and ultimately cell survival. KATP channel-dependent membrane hyperpolarization can also lead to vasodilation via reduction in Ca2+ influx through the voltage-gated Ca2+ channels and regulation of intracellular Ca2+ mobilization in smooth muscle cells. Nicorandil contain a nitrate moiety in its structure, making it a good dilator of vascular smooth muscle like other nitroglycerin esters. Direct relaxation of venous vascular system arises from NO-donor mediated stimulation of guanylyl cyclase and increased levels of intracellular cyclic GMP (cGMP). Elevated levels of cGMP contributes to the total relaxing effect of nicorandil at higher concentrations of the drug.

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    About the Company : Macsen is a USFDA registered, TGA GMP & WHO-GMP certified manufacturer and supplier of Active Pharmaceutical Ingredients (APIs), Biological Stains & Specialty Fine Chemicals. Our c...

    Macsen is a USFDA registered, TGA GMP & WHO-GMP certified manufacturer and supplier of Active Pharmaceutical Ingredients (APIs), Biological Stains & Specialty Fine Chemicals. Our comprehensive offerings extend to Contract Research & Custom Synthesis. With a legacy of over seven decades, Macsen combines tradition with innovation to meet the evolving needs of the chemical and pharmaceutical sectors. Our commitment to quality is evident in every aspect of our operations, from state-of-the-art manufacturing facilities to advanced analytical capabilities.
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    05

    Beijing Fukangren Biopharmaceutical

    China
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    Beijing Fukangren Biopharmaceutical

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    About the Company : Beijing Fukangren Biopharmaceutical Technology Co., Ltd. started its drug R&D service in 1999 and is the CRO company with the longest continuous service time in China. Fukangren no...

    Beijing Fukangren Biopharmaceutical Technology Co., Ltd. started its drug R&D service in 1999 and is the CRO company with the longest continuous service time in China. Fukangren now has 3 pharmaceutical R&D centers, 1 clinical R&D center, 4 API production bases and 1 preparation production base, forming an end-to-end CDMO service system that can provide customers with drug R&D and production. The development of high-end formulations is a major advantage of Fukangren. Among them, multiple platform projects such as sustained and controlled release formulations.
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    Jinzhou Jiutai Pharmaceutical

    China
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    Jinzhou Jiutai Pharmaceutical

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    About the Company : Jinzhou Jiutai Pharmaceutical is a comprehensive pharmaceutical enterprise which has more than 60 years manufacturing history. It was set up in 1951. There are 5 workshops, one res...

    Jinzhou Jiutai Pharmaceutical is a comprehensive pharmaceutical enterprise which has more than 60 years manufacturing history. It was set up in 1951. There are 5 workshops, one research institute, and 620 staff members, including 310 technical personnel. The company owns advanced production technology, mature process route and complete system for quality inspection and control.
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    07

    Pramukh Pharmachem

    India
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    About the Company : Pramukh Pharmachem, a global supplier of active pharmaceutical ingredients, is Schedule-M certified and WHO-GMP compliant. Located on the Chhatral, Mehsana-Ahmedabad Highway in Guj...

    Pramukh Pharmachem, a global supplier of active pharmaceutical ingredients, is Schedule-M certified and WHO-GMP compliant. Located on the Chhatral, Mehsana-Ahmedabad Highway in Gujarat, India, we have been delivering quality pharmaceuticals since 2017. We are dedicated to providing the highest quality medicines and adding effective value to the industry. Our commitment extends to researching globally significant chemical molecules, supported by our team of highly qualified professionals.
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    Sailong Pharmaceutical

    China
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    About the Company : Sailong Pharmaceutical Group Co., Ltd. ("Salon Pharmaceutical" for short) was established in 2002. It is a high-tech enterprise integrating drug research and development, productio...

    Sailong Pharmaceutical Group Co., Ltd. ("Salon Pharmaceutical" for short) was established in 2002. It is a high-tech enterprise integrating drug research and development, production and sales. Its current products are mainly concentrated in the nervous system, cardiovascular and cerebrovascular systems. and digestive system. After twenty years of hard work, the company has established the corporate purpose of "leading technology to achieve health care" since its establishment, focusing on drug research and development in line with international standards, and has successfully developed monosialotetrahexosylganglioside.
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    09

    Trifarma

    Italy
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    Trifarma

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    Nicorandil

    About the Company : TRIFARMA S.p.A. is an international and independent Group with the Mission to develop, manufacture and supply worldwide high quality APIs (Active Pharmaceutical Ingredients) to the...

    TRIFARMA S.p.A. is an international and independent Group with the Mission to develop, manufacture and supply worldwide high quality APIs (Active Pharmaceutical Ingredients) to the global pharmaceutical industry. In order to further improve its presence on the globalized pharmaceutical marketplace, the two Italian API factories (formerly named Alchymars SpA and ICM Industria Chimica Milanese SpA) have merged into TRIFARMA SpA, thus creating a larger and industrially, commercially stronger organization. The Shareholders of Trifarma also control the Indian company Alchymars ICM SM Pvt Ltd (abbreviated as AIS) located in Chennai, India.
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    10

    Xian Libang Pharmaceutical Co.,Ltd

    China
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    Xian Libang Pharmaceutical Co.,Ltd

    China
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    Nicorandil

    About the Company : Xi’an Libang Enterprises, established in 1996, a hi-tech biopharmaceutical-oriented corporate group specialized in the development, production and distribution of pharmaceutical ...

    Xi’an Libang Enterprises, established in 1996, a hi-tech biopharmaceutical-oriented corporate group specialized in the development, production and distribution of pharmaceutical products and healthy nutrition products, also presenting in the cultural industry. Libang Group, with Xi’an Libang Holdings Ltd. as the parent company, divided into Libang Pharmaceutical Group, Healthy Nutrition Group and other wholly owned subsidiaries engaged in culture, financial, property etc, totally over 1000 employees.
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    API Reference Price

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ISLAMABA","customer":"TO THE ORDER OF","customerCountry":"PAKISTAN","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"215","totalValueFC":"3185.3","currency":"USD","unitRateINR":10677.25,"date":"09-Sep-2024","totalValueINR":"266931.25","totalValueInUsd":"3185.3","indian_port":"Bombay Air","hs_no":"29333990","bill_no":"3854758","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"PAKISTAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"CEAT MAHAL, 463, ANNIE BESANT ROAD,, MUMBAI, MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725820200,"product":"NICORANDIL","address":"CEAT MAHAL, 463, ANNIE BESANT ROAD,","city":"MUMBAI, MAHARASHTRA","supplier":"RPG LIFE SCIENCES LTD.","supplierCountry":"INDIA","foreign_port":"ISLAMABAD - ISLAMABA","customer":"TO THE ORDER OF","customerCountry":"PAKISTAN","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"215","totalValueFC":"5112.5","currency":"USD","unitRateINR":17137.25,"date":"09-Sep-2024","totalValueINR":"428431.25","totalValueInUsd":"5112.5","indian_port":"Bombay Air","hs_no":"29333990","bill_no":"3860220","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"PAKISTAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"CEAT MAHAL, 463, ANNIE BESANT ROAD,, MUMBAI, MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1726165800,"product":"ACTIVE PHARMACEUTICAL INGREDIENT -NICORANDIL BP2024","address":"207\/208,UDYOG BHAVAN,SONAWALA ROAD,","city":"MUMBAI ,MAHARASHTRA","supplier":"SUPRIYA LIFESCIENCE","supplierCountry":"INDIA","foreign_port":"HO CHI MINH C","customer":"CONSIGNEE","customerCountry":"VIETNAM","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"285","totalValueFC":"6924.8","currency":"USD","unitRateINR":23212.118399999999,"date":"13-Sep-2024","totalValueINR":"580302.96","totalValueInUsd":"6924.8","indian_port":"Bombay Air","hs_no":"29362990","bill_no":"3979023","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"VIETNAM","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"207\/208,UDYOG BHAVAN,SONAWALA ROAD,, MUMBAI ,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729276200,"product":"NICORANDIL","address":"CEAT MAHAL, 463, ANNIE BESANT ROAD,","city":"MUMBAI, MAHARASHTRA","supplier":"RPG LIFE SCIENCES LTD.","supplierCountry":"INDIA","foreign_port":"HO CHI MINH C","customer":"TO THE ORDER OF AND NA","customerCountry":"VIETNAM","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"525","totalValueFC":"2491.8","currency":"USD","unitRateINR":41875.196000000004,"date":"19-Oct-2024","totalValueINR":"209375.98","totalValueInUsd":"2491.8","indian_port":"Bombay Air","hs_no":"29333990","bill_no":"4965373","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"VIETNAM","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"CEAT MAHAL, 463, ANNIE BESANT ROAD,, MUMBAI, MAHARASHTRA","customerAddress":""}]
    07-Jan-2021
    19-Oct-2024
    KGS
    overview
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    Europe

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    01

    Rivopharm SA

    Switzerland
    Medlab Asia & Asia Health
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    Rivopharm SA

    Switzerland
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    Registration Country : Switzerland

    Nicorandilum

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    Rivopharm SA

    Switzerland
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    Registration Country : Switzerland

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    03

    Rivopharm SA

    Switzerland
    Medlab Asia & Asia Health
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    Switzerland
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    Medlab Asia & Asia Health
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    Nicorandilum

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    Registration Country : Switzerland

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    Rivopharm SA

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    Rivopharm SA

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    Medlab Asia & Asia Health
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    Nicorandilum

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    Registration Country : Switzerland

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    Australia

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    01

    Alphapharm Pty Ltd

    Australia
    Medlab Asia & Asia Health
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    Alphapharm Pty Ltd

    Australia
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    Registration Country : Australia

    nicorandil

    Brand Name : Ikotab

    Dosage Form : tablet

    Dosage Strength : 10 mg

    Packaging : 1

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    Registration Country : Australia

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    Alphapharm Pty Ltd

    Australia
    Medlab Asia & Asia Health
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    Alphapharm Pty Ltd

    Australia
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    Medlab Asia & Asia Health
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    nicorandil

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    03

    Alphapharm Pty Ltd

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    Medlab Asia & Asia Health
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    nicorandil

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    Alphapharm Pty Ltd

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    nicorandil

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    05

    Apotex Pty Ltd

    Canada
    Medlab Asia & Asia Health
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    nicorandil

    Brand Name : APO-Nicorandil

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    Dosage Strength : 10 mg

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    Registration Country : Australia

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    Apotex Pty Ltd

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    Medlab Asia & Asia Health
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    nicorandil

    Brand Name : APO-Nicorandil

    Dosage Form : tablet

    Dosage Strength : 20 mg

    Packaging : 1

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Australia

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    07

    Apotex Pty Ltd

    Canada
    Medlab Asia & Asia Health
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    Medlab Asia & Asia Health
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    nicorandil

    Brand Name : APO-Nicorandil

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    Registration Country : Australia

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    Apotex Pty Ltd

    Canada
    Medlab Asia & Asia Health
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    Canada
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    Medlab Asia & Asia Health
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    nicorandil

    Brand Name : APO-Nicorandil

    Dosage Form : tablet

    Dosage Strength : 20 mg

    Packaging : 1

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Australia

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    Listed Dossiers

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    01

    Naprod Life Sciences

    India
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    Regulatory Info :

    Registration Country : India

    Nicorandil

    Brand Name :

    Dosage Form : Lyophilised Injection

    Dosage Strength : 2MG/Vial

    Packaging :

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    Application Number :

    Regulatory Info :

    Registration Country : India

    Naprod Life Sciences

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    Naprod Life Sciences

    India
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    Virtual BoothNaprod is a top player in Oncology & Anesthesia FDF through excellent innovation, discovery of new processes & high-quality production.

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    Nicorandil

    Dosage : Lyophilised Injection

    Dosage Strength : 2MG/Vial

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    Application Number :

    Registration Country : India

    Naprod Life Sciences

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    Naprod Life Sciences

    India
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    Virtual BoothNaprod is a top player in Oncology & Anesthesia FDF through excellent innovation, discovery of new processes & high-quality production.

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    Nicorandil

    Brand Name :

    Dosage Form : Lyophilised Injection

    Dosage Strength : 48MG/Vial

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    Application Number :

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    Naprod Life Sciences

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    Naprod Life Sciences

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    Dosage Form : Tabl

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    Dosage Form : Tabl

    Dosage Strength : 20mg

    Price Per Pack (Euro) : 11.42

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    Country : Switzerland

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    india-flag.png
    IP/BP grade Nicorandil (1kg) needed in India [ENA18811]
    A new-generation generic manufacturer based out of India is looking for suppliers of Nicorandil (1kg) for R&D Purposes. The suppliers must support this inquiry with CoA and an open DMF.
    24 Dec 2023

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    24 Dec 2023

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    24 Dec 2023

    india-flag.png
    Various APIs needed in India [ENA11054]
    Akash Medicals and Pharmaceuticals, a company that deals in the import, export & distribution of ayurvedic drugs, veterinary drugs and allopathic medicines is looking for suppliers of Various APIs for commercial purpose. The suppliers must support this enquiry with CoA. Interested suppliers can contact them via their email: akashexportsandimports@gmail.com. 1. BP Grade Nicorandil (100 kg) API 2. USP Grade Acitretin (25 kg) API
    07 Aug 2021

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    07 Aug 2021

    Egypt.png
    Various APIs needed in Egypt [ENA09765]
    A company that deals in various pharmaceutical products including hard gelatin capsules, tablets and dietary supplements is looking for suppliers of Various APIs for commercial purposes. The suppliers must support this enquiry with CoA and GMP or FDA. 1. Nicorandil (100 kg) API 2. D-Biotin (100 kg) API 3. Sodium Bicarbonate (100 kg) API 4. Dexpanthenol (120 kg) API 5. Pantolactone (50 kg) API 6. Palonosetron HCl (50 kg) API 7. Ivy Leaf Extract (100 kg) API 8. Dantrolene Sodium (50 kg) API 9. Efinaconazole (50 kg) API
    19 Feb 2021

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    19 Feb 2021

    SriLanka.png
    Mebendazole and various other APIs needed in Sri Lanka [ENA03955]
    A company involved in well-targeted portfolio of pharmaceutical products is looking for suppliers for various APIs mentioned below: 1. Mebendazole BP- Qty: 500 g 2. Nicorandil BP- Qty: 250 g 3. Carvedilol BP- Qty: 250 g 4. Risperidone USP- Qty: 250 g 5. Amlodipine Besylate BP- Qty: 250 g 6. Olanzapine BP- Qty: 250 g 7. Potassium Chloride BP- Qty: 500 g Suppliers must provide GMP certificate and CoA.
    17 Apr 2019

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    17 Apr 2019

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    17 Apr 2019

    india-flag.png
    Injection Grade Nicorandil and Dalteparin Sodium (40kg) needed in India [ENA02671]
    Sai Parenterals Pvt Ltd is a fast-growing company manufacturer of small volume parenterals in injectables and sterile dry powder injections is looking for suppliers of Injection Grade Nicorandil and Dalteparin Sodium (40kg). Interested supplier must contact- Purchase Department via Tel: 040-6688558 |MOBILE: 9703698869/9441735825.
    17 Nov 2018

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    17 Nov 2018

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    17 Nov 2018

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    BP grade Nicorandil API (65kg) needed in India [ENA01887]
    A leading exporter, manufacturer & supplier of pharmaceuticals medicines and capsules based in India is looking for suppliers of BP grade Nicorandil API (65kg) for domestic consumption.
    13 Sep 2018

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    13 Sep 2018

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    13 Sep 2018

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