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    Chemistry

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    Also known as: 33069-62-4, P88xt4is4d, Taxol, Taxol a, Yewtaxan, Abraxane
    Molecular Formula
    C47H51NO14
    Molecular Weight
    853.9  g/mol
    InChI Key
    RCINICONZNJXQF-MZXODVADSA-N
    FDA UNII
    P88XT4IS4D
    Paclitaxel
    Nab-paclitaxel is a Cremophor EL-free, albumin-stabilized nanoparticle formulation of the natural taxane paclitaxel with antineoplastic activity. Paclitaxel binds to and stabilizes microtubules, preventing their depolymerization and so inhibiting cellular motility, mitosis, and replication. This formulation solubilizes paclitaxel without the use of the solvent Cremophor, thereby permitting the administration of larger doses of paclitaxel while avoiding the toxic effects associated with Cremophor.
    Paclitaxel is a Microtubule Inhibitor. The physiologic effect of paclitaxel is by means of Microtubule Inhibition.
    1 2D Structure

    Paclitaxel

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
    2.1.2 InChI
    InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1
    2.1.3 InChI Key
    RCINICONZNJXQF-MZXODVADSA-N
    2.1.4 Canonical SMILES
    CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
    2.1.5 Isomeric SMILES
    CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
    2.2 Other Identifiers
    2.2.1 UNII
    P88XT4IS4D
    2.3 Synonyms
    2.3.1 Depositor-Supplied Synonyms

    1. 33069-62-4

    2. P88xt4is4d

    3. Taxol

    4. Taxol A

    5. Yewtaxan

    6. Abraxane

    7. Plaxicel

    8. Genaxol

    9. Ebetaxel

    10. Genetaxyl

    11. Capxol

    12. Paxene

    13. Onxol

    14. Oncogel

    15. Cyclopax

    16. Genexol

    17. Intaxel

    18. Mitotax

    19. Pacliex

    20. Paxceed

    21. Taxalbin

    22. Empac

    23. Abi-007

    24. Onxal

    25. Zisu

    26. Lipopac

    27. Taxus Liberte

    28. Taxus Stent

    29. Paclitaxel (taxol)

    30. Endotag 1

    31. Lep-etu

    32. Genexol-pm

    33. Tocosol Paclitaxel

    34. Nsc-125973

    35. (-)-paclitaxel

    36. Taxus

    37. Abi 007

    38. Bms 181339-01

    39. Mbt 0206

    40. Nsc 125973

    41. Bms-181339-01

    42. Hsdb 6839

    43. Dhp 107

    44. Dhp-107

    45. Drg-0190

    46. Nk 105

    47. Nsc125973

    48. Qw 8184

    49. Liposome-entrapped Paclitaxel Easy-to-use

    50. Paclitaxel (taxus Canadensis)

    51. Chembl428647

    52. (2ar,4s,4as,6r,9s,11s,12s,12ar,12bs)-9-(((2r,3s)-3-benzamido-2-hydroxy-3-phenylpropanoyl)oxy)-12-(benzoyloxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1h-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b-diyl Diacetate

    53. 5beta,20-epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester With (2r,3s)-n-benzoyl-3-phenylisoserine

    54. Chebi:45863

    55. Nab-paclitaxel

    56. Mbt-0206

    57. Abi-007 Component Paclitaxel

    58. Nk-105

    59. (2ar-(2aalpha,4beta,4abeta,6beta,9alpha(alpha R*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoic Acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1h-cyclodeca(3,4)benz(1,2-b)oxet-9-yl Ester

    60. Qw-8184

    61. Ncgc00164367-01

    62. Padexol

    63. Mfcd00869953

    64. Cynviloq

    65. Nanoxel

    66. Sindaxel

    67. Xorane

    68. Cypher Select

    69. Coroflex Please

    70. Taxus Express

    71. 7,11-methano-1h-cyclodeca[3,4]benz[1,2-b]oxete, Benzenepropanoic Acid Deriv.

    72. (1s,2s,3r,4s,7r,9s,10s,12r,15s)-4,12-bis(acetyloxy)-1,9-dihydroxy-15-{[(2r,3s)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0^{3,10}.0^{4,7}]heptadec-13-en-2-yl Benzoate

    73. (nab)-paclitaxel

    74. [(1s,2s,3r,4s,7r,9s,10s,12r,15s)-4,12-diacetyloxy-15-[(2r,3s)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] Benzoate

    75. Smr000857385

    76. Endotag-1

    77. Sr-01000075350

    78. Abraxane I.v. Suspension

    79. Unii-p88xt4is4d

    80. Anzatax

    81. Infinnium

    82. Nanotaxel

    83. Paclical

    84. Pacligel

    85. Paxoral

    86. Ccris 8143

    87. Paclitaxel,(s)

    88. Paclitaxel [usan:usp:inn:ban]

    89. Abraxane (tn)

    90. (2alpha,5beta,7beta,10beta,13alpha)-4,10-bis(acetyloxy)-1,7-dihydroxy-13-({(2r,3s)-2-hydroxy-3-phenyl-3-[(phenylcarbonyl)amino]propanoyl}oxy)-9-oxo-5,20-epoxytax-11-en-2-yl Benzoate

    91. [diacetoxy-[(2r,3s)-3-benzamido-2-hydroxy-3-phenyl-propanoyl]oxy-dihydroxy-tetramethyl-oxo-[?]yl] Benzoate

    92. 5?,20-epoxy-1,7?-dihydroxy-9-oxotax-11-ene-2?,4,10?,13?-tetrayl 4,10-diacetate 2-benzoate 13-[(2r,3s)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate]

    93. Nanoparticle Albumin Bound Paclitaxel

    94. Cas-33069-62-4

    95. Ig 001

    96. Bms-181339

    97. Paclitaxel-ssmm-vip

    98. P-ssmm-vip

    99. Paclitaxel [mi]

    100. Paclitaxel [inn]

    101. Paclitaxel [jan]

    102. Prestwick3_000155

    103. Paclitaxel [hsdb]

    104. Paclitaxel [usan]

    105. Dsstox_cid_3413

    106. Taxol (tn)

    107. Paclitaxel [vandf]

    108. Paclitaxel [mart.]

    109. Schembl3976

    110. Dsstox_rid_77016

    111. Nova-12005

    112. Paclitaxel [usp-rs]

    113. Paclitaxel [who-dd]

    114. Paclitaxel, Taxus Brevifolia

    115. Bidd:pxr0046

    116. Dsstox_gsid_23413

    117. Bspbio_000290

    118. Kbiogr_002509

    119. Kbioss_002517

    120. Paclitaxel (jan/usp/inn)

    121. Mls002154218

    122. Mls002695976

    123. Oas-pac-100

    124. Paclitaxel [ema Epar]

    125. Bpbio1_000320

    126. Gtpl2770

    127. Megxp0_001940

    128. Taxol (tn) (bristol Meyers)

    129. Paclitaxel [green Book]

    130. Dtxsid9023413

    131. Paclitaxel [orange Book]

    132. Tsd-001 [who-dd]

    133. Acon1_002231

    134. Kbio2_002509

    135. Kbio2_005077

    136. Kbio2_007645

    137. Kbio3_002987

    138. Anx-513

    139. Dhp-208

    140. Dts-301

    141. Paclitaxel [ep Monograph]

    142. Paclitaxel [usp Impurity]

    143. Sdp-013

    144. Cmap_000068

    145. Oraxol Component Paclitaxel

    146. Hms2090d07

    147. Hms2095o12

    148. Hms2231a16

    149. Hms3712o12

    150. Paclitaxel [usp Monograph]

    151. Abraxane (albumin-bound Suspension)

    152. Abraxane Component Paclitaxel

    153. Act02709

    154. Hy-b0015

    155. Mpi-5018

    156. Tox21_112107

    157. Bdbm50001839

    158. Nsc745099

    159. Zinc96006020

    160. Abi 007 Component Paclitaxel

    161. Akos007930675

    162. Akos015969673

    163. Akos025312303

    164. Ccg-220155

    165. Cs-1145

    166. Db01229

    167. Gs-6554

    168. Nsc-745099

    169. Ncgc00164367-02

    170. Ncgc00164367-03

    171. Ncgc00164367-04

    172. Ncgc00164367-05

    173. Ncgc00164367-10

    174. Paclitaxel, From Taxus Brevifolia, 95%

    175. (2ar,4s,4as,6r,9s,11s,12s,12ar,12bs)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11,12,12b-hexahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5h-cyclodeca(3,4)benz(1,2-b)oxet-5-one 6,12b-diacetate, 12-benzoate, 9-ester With (2r,3s)-n-benzoyl-3-phenylisoserine

    176. Nab-paclitaxel Component Paclitaxel

    177. Nci60_000601

    178. Paclitaxel, From Taxus Yannanensis, Powder

    179. Ab00513812

    180. N1361

    181. D00491

    182. M02242

    183. N88686

    184. Ab00513812-02

    185. Ab00513812-03

    186. 069p624

    187. Paclitaxel, Antibiotic For Culture Media Use Only

    188. Q423762

    189. 7,4]benz[1,2-b]oxete,benzenepropanoic Acid Deriv.

    190. Q-201533

    191. Sr-01000075350-1

    192. Sr-01000075350-3

    193. Sr-01000075350-6

    194. Sr-01000075350-7

    195. Sr-01000075350-9

    196. Brd-k62008436-001-03-1

    197. Brd-k62008436-001-05-6

    198. Brd-k62008436-001-22-1

    199. Paclitaxel, From Semisynthetic (from Taxus Sp.), >=97%

    200. Paclitaxel, European Pharmacopoeia (ep) Reference Standard

    201. Paclitaxel, From Taxus Brevifolia, >=95% (hplc), Powder

    202. Paclitaxel, United States Pharmacopeia (usp) Reference Standard

    203. 12-benzoate, 9-ester With (2r,3s)-n-benzoyl-3-phenylisoserine

    204. Paclitaxel, Pharmaceutical Secondary Standard; Certified Reference Material

    205. Paclitaxel Natural For Peak Identification, European Pharmacopoeia (ep) Reference Standard

    206. (2ar,4s,4as,6r,9s,11s,12s,12ar,12bs)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro 4,6,9,11,12,12b-hexahydroxy-4a,8,13,13-tetramethyl-7,11-methano 5hcyclodeca(3,4)benz(1,2-b)oxet-5-one 6,12b-diacetate,

    207. (2ar,4s,4as,6r,9s,11s,12s,12ar,12bs)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1h-cyclodeca[3,4]benz[1,2-b]oxet-9-yl (ar,bs)-b-(benzoylamino)-a-hydroxybenzenepropanoate

    208. (2ar,4s,4as,6r,9s,11s,12s,12ar,12bs)-9-(((2r,3s)-3-benzamido-2-hydroxy-3-phenylpropanoyl)oxy)-12-(benzoyloxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-3,4,4a,5,6,9,10,11,12,12a-decahydro-1h-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b(2ah)-diyl Diacetate

    209. (2ar-(2aalpha,4beta,4abeta,6beta,9alpha(alpha R*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoic Acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12

    210. (2beta,5beta,7alpha,8alpha,10alpha,13alpha)-4,10-bis(acetyloxy)-1,7-dihydroxy-13-({(2r,3s)-2-hydroxy-3-phenyl-3-[(phenylcarbonyl)amino]propanoyl}oxy)-9-oxo-5,20-epoxytax-11-en-2-yl Benzoate

    211. 1203669-79-7

    212. 4alpha,10beta-bis(acetyloxy)-13alpha-[(2s,3s)-3-benzamido-2-hydroxy-3-phenylpropanoyloxy]-1,7beta-dihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl Benzoate

    213. Benzenepropanoic Acid, .beta.-(benzoylamino)-.alpha.-hydroxy-, (2ar,4s,4as,6r,9s,11s,12s,12ar,12bs)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1h-cyclodeca(3,4)benz(1,2-b)oxet-9-yl Ester, (.alpha.r,.beta.s)-

    214. Benzenepropanoic Acid, 6,12b-bis(acetyl Oxy)-12-(benzoyloxy)- 2a,3,4,4a,5,6,9,10,11,12,12a,12b,- Dodecahydro-4,11- Dihydroxy-4a,8,13,13-tetramethyl-5-oxo- 7,11-methano- 1h-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester, [2ar- [2a.alpha.,4.beta.,4a.beta.,6.beta.,9.alpha.(alpha. R*,.beta.s*),11.alpha.,12.alpha.,12a.alpha.,12b.alpha.]]-

    215. Benzenepropanoic Acid, B-(benzoylamino)-.alpha.-hydroxy-, (2ar,4s,4as,6r,9s,11s,12s,12ar,12bs)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1h-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester, (ar,bs)-

    216. Benzenepropanoic Acid, Beta-(benzoylamino)-alpha-hydroxy-, (2ar,4s,4as,6r,9s,11s,12s,12ar,12bs)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13

    217. Benzenepropanoic Acid, Beta-(benzoylamino)-alpha-hydroxy-, (2ar,4s,4as,6r,9s,11s,12s,12ar,12bs)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1h-cyclodeca(3,4)benz(1,2-b)oxet-9-yl Ester, (alphar,betas)-

    218. Benzenepropanoic Acid, Beta-(benzoylamino)-alpha-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1h

    219. Benzenepropanoic Acid, Beta-(benzoylamino)-alpha-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1h-cyclodeca(3,4)benz(1,2-b)oxet-9-yl Ester, (2ar-(2a-alpha,4-beta,4a-beta,6-beta,9-alpha(alpha-r*,beta-s*),11-alpha,12-alpha,12a-alpha, 12b-alpha))-

    220. Benzenepropanoic Acid, Beta-(benzoylamino)-alpha-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1h-cyclodeca(3,4)benz(1,2-b)oxet-9-yl Ester, (2ar-(2aalpha,4beta,4abeta,6beta,9alpha(alphar*,betas*),11alpha,12alpha,12aalpha,12balpha))-

    221. Paclitaxel Semi-synthetic For Peak Identification, European Pharmacopoeia (ep) Reference Standard

    222. Paclitaxel Semi-synthetic For System Suitability, European Pharmacopoeia (ep) Reference Standard

    223. Tax-11-en-9-one, 5beta,20-epoxy-1,2alpha,4,7beta,10beta,13alpha- Hexahydroxy-, 4,10-diacetate 2-benzoate, 13-ester With (2r,3s)-n-benzoyl-3-phenylisoserine

    224. Tax-11-en-9-one, 5beta,20-epoxy-1,2alpha,4,7beta,10beta,13alpha-hexahydroxy-, 4,10-diacetate 2-benzoate 13-ester With (2r,3s)-n-benzoyl-3-phenylisoserine (8ci)

    225. Tax-11-en-9-one,20-epoxy-1,2.alpha.,4,7.beta., 10.beta.,13.alpha.- Hexahydroxy-, 4,10-diacetate 2- Benzoate,13-ester With (2r,3s)-n-benzoyl-3-phenylisoserine

    2.4 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 853.9 g/mol
    Molecular Formula C47H51NO14
    XLogP32.5
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count14
    Rotatable Bond Count14
    Exact Mass853.33095530 g/mol
    Monoisotopic Mass853.33095530 g/mol
    Topological Polar Surface Area221 Ų
    Heavy Atom Count62
    Formal Charge0
    Complexity1790
    Isotope Atom Count0
    Defined Atom Stereocenter Count11
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 6  
    Drug NameAbraxane
    PubMed HealthPaclitaxel Protein-bound (Injection)
    Drug ClassesAntineoplastic Agent
    Active IngredientPaclitaxel
    Dosage FormFor suspension
    RouteIv (infusion)
    Strength100mg/vial
    Market StatusPrescription
    CompanyAbraxis Bioscience

    2 of 6  
    Drug NamePaclitaxel
    PubMed HealthPaclitaxel (Injection)
    Drug ClassesAntineoplastic Agent
    Active IngredientPaclitaxel
    Dosage FormInjectable
    RouteInjection
    Strength6mg/ml
    Market StatusPrescription
    CompanyHospira; Fresenius Kabi Oncol; Actavis Elizabeth; Teva Pharms; Ebewe Pharma; Onco Therapies; Eurohlth Intl

    3 of 6  
    Drug NameTaxol
    PubMed HealthPaclitaxel (Injection)
    Drug ClassesAntineoplastic Agent
    Drug LabelPaclitaxel Injection, USP is a clear colorless to slightly yellow viscous solution. It is supplied as a nonaqueous solution intended for dilution with a suitable parenteral fluid prior to intravenous infusion. Paclitaxel Injection, USP is available i...
    Active IngredientPaclitaxel
    Dosage FormInjectable
    RouteInjection
    Strength6mg/ml
    Market StatusPrescription
    CompanyHq Spclt Pharma

    4 of 6  
    Drug NameAbraxane
    PubMed HealthPaclitaxel Protein-bound (Injection)
    Drug ClassesAntineoplastic Agent
    Active IngredientPaclitaxel
    Dosage FormFor suspension
    RouteIv (infusion)
    Strength100mg/vial
    Market StatusPrescription
    CompanyAbraxis Bioscience

    5 of 6  
    Drug NamePaclitaxel
    PubMed HealthPaclitaxel (Injection)
    Drug ClassesAntineoplastic Agent
    Active IngredientPaclitaxel
    Dosage FormInjectable
    RouteInjection
    Strength6mg/ml
    Market StatusPrescription
    CompanyHospira; Fresenius Kabi Oncol; Actavis Elizabeth; Teva Pharms; Ebewe Pharma; Onco Therapies; Eurohlth Intl

    6 of 6  
    Drug NameTaxol
    PubMed HealthPaclitaxel (Injection)
    Drug ClassesAntineoplastic Agent
    Drug LabelPaclitaxel Injection, USP is a clear colorless to slightly yellow viscous solution. It is supplied as a nonaqueous solution intended for dilution with a suitable parenteral fluid prior to intravenous infusion. Paclitaxel Injection, USP is available i...
    Active IngredientPaclitaxel
    Dosage FormInjectable
    RouteInjection
    Strength6mg/ml
    Market StatusPrescription
    CompanyHq Spclt Pharma

    4.2 Therapeutic Uses

    Antineoplastic Agents, Phytogenic; Radiation-Sensitizing Agents

    National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

    Standard formulation paclitaxel requires the use of solvents, such as Cremphor-EL, which contribute to some of the toxicities commonly associated with paclitaxel-based therapy. Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) is a novel solvent-free formulation of paclitaxel. The formulation is prepared by high-pressure homogenization of paclitaxel in the presence of serum albumin into a nanoparticle colloidal suspension. The human albumin-stabilized paclitaxel particles have an average size of 130 nm. Nab-paclitaxel has several practical advantages over Cremphor-EL-paclitaxel, including a shorter infusion time (30 min) and no need for premedications for hypersensitivity reactions. The nab-paclitaxel formulation eliminates the impact of Cremphor-EL on paclitaxel pharmacokinetics and utilizes the endogenous albumin transport mechanisms to concentrate nab-paclitaxel within the tumor. A recent Phase III trial compared nab- and Cremphor-EL-paclitaxel in patients with metastatic breast cancer. Patients treated with nab-paclitaxel experienced a higher response, longer time to tumor progression and, in patients receiving second-line or greater therapy, a longer median survival. Patients treated with nab-paclitaxel had a significantly lower rate of severe neutropenia and a higher rate of sensory neuropathy. The preclinical and clinical data indicate that the nab-paclitaxel formulation has significant advantages over Cremphor-EL-paclitaxel.

    PMID:17716129 Stinchcombe TE; Nanomed 2 (4): 415-23 (2007)

    As first line and subsequent therapy for the treatment of advanced carcinoma of the ovary. As first-line therapy, paclitaxel is indicated in combination with cisplatin.

    Novak, K.M. (ed.). Drug Facts and Comparisons2008 Edition. Wolters Kluwer Health. St. Louis, Missouri 2008., p. 2833

    Adjuvant treatment of node-positive breast cancer administration sequentially to standard doxorubicin-containing combination chemotherapy. In the clinical trial, there was an overall favorable effect on disease-free and overall survival in the total population of patients with receptor-positive and receptor-negative tumors, but the benefit has been specifically demonstrated by available data (mean follow-up, 30 months) only in the patients with estrogen and progesterone receptor-negative tumors. Indicated for the treatment of breast cancer after failure of combination chemotherapy for metastatic disease or relapse within 6 months of adjuvant chemotherapy. Previous therapy should have included an anthracycline unless clinically contraindicated.

    Novak, K.M. (ed.). Drug Facts and Comparisons2008 Edition. Wolters Kluwer Health. St. Louis, Missouri 2008., p. 2833

    For more Therapeutic Uses (Complete) data for TAXOL (9 total), please visit the HSDB record page.

    4.3 Drug Warning

    Administer paclitaxel under the supervision of a health care provider experienced in the use of cancer chemotherapeutic agents. Appropriate management of complications is possible only when adequate diagnostic and treatment facilitates are readily available.

    Novak, K.M. (ed.). Drug Facts and Comparisons2008 Edition. Wolters Kluwer Health. St. Louis, Missouri 2008., p. 2833

    Do not give paclitaxel therapy to patients with solid tumors who have baseline neutrophil counts of less than 1,500 cells/cu mm, and do not give to patients with AIDS-related Kaposi sarcoma if the baseline neutrophil count is less than 1,000 cells/cu mm. In order to monitor the occurrence of bone marrow suppression, primarily neutropenia, which may be severe and result in infection, perform frequent peripheral blood cell counts on all patients receiving paclitaxel.

    Novak, K.M. (ed.). Drug Facts and Comparisons2008 Edition. Wolters Kluwer Health. St. Louis, Missouri 2008., p. 2833

    Anaphylaxis and severe hypersensitivity reactions characterized by dyspnea and hypotension requiring treatment, angioedema, and generalized urticaria have occurred in 2% to 4% of patients receiving paclitaxel in clinical trials. Fatal reactions have occurred in patients despite premedication. Pretreat all patients with corticosteroids, diphenhydramine, and H2 antagonists. Do not rechallenge patients who experience severe hypersensitivity reactions to paclitaxel with the drug.

    Novak, K.M. (ed.). Drug Facts and Comparisons2008 Edition. Wolters Kluwer Health. St. Louis, Missouri 2008., p. 2833

    An albumin form of paclitaxel may substantially affect a drug's functional properties relative to those of drug in solution. Do not substitute for or with other paclitaxel formulations. /Paclitaxel (albumin-bound)/

    Novak, K.M. (ed.). Drug Facts and Comparisons2008 Edition. Wolters Kluwer Health. St. Louis, Missouri 2008., p. 2833

    For more Drug Warnings (Complete) data for TAXOL (62 total), please visit the HSDB record page.

    4.4 Drug Indication

    Used in the treatment of Kaposi's sarcoma and cancer of the lung, ovarian, and breast. Abraxane is specfically indicated for the treatment of metastatic breast cancer and locally advanced or metastatic non-small cell lung cancer.

    FDA Label

    Pazenir monotherapy is indicated for the treatment of metastatic breast cancer in adult patients who have failed first-line treatment for metastatic disease and for whom standard, anthracycline containing therapy is not indicated.

    Pazenir in combination with carboplatin is indicated for the first-line treatment of non-small cell lung cancer in adult patients who are not candidates for potentially curative surgery and/or radiation therapy.

    Abraxane monotherapy is indicated for the treatment of metastatic breast cancer in adult patients who have failed first-line treatment for metastatic disease and for whom standard, anthracycline containing therapy is not indicated.

    Abraxane in combination with gemcitabine is indicated for the first-line treatment of adult patients with metastatic adenocarcinoma of the pancreas.

    Abraxane in combination with carboplatin is indicated for the first-line treatment of non-small cell lung cancer in adult patients who are not candidates for potentially curative surgery and/or radiation therapy.

    Apealea in combination with carboplatin is indicated for the treatment of adult patients with first relapse of platinumsensitive epithelial ovarian cancer , primary peritoneal cancer and fallopian tube cancer .

    Paxene is indicated for the treatment of patients with:

    advanced AIDS-related Kaposi's sarcoma (AIDS-KS) who have failed prior liposomal anthracycline therapy;

    metastatic carcinoma of the breast (MBC) who have failed, or are not candidates for standard anthracycline-containing therapy;

    advanced carcinoma of the ovary (AOC) or with residual disease (> 1 cm) after initial laparotomy, in combination with cisplatin as first-line treatment;

    metastatic carcinoma of the ovary (MOC) after failure of platinum-containing combination therapy without taxanes as second-line treatment;

    non-small cell lung carcinoma (NSCLC) who are not candidates for potentially curative surgery and/or radiation therapy, in combination with cisplatin. Limited efficacy data supports this indication (see section 5. 1).

    Treatment of solid malignant tumours

    Treatment of soft tissue sarcoma

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Paclitaxel is a taxoid antineoplastic agent indicated as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast cancer. Paclitaxel is a novel antimicrotubule agent that promotes the assembly of microtubules from tubulin dimers and stabilizes microtubules by preventing depolymerization. This stability results in the inhibition of the normal dynamic reorganization of the microtubule network that is essential for vital interphase and mitotic cellular functions. In addition, paclitaxel induces abnormal arrays or "bundles" of microtubules throughout the cell cycle and multiple asters of microtubules during mitosis.

    5.2 FDA Pharmacological Classification
    5.2.1 Active Moiety
    PACLITAXEL
    5.2.2 FDA UNII
    P88XT4IS4D
    5.2.3 Pharmacological Classes
    Microtubule Inhibitor [EPC]; Microtubule Inhibition [PE]
    5.3 ATC Code

    L01CD01

    L01CD01

    L01CD01

    L01CD01

    L01CD01

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    L - Antineoplastic and immunomodulating agents

    L01 - Antineoplastic agents

    L01C - Plant alkaloids and other natural products

    L01CD - Taxanes

    L01CD01 - Paclitaxel

    5.4 Absorption, Distribution and Excretion

    Absorption

    When a 24 hour infusion of 135 mg/m^2 is given to ovarian cancer patients, the maximum plasma concentration (Cmax) is 195 ng/mL, while the AUC is 6300 ngh/mL.

    Route of Elimination

    In 5 patients administered a 225 or 250 mg/m2 dose of radiolabeled paclitaxel as a 3-hour infusion, a mean of 71% of the radioactivity was excreted in the feces in 120 hours, and 14% was recovered in the urine.

    Volume of Distribution

    227 to 688 L/m^2 [apparent volume of distribution at steady-state, 24 hour infusion]

    Clearance

    21.7 L/h/m2 [Dose 135 mg/m2, infusion duration 24 h]

    23.8 L/h/m2 [Dose 175 mg/m2, infusion duration 24 h]

    7 L/h/m2 [Dose 135 mg/m2, infusion duration 3 h]

    12.2 L/h/m2 [Dose 175 mg/m2, infusion duration 3 h]

    Paclitaxel bound to nanoparticles of the serum protein albumin is delivered via endothelial transport mediated by albumin receptors, and the resulting concentration of paclitaxel in tumor cells is increased compared with that achieved using an equivalent dose of conventional paclitaxel. Like conventional paclitaxel, albumin-bound paclitaxel has a large volume of distribution. Following 30-minute or 3-hour IV infusion of 80-375 mg/sq m albumin-bound paclitaxel, the volume of distribution averaged 632 L/sq m. The volume of distribution of albumin-bound paclitaxel 260 mg/sq m by 30-minute IV infusion was 53% larger than the volume of distribution of conventional paclitaxel 175 mg/sq m by 3-hour IV infusion. /Paclitaxel (albumin-bound)/

    American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 1188

    Following IV administration, paclitaxel is widely distributed into body fluids and tissues. Paclitaxel has a large volume of distribution that appears to be affected by dose and duration of infusion. Following administration of paclitaxel doses of 135 or 175 mg/sq m by IV infusion over 24 hours in patients with advanced ovarian cancer, the mean apparent volume of distribution at steady state ranged from 227-688 L/sq m. The steady-state volume of distribution ranged from 18.9-260 L/sq m in children with solid tumors or refractory leukemia receiving paclitaxel 200-500 mg/sq m by 24-hour IV infusion. Paclitaxel does not appear to readily penetrate the CNS, but paclitaxel has been detected in ascitic fluid following IV infusion of the drug. It is not known whether paclitaxel is distributed into human milk, but in lactating rats given radiolabeled paclitaxel, concentrations of radioactivity in milk were higher than those in plasma and declined in parallel with plasma concentrations of the drug.

    American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 1188

    For the dose range 80-375 mg/sq m, increase in dose of albumin-bound paclitaxel was associated with a proportional increase in AUC.354 The duration of infusion did not affect the pharmacokinetic disposition of albumin-bound paclitaxel. Following 30-minute or 3-hour IV infusion of albumin-bound paclitaxel 260 mg/sq m, the peak plasma concentration averaged 18,741 ng/mL. /Paclitaxel (albumin-bound)/

    American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 1188

    Peak plasma concentrations and areas under the plasma concentration-time curve (AUCs) following IV administration of paclitaxel exhibit marked interindividual variation. Plasma concentrations of paclitaxel increase during continuous IV administration of the drug and decline immediately following completion of the infusion. Following 24-hour IV infusion of paclitaxel at doses of 135 or 175 mg/sq m in patients with advanced ovarian cancer, peak plasma concentrations averaged 195 or 365 ng/mL, respectively; the increase in dose (30%) was associated with a disproportionately greater increase in peak plasma concentration (87%), but the increase in AUC was proportional. When paclitaxel was administered by continuous IV infusion over 3 hours at doses of 135 or 175 mg/sq m in patients with advanced ovarian cancer, peak plasma concentrations averaged 2.17 or 3.65 ug/mL, respectively; the increase in dose (30%) was associated with disproportionately greater increases in peak plasma concentration (68%) and AUC (89%).

    American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 1188

    For more Absorption, Distribution and Excretion (Complete) data for TAXOL (8 total), please visit the HSDB record page.

    5.5 Metabolism/Metabolites

    Hepatic. In vitro studies with human liver microsomes and tissue slices showed that paclitaxel was metabolized primarily to 6a-hydrox-ypaclitaxel by the cytochrome P450 isozyme CYP2C8; and to two minor metabolites, 3’-p-hydroxypaclitaxel and 6a, 3’-p-dihydroxypaclitaxel, by CYP3A4.

    Paclitaxel is extensively metabolized in the liver. Metabolism of paclitaxel to its major metabolite, 6alpha-hydroxypaclitaxel, is mediated by cytochrome P-450 isoenzyme CYP2C8,1 185 187 202 354 while metabolism to 2 of its minor metabolites, 3'-p-hydroxypaclitaxel and 6alpha,3'-p-dihydroxypaclitaxel, is catalyzed by CYP3A4.

    American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 1188

    The elimination of nonradioactive taxol in bile and urine was investigated in the rat after administration via the caudal vein (10 mg/kg). As in humans, no metabolites of taxol were detected by HPLC in rat urine, and only 10% of the injected taxol was recovered in urine over a 24 hr period. In contrast, 11.5% and 29% of the injected taxol was recovered in rat bile as unchanged taxol and metabolites, respectively. Among the nine taxol metabolites detected by HPLC, the side chain at C13, which is required for pharmacological activity, had been removed in only one minor metabolite, baccatin III. The chemical structures of the two major hydroxylated metabolites were determined by MS (fast atom bombardment and desorption chemical ionization) and (1)H NMR spectroscopy. One was a taxol derivative hydroxylated on the phenyl group at C3 of the side chain at C13, while the other corresponded to a taxol derivative hydroxylated in the m-position on the benzoate of the side chain at C2. Although these two major taxol metabolites were as active as taxol in preventing cold microtubule disassembly, they were, respectively, 9 and 39 times less cytotoxic as taxol on in vitro L1210 leukemia growth. These results show for the first time that there is a significant hepatic metabolism of taxol.

    PMID:1981534 Monsarrat B et al; Drug Metab Dispos Biol Fate Chem 18 (6): 895-901 (1990)

    To investigate how taxane's substituents at C3' affect its metabolism, ... the metabolism of cephalomannine and paclitaxel, a pair of analogs that differ slightly at the C3' position /was compared/. After cephalomannine was incubated with human liver microsomes in an NADPH-generating system, two monohydroxylated metabolites (M1 and M2) were detected by liquid chromatography/tandem mass spectrometry. C4'' (M1) and C6alpha (M2) were proposed as the possible hydroxylation sites, and the structure of M1 was confirmed by (1)H NMR. Chemical inhibition studies and assays with recombinant human cytochromes P450 (P450s) indicated that 4''-hydroxycephalomannine was generated predominantly by CYP3A4 and 6alpha-hydroxycephalomannine by CYP2C8. The overall biotransformation rate between paclitaxel and cephalomannine differed slightly (184 vs. 145 pmol/min/mg), but the average ratio of metabolites hydroxylated at the C13 side chain to C6alpha for paclitaxel and cephalomannine varied significantly (15:85 vs. 64:36) in five human liver samples. Compared with paclitaxel, the major hydroxylation site transferred from C6alpha to C4'', and the main metabolizing P450 changed from CYP2C8 to CYP3A4 for cephalomannine. In the incubation system with rat or minipig liver microsomes, only 4''-hydroxycephalomannine was detected, and its formation was inhibited by CYP3A inhibitors. Molecular docking by AutoDock suggested that cephalomannine adopted an orientation in favor of 4''-hydroxylation, whereas paclitaxel adopted an orientation favoring 3'-p-hydroxylation. Kinetic studies showed that CYP3A4 catalyzed cephalomannine more efficiently than paclitaxel due to an increased V(m). Our results demonstrate that relatively minor modification of taxane at C3' has major consequence on the metabolism.

    PMID:18039807 Zhang JW et al; Drug Metab Dispos 36 (2): 418-26 (2008)

    5.6 Biological Half-Life

    When a 24 hour infusion of 135 mg/m^2 is given to ovarian cancer patients, the elimination half=life is 52.7 hours.

    5.3-17.4 hours after 1 and 6 hour infusions at dosing levels of 15-275 mg/sq m

    Lelkin, J.B., Paloucek, F.P., Poisoning & Toxicology Compendium. LEXI-COMP Inc. & American Pharmaceutical Association, Hudson, OH 1998., p. 433

    Following IV infusion of paclitaxel over periods ranging from 6-24 hours in adults with malignancy, plasma concentrations of paclitaxel appeared to decline in a biphasic manner in some studies, with an average distribution half-life of 0.34 hours and an average elimination half-life of 5.8 hours. However, additional studies, particularly those in which paclitaxel is administered over shorter periods of infusion, show that the drug exhibits nonlinear pharmacokinetic behavior. In patients receiving paclitaxel 175 mg/sq m administered by 3-hour IV infusion, the distribution half-life averages 0.27 hours and the elimination half-life averages 2.33 hours.

    American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 1188

    Following 30-minute or 3-hour IV infusion of 80-375 mg/sq m albumin-bound paclitaxel, ... terminal half-life albumin-bound paclitaxel was about 27 hours. ... /Paclitaxel (albumin-bound)/

    American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 1188

    5.7 Mechanism of Action

    Paclitaxel interferes with the normal function of microtubule growth. Whereas drugs like colchicine cause the depolymerization of microtubules in vivo, paclitaxel arrests their function by having the opposite effect; it hyper-stabilizes their structure. This destroys the cell's ability to use its cytoskeleton in a flexible manner. Specifically, paclitaxel binds to the β subunit of tubulin. Tubulin is the "building block" of mictotubules, and the binding of paclitaxel locks these building blocks in place. The resulting microtubule/paclitaxel complex does not have the ability to disassemble. This adversely affects cell function because the shortening and lengthening of microtubules (termed dynamic instability) is necessary for their function as a transportation highway for the cell. Chromosomes, for example, rely upon this property of microtubules during mitosis. Further research has indicated that paclitaxel induces programmed cell death (apoptosis) in cancer cells by binding to an apoptosis stopping protein called Bcl-2 (B-cell leukemia 2) and thus arresting its function.

    Evidence suggests that paclitaxel also may induce cell death by triggering apoptosis. In addition, paclitaxel and docetaxel enhance the effects of ionizing radiation, possibly by blocking cells in the G2 phase, the phase of the cell cycle in which cells are most radiosensitive.

    American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 1187

    Paclitaxel is an antimicrotubule antineoplastic agent. Unlike some other common antimicrotubule agents (e.g., vinca alkaloids, colchicine, podophyllotoxin), which inhibit microtubule assembly, paclitaxel and docetaxel (a semisynthetic taxoid) promote microtubule assembly. Microtubules are organelles that exist in a state of dynamic equilibrium with their components, tubulin dimers. They are an essential part of the mitotic spindle and also are involved in maintenance of cell shape and motility, and transport between organelles within the cell. By binding in a reversible, concentration-dependent manner to the beta-subunit of tubulin at the N-terminal domain, paclitaxel enhances the polymerization of tubulin, the protein subunit of the spindle microtubules, even in the absence of factors that are normally required for microtubule assembly (e.g., guanosine triphosphate [GTP]), and induces the formation of stable, nonfunctional microtubules. Paclitaxel promotes microtubule stability even under conditions that typically cause depolymerization in vitro (e.g., cold temperature, the addition of calcium, the presence of antimitotic drugs). While the precise mechanism of action of the drug is not understood fully, paclitaxel disrupts the dynamic equilibrium within the microtubule system and blocks cells in the late G2 phase and M phase of the cell cycle, inhibiting cell replication.

    American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 1187

    ... Taxol induces tubulin polymerization and forms extremely stable and nonfunctional microtubules. Taxol has demonstrated broad activity in preclinical screening studies, and antineoplastic activity has been observed in several classically refractory tumors. These tumors include cisplatin resistant ovarian carcinoma in phase II trials and malignant melanoma and non-small cell lung carcinoma in phase I studies.

    PMID:1973737 Rowinsky EK et al; J Natl Cancer Inst 82 (15): 1247-59 (1990)

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    Valid
    Chemical
    2018-10-30
    1794
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    PHYTON BIOTECH LLC Delta CA

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    Paclitaxel, Semi synthetic process

    Certificate Number : R1-CEP 2008-077 - Rev 02

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    Substance Number : 1794

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    SERIPHARM S.A.S. Le Mans FR

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    R1-CEP 2008-327 - Rev 00
    Valid
    Chemical
    2014-09-02
    1794
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    Issue Date : 2014-09-02

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    Substance Number : 1794

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    CHONGQING SINTAHO PHARMACEUTICAL CO...

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      R0-CEP 2022-006 - Rev 00
      Valid
      Chemical
      2023-02-07
      1794
      Chongqing Sintaho Pharmaceutical

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      CHONGQING SINTAHO PHARMACEUTICAL CO...

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      Certificate Number : R0-CEP 2022-006 - Rev 00

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      Substance Number : 1794

      Chongqing Sintaho Pharmaceutical

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      CENWAY PHARMACEUTICALS CO., LTD. Ti...

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        Withdrawn by Holder
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        2010-11-22
        2013-07-23
        1794
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        Paclitaxel, Isolated from natural sources

        Certificate Number : R0-CEP 2009-064 - Rev 00

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        INDENA S.P.A. Milano IT

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        Paclitaxel, isolated from natural source: roots of Taxu...

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        R1-CEP 2006-319 - Rev 00
        Withdrawn by Holder
        Chemical
        2013-03-26
        2022-01-14
        1794
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        INDENA S.P.A. Milano IT

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        Paclitaxel, isolated from natural source: roots of Taxus x media

        Certificate Number : R1-CEP 2006-319 - Rev 00

        Status : Withdrawn by Holder

        Issue Date : 2013-03-26

        Type : Chemical

        Substance Number : 1794

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        SAMYANG BIOPHARMACEUTICALS CORPORAT...

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        R0-CEP 2014-061 - Rev 00
        Expired
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        2016-01-14
        2021-01-14
        1794
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        SAMYANG BIOPHARMACEUTICALS CORPORAT...

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        TAIHUA NATURAL PLANT PHARMACEUTICAL...

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          Withdrawn by EDQM F...
          Chemical
          2009-09-24
          2011-09-15
          1794
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          TAIHUA NATURAL PLANT PHARMACEUTICAL...

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          Paclitaxel, Isolated from natural sources

          Certificate Number : R0-CEP 2008-005 - Rev 00

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          Issue Date : 2009-09-24

          Type : Chemical

          Substance Number : 1794

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          TEVA CZECH INDUSTRIES S.R.O. Opava ...

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          R1-CEP 2007-212 - Rev 00
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          Chemical
          2013-10-18
          1794
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          TEVA CZECH INDUSTRIES S.R.O. Opava ...

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          Phyton Biotech LLC

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          Virtual BoothPhyton is a World Leader in Plant Cell Fermentation Technology and Commercial Manufacturing.

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          Paclitaxel

          Registration Number : 224MF10111

          Registrant's Address : 1527 Cliveden Avenue, Delta, BC, Canada, V3M6P7

          Initial Date of Registration : 2012-07-04

          Latest Date of Registration : 2020-06-19

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          Corden Pharma Boulder, Inc.

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          Corden Pharma Boulder, Inc.

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          Semi-Synthetic Paclitaxel

          Registration Number : 221MF10272

          Registrant's Address : 4876 Sterling Drive Boulder, CO 80301, USA

          Initial Date of Registration : 2009-12-09

          Latest Date of Registration : 2015-11-11

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          INDENA S. p. A.

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          INDENA S. p. A.

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          Paclitaxel/S

          Registration Number : 226MF10210

          Registrant's Address : Viale Ortles 12 Milan Italy

          Initial Date of Registration : 2014-10-27

          Latest Date of Registration : 2021-08-25

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          INDENA S. p. A.

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          INDENA S. p. A.

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          Paclitaxel/PI

          Registration Number : 218MF10269

          Registrant's Address : Viale Ortles 12 Milan Italy

          Initial Date of Registration : 2006-05-22

          Latest Date of Registration : 2021-12-09

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          INDENA S. p. A.

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          Paclitaxel/S

          Registration Number : 221MF10053

          Registrant's Address : Viale Ortles 12 Milan Italy

          Initial Date of Registration : 2009-03-16

          Latest Date of Registration : 2019-06-12

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          Samyang Holdings Corporation

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          Paclitaxel

          Registration Number : 221MF10165

          Registrant's Address : 31 Jongno 33-gil, Jongno-gu, Seoul, Korea

          Initial Date of Registration : 2009-07-23

          Latest Date of Registration : 2014-05-14

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          ScinoPharm Taiwan, Ltd.

          Taiwan
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          Paclitaxel

          Registration Number : 223MF10128

          Registrant's Address : No. 1, Nan-Ke 8th Road, Shan-Hua, Tainan 74144 Taiwan

          Initial Date of Registration : 2011-08-19

          Latest Date of Registration : 2011-08-19

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          Teva Czech Industries s. r. o.

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          Paclitaxel "Teva"

          Registration Number : 305MF10109

          Registrant's Address : Ostravska 305/29, Komarov, 747 70 Opava, Czech Republic

          Initial Date of Registration : 2023-09-20

          Latest Date of Registration : 2023-09-20

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          Yunnan Hande Bio-Tech Co. , Ltd.

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          Yunnan Hande Bio-Tech Co. , Ltd.

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          Paclitaxel

          Registration Number : 227MF10193

          Registrant's Address : Jinding Tech-Zone, Jinding Hill, Kunming, P. R. China 650033

          Initial Date of Registration : 2015-08-03

          Latest Date of Registration : 2015-08-03

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          Zhejiang Starry Pharmaceutical Co. ...

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          Iohexol

          Registration Number : 221MF10160

          Registrant's Address : No. 1 Starry Road of Xianju Modern Industrial Centralization Zone, Xianju, Zhejiang, ...

          Initial Date of Registration : 2009-07-23

          Latest Date of Registration : 2009-07-23

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          Alchem International Private Ltd

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          Paclitaxel EP/USP

          Date of Issue : 2022-05-27

          Valid Till : 2025-05-26

          Written Confirmation Number : WC-0006

          Address of the Firm : 25/2, Main Mathura Road, Village Kalli, Ballabgarh, Faridabad-121 004, Haryana, ...

          Alchem

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          Phyton Biotech LLC

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          Paclitaxel

          Date of Issue : 2020-04-14

          Valid Till : 2022-12-03

          Written Confirmation Number : 67771B0D

          Address of the Firm : 1527 Cliveden Avenue, Delta, British Columbia. V3M 6P7

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          Cipla

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          Paclitaxel IH/USP

          Date of Issue : 2019-08-09

          Valid Till : 2022-08-08

          Written Confirmation Number : WC-0138

          Address of the Firm : Plot No. 285, 286 & 287, Bommasandra-Jigani Link Road, Industrial Area, KIADB, 4...

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          Fresenius Kabi Oncology Limited

          India
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          Paclitaxel (Ph. Eur.) (Semi-synthetic)

          Date of Issue : 2019-07-08

          Valid Till : 2022-07-07

          Written Confirmation Number : WC-0115

          Address of the Firm : D-35, Industrial Area, Kalyani, Dist Nadia-741 235, West Bengal 

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          Hetero Drugs

          India
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          Paclitaxel (USP/Ph. Eur)

          Date of Issue : 2022-09-16

          Valid Till : 2025-08-08

          Written Confirmation Number : WC-0041

          Address of the Firm : Unit-I, Survey No.10, I.D.A, Gaddapotharam Village, Jinnaram Mandal,Medak Dist, ...

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          Mac-Chem Products (India) Pvt.Ltd

          India
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          Mac-Chem Products (India) Pvt.Ltd

          India
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          Paclitaxel (USP)

          Date of Issue : 2021-01-22

          Valid Till : 2023-08-01

          Written Confirmation Number : WC-0275

          Address of the Firm : N-211/2/10, MIDC, Boisar, Dist-Thane-401506, Mahrashtra

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          MSN Laboratories

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          MSN Laboratories

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          Paclitaxel USP/EP

          Date of Issue : 2022-09-02

          Valid Till : 2025-05-05

          Written Confirmation Number : WC-0349

          Address of the Firm : MIs. MSN Laboratories Private Limited, Unit-II, sv. No, 50, Kardanur (Village), ...

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          MSN Laboratories

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          Paclitaxel USP/EP

          Date of Issue : 2019-08-05

          Valid Till : 2022-05-05

          Written Confirmation Number : WC-0349A3

          Address of the Firm : Unit-||, Sy. No. 50, Kardanur Village, Patti/Post Patancheru Mandal,Medak Distri...

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          Alchem International Private Ltd

          India
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          • fda
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          Virtual BoothAlchem offers Phytochemical APIs for Pharmaceuticals, Cosmetics and Nutraceuticals// FDA-inspected and EU-GMP certified.

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          Paclitaxel

          Registrant Name : Hwail Pharmaceutical Co., Ltd.

          Registration Date : 2024-07-04

          Registration Number : 20240704-68-A-381-19

          Manufacturer Name : Alchem ​​International P...

          Manufacturer Address : 25/2, Main Mathura Road, Village Kaili, Ballabhgarh Faridabad (Haryana), India

          Alchem

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          Phyton Biotech LLC

          Canada
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          Virtual BoothPhyton is a World Leader in Plant Cell Fermentation Technology and Commercial Manufacturing.

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          Paclitaxel

          Registrant Name : Boryeong Co., Ltd.

          Registration Date : 2013-09-05

          Registration Number : 20130614-68-A-278-15(1)

          Manufacturer Name : Phyton Biotech LLC@[partial ...

          Manufacturer Address : 1527 Cliveden Avenue, Delta, British Columbia, V3M6P7, Canada.@Alter Postweg 1 D-2292...

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          Phyton Biotech LLC

          Canada
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          Virtual BoothPhyton is a World Leader in Plant Cell Fermentation Technology and Commercial Manufacturing.

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          Paclitaxel

          Registrant Name : JDW Pharmaceutical Co., Ltd.

          Registration Date : 2014-04-10

          Registration Number : 20130614-68-A-278-15(2)

          Manufacturer Name : Phyton Biotech LLC@[Some pro...

          Manufacturer Address : 1527 Cliveden Avenue, Delta, British Columbia, V3M6P7, Canada@Alter Postweg 1 D-22926...

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          Phyton Biotech LLC

          Canada
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          Virtual BoothPhyton is a World Leader in Plant Cell Fermentation Technology and Commercial Manufacturing.

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          Paclitaxel

          Registrant Name : Sampoong Pharmachem Co., Ltd.

          Registration Date : 2012-10-11

          Registration Number : 20121011-68-A-265-13

          Manufacturer Name : Phyton Biotech LLC

          Manufacturer Address : 1527 Cliveden Avenue, Delta, British Columbia, Canada, V3M6P7

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          Phyton Biotech LLC

          Canada
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          Virtual BoothPhyton is a World Leader in Plant Cell Fermentation Technology and Commercial Manufacturing.

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          Paclitaxel

          Registrant Name : Sampoong Pharmachem Co., Ltd.

          Registration Date : 2013-06-14

          Registration Number : 20130614-68-A-278-15

          Manufacturer Name : Phyton Biotech LLC@[partial ...

          Manufacturer Address : 1527 Cliveden Avenue, Delta, British Columbia, V3M6P7, Canada@Alter Postweg 1 D-22926...

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          06

          Phyton Biotech LLC

          Canada
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          Virtual BoothPhyton is a World Leader in Plant Cell Fermentation Technology and Commercial Manufacturing.

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          Paclitaxel

          Registrant Name : Korea Pfizer Pharmaceutical Co., Ltd.

          Registration Date : 2017-11-01

          Registration Number : 20130614-68-A-278-15(3)

          Manufacturer Name : Phyton Biotech, LLC@Phyton B...

          Manufacturer Address : 1527 Cliveden Avenue, Delta, British Columbia, V3M6P7, Canada@Alter Postweg 1 D-22926...

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          07

          Fresenius Kabi AB Brunna

          Sweden
          SupplySide West 2024
          Not Confirmed
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          Fresenius Kabi AB Brunna

          Sweden
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          Not Confirmed
          • fda
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          Paclitaxel

          Registrant Name : Samyang Holdings Co., Ltd.

          Registration Date : 2024-08-13

          Registration Number : 20061031-68-A-193-08(5)

          Manufacturer Name : Fresenius Kabi Oncology Limi...

          Manufacturer Address : D-35, industrial Area, Kalyani, Nadia, West Bengal-741 235, INDIA

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          Fresenius Kabi AB Brunna

          Sweden
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          Fresenius Kabi AB Brunna

          Sweden
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          Paclitaxel

          Registrant Name : Aging Life Science Co., Ltd.

          Registration Date : 2022-01-19

          Registration Number : 20061031-68-A-193-08(A)

          Manufacturer Name : Fresenius Kabi Oncology Limi...

          Manufacturer Address : D-35, Industrial Area, Kalyani, Dist-Nadia, Pin-741235, India

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          Fresenius Kabi AB Brunna

          Sweden
          SupplySide West 2024
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          Fresenius Kabi AB Brunna

          Sweden
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          Paclitaxel

          Registrant Name : Kyungbo Pharmaceutical Co., Ltd.

          Registration Date : 2023-10-27

          Registration Number : 20061031-68-A-193-08(4)

          Manufacturer Name : Fresenius Kabi Oncology Limi...

          Manufacturer Address : D-35, industrial Area, Kalyani, Nadia, West Bengal-741 235, INDIA

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          10

          Ind Swift Laboratories Limited

          India
          SupplySide West 2024
          Not Confirmed
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          Ind Swift Laboratories Limited

          India
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          SupplySide West 2024
          Not Confirmed
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          Paclitaxel

          Registrant Name : Korea Sandoz Co., Ltd.

          Registration Date : 2021-03-10

          Registration Number : 20050831-68-A-137-04(1)

          Manufacturer Name : Indena SpA

          Manufacturer Address : Via Don Minzoni, 6-20090 SETTLA (MI), Italy(n.12, Viale Ortles, Milano, Italy)

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          NDC API

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          01

          Phyton Biotech LLC

          Canada
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          Attending
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          Virtual BoothPhyton is a World Leader in Plant Cell Fermentation Technology and Commercial Manufacturing.

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          PACLITAXEL

          NDC Package Code : 51446-0110

          Start Marketing Date : 2011-06-20

          End Marketing Date : 2024-12-31

          Dosage Form (Strength) : POWDER (1g/g)

          Marketing Category : BULK INGREDIENT

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          02

          Phyton Biotech LLC

          Canada
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          Bio-Europe 2024
          Attending
          • fda
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          Virtual BoothPhyton is a World Leader in Plant Cell Fermentation Technology and Commercial Manufacturing.

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          PACLITAXEL

          NDC Package Code : 51446-0120

          Start Marketing Date : 2012-11-20

          End Marketing Date : 2024-12-31

          Dosage Form (Strength) : POWDER (1g/g)

          Marketing Category : BULK INGREDIENT

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          03

          SERIPHARM

          Germany
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          World ADC- San Diego
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          Virtual BoothAxplora- The partner of choice for complex APIs.

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          PACLITAXEL

          NDC Package Code : 62422-0004

          Start Marketing Date : 1996-12-27

          End Marketing Date : 2024-12-31

          Dosage Form (Strength) : POWDER (1g/g)

          Marketing Category : BULK INGREDIENT

          Axplora CB

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          SERIPHARM

          Germany
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          World ADC- San Diego
          Attending
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          Virtual BoothAxplora- The partner of choice for complex APIs.

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          PACLITAXEL

          NDC Package Code : 62422-0002

          Start Marketing Date : 1996-12-27

          End Marketing Date : 2024-12-31

          Dosage Form (Strength) : POWDER (1g/g)

          Marketing Category : BULK INGREDIENT

          Axplora CB

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          Chongqing Sintaho Pharmaceutical Co...

          China
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          World Vaccine Congress
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          Virtual BoothChongqing Sintaho Pharma: A trusted partner globally for chemosynthetic APIs.

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          PACLITAXEL

          NDC Package Code : 84172-111

          Start Marketing Date : 2024-07-01

          End Marketing Date : 2025-12-31

          Dosage Form (Strength) : INJECTION, POWDER, FOR SOLUTION (1g/g)

          Marketing Category : BULK INGREDIENT

          Chongqing Sintaho Pharmaceutical

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          06

          Aurobindo Pharma Limited

          India
          World Vaccine Congress
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          Aurobindo Pharma Limited

          India
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          World Vaccine Congress
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          PACLITAXEL

          NDC Package Code : 59651-605

          Start Marketing Date : 2024-01-12

          End Marketing Date : 2025-12-31

          Dosage Form (Strength) : POWDER (50kg/50kg)

          Marketing Category : BULK INGREDIENT

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          Indena SpA

          Italy
          World Vaccine Congress
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          Indena SpA

          Italy
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          PACLITAXEL

          NDC Package Code : 17359-4056

          Start Marketing Date : 2020-04-02

          End Marketing Date : 2024-12-31

          Dosage Form (Strength) : POWDER (1g/g)

          Marketing Category : BULK INGREDIENT

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          Indena SpA

          Italy
          World Vaccine Congress
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          Indena SpA

          Italy
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          World Vaccine Congress
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          PACLITAXEL

          NDC Package Code : 17359-4055

          Start Marketing Date : 2007-09-01

          End Marketing Date : 2024-12-31

          Dosage Form (Strength) : POWDER (1g/g)

          Marketing Category : BULK INGREDIENT

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          ScinoPharm Taiwan Ltd.

          Taiwan
          World Vaccine Congress
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          ScinoPharm Taiwan Ltd.

          Taiwan
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          World Vaccine Congress
          Not Confirmed
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          PACLITAXEL

          NDC Package Code : 65129-2039

          Start Marketing Date : 2003-12-26

          End Marketing Date : 2025-12-31

          Dosage Form (Strength) : POWDER (1kg/kg)

          Marketing Category : BULK INGREDIENT

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          10

          Teva Czech Industries s.r.o

          Israel
          World Vaccine Congress
          Not Confirmed
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          Teva Czech Industries s.r.o

          Israel
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          World Vaccine Congress
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          PACLITAXEL

          NDC Package Code : 47848-034

          Start Marketing Date : 2017-11-21

          End Marketing Date : 2024-12-31

          Dosage Form (Strength) : POWDER (100kg/100kg)

          Marketing Category : BULK INGREDIENT

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          Alchem International Private Ltd

          India
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          CPhI India 2024
          Booth #1.C02
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          Virtual BoothAlchem offers Phytochemical APIs for Pharmaceuticals, Cosmetics and Nutraceuticals// FDA-inspected and EU-GMP certified.

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          Paclitaxel

          About the Company : Alchem International, established in 1935, is a pioneer in phytochemicals, providing plant-derived active pharmaceutical ingredients to the pharmaceutical, cosmetic and nutraceutic...

          Alchem International, established in 1935, is a pioneer in phytochemicals, providing plant-derived active pharmaceutical ingredients to the pharmaceutical, cosmetic and nutraceutical industries. With over 75 years of experience, Alchem has established a global presence, selling its products in more than 35 countries. Alchem has three manufacturing sites spread across 62 acres in India and four international divisions with offices in India, Europe, Hong Kong and the US. Alchem has two divisions – Phytoceuticals and EpiQue – that provide healthcare and cosmetic products to the Indian market and employs over 1,000 people worldwide.
          Alchem

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          02

          Phyton Biotech LLC

          Canada
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          Bio-Europe 2024
          Attending
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          Virtual BoothPhyton is a World Leader in Plant Cell Fermentation Technology and Commercial Manufacturing.

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          Paclitaxel

          About the Company : Phyton Biotech, a division of DFB Pharmaceuticals, was founded in 1990. Using its Plant Cell Fermentation (PCF) technology, Phyton Biotech is currently the world’s largest produc...

          Phyton Biotech, a division of DFB Pharmaceuticals, was founded in 1990. Using its Plant Cell Fermentation (PCF) technology, Phyton Biotech is currently the world’s largest producer of high-quality paclitaxel and docetaxel. It offers clients a full range of integrated contract product and process development and commercial manufacturing services across the entire development chain, from feasibility to commercial production, to the pharmaceutical, cosmetic, agricultural and food ingredient industries. Its facilities in Germany and Canada have been inspected by multiple regulatory agencies and comply with international GMP requirements.
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          03

          Sarv Biolabs Pvt Ltd

          India
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          CPhI India 2024
          Booth #1.B24
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          Virtual BoothSarv BioLabs manufactures high-quality Phytochemicals & Active Pharmaceutical Ingredients.

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          Paclitaxel

          About the Company : Sarv Biolabs Pvt Ltd is a WHO GMP Certified company that was established in the year 2005 with thought of Providing a “Happy Life Through Nature” in the serene Himalayan foothi...

          Sarv Biolabs Pvt Ltd is a WHO GMP Certified company that was established in the year 2005 with thought of Providing a “Happy Life Through Nature” in the serene Himalayan foothills of India. We are wholly committed to developing & producing APIs, Phytochemicals, Anti Cancer APIs & intermediates. Housed within a cutting-edge facility located in KalaAmb, India & Panchkula, Haryana. We leverage state-of-the-art technology & our operations strictly adhere to USFDA guidelines. This rigorous oversight guarantees unwavering compliance with regulatory authorities & the consistent supply of our Phytochemicals by prevailing pharmacopeial standards.
          Sarv BioLabs

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          04

          LGM Pharma

          U.S.A
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          BioFlorida Conference
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          Virtual BoothLGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

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          Paclitaxel

          About the Company : LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, ...

          LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, analytical method development and testing, and commercial manufacturing. LGM Pharma offers custom API synthesis, analytical development, and regulatory services. With a network of over 300 accredited CGMP manufacturing partners, LGM provides unparalleled supply chain security. And, with over 100,000 square feet of FDA-inspected cGMP manufacturing and warehouse capacity, LGM Pharma provides a one-stop solution for solid dose, powder, semi-solid and liquid drugs.
          LGM Pharma CB

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          05

          Rochem International Inc

          U.S.A
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          SupplySide West 2024
          Not Confirmed
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          Virtual BoothRochem, your partner in developing, sourcing, and supplying pharmaceutical & animal health ingredients of Chinese origin.

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          Paclitaxel

          About the Company : Established in 1994, Rochem is a distributor of pharmaceutical, food, nutritional and animal health ingredients to some of the largest companies in the world. It sources high-quali...

          Established in 1994, Rochem is a distributor of pharmaceutical, food, nutritional and animal health ingredients to some of the largest companies in the world. It sources high-quality ingredients manufactured in China. Headquartered in the Hauppauge, New York, Rochem has 16 offices spread across the globe to cater to the needs of its customers. Rochem’s operations are fully cGMP compliant and has been audited by the USFDA as well as several multinational organizations. It also trains and audits its partners to ensure all of their technologies and systems are FDA-compliant.
          Rochem

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          06

          DKSH

          Switzerland
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          Fi Europe 2024
          Exhibiting
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          Virtual BoothDKSH is your trusted partner for companies looking to grow their business in Asia & beyond.

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          Paclitaxel

          About the Company : DKSH, founded with the goal of improving people's lives, assists businesses with market expansion and business growth in both existing and emerging markets. It has been fostering g...

          DKSH, founded with the goal of improving people's lives, assists businesses with market expansion and business growth in both existing and emerging markets. It has been fostering growth for businesses in Asia and beyond for over 155 years. DKSH operates in 36 markets, is listed on the SIX Swiss Exchange, employs 33,100 specialists, and generated net sales of CHF 11.1 billion in 2021. It is the leading global distributor of innovative pharma ingredients for pharmaceutical synthesis and formulation. It offers a range of products, ranging from animal care products to packaging materials, intermediates to nutraceuticals, and APIs to excipients.
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          07

          Chongqing Sintaho Pharmaceutical

          China
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          SupplySide West 2024
          Not Confirmed
          • fda
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          • WHO-GMP

          Virtual BoothChongqing Sintaho Pharma: A trusted partner globally for chemosynthetic APIs.

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          Paclitaxel

          About the Company : Sintaho Pharmaceutical Co., Ltd., located in Chongqing, China, contributes to being the most dependable partner for global pharmaceutical companies. Sintaho specializes in chemosyn...

          Sintaho Pharmaceutical Co., Ltd., located in Chongqing, China, contributes to being the most dependable partner for global pharmaceutical companies. Sintaho specializes in chemosynthetic APIs (application contains oncology, nervous system, and metabolic diseases and etc.,) with a product portfolio ranging from small molecule APIs, ADC compounds (linkers and payloads) to polypeptides, also provides CDMO services of cytotoxic and OEB4/5 grade APIs.
          Chongqing Sintaho Pharmaceutical

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          08

          HRV Global Life Sciences

          India
          arrow
          CPhI India 2024
          Booth #2.D38
          • fda
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          Virtual BoothHRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

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          Paclitaxel

          About the Company : HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It...

          HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It offers services such as sourcing, manufacturing and supply, helping partners enter new markets worldwide. Its strong partnerships with major players in the pharma and food additive industries help HRV Global effectively promote projects and products. HRV Global represents over 30 large Indian drugmakers, primarily targeting Europe, the US and the Middle East markets. Headquartered in India, HRV Global has offices in the US, Switzerland, Dubai, Lithuania & Turkey.
          HRV Global Life Sciences

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          09

          Octavius Pharma Pvt. Ltd

          India
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          Virtual BoothOctavius has been empowering lives since 1980 by providing quality products like DC granules, APIs and FDFs.

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          Paclitaxel

          About the Company : Octavius Pharma is a global leader in Directly Compressible Granules with over 40 years of experience in Formulation development, manufacturing and commercialization. It offers a w...

          Octavius Pharma is a global leader in Directly Compressible Granules with over 40 years of experience in Formulation development, manufacturing and commercialization. It offers a wide range of products such as tablets, capsules, syrups and ointments. Its portfolio includes finished dosage formulations, herbal/food supplements and APIs. It exports bulk drugs, finished formulations and APIs, while maintaining quality in compliance with WHO GMP norms. With an experienced team, Octavius Pharma provides consulting services for formulation development and marketing. Octavius exports to LATAM, Middle East, African, Asian and CIS countries.
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          10

          Indena

          Italy
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          Indena

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          Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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          Paclitaxel

          About the Company : Indena is the world’s leading company in the identification, development and production of active principles derived from plants, for use in the pharmaceutical, health-food and p...

          Indena is the world’s leading company in the identification, development and production of active principles derived from plants, for use in the pharmaceutical, health-food and personal care industries. Indena, a privately owned Italian company, has around 800 employees (10% of them dedicated to full-time research) and has cultivation, manufacturing, and sales in more than 70 countries throughout the world. The key to Indena’s success is its research, covering: the screening of medicinal plants for pharmacological benefits; the identification of new active principles; the development of cutting-edge extraction and purification systems.
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          13-Jan-2021
          23-Sep-2024
          KGS
          overview
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          Average Price (USD/KGS)

          Number of Transactions

          Total Quantity (KGS)

          Total Value (USD)

          Quantity (KGS) & Unit rate (USD/KGS) over time

          API Imports and Exports

          Importing Country Total Quantity
          (KGS)          		 Average Price
          (USD/KGS)          		 Number of Transactions

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          INTERMEDIATES SUPPLIERS

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          01

          USV Private Limited

          India
          CPhI India 2024
          Attending
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          • fda
          • EDQM
          • WHO-GMP

          Virtual BoothUSV offers custom peptide synthesis ranging from gram to multi-gram to multi-kilogram quantities.

          (S)-2-(Boc-Amino)-1-Propanol

          CAS Number : 79069-13-9

          End Use API : Paclitaxel

          About The Company : USV is a leading health care company with focus on Active Pharmaceutical Ingredients (marketed globally with emphasis on regulated markets of USA, European Unio...

          USV Private Limited

          Portfolio PDF

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          Website

          Corporate PDF

          02

          Fujian South Pharmaceutical

          China
          SupplySide West 2024
          Not Confirmed
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          Fujian South Pharmaceutical

          China
          SupplySide West 2024
          Not Confirmed
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          • EDQM
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          Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

          60%~70% Paclitaxel (natural) Crude

          CAS Number : 33069-62-4

          End Use API : Paclitaxel

          About The Company : Fujian South Pharmaceutical Co., Ltd. (Southern Pharmaceutical) was established in September 2001 and is located in Mingxi County, Fujian Province. After 16 ye...

          blank

          Portfolio PDF

          Product Web Link

          Virtual Booth

          Digital Content

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          03

          Fujian South Pharmaceutical

          China
          SupplySide West 2024
          Not Confirmed
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          Fujian South Pharmaceutical

          China
          SupplySide West 2024
          Not Confirmed
          arrow
          • fda
          • EDQM
          • WHO-GMP
          Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

          7-Troc-Paclitaxel

          CAS Number : 114915-17-2

          End Use API : Paclitaxel

          About The Company : Fujian South Pharmaceutical Co., Ltd. (Southern Pharmaceutical) was established in September 2001 and is located in Mingxi County, Fujian Province. After 16 ye...

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          Portfolio PDF

          Product Web Link

          Virtual Booth

          Digital Content

          Website

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          04

          Fujian South Pharmaceutical

          China
          SupplySide West 2024
          Not Confirmed
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          Fujian South Pharmaceutical

          China
          SupplySide West 2024
          Not Confirmed
          arrow
          • fda
          • EDQM
          • WHO-GMP
          Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

          Baccatin III

          CAS Number : 27548-93-2

          End Use API : Paclitaxel

          About The Company : Fujian South Pharmaceutical Co., Ltd. (Southern Pharmaceutical) was established in September 2001 and is located in Mingxi County, Fujian Province. After 16 ye...

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          Portfolio PDF

          Product Web Link

          Virtual Booth

          Digital Content

          Website

          Corporate PDF

          05

          Fujian South Pharmaceutical

          China
          SupplySide West 2024
          Not Confirmed
          arrow

          Fujian South Pharmaceutical

          China
          SupplySide West 2024
          Not Confirmed
          arrow
          • fda
          • EDQM
          • WHO-GMP
          Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

          Cephalomannine

          CAS Number : 71610-00-9

          End Use API : Paclitaxel

          About The Company : Fujian South Pharmaceutical Co., Ltd. (Southern Pharmaceutical) was established in September 2001 and is located in Mingxi County, Fujian Province. After 16 ye...

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          Portfolio PDF

          Product Web Link

          Virtual Booth

          Digital Content

          Website

          Corporate PDF

          06

          Fujian South Pharmaceutical

          China
          SupplySide West 2024
          Not Confirmed
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          Fujian South Pharmaceutical

          China
          SupplySide West 2024
          Not Confirmed
          arrow
          • fda
          • EDQM
          • WHO-GMP
          Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

          10-Deacetyl Paclitaxel

          CAS Number : 78432-77-6

          End Use API : Paclitaxel

          About The Company : Fujian South Pharmaceutical Co., Ltd. (Southern Pharmaceutical) was established in September 2001 and is located in Mingxi County, Fujian Province. After 16 ye...

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          Portfolio PDF

          Product Web Link

          Virtual Booth

          Digital Content

          Website

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          07

          Fujian South Pharmaceutical

          China
          SupplySide West 2024
          Not Confirmed
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          Fujian South Pharmaceutical

          China
          SupplySide West 2024
          Not Confirmed
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          (4S,5R)-3-Benzoyl-2-(4-methoxyphenyl)-4-phenyl-5- ...

          CAS Number : 949023-16-9

          End Use API : Paclitaxel

          About The Company : Fujian South Pharmaceutical Co., Ltd. (Southern Pharmaceutical) was established in September 2001 and is located in Mingxi County, Fujian Province. After 16 ye...

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          Fujian South Pharmaceutical

          China
          SupplySide West 2024
          Not Confirmed
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          Fujian South Pharmaceutical

          China
          SupplySide West 2024
          Not Confirmed
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          (3R,4S)-1-Benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2- a...

          CAS Number : 201856-53-3

          End Use API : Paclitaxel

          About The Company : Fujian South Pharmaceutical Co., Ltd. (Southern Pharmaceutical) was established in September 2001 and is located in Mingxi County, Fujian Province. After 16 ye...

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          09

          Fujian South Pharmaceutical

          China
          SupplySide West 2024
          Not Confirmed
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          Fujian South Pharmaceutical

          China
          SupplySide West 2024
          Not Confirmed
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          (3R,4S)-3-hydroxy-4-phenyl-2-azetidinone

          CAS Number : 132127-34-5

          End Use API : Paclitaxel

          About The Company : Fujian South Pharmaceutical Co., Ltd. (Southern Pharmaceutical) was established in September 2001 and is located in Mingxi County, Fujian Province. After 16 ye...

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          Hangzhou Longshine Bio-Tech Co.,LTD

          China
          SupplySide West 2024
          Not Confirmed
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          Hangzhou Longshine Bio-Tech Co.,LTD

          China
          SupplySide West 2024
          Not Confirmed
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          (4S,5R)-3-benzoyl-2-(4-anisyl)-4-phenyl-5-oxazolid...

          CAS Number : 949023-16-9

          End Use API : Paclitaxel

          About The Company : Established in 2011 and situated in Hangzhou, Zhejiang, China, Hangzhou Longshine Bio-Tech CO., Ltd is dedicated to providing services for pharmaceutical and ch...

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          FDA Orange Book

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          01

          ACCORD HLTHCARE

          United Kingdom
          World Vaccine Congress
          Not Confirmed
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          ACCORD HLTHCARE

          United Kingdom
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          World Vaccine Congress
          Not Confirmed
          • fda
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          Virtual Booth Virtual Booth
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          RLD : No

          TE Code :

          PACLITAXEL

          Brand Name : PACLITAXEL

          Dosage Form : INJECTABLE;INJECTION

          Dosage Strength : 6MG/ML

          Approval Date : 2004-11-12

          Application Number : 75436

          RX/OTC/DISCN : DISCN

          RLD : No

          TE Code :

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          02

          ACCORD HLTHCARE

          United Kingdom
          World Vaccine Congress
          Not Confirmed
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          ACCORD HLTHCARE

          United Kingdom
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          World Vaccine Congress
          Not Confirmed
          • fda
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          RLD : No

          TE Code : AP

          PACLITAXEL

          Brand Name : PACLITAXEL

          Dosage Form : INJECTABLE;INJECTION

          Dosage Strength : 6MG/ML

          Approval Date : 2018-08-17

          Application Number : 205720

          RX/OTC/DISCN : RX

          RLD : No

          TE Code : AP

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          03

          ACTAVIS TOTOWA

          Ireland
          World Vaccine Congress
          Not Confirmed
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          ACTAVIS TOTOWA

          Ireland
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          World Vaccine Congress
          Not Confirmed
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          RLD : No

          TE Code : AP

          PACLITAXEL

          Brand Name : PACLITAXEL

          Dosage Form : INJECTABLE;INJECTION

          Dosage Strength : 6MG/ML

          Approval Date : 2009-12-09

          Application Number : 90130

          RX/OTC/DISCN : RX

          RLD : No

          TE Code : AP

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          04

          DASH PHARMS

          U.S.A
          World Vaccine Congress
          Not Confirmed
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          DASH PHARMS

          U.S.A
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          Not Confirmed
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          RLD : No

          TE Code :

          PACLITAXEL

          Brand Name : PACLITAXEL

          Dosage Form : INJECTABLE;INJECTION

          Dosage Strength : 6MG/ML

          Approval Date : 2011-09-29

          Application Number : 91540

          RX/OTC/DISCN : DISCN

          RLD : No

          TE Code :

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          05

          FRESENIUS KABI USA

          U.S.A
          World Vaccine Congress
          Not Confirmed
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          FRESENIUS KABI USA

          U.S.A
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          World Vaccine Congress
          Not Confirmed
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          Virtual Booth Virtual Booth
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          RLD : No

          TE Code : AP

          PACLITAXEL

          Brand Name : PACLITAXEL

          Dosage Form : INJECTABLE;INJECTION

          Dosage Strength : 6MG/ML

          Approval Date : 2006-11-27

          Application Number : 77574

          RX/OTC/DISCN : RX

          RLD : No

          TE Code : AP

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          06

          GLAND PHARMA LTD

          India
          World Vaccine Congress
          Not Confirmed
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          GLAND PHARMA LTD

          India
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          World Vaccine Congress
          Not Confirmed
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          RLD : No

          TE Code : AP

          PACLITAXEL

          Brand Name : PACLITAXEL

          Dosage Form : INJECTABLE;INJECTION

          Dosage Strength : 6MG/ML

          Approval Date : 2016-08-23

          Application Number : 207326

          RX/OTC/DISCN : RX

          RLD : No

          TE Code : AP

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          07

          HOSPIRA

          U.S.A
          World Vaccine Congress
          Not Confirmed
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          HOSPIRA

          U.S.A
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          Not Confirmed
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          RLD : No

          TE Code : AP

          PACLITAXEL

          Brand Name : PACLITAXEL

          Dosage Form : INJECTABLE;INJECTION

          Dosage Strength : 6MG/ML

          Approval Date : 2002-05-08

          Application Number : 76131

          RX/OTC/DISCN : RX

          RLD : No

          TE Code : AP

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          08

          HOSPIRA

          U.S.A
          World Vaccine Congress
          Not Confirmed
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          HOSPIRA

          U.S.A
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          Not Confirmed
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          Virtual Booth Virtual Booth
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          RLD : No

          TE Code :

          PACLITAXEL

          Brand Name : PACLITAXEL

          Dosage Form : INJECTABLE;INJECTION

          Dosage Strength : 6MG/ML

          Approval Date : 2002-08-01

          Application Number : 76233

          RX/OTC/DISCN : DISCN

          RLD : No

          TE Code :

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          09

          PLIVA LACHEMA

          Croatia
          World Vaccine Congress
          Not Confirmed
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          PLIVA LACHEMA

          Croatia
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          World Vaccine Congress
          Not Confirmed
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          RLD : No

          TE Code :

          PACLITAXEL

          Brand Name : PACLITAXEL

          Dosage Form : INJECTABLE;INJECTION

          Dosage Strength : 6MG/ML

          Approval Date : 2008-03-12

          Application Number : 77413

          RX/OTC/DISCN : DISCN

          RLD : No

          TE Code :

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          10

          SANDOZ

          Switzerland
          World Vaccine Congress
          Not Confirmed
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          SANDOZ

          Switzerland
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          World Vaccine Congress
          Not Confirmed
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          RLD : No

          TE Code :

          PACLITAXEL

          Brand Name : PACLITAXEL

          Dosage Form : INJECTABLE;INJECTION

          Dosage Strength : 6MG/ML

          Approval Date : 2007-12-26

          Application Number : 78167

          RX/OTC/DISCN : DISCN

          RLD : No

          TE Code :

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          Canada

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          01

          ACCORD HEALTHCARE INC

          United Kingdom
          SupplySide West 2024
          Not Confirmed
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          ACCORD HEALTHCARE INC

          United Kingdom
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          SupplySide West 2024
          Not Confirmed
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          Regulatory Info : Prescription

          Registration Country : Canada

          PACLITAXEL

          Brand Name : PACLITAXEL INJECTION USP

          Dosage Form : SOLUTION

          Dosage Strength : 6MG/ML

          Packaging : 5/16.7/50ML

          Approval Date :

          Application Number : 2391465

          Regulatory Info : Prescription

          Registration Country : Canada

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          02

          BIOLYSE PHARMA CORPORATION

          Canada
          SupplySide West 2024
          Not Confirmed
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          BIOLYSE PHARMA CORPORATION

          Canada
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          SupplySide West 2024
          Not Confirmed
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          Regulatory Info : Prescription

          Registration Country : Canada

          PACLITAXEL

          Brand Name : PACLITAXEL FOR INJECTION

          Dosage Form : SOLUTION

          Dosage Strength : 6MG/ML

          Packaging : 6MG

          Approval Date :

          Application Number : 2244372

          Regulatory Info : Prescription

          Registration Country : Canada

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          03

          BRISTOL-MYERS SQUIBB CANADA

          U.S.A
          SupplySide West 2024
          Not Confirmed
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          BRISTOL-MYERS SQUIBB CANADA

          U.S.A
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          Not Confirmed
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          Regulatory Info : Prescription

          Registration Country : Canada

          PACLITAXEL

          Brand Name : ABRAXANE FOR INJECTABLE SUSPENSION

          Dosage Form : POWDER FOR SUSPENSION

          Dosage Strength : 100MG/VIAL

          Packaging : 1 VIAL

          Approval Date :

          Application Number : 2281066

          Regulatory Info : Prescription

          Registration Country : Canada

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          04

          PANACEA BIOTEC PHARMA LIMITED

          India
          SupplySide West 2024
          Not Confirmed
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          PANACEA BIOTEC PHARMA LIMITED

          India
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          SupplySide West 2024
          Not Confirmed
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          Regulatory Info : Prescription

          Registration Country : Canada

          PACLITAXEL

          Brand Name : PACLITAXEL POWDER FOR INJECTABLE SUSPENSION NANOPARTICLE, ALBUMIN-BOUND PACLITAXEL

          Dosage Form : POWDER FOR SUSPENSION

          Dosage Strength : 100MG/VIAL

          Packaging :

          Approval Date :

          Application Number : 2496097

          Regulatory Info : Prescription

          Registration Country : Canada

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          SANDOZ CANADA INCORPORATED

          Switzerland
          SupplySide West 2024
          Not Confirmed
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          SANDOZ CANADA INCORPORATED

          Switzerland
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          Not Confirmed
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          Regulatory Info : Prescription

          Registration Country : Canada

          PACLITAXEL

          Brand Name : PACLITAXEL INJECTION USP

          Dosage Form : SOLUTION

          Dosage Strength : 6MG/ML

          Packaging : 5ML/16.7ML/25ML/50ML

          Approval Date :

          Application Number : 2320150

          Regulatory Info : Prescription

          Registration Country : Canada

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          DRUG PRODUCT COMPOSITIONS

          Do you need Business Intel? Ask us

          DOSAGE - INJECTABLE;INJECTION - 6MG/ML **Fede...DOSAGE - INJECTABLE;INJECTION - 6MG/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

          USFDA APPLICATION NUMBER - 20262

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          DOSAGE - POWDER;INTRAVENOUS - 100MG/VIAL

          USFDA APPLICATION NUMBER - 211875

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          Nanjing Well Pharmaceutical

          China
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          Virtual BoothNanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.

          Brand Name : Polyoxyethylene (35) Castor Oil

          Application : Emulsifying Agents, Parenteral, Solubilizers, Surfactant & Foaming Agents, Topical

          Excipient Details : Polyxyl 35 castor oil is used as surfactant & emulsifier in parenteral formulations. It acts as solubilizer & emulsifier in oral & topical products.

          Pharmacopoeia Ref : ChP/USP/EP

          Technical Specs : NA

          Ingredient(s) : Polyoxyl 35 Castor Oil

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          Nanjing Bold Chemical

          China
          SupplySide West 2024
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          BASF

          Germany
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          Granulation

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          DATA COMPILATION #PharmaFlow

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          FDA’s June 2024 list of off-patent, off-exclusivity drugs sees rise in cancer, HIV treatments

          FDA’s June 2024 list of off-patent, off-exclusivity drugs sees rise in cancer, HIV treatments

          This week PharmaCompass brings to you key highlights of the US Food and Drug Administration’s recently released June 2024 list of Off-Patent, Off-Exclusivity Drugs without an Approved Generic (OPOE list). The list is a crucial resource for promoting competition and affordability in the pharmaceutical industry. Updated biannually in December and June, the OPOE list serves as a transparent guide for drug manufacturers. Since December 2021, the FDA has enhanced its transparency efforts by providing separate lists for prescription (Rx) and over-the-counter (OTC) drugs approved under a New Drug Application (NDA). This initiative is a significant cog in the FDA’s broader strategy to encourage the development and submission of Abbreviated New Drug Applications (ANDAs). ANDAs are a streamlined pathway for generic drug development, offering a more cost-effective alternative to brand-name drugs. By highlighting drugs that lack generic competition on the OPOE list, FDA aims to incentivize manufacturers to develop generics, ultimately leading to greater affordability and access for patients. Access the Interactive Dashboard on FDA's June 2024 List of Off-Patent Drugs (Free Excel) ALS drugs, cancer, asthma, HIV treatments among new drugs added to OPOE list The December 2023 OPOE list had 23 new applications of branded drugs eligible for but without generic competition. The June list further added 21 new applications of drugs that had never appeared before. These include bendamustine hydrochloride (to treat chronic lymphocytic leukemia), fluticasone propionate (to treat asthma), maraviroc (to treat HIV-1 infection in patients two years of age and older weighing at least 10 kilograms), carbamazepine (to treat epilepsy and bipolar I disorder), and posaconazole (an antifungal agent indicated for Aspergillus and Candida infections). There are two other drugs on the list – edaravone and riluzole – to treat amyotrophic lateral sclerosis (ALS) or Lou Gehrig’s disease (a neurological disorder).  Much like the June 2023 OPOE list, nearly one-third of the prescription drugs listed are injectables – 170 out of 499. There are 74 prescription entries for oral solid dosage forms (such as tablets, capsules and modified release forms). The June 2024 OPOE list has 57 OTC drugs, a tad shy of the 60 drugs in last year’s list. Among them are antihistamine drugs (used to treat allergies), cetirizine hydrochloride, nizatidine, famotidine, loratadine and anti-obesity medication orlistat. The list also had a newly listed drug, which is a combination of chlorpheniramine maleate, ibuprofen and pseudoephedrine hydrochloride for treating allergic sinusitis. Out of the 57 OTC drug products on the list, 18 are delivered as oral solid dosage forms. Access the Interactive Dashboard on FDA's June 2024 List of Off-Patent Drugs (Free Excel)  Novartis blockbusters lose exclusivity, Lupin wins FDA nod for copycat of Neurocrine’s bestseller This year, several large-selling drugs from drugmakers like Eisai, AbbVie, Gilead, Sanofi, Fresenius Kabi and others are due to face their first generic or biosimilar challengers in the US market. “First generics” are given for a first-to-file ANDA, for which there is no previously-approved ANDA by the FDA for the drug product. The agency considers first generics to be important to public health and prioritizes review of these submissions. First generics are eligible for a 180-day exclusivity period.  Three of Novartis’ drugs have lost exclusivity so far, this year. These include Promacta/Revolade (eltrombopag) used to treat thrombocytopenia (low platelet count). Promacta was approved in 2015 and saw sales of US$ 2.27 billion last year. Annora Pharma scored an FDA approval for eltrombopag’s first generic in April. Tasigna (nilotinib), the Swiss drugmaker’s oral treatment for Philadelphia chromosome-positive chronic myeloid leukemia (a kind of leukemia where patients have an abnormal chromosome in their blood cells called the Philadelphia chromosome), got its first generic in January, which was introduced by Apotex. Tasigna brought in sales of US$ 1.85 billion in 2023 and its sales are projected to plummet to US$ 79 million by 2029. Novartis’ Rydapt (midostaurin) for treating adult patients with newly diagnosed acute myeloid leukemia (AML) also lost exclusivity in April. Neurocrine Biosciences’ top-selling drug Ingrezza (valbenazine) was the first FDA-approved drug to treat tardive dyskinesia, a disorder that involves involuntary movements. It raked in US$ 1.84 billion in 2023, registering a year-on-year growth of 29 percent. In April, Lupin won FDA’s approval for the first generic of valbenazine capsules. Access the Interactive Dashboard on FDA's June 2024 List of Off-Patent Drugs (Free Excel)  Our view The Biden administration has been pushing hard to lower the price of prescription drugs. It is one of President Joe Biden’s central campaign promises this year. However, lowering drug prices is a bipartisan issue in the US. So whether a republican or a democrat takes over the US administration, making medicines affordable should remain a priority. In 2023, generic drugs accounted for US$ 424 billion of the US$ 1.6 trillion global pharmaceutical market. A determined FDA that is proactively looking to approve generic drugs will no doubt help this segment grow even further.  
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          NEWS #PharmaBuzz

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          Sandoz US launches generic paclitaxel in single-dose vial
          Sandoz US launches generic paclitaxel in single-dose vial

          11 Oct 2024

          // GLOBENEWSWIRE

          https://www.globenewswire.com/news-release/2024/10/11/2961786/0/en/Sandoz-US-launches-generic-paclitaxel-in-single-dose-vial-further-expanding-US-oncology-portfolio.html

          GLOBENEWSWIRE
          11 Oct 2024
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          Theriva Reaches VIRAGE Trial Enrollment For Pancreatic Cancer
          Theriva Reaches VIRAGE Trial Enrollment For Pancreatic Cancer

          23 Sep 2024

          // GLOBENEWSWIRE

          https://www.globenewswire.com/news-release/2024/09/23/2951321/0/en/Theriva-Biologics-Achieves-Target-Patient-Enrollment-in-the-VIRAGE-Phase-2b-Trial-of-VCN-01-with-Gemcitabine-nab-Paclitaxel-for-the-Treatment-of-Metastatic-Pancreatic-Cancer.html

          GLOBENEWSWIRE
          23 Sep 2024
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          Incyte's Retifanlimab Extends PFS In Anal Carcinoma At ESMO 2024
          Incyte's Retifanlimab Extends PFS In Anal Carcinoma At ESMO 2024

          14 Sep 2024

          // BUSINESSWIRE

          https://www.businesswire.com/news/home/20240914370391/en

          BUSINESSWIRE
          14 Sep 2024
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          Immuneering Reports Positive Phase 2a Data For IMM-1-104
          Immuneering Reports Positive Phase 2a Data For IMM-1-104

          12 Sep 2024

          // GLOBENEWSWIRE

          https://www.globenewswire.com/news-release/2024/09/12/2945572/0/en/Immuneering-Announces-Positive-Initial-Phase-2a-Data-Including-Complete-and-Partial-Responses-with-IMM-1-104-in-Combination-with-Chemotherapy-in-First-Line-Pancreatic-Cancer-Patien.html

          GLOBENEWSWIRE
          12 Sep 2024
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          CanariaBio Completes Enrollment For Oregovomab Phase 2 In Ovarian Cancer
          CanariaBio Completes Enrollment For Oregovomab Phase 2 In Ovarian Cancer

          23 Aug 2024

          // PR NEWSWIRE

          https://www.prnewswire.com/news-releases/canariabio-inc-announces-enrollment-completion-of-randomized-phase-2-study-of-oregovomab-in-combination-with-chemotherapy-as-neo-adjuvant-treatment-of-patients-with-advanced-ovarian-cancer-302228497.html

          PR NEWSWIRE
          23 Aug 2024
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          Compass Therapeutics Completes Enrollment For CTX-009 Study
          Compass Therapeutics Completes Enrollment For CTX-009 Study

          06 Aug 2024

          // GLOBENEWSWIRE

          https://www.globenewswire.com/news-release/2024/08/06/2925007/0/en/Compass-Therapeutics-Completes-Patient-Enrollment-in-COMPANION-002-a-Randomized-Study-of-CTX-009-in-Combination-with-Paclitaxel-and-Provides-an-Update-on-the-Development-Plan-in-Bi.html

          GLOBENEWSWIRE
          06 Aug 2024
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          Global Sales Information

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          Annual Reports

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          01

          Brand Name : Abraxane

          Paclitaxel Protein Bound

          arrow
          SupplySide West 2024
          Not Confirmed

          Brand Name : Abraxane

          U.S.A
          arrow
          SupplySide West 2024
          Not Confirmed

          Bristol Myers Squibb

          Paclitaxel Protein Bound

          Main Therapeutic Indication : Oncology

          Currency : USD

          2020 Revenue in Millions : 1,247

          2019 Revenue in Millions : 1,086

          Growth (%) : 15

          blank

          Portfolio PDF

          Product Web Link

          Virtual Booth

          Digital Content

          Website

          Corporate PDF

          02

          Brand Name : Abraxane

          Paclitaxel Protein Bound

          arrow
          SupplySide West 2024
          Not Confirmed

          Brand Name : Abraxane

          U.S.A
          arrow
          SupplySide West 2024
          Not Confirmed

          Bristol Myers Squibb

          Paclitaxel Protein Bound

          Main Therapeutic Indication : Oncology

          Currency : USD

          2021 Revenue in Millions : 1,181

          2020 Revenue in Millions : 1,247

          Growth (%) : -5

          blank

          Portfolio PDF

          Product Web Link

          Virtual Booth

          Digital Content

          Website

          Corporate PDF

          03

          Brand Name : Abraxane

          Paclitaxel Protein Bound

          arrow
          SupplySide West 2024
          Not Confirmed

          Brand Name : Abraxane

          Japan
          arrow
          SupplySide West 2024
          Not Confirmed

          Otsuka

          Paclitaxel Protein Bound

          Main Therapeutic Indication : Oncology

          Currency : USD

          2020 Revenue in Millions : 292

          2019 Revenue in Millions : 275

          Growth (%) : 6

          blank

          Portfolio PDF

          Product Web Link

          Virtual Booth

          Digital Content

          Website

          Corporate PDF

          04

          Brand Name : Abraxane

          Paclitaxel protein bound)

          arrow
          SupplySide West 2024
          Not Confirmed

          Brand Name : Abraxane

          China
          arrow
          SupplySide West 2024
          Not Confirmed

          Beigene

          Paclitaxel protein bound)

          Main Therapeutic Indication : Oncology

          Currency : USD

          2021 Revenue in Millions : 0

          2020 Revenue in Millions : 19

          Growth (%) : -100

          blank

          Portfolio PDF

          Product Web Link

          Virtual Booth

          Digital Content

          Website

          Corporate PDF

          05

          Brand Name : Abraxane

          Paclitaxel Protein Bound

          arrow
          SupplySide West 2024
          Not Confirmed

          Brand Name : Abraxane

          Japan
          arrow
          SupplySide West 2024
          Not Confirmed

          Otsuka

          Paclitaxel Protein Bound

          Main Therapeutic Indication : Oncology

          Currency : USD

          2021 Revenue in Millions : 242

          2020 Revenue in Millions : 280

          Growth (%) : -7

          blank

          Portfolio PDF

          Product Web Link

          Virtual Booth

          Digital Content

          Website

          Corporate PDF

          06

          Brand Name : Abraxane

          Paclitaxel Protein Bound

          arrow
          SupplySide West 2024
          Not Confirmed

          Brand Name : Abraxane

          U.S.A
          arrow
          SupplySide West 2024
          Not Confirmed

          Bristol Myers Squibb

          Paclitaxel Protein Bound

          Main Therapeutic Indication : Oncology

          Currency : USD

          2022 Revenue in Millions : 811

          2021 Revenue in Millions : 1,181

          Growth (%) : -31

          blank

          Portfolio PDF

          Product Web Link

          Virtual Booth

          Digital Content

          Website

          Corporate PDF

          07

          Brand Name : Abraxane

          Paclitaxel Protein Bound

          arrow
          SupplySide West 2024
          Not Confirmed

          Brand Name : Abraxane

          Japan
          arrow
          SupplySide West 2024
          Not Confirmed

          Otsuka

          Paclitaxel Protein Bound

          Main Therapeutic Indication : Oncology

          Currency : USD

          2022 Revenue in Millions : 153

          2021 Revenue in Millions : 242

          Growth (%) : -37

          blank

          Portfolio PDF

          Product Web Link

          Virtual Booth

          Digital Content

          Website

          Corporate PDF

          08

          Brand Name : Abraxane

          Paclitaxel Protein Bound

          arrow
          SupplySide West 2024
          Not Confirmed

          Brand Name : Abraxane

          U.S.A
          arrow
          SupplySide West 2024
          Not Confirmed

          Bristol Myers Squibb

          Paclitaxel Protein Bound

          Main Therapeutic Indication : Oncology

          Currency : USD

          2023 Revenue in Millions : 1,004

          2022 Revenue in Millions : 811

          Growth (%) : 24

          blank

          Portfolio PDF

          Product Web Link

          Virtual Booth

          Digital Content

          Website

          Corporate PDF

          09

          Brand Name : Abraxane

          Paclitaxel Protein Bound

          arrow
          SupplySide West 2024
          Not Confirmed

          Brand Name : Abraxane

          Japan
          arrow
          SupplySide West 2024
          Not Confirmed

          Otsuka

          Paclitaxel Protein Bound

          Main Therapeutic Indication : Oncology

          Currency : USD

          2023 Revenue in Millions : 213

          2022 Revenue in Millions : 153

          Growth (%) : 58

          blank

          Portfolio PDF

          Product Web Link

          Virtual Booth

          Digital Content

          Website

          Corporate PDF

          10

          Brand Name : Abraxane

          Paclitaxel protein-bound

          arrow
          SupplySide West 2024
          Not Confirmed

          Brand Name : Abraxane

          U.S.A
          arrow
          SupplySide West 2024
          Not Confirmed

          Celgene Corpoartion

          Paclitaxel protein-bound

          Main Therapeutic Indication : Oncology

          Currency : USD

          2015 Revenue in Millions : 848

          2014 Revenue in Millions : 968

          Growth (%) : 14%

          blank

          Portfolio PDF

          Product Web Link

          Virtual Booth

          Digital Content

          Website

          Corporate PDF

          Only 10 entries up to this point, click to access all click full view read-more
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          APIs

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          india-flag.png
          Injectable Grade Paclitaxel (45 kg - 50 kg/ annum) API needed in India [ENA20982]
          A company that focuses on research, development and manufacturing of APIs and FDFs is looking for suppliers of Injectable Grade Paclitaxel (45 kg - 50 kg/ annum) API for commercial purposes. The suppliers must support this enquiry with USDMF, GMP & CoA.
          29 Oct 2024

          Reply

          29 Oct 2024

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          Reply Comment (1)

          29 Oct 2024

          United_States_of_America.png
          Paclitaxel API needed in the U.S.A [ENA20051]
          A company specializing in contract research and development, with a focus on offering services for the development of pharmaceutical products is looking for suppliers of Paclitaxel API for development purposes. The suppliers must support this enquiry with USDMF & CoA.
          20 Jul 2024

          Reply

          20 Jul 2024

          Reply text-arrow

          Reply Comment (3)

          20 Jul 2024

          india-flag.png
          Paclitaxel (25 kg) API needed in India [ENA19503]
          A company that focuses on research, development & manufacturing of oral solid, parenteral and topical finished formulations is looking for suppliers of Paclitaxel (25 kg) API for both development & commercial purposes. The suppliers must support this enquiry with DMF & CoA.
          13 May 2024

          Reply

          13 May 2024

          Reply text-arrow

          Reply Comment (3)

          13 May 2024

          india-flag.png
          Paclitaxel (1 kg - 3 kg) API needed in India [ENA19385]
          A company that focuses on manufacturing and development of active pharmaceutical ingredients and finished formulations in Oncology, Critical care, Gynecology & Neurology therapeutic segments is looking for suppliers of Paclitaxel (1 kg - 3 kg) API for development purposes. The suppliers must support this enquiry with USDMF, EDMF/CEP & CoA.
          19 Apr 2024

          Reply

          19 Apr 2024

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          Reply Comment (5)

          19 Apr 2024

          United_States_of_America.png
          Paclitaxel API needed in U.S.A [ENA19108]
          A company that focuses on development of first in class RNA therapeutics as well as small molecule drugs against cancer and infectious diseases is looking for suppliers of Paclitaxel API for development purposes. The suppliers must support this enquiry with DMF, USFDA & CoA.
          28 Feb 2024

          Reply

          28 Feb 2024

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          Reply Comment (6)

          28 Feb 2024

          Brazil.png
          Paclitaxel API needed in Brazil [ENA19047]
          A company that focuses on manufacturing, development and distribution of various cardiovascular medical devices is looking for suppliers of Paclitaxel API for development purposes. The required quantity is MOQ. The suppliers must support this enquiry with GMP & CoA.
          15 Feb 2024

          Reply

          15 Feb 2024

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          Reply Comment (7)

          15 Feb 2024

          india-flag.png
          Paclitaxel (0.1 kg) API needed in India [ENA18964]
          A company that focuses on fostering improved quantity, quality, and dependability of production systems and basic cereals such as maize, wheat, triticale, sorghum, millets, and associated crops through applied agricultural science is looking for suppliers of Paclitaxel (0.1 kg) for development purposes. The suppliers must support this enquiry with CoA.
          29 Jan 2024

          Reply

          29 Jan 2024

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          Reply Comment (3)

          29 Jan 2024

          Netherlands1.png
          Paclitaxel (20 kg) API needed in Netherlands [ENA18692]
          A company that focuses on manufacturing of generic medicines is looking for suppliers of Paclitaxel (20 kg) API for commercial purposes. The suppliers must support this enquiry with USDMF, EUDMF, JDMF, Canada DMF, CEP & CoA.
          28 Nov 2023

          Reply

          28 Nov 2023

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          Reply Comment (8)

          28 Nov 2023

          Belarus.png
          Various APIs needed in Belarus [ENA17152]
          A company that focuses on the manufacturing of tablets, capsules, liquids and injectables is looking for suppliers of Various APIs for both development & commercial purposes. The suppliers must support this enquiry with DMF & CoA. 1. Docetaxel (10 kg/ annum) API 2. Cabazitaxel (200 g/ annum) API 3. Oxaliplatin (30 kg/ annum) API 4. Gemcitabine (100 kg/ annum) API 5. Eribulin (200 g/ annum) API 6. Paclitaxel (40 kg/ annum) API 7. Carfilzomib (1 kg/ annum) API 8. Pemetrexed (5 kg/ annum) API 9. Irinotecan (20 kg/ annum) API 10. Carboplatin (90 kg/ annum) API 11. Axitinib (2 kg/ annum) API 12. Cabozantinib (11 kg/ annum) API 13. Vemurafenib (150 kg/ annum) API 14. Cobimetinib (3 kg/ annum) API 15. Tofacitinib (20 kg/ annum) API
          24 May 2023

          Reply

          24 May 2023

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          Reply Comment (14)

          24 May 2023

          Malaysia.png
          Various APIs needed in Malaysia [ENA15839]
          A pharmaceutical company that focuses on research, development & manufacturing of complex, niche, technology-intensive and highly technical generics for all therapeutic areas is looking for suppliers of Various APIs for development purposes. The suppliers must support this enquiry with CoA. 1. Paclitaxel API 2. Azacitidine API 3. Bendamustine HCl API 4. Bortezomib API 5. Deferoxamine Mesylate API 6. Pemetrexed Disodium Heptahydrate API 7. Docetaxel Trihydrate API 8. Fulvestrant API
          16 Dec 2022

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          16 Dec 2022

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          Reply Comment (15)

          16 Dec 2022

          Only 10 entries up to this point, click to access all click full view read-more
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          FDF DOSSIERS

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          india-flag.png
          Various RLDs needed in India [ENA19217]
          A CDMO that focuses on the development, manufacturing & marketing of niche finished formulations is looking for suppliers of Various RLDs for commercial purposes. 1. Paclitaxel (100 mg/ ml) Injection - Acopacli Na 100 mg. The required quantity is 1 Unit. 2. Dasatinib (100 mg) Tablet - Asatinib 100 Mg. The required quantity is 30 Units. 3. Dasatinib (50 mg) Tablet - Asatinib 50 Mg. The required quantity is 60 Units. 4. Lenvatinib (4 mg) Capsules - Lentinib 4 mg. The required quantity is 30 Units. 5. Lenvatinib (10 mg) Capsules - Lentinib 10 mg. The required quantity is 30 Units. 6. Abiraterone Acetate (250 mg) Tablet - Acobirate 250mg. The required quantity is 120 Units.
          19 Mar 2024

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          19 Mar 2024

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          Reply Comment (2)

          19 Mar 2024

          Italy.png
          Various Finished Dosage Formulation needed in Italy [ENA18853]
          A CMO that focuses on manufacturing of penicillin and cephalosporins finished formulations is looking for suppliers of various finished dosage formulation for commercial purposes. The supplier must support this enquiry with EUCTD. 1. Docetaxel (20 mg/ 2ml) Injection 2. Docetaxel (80 mg/ 4 ml) Injection 3. Docetaxel (160 mg/ 8 ml) Injection 4. Epirubicin (10 mg/ 5 ml) Injection 5. Epirubicin (50 mg/ 25 ml) Injection 6. Epirubicin (200 mg/ 100 ml) Injection 7. Irinotecan (20 mg/ ml) Injection 8. Paclitaxel (30 mg/ 5 ml) Injection 9. Paclitaxel (100 mg/ 7 ml) Injection 10. Paclitaxel (300 mg/ 50 ml) Injection
          03 Jan 2024

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          03 Jan 2024

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          Reply Comment (5)

          03 Jan 2024

          Brazil.png
          Various Finished Dosage Formulations needed in Brazil [ENA16235]
          A company that deals in the research, development & trading of health products is looking for suppliers of Various Finished Dosage Formulations for commercial purposes. The suppliers must support this enquiry with CTD Dossier. 1. Pembrolizumab (100 mg) Injections 2. Paclitaxel (6 mg, 30 mg, 100 mg, 150 mg & 300 mg) Injections 3. Nivolumab (40 mg & 100 mg) Injections 4. Oxaliplatin (5 mg, 50 mg & 100 mg) Injections 5. Bevacizumab (25 mg) Injections
          28 Jan 2023

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          28 Jan 2023

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          Reply Comment (9)

          28 Jan 2023

          CzechRepublic.png
          Tender// Various Finished Dosage Formulations needed in Czech Republic [ENA15430]
          Masaryk Institute of Oncology is looking for supplies of Various Finished Dosage Formulations for commercial purposes. The deadline is 21-Nov-2022. 1. Paclitaxel (100 mg) Injections. The required quantity is 2,500 units. 2. Tamoxifen (20 mg) Tablets. The required quantity is 8,000 units. 3. Abiraterone (500 mg) Tablets. The required quantity is 1,500 units.
          31 Oct 2022

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          31 Oct 2022

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          Reply Comment (7)

          31 Oct 2022

          Bulgaria.png
          Tender// Various Finished Dosage Formulations needed in Bulgaria [ENA15105]
          Spetsializirana Bolnitsa Za Aktivno Lechenie Na Onkologichni Zabolyavaniya "Prof. Dr Marin Mushmov" Eood is looking for supplies of Various Finished Dosage Formulations for commercial purpose. The deadline is 17-Oct-2022. 1. Paclitaxel (100 mg) Powder for Dispersion for Infusions. The required quantity is 190,000 units. 2. Imatinib (100 mg) Film Coated Tablets. The required quantity is 1,360,800 units.
          23 Sep 2022

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          23 Sep 2022

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          Reply Comment (5)

          23 Sep 2022

          Bulgaria.png
          Tender// Various Finished Dosage Formulations needed in Bulgaria [ENA13393]
          Specialized Hospital For Active Treatment in Oncology - Haskovo Eood is looking for supplies of Various Finished Dosage Formulations for commercial purpose. The deadline is 16-May-2022. 1. Mannitol (15% in 500 ml) Solution for Infusions. The required quantity is 150,000 units. 2. Paclitaxel (6 mg/ ml in 16.7 ml) Concentrate for Solution for Infusions. The required quantity is 100,000 units.
          21 Apr 2022

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          21 Apr 2022

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          Reply Comment (5)

          21 Apr 2022

          VietNam.png
          Various Finished Dosage Formulations needed in Vietnam [ENA12692]
          A company that deals in the distribution of a wide range of products in allopathic formulations, herbal formulations, nutraceuticals, vaccines and orthopedic implants is looking for suppliers of Various Finished Dosage Formulations for commercial purpose. The required quantity is 500,000 units for each. 1. Naproxen (375 mg & 500 mg) + Esomeprazole (20 mg) Tablets. 2. Sodium Carboxymethyl Cellulose (0.50%) Eye Drops. 3. Sodium Carboxymethyl Cellulose (5 mg/ ml) + Glycerin (9 mg/ ml) Eye Drops. 4. Paclitaxel (6 mg/ ml, 100 mg/ 16.67 ml & 30 mg/ 5 ml) Injections or Infusions.
          14 Feb 2022

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          14 Feb 2022

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          Reply Comment (6)

          14 Feb 2022

          Brazil.png
          Various Finished Dosage Formulations needed in Brazil [ENA12424]
          A company that deals in the research, development & trading of health products is looking for suppliers of Various Finished Dosage Formulations for commercial purpose. The suppliers must support this enquiry with CTD Dossier, ANVISA, DMF & PIC/s GMP. 1. Semaglutide (4 mg in 3 ml & 2 mg in 1.5 ml) Prefilled Syringes. The required quantity is 1 million units & 500,000 units respectively. 2. Liraglutide (6 mg in 3 ml & 6 mg in 2 ml) Prefilled Syringes. The required quantity is 1 million units for each. 3. Paclitaxel (100 mg in 16.7 ml & 300 mg in 50 ml) Prefilled Syringes. The required quantity is 5 million units for each. 4. Rivaroxaban (20 mg, 15 mg & 10 mg) Coated Tablets. The required quantity is 100 million units, 80 million units & 70 million units respectively. 5. Nivolumab (100 mg in 10 ml & 40 mg in 4 ml) IV Solution. The required quantity is 200 million units & 100 million units respectively.
          17 Jan 2022

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          17 Jan 2022

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          Reply Comment (8)

          17 Jan 2022

          Sweden.png
          Tender// Paclitaxel (5 mg/ ml) Infusions needed in Sweden [ENA12082]
          Region Uppsala is looking for supplies of Paclitaxel (5 mg/ ml) Infusions for commercial purpose. The required quantity is 2,016 units. The deadline is 10-Jan-2022.
          10 Dec 2021

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          10 Dec 2021

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          Reply Comment (5)

          10 Dec 2021

          Poland.png
          Tender// Various Finished Dosage Formulations needed in Poland [ENA11713]
          Provincial Zespol Szpital im. dr. Roman Ostrzycki in Konin is looking for supplies of Various Finished Dosage Formulations for commercial purpose. The deadline is 22-Nov-2021. 1. Olaparib (100 mg & 150 mg) Capsules. The required quantity is 1,680 units & 5,840 units respectively. 2. Capecitabine (150 mg & 500 mg) Tablets. The required quantity is 4,320 units & 10,320 units respectively. 3. Thalidomide (100 mg) Capsules. The required quantity is 7,710 units. 4. Paclitaxel (300 mg & 100 mg) Infusions. The required quantity is 81,000 units & 27,000 units respectively.
          22 Oct 2021

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          22 Oct 2021

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          22 Oct 2021

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