DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

Contact Supplier

Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

4 API Suppliers, 1 USDMF, 2 JDMF, 1 NDC API, 1 Listed Suppliers

4 API Suppliers
1 USDMF
2 JDMF
1 NDC API
1 Listed Suppliers

FINISHED DOSAGE FORMULATIONS

19 FDF Dossiers, 1 FDA Orange Book, 15 Europe, 1 Canada, 2 Australia

19 FDF Dossiers
1 FDA Orange Book
15 Europe
1 Canada
2 Australia

RELATED EXCIPIENT COMPANIES

1 Rochem International Inc, 2 SPI Pharma, 1 Gangwal Healthcare, 1 Nanjing Well Pharmaceutical, 3 Actylis, 1 Finar, 11 Roquette, 1 Shijiazhuang Huaxu Pharmaceutical, 1 Zhejiang Huakang Pharmaceutical

relatedExcipients
1 Rochem International Inc
2 SPI Pharma
1 Gangwal Healthcare
1 Nanjing Well Pharmaceutical
3 Actylis
1 Finar
11 Roquette
1 Shijiazhuang Huaxu Pharmaceutical
1 Zhejiang Huakang Pharmaceutical

EXCIPIENTS BY APPLICATIONS

9 Film Formers & Plasticizers, 4 Coating Systems & Additives, 4 Parenteral, 4 Fillers, Diluents & Binders, 4 Taste Masking, 2 Chewable & Orodispersible Aids, 2 Solubilizers, 1 Soft Gelatin, 1 Co-Processed Excipients, 1 Direct Compression

excipientsByApplications
9 Film Formers & Plasticizers
4 Coating Systems & Additives
4 Parenteral
4 Fillers, Diluents & Binders
4 Taste Masking
2 Chewable & Orodispersible Aids
2 Solubilizers
1 Soft Gelatin
1 Co-Processed Excipients
1 Direct Compression

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow

media
1 DATA COMPILATION #PharmaFlow

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 4 Finished Drug Prices

globalSalesInformation
1 US Medicaid Prescriptions
4 Finished Drug Prices

MARKET PLACE

1 APIs

marketPlace
1 APIs

PATENTS & EXCLUSIVITIES

1 Health Canada Patents

patents
1 Health Canada Patents

REF. STANDARDS & IMPURITIES

1 Others

otherSolutions
1 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

211,702

Annual Reports (USD Million)

Finished Drug Prices

22 RELATED EXCIPIENT COMPANIES

32EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: Nafarelin acetate hydrate (jan), Synarel (tn), Chebi:7446, Bcp19032, Ft-0642036, D00990

Molecular Formula

C₆₈H₈₉N₁₇O₁₆

Molecular Weight

1400.5 g/mol

InChI Key

FSBTYDWUUWLHBD-UHFFFAOYSA-N

1 2D Structure

Nafarelin Acetate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

acetic acid;N-[1-[[1-[[1-[[1-[[1-[[1-[[1-[2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide;hydrate

2.1.2 InChI

InChI=1S/C66H83N17O13.C2H4O2.H2O/c1-36(2)25-48(58(89)76-47(13-7-23-71-66(68)69)65(96)83-24-8-14-54(83)64(95)73-33-55(67)86)77-60(91)50(28-38-15-18-39-9-3-4-10-40(39)26-38)78-59(90)49(27-37-16-19-43(85)20-17-37)79-63(94)53(34-84)82-61(92)51(29-41-31-72-45-12-6-5-11-44(41)45)80-62(93)52(30-42-32-70-35-74-42)81-57(88)46-21-22-56(87)75-46;1-2(3)4;/h3-6,9-12,15-20,26,31-32,35-36,46-54,72,84-85H,7-8,13-14,21-25,27-30,33-34H2,1-2H3,(H2,67,86)(H,70,74)(H,73,95)(H,75,87)(H,76,89)(H,77,91)(H,78,90)(H,79,94)(H,80,93)(H,81,88)(H,82,92)(H4,68,69,71);1H3,(H,3,4);1H2

2.1.3 InChI Key

FSBTYDWUUWLHBD-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NCC(=O)N)NC(=O)C(CC2=CC3=CC=CC=C3C=C2)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CC7=CN=CN7)NC(=O)C8CCC(=O)N8.CC(=O)O.O

2.2 Synonyms

2.2.1 Depositor-Supplied Synonyms

1. Nafarelin Acetate Hydrate (jan)

2. Synarel (tn)

3. Chebi:7446

4. Bcp19032

5. Ft-0642036

6. D00990

7. Rs 94991 298;rs-94991-298;rs94991298

2.3 Create Date

2008-12-10

3 Chemical and Physical Properties

Molecular Formula	C₆₈H₈₉N₁₇O₁₆
Molecular Weight	1400.5 g/mol
Hydrogen Bond Donor Count	18
Hydrogen Bond Acceptor Count	18
Rotatable Bond Count	33
Exact Mass	1399.66731982 g/mol
Monoisotopic Mass	1399.66731982 g/mol
Topological Polar Surface Area	513 Å²
Heavy Atom Count	101
Formal Charge	0
Complexity	2760
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	9
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Synarel
PubMed Health	Nafarelin (Into the nose)
Drug Classes	Endocrine-Metabolic Agent
Drug Label	SYNAREL (nafarelin acetate) Nasal Solution is intended for administration as a spray to the nasal mucosa. Nafarelin acetate, the active component of SYNAREL Nasal Solution, is a decapeptide with the chemical name: 5-oxo-L-prolyl-L-histidyl-L-tryptoph...
Active Ingredient	Nafarelin acetate
Dosage Form	Spray, metered
Route	Nasal
Strength	eq 0.2mg base/spray
Market Status	Prescription
Company	Gd Searle

2 of 2
Drug Name	Synarel
PubMed Health	Nafarelin (Into the nose)
Drug Classes	Endocrine-Metabolic Agent
Drug Label	SYNAREL (nafarelin acetate) Nasal Solution is intended for administration as a spray to the nasal mucosa. Nafarelin acetate, the active component of SYNAREL Nasal Solution, is a decapeptide with the chemical name: 5-oxo-L-prolyl-L-histidyl-L-tryptoph...
Active Ingredient	Nafarelin acetate
Dosage Form	Spray, metered
Route	Nasal
Strength	eq 0.2mg base/spray
Market Status	Prescription
Company	Gd Searle