Find Nafithromycin manufacturers, exporters & distributors on PharmaCompass

Nafithromycin

Granules India Limited has high volume world-class facilities for APIs, PFIs, & FDFs, serving customers in over 80 countries.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

$ API Reference Price

$ API Reference Price

DEVELOPMENTS

2 Drugs in Development

2 Drugs in Development

DIGITAL CONTENT

1 NEWS #PharmaBuzz

media
1 NEWS #PharmaBuzz

MARKET PLACE

1 APIs

marketPlace
1 APIs

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: Nafithromycin [inn], 75f74y2r70, 1691240-78-4, Wck 4873, Chembl4297519, Unii-75f74y2r70

Molecular Formula

C₄₂H₆₂N₆O₁₁S

Molecular Weight

859.0 g/mol

InChI Key

RLFCSBSRGRJFRO-QAOQTAGDSA-N

FDA UNII

75F74Y2R70

1 2D Structure

Nafithromycin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(1S,2R,5R,7R,8R,9R,11R,13R,14S,15R)-8-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-9-methoxy-1,5,7,9,11,13-hexamethyl-4,6,12,16-tetraoxo-N'-[(1S)-1-(5-pyridin-2-yl-1,3,4-thiadiazol-2-yl)ethoxy]-3,17-dioxabicyclo[12.3.0]heptadecane-15-carboximidamide

2.1.2 InChI

InChI=1S/C42H62N6O11S/c1-13-28-42(9)30(29(39(53)58-42)35(43)47-59-25(7)36-45-46-37(60-36)26-16-14-15-17-44-26)22(4)31(49)20(2)19-41(8,54-12)34(23(5)32(50)24(6)38(52)56-28)57-40-33(51)27(48(10)11)18-21(3)55-40/h14-17,20-25,27-30,33-34,40,51H,13,18-19H2,1-12H3,(H2,43,47)/t20-,21-,22-,23+,24-,25+,27+,28-,29-,30+,33-,34-,40+,41-,42-/m1/s1

2.1.3 InChI Key

RLFCSBSRGRJFRO-QAOQTAGDSA-N

2.1.4 Canonical SMILES

CCC1C2(C(C(C(=O)C(CC(C(C(C(=O)C(C(=O)O1)C)C)OC3C(C(CC(O3)C)N(C)C)O)(C)OC)C)C)C(C(=O)O2)C(=NOC(C)C4=NN=C(S4)C5=CC=CC=N5)N)C

2.1.5 Isomeric SMILES

CC[C@@H]1[C@@]2([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H](C(=O)[C@H](C(=O)O1)C)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)[C@@H](C(=O)O2)/C(=N/O[C@@H](C)C4=NN=C(S4)C5=CC=CC=N5)/N)C

2.2 Other Identifiers

2.2.1 UNII

75F74Y2R70

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Wck 4873

2.3.2 Depositor-Supplied Synonyms

1. Nafithromycin [inn]

2. 75f74y2r70

3. 1691240-78-4

4. Wck 4873

5. Chembl4297519

6. Unii-75f74y2r70

7. (3r,31z,3as,4r,6r,8r,9r,10r,12r,15r,15as)-15-ethyl-8-methoxy-4,6,8,10,12,15a-hexamethyl-2,5,11,13-tetraoxo-n'-((1s)-1-(5-(pyridin-2-yl)-1,3,4-thiadiazol-2-yl)ethoxy)-9-((3,4,6-trideoxy-3-(dimethylamino)-.beta.-d-xylohexopyranosyl)oxy)tetradecahydro-2h-furo(2,3-c)oxacyclotetradecine-3-carboximidamide

8. (3r,31z,3as,4r,6r,8r,9r,10r,12r,15r,15as)-15-ethyl-8-methoxy-4,6,8,10,12,15a-hexamethyl-2,5,11,13-tetraoxo-n'-((1s)-1-(5-(pyridin-2-yl)-1,3,4-thiadiazol-2-yl)ethoxy)-9-((3,4,6-trideoxy-3-(dimethylamino)-beta-d-xylohexopyranosyl)oxy)tetradecahydro-2

9. 2h-furo(2,3-c)oxacyclotetradecin-3-carboximidamide, 15-ethyltetradecahydro-8-methoxy-4,6,8,10,12,15a-hexamethyl-2,5,11,13-tetraoxo-n'-((1s)-1-(5-(2-pyridinyl)-1,3,4-thiadiazol-2-yl)ethoxy)-9-((3,4,6-trideoxy-3-(dimethylamino)-.beta.-d-xylo-hexopyranosyl)oxy)-, (c(z),3r,3as,4r,6r,8r,9r,10r,12r,15r,15as)-

10. 2h-furo(2,3-c)oxacyclotetradecin-3-carboximidamide, 15-ethyltetradecahydro-8-methoxy-4,6,8,10,12,15a-hexamethyl-2,5,11,13-tetraoxo-n'-((1s)-1-(5-(2-pyridinyl)-1,3,4-thiadiazol-2-yl)ethoxy)-9-((3,4,6-trideoxy-3-(dimethylamino)-beta-d-xylo-hexopyrano

2.4 Create Date

2016-02-16

3 Chemical and Physical Properties

Molecular Formula	C₄₂H₆₂N₆O₁₁S
Molecular Weight	859.0 g/mol
XLogP3	4.5
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	17
Rotatable Bond Count	10
Exact Mass	858.41972799 g/mol
Monoisotopic Mass	858.41972799 g/mol
Topological Polar Surface Area	252 Å²
Heavy Atom Count	60
Formal Charge	0
Complexity	1580
Isotope Atom Count	0
Defined Atom Stereocenter Count	15
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

Protein Synthesis Inhibitors

Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins. (See all compounds classified as Protein Synthesis Inhibitors.)

Drugs in Development