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Synopsis

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Chemistry

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Also known as: Nafithromycin [inn], 75f74y2r70, 1691240-78-4, Wck 4873, Chembl4297519, Unii-75f74y2r70
Molecular Formula
C42H62N6O11S
Molecular Weight
859.0  g/mol
InChI Key
RLFCSBSRGRJFRO-QAOQTAGDSA-N
FDA UNII
75F74Y2R70

Nafithromycin
1 2D Structure

Nafithromycin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(1S,2R,5R,7R,8R,9R,11R,13R,14S,15R)-8-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-9-methoxy-1,5,7,9,11,13-hexamethyl-4,6,12,16-tetraoxo-N'-[(1S)-1-(5-pyridin-2-yl-1,3,4-thiadiazol-2-yl)ethoxy]-3,17-dioxabicyclo[12.3.0]heptadecane-15-carboximidamide
2.1.2 InChI
InChI=1S/C42H62N6O11S/c1-13-28-42(9)30(29(39(53)58-42)35(43)47-59-25(7)36-45-46-37(60-36)26-16-14-15-17-44-26)22(4)31(49)20(2)19-41(8,54-12)34(23(5)32(50)24(6)38(52)56-28)57-40-33(51)27(48(10)11)18-21(3)55-40/h14-17,20-25,27-30,33-34,40,51H,13,18-19H2,1-12H3,(H2,43,47)/t20-,21-,22-,23+,24-,25+,27+,28-,29-,30+,33-,34-,40+,41-,42-/m1/s1
2.1.3 InChI Key
RLFCSBSRGRJFRO-QAOQTAGDSA-N
2.1.4 Canonical SMILES
CCC1C2(C(C(C(=O)C(CC(C(C(C(=O)C(C(=O)O1)C)C)OC3C(C(CC(O3)C)N(C)C)O)(C)OC)C)C)C(C(=O)O2)C(=NOC(C)C4=NN=C(S4)C5=CC=CC=N5)N)C
2.1.5 Isomeric SMILES
CC[C@@H]1[C@@]2([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H](C(=O)[C@H](C(=O)O1)C)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)[C@@H](C(=O)O2)/C(=N/O[C@@H](C)C4=NN=C(S4)C5=CC=CC=N5)/N)C
2.2 Other Identifiers
2.2.1 UNII
75F74Y2R70
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Wck 4873

2.3.2 Depositor-Supplied Synonyms

1. Nafithromycin [inn]

2. 75f74y2r70

3. 1691240-78-4

4. Wck 4873

5. Chembl4297519

6. Unii-75f74y2r70

7. (3r,31z,3as,4r,6r,8r,9r,10r,12r,15r,15as)-15-ethyl-8-methoxy-4,6,8,10,12,15a-hexamethyl-2,5,11,13-tetraoxo-n'-((1s)-1-(5-(pyridin-2-yl)-1,3,4-thiadiazol-2-yl)ethoxy)-9-((3,4,6-trideoxy-3-(dimethylamino)-.beta.-d-xylohexopyranosyl)oxy)tetradecahydro-2h-furo(2,3-c)oxacyclotetradecine-3-carboximidamide

8. (3r,31z,3as,4r,6r,8r,9r,10r,12r,15r,15as)-15-ethyl-8-methoxy-4,6,8,10,12,15a-hexamethyl-2,5,11,13-tetraoxo-n'-((1s)-1-(5-(pyridin-2-yl)-1,3,4-thiadiazol-2-yl)ethoxy)-9-((3,4,6-trideoxy-3-(dimethylamino)-beta-d-xylohexopyranosyl)oxy)tetradecahydro-2

9. 2h-furo(2,3-c)oxacyclotetradecin-3-carboximidamide, 15-ethyltetradecahydro-8-methoxy-4,6,8,10,12,15a-hexamethyl-2,5,11,13-tetraoxo-n'-((1s)-1-(5-(2-pyridinyl)-1,3,4-thiadiazol-2-yl)ethoxy)-9-((3,4,6-trideoxy-3-(dimethylamino)-.beta.-d-xylo-hexopyranosyl)oxy)-, (c(z),3r,3as,4r,6r,8r,9r,10r,12r,15r,15as)-

10. 2h-furo(2,3-c)oxacyclotetradecin-3-carboximidamide, 15-ethyltetradecahydro-8-methoxy-4,6,8,10,12,15a-hexamethyl-2,5,11,13-tetraoxo-n'-((1s)-1-(5-(2-pyridinyl)-1,3,4-thiadiazol-2-yl)ethoxy)-9-((3,4,6-trideoxy-3-(dimethylamino)-beta-d-xylo-hexopyrano

2.4 Create Date
2016-02-16
3 Chemical and Physical Properties
Molecular Weight 859.0 g/mol
Molecular Formula C42H62N6O11S
XLogP34.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count17
Rotatable Bond Count10
Exact Mass858.41972799 g/mol
Monoisotopic Mass858.41972799 g/mol
Topological Polar Surface Area252 Ų
Heavy Atom Count60
Formal Charge0
Complexity1580
Isotope Atom Count0
Defined Atom Stereocenter Count15
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


Protein Synthesis Inhibitors

Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins. (See all compounds classified as Protein Synthesis Inhibitors.)


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Looking for 1691240-78-4 / Nafithromycin API manufacturers, exporters & distributors?

Nafithromycin manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Nafithromycin API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Nafithromycin manufacturer or Nafithromycin supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Nafithromycin manufacturer or Nafithromycin supplier.

PharmaCompass also assists you with knowing the Nafithromycin API Price utilized in the formulation of products. Nafithromycin API Price is not always fixed or binding as the Nafithromycin Price is obtained through a variety of data sources. The Nafithromycin Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Nafithromycin

Synonyms

Nafithromycin [inn], 75f74y2r70, 1691240-78-4, Wck 4873, Chembl4297519, Unii-75f74y2r70

Cas Number

1691240-78-4

Unique Ingredient Identifier (UNII)

75F74Y2R70

Nafithromycin Manufacturers

A Nafithromycin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Nafithromycin, including repackagers and relabelers. The FDA regulates Nafithromycin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Nafithromycin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Nafithromycin Suppliers

A Nafithromycin supplier is an individual or a company that provides Nafithromycin active pharmaceutical ingredient (API) or Nafithromycin finished formulations upon request. The Nafithromycin suppliers may include Nafithromycin API manufacturers, exporters, distributors and traders.

Nafithromycin GMP

Nafithromycin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Nafithromycin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Nafithromycin GMP manufacturer or Nafithromycin GMP API supplier for your needs.

Nafithromycin CoA

A Nafithromycin CoA (Certificate of Analysis) is a formal document that attests to Nafithromycin's compliance with Nafithromycin specifications and serves as a tool for batch-level quality control.

Nafithromycin CoA mostly includes findings from lab analyses of a specific batch. For each Nafithromycin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Nafithromycin may be tested according to a variety of international standards, such as European Pharmacopoeia (Nafithromycin EP), Nafithromycin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Nafithromycin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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