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Nafoxidine

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INTERMEDIATES

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Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: 1845-11-0, Nafoxidine [inn], Nafoxidinum [inn-latin], Nafoxidina [inn-spanish], 1-[2-[4-(6-methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy]ethyl]pyrrolidine, U-11000a

Molecular Formula

C₂₉H₃₁NO₂

Molecular Weight

425.6 g/mol

InChI Key

JEYWNNAZDLFBFF-UHFFFAOYSA-N

FDA UNII

4RIY10WM82

An estrogen antagonist that has been used in the treatment of breast cancer.

1 2D Structure

Nafoxidine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1-[2-[4-(6-methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy]ethyl]pyrrolidine

2.1.2 InChI

InChI=1S/C29H31NO2/c1-31-26-14-16-28-24(21-26)11-15-27(22-7-3-2-4-8-22)29(28)23-9-12-25(13-10-23)32-20-19-30-17-5-6-18-30/h2-4,7-10,12-14,16,21H,5-6,11,15,17-20H2,1H3

2.1.3 InChI Key

JEYWNNAZDLFBFF-UHFFFAOYSA-N

2.1.4 Canonical SMILES

COC1=CC2=C(C=C1)C(=C(CC2)C3=CC=CC=C3)C4=CC=C(C=C4)OCCN5CCCC5

2.2 Other Identifiers

2.2.1 UNII

4RIY10WM82

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Hydrochloride, Nafoxidine

2. Nafoxidine Hydrochloride

3. U 11,100a

4. U 11000a

5. U-11,100a

6. U-11000a

7. U11,100a

8. U11000a

2.3.2 Depositor-Supplied Synonyms

1. 1845-11-0

2. Nafoxidine [inn]

3. Nafoxidinum [inn-latin]

4. Nafoxidina [inn-spanish]

5. 1-[2-[4-(6-methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy]ethyl]pyrrolidine

6. U-11000a

7. Pyrrolidine, 1-(2-(4-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy)ethyl)-

8. Chembl28211

9. 4riy10wm82

10. Chebi:34881

11. Nsc 70735

12. 1-(2-(p-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthyl)phenoxy)ethyl)pyrrolidine

13. 1-(2-(4-(6-methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy)ethyl)pyrrolidine

14. 1-{2-[4-(6-methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy]ethyl}pyrrolidine

15. Pyrrolidine, 1-(2-(p-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthyl)phenoxy)ethyl)-

16. Pyrrolidine,1-[2-[4-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy]ethyl]-

17. Nafoxidina

18. Nafoxidinum

19. Nsc70735

20. Brn 1440873

21. Unii-4riy10wm82

22. Spectrum5_000222

23. Nafoxidine [who-dd]

24. 5-20-01-00210 (beilstein Handbook Reference)

25. Bidd:er0063

26. Schembl153125

27. 11100a (*hydrochloride*)

28. Gtpl4263

29. Dtxsid7022386

30. U 11100 (*hydrochloride*)

31. U 11100a (*hydrochloride*)

32. U-11100a (*hydrochloride*)

33. Zinc538045

34. Bdbm50065941

35. Ncgc00188970-01

36. 845n110

37. Q6958201

38. 1-(2-(4-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy)ethyl)pyrrolidine

39. 1-(2-[4-(6-methoxy-2-phenyl-3,4-dihydro-1-naphthalenyl)phenoxy]ethyl)pyrrolidine #

40. 1-{2-[4-(6-methoxy-2-phenyl-3,4-dihydro-naphthalen-1-yl)-phenoxy]-ethyl}-pyrrolidine

2.4 Create Date

2005-03-25

3 Chemical and Physical Properties

Molecular Formula	C₂₉H₃₁NO₂
Molecular Weight	425.6 g/mol
XLogP3	5.8
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	7
Exact Mass	425.235479232 g/mol
Monoisotopic Mass	425.235479232 g/mol
Topological Polar Surface Area	21.7 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	611
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Antineoplastic Agents, Hormonal

Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079) (See all compounds classified as Antineoplastic Agents, Hormonal.)

Estrogen Antagonists

Compounds which inhibit or antagonize the action or biosynthesis of estrogenic compounds. (See all compounds classified as Estrogen Antagonists.)

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ABOUT THIS PAGE

Nafoxidine Manufacturers

A Nafoxidine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Nafoxidine, including repackagers and relabelers. The FDA regulates Nafoxidine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Nafoxidine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Nafoxidine Suppliers

A Nafoxidine supplier is an individual or a company that provides Nafoxidine active pharmaceutical ingredient (API) or Nafoxidine finished formulations upon request. The Nafoxidine suppliers may include Nafoxidine API manufacturers, exporters, distributors and traders.

Nafoxidine GMP

Nafoxidine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Nafoxidine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Nafoxidine GMP manufacturer or Nafoxidine GMP API supplier for your needs.

Nafoxidine CoA

A Nafoxidine CoA (Certificate of Analysis) is a formal document that attests to Nafoxidine's compliance with Nafoxidine specifications and serves as a tool for batch-level quality control.

Nafoxidine CoA mostly includes findings from lab analyses of a specific batch. For each Nafoxidine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Nafoxidine may be tested according to a variety of international standards, such as European Pharmacopoeia (Nafoxidine EP), Nafoxidine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Nafoxidine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.