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Chemistry

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Also known as: Nalorphine hcl, 57-29-4, 9fpe56z2tw, Nalorphine hydrochloride ciii, Nalorphine hydrochloride [usp], Dea no. 9400
Molecular Formula
C19H22ClNO3
Molecular Weight
347.8  g/mol
InChI Key
NAHATSPWSULUAA-ZQGPYOJVSA-N
FDA UNII
9FPE56Z2TW

Nalorphine Hydrochloride
A narcotic antagonist with some agonist properties. It is an antagonist at mu opioid receptors and an agonist at kappa opioid receptors. Given alone it produces a broad spectrum of unpleasant effects and it is considered to be clinically obsolete.
1 2D Structure

Nalorphine Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(4R,4aR,7S,7aR,12bS)-3-prop-2-enyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol;hydrochloride
2.1.2 InChI
InChI=1S/C19H21NO3.ClH/c1-2-8-20-9-7-19-12-4-6-15(22)18(19)23-17-14(21)5-3-11(16(17)19)10-13(12)20;/h2-6,12-13,15,18,21-22H,1,7-10H2;1H/t12-,13+,15-,18-,19-;/m0./s1
2.1.3 InChI Key
NAHATSPWSULUAA-ZQGPYOJVSA-N
2.1.4 Canonical SMILES
C=CCN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O.Cl
2.1.5 Isomeric SMILES
C=CCN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3[C@H](C=C4)O.Cl
2.2 Other Identifiers
2.2.1 UNII
9FPE56Z2TW
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Allylnormorphine

2. Hydrobromide, Nalorphine

3. Hydrochloride, Nalorphine

4. Lethidrone

5. Nalorphine

6. Nalorphine Hydrobromide

7. Nalorphine, (14 Alpha)-isomer

8. Nalorphine, L-tartrate (1:1)

2.3.2 Depositor-Supplied Synonyms

1. Nalorphine Hcl

2. 57-29-4

3. 9fpe56z2tw

4. Nalorphine Hydrochloride Ciii

5. Nalorphine Hydrochloride [usp]

6. Dea No. 9400

7. Miromorfalil

8. (4r,4ar,7s,7ar,12bs)-3-prop-2-enyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol;hydrochloride

9. Nalorphine Hydrochloride (usp)

10. N-allylnormorphine Hydrochloride

11. Allylmorphine Hydrochloride

12. Ncgc00168255-01

13. Einecs 200-321-8

14. Normorphine, N-allyl-, Hydrochloride

15. Unii-9fpe56z2tw

16. N-allyl-2,12-dihydroxy-1,11-epoxymorphinene-13 Hydrochloride

17. 17-allyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol Hydrochloride

18. Dsstox_cid_27825

19. Dsstox_rid_82588

20. Nalline [veterinary] (tn)

21. Dsstox_gsid_47847

22. Cloridrato De Nalorfina (tn)

23. Schembl149571

24. Chembl1908349

25. Dtxsid3047847

26. Tox21_112614

27. Nalorphine Hydrochloride [mi]

28. Cas-57-29-4

29. Morphinan-3,6-alpha-diol, 17-allyl-7,8-didehydro-4,5-alpha-epoxy-, Hydrochloride

30. Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-(2-propenyl)-(5alpha,6alpha)-, Hydrochloride

31. Nalorphine Hydrochloride [mart.]

32. Nalorphine Hydrochloride [who-dd]

33. Nalorphinehydrochlorideciii(250mg)

34. Nalorphine Hydrochloride [green Book]

35. Nalorphine Hydrochloride Ciii [usp-rs]

36. D08248

37. Nalorphine Hydrochloride [usp Monograph]

38. Q27272499

39. Nalorphine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

40. 17-allyl-7,8-didehydro-4,5.alpha.-epoxymorphinan-3,6.alpha.-diol Hydrochloride

41. Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-(2-propenyl)-(5.alpha.,6.alpha.)-, Hydrochloride

42. Nalorphine Hydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 347.8 g/mol
Molecular Formula C19H22ClNO3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass347.1288213 g/mol
Monoisotopic Mass347.1288213 g/mol
Topological Polar Surface Area52.9 Ų
Heavy Atom Count24
Formal Charge0
Complexity549
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Narcotic Antagonists

Agents inhibiting the effect of narcotics on the central nervous system. (See all compounds classified as Narcotic Antagonists.)


ABOUT THIS PAGE

Nalorphine Hydrochloride Manufacturers

A Nalorphine Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Nalorphine Hydrochloride, including repackagers and relabelers. The FDA regulates Nalorphine Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Nalorphine Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Nalorphine Hydrochloride Suppliers

A Nalorphine Hydrochloride supplier is an individual or a company that provides Nalorphine Hydrochloride active pharmaceutical ingredient (API) or Nalorphine Hydrochloride finished formulations upon request. The Nalorphine Hydrochloride suppliers may include Nalorphine Hydrochloride API manufacturers, exporters, distributors and traders.

Nalorphine Hydrochloride GMP

Nalorphine Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Nalorphine Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Nalorphine Hydrochloride GMP manufacturer or Nalorphine Hydrochloride GMP API supplier for your needs.

Nalorphine Hydrochloride CoA

A Nalorphine Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Nalorphine Hydrochloride's compliance with Nalorphine Hydrochloride specifications and serves as a tool for batch-level quality control.

Nalorphine Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Nalorphine Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Nalorphine Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Nalorphine Hydrochloride EP), Nalorphine Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Nalorphine Hydrochloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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